2013, he scored in a 1–1 draw at home to Arsenal. After suffering a leg injury, Ramírez went on to score two more goals later in the season on 2 March 2013, in a 2–1 loss against Queens Park Rangers. and another on 13 April 2013, in a 1–1 draw against West Ham United. However, on 27 April, Ramírez was sent off for an incident involving West Bromwich Albion's Marc-Antoine Fortuné following an elbow on Shane Long. As a result, he was suspended for the last three matches of the season. Ramírez finished his first season at Southampton making twenty-two appearances and scoring five times. Ahead of the 2013–14 season, Ramírez was linked with a move to clubs around Europe, such as Atlético Madrid and Borussia Dortmund for around 15 million euros. However, Southampton ruled out selling Ramírez and were prepared to reject any bid for him. Ramírez eventually stayed at the club but by the second half of the season, he was featured less in the first team. Despite this, Ramírez scored two goals in the Football League Trophy against Barnsley and Bristol City. Ramírez then scored his first league goal of the season, in a 2–1 loss against Everton on 29 December 2013. However, on 23 January 2014, it was announced that along with Dejan Lovren, Ramírez would be out for six to eight weeks with ankle ligament damage. After being sidelined for six weeks, Ramírez made his return to the first team on 22 February 2014, coming on as a substitute in the 63rd minute, in a 3–1 loss against West Ham United. He finished the 2013–14 season with 18 appearances and scoring once for the club. Although he made one appearance in the 2014–15 season, in a 3–1 win against West Ham United on 30 August 2014, newly appointed manager Ronald Koeman was keen on using him in the first team, due to his playing style, and expressed reluctance to let him leave the club. After his loan spell at Hull City came to an end, Ramírez was told by manager Koeman he had no future at the club. In response to this, he showed that he wanted to leave Southampton by ripping up his contract in an attempt to return to Uruguay. Despite this, he made his first appearance for the club in a year, coming on as a substitute in a 6–0 win over