/ Madame Hydra appears in the X-Men: Evolution episode "Target X", voiced by Lisa Ann Beley. This version is the leader of HYDRA and is served by Gauntlet. She is apparently killed after her base is destroyed by X-23. Viper appears in The Avengers: Earth's Mightiest Heroes, voiced by Vanessa Marshall. While she does not make her first official appearance until the episode "Prisoner of War", a Skrull infiltrator disguised as Viper appears in the earlier episode "Widow's Sting", wherein they are captured by S.H.I.E.L.D. and their identity is exposed. In "Prisoner of War" and "Secret Invasion", the real Viper joins forces with Captain America and their fellow captives to escape from Skrull imprisonment and aid Earth's heroes in repelling a Skrull invasion. In "Along Came a Spider", Viper and King Cobra are captured by S.H.I.E.L.D., but are rescued by the Serpent Society and escape despite Captain America and Spider-Man's intervention. A variation of Ophelia / Madame Hydra appears in season four of Agents of S.H.I.E.L.D. as the Framework alias of the AI AIDA, portrayed by Mallory Jansen. Introduced in the episode "What If...?", she maintains the Framework, a virtual reality world of an alternate timeline ruled by HYDRA, and pursues a relationship with HYDRA's lead scientist the "Doctor", S.H.I.E.L.D. scientist Leo Fitz's Framework counterpart, to help her enact Project: Looking Glass, which will allow her to exist in the real world. Successfully enacting the project, Ophelia grants herself various powers, such as imperviousness to conventional forms of harm, and kidnaps Fitz. Taking advantage of her experiencing human emotions, he convinces Ophelia to rescue his teammates, though they are captured by Fitz's partner, Jemma Simmons. Learning Fitz loves Simmons instead of her, Ophelia escapes and joins forces with Anton Ivanov in the hopes of making S.H.I.E.L.D. suffer for the pain they caused her. As part of her plan, Ophelia attempts to retrieve the Darkhold, only to be stopped by Robbie Reyes, whose supernatural powers allow him to harm her. Using this, S.H.I.E.L.D. agent Phil Coulson borrows Reyes' powers to successfully destroy Ophelia. Film "Viper" appears in Nick Fury: Agent of S.H.I.E.L.D. as the alias of Andrea von Strucker, portrayed by Sandra Hess. Viper appears in 20th Century Fox's The Wolverine, portrayed by Svetlana Khodchenkova. Due to rights issues with Marvel Studios at the time, this version is never referred to as "Madame Hydra" nor is her affiliation with the organization