day for men. The view of consuming wine in moderation has a history recorded as early as the Greek poet Eubulus (360 BC) who believed that three bowls (kylix) were the ideal amount of wine to consume. The number of three bowls for moderation is a common theme throughout Greek writing; today the standard 750 ml wine bottle contains roughly the volume of three kylix cups (250 ml or 8 fl oz each). However, the kylix cups would have contained a diluted wine, at a 1:2 or 1:3 dilution with water. In his circa 375 BC play Semele or Dionysus, Eubulus has Dionysus say: Emerging evidence suggests that "even drinking within the recommended limits may increase the overall risk of death from various causes". A systematic analysis found that "The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0·0–0·8) standard drinks per week". As of 2022, "moderate" consumption is usually defined in average consumption per day while the patterns of consumption vary and may have implications for risks and effects on health (such as habituation from daily consumption or nonlinear dosage-harm associations from intermittent excessive alcohol use). According to the CDC, it would be important to focus on the amount people drink on the days that they drink. Effect on the body Bones Heavy alcohol consumption has been shown to have a damaging effect on the cellular processes that create bone tissue, and long-term alcoholic consumption at high levels increases the frequency of fractures. A 2012 study found no relation between wine consumption and BMD. Cancer The International Agency for Research on Cancer of the World Health Organization has classified alcohol as a Group 1 carcinogen. Cardiovascular system Professional cardiology associations recommend that people who are currently nondrinkers should abstain from drinking alcohol. Heavy drinkers have increased risk for heart disease, cardiac arrhythmias, hypertension, and elevated cholesterol levels. The alcohol in wine has anticoagulant properties that may limit blood clotting. Digestive system The risk of infection from the bacterium Helicobacter pylori, which is associated with gastritis and peptic ulcers, appears to be lower with moderate alcohol consumption. Headaches There are several potential causes of so-called "red wine headaches", including histamine and tannins from grape skin or other phenolic compounds in wine. Sulfites – which are used as a preservative in wine – are unlikely to be a headache factor. Wine, like other alcoholic beverages,