Mississippi Highway 4 (MS 4) runs east–west from an intersection in the community of Fox Island west of Tunica, Mississippi, near the border with Arkansas, to MS 25 in Tishomingo County, Mississippi. It travels a distance of , serving Tunica, Tate, Marshall, Benton, Tippah, Prentiss, and Tishomingo counties. Route description MS 4 begins in the Mississippi Delta region on a Levee of the Mississippi River, in Tunica County, at the community of Fox Island. It heads east as a narrow two-lane road (Bailey Road) through farmland for a couple miles to make a right turn onto Fox Island Road. The highway enters the Tunica city limits and immediately enters downtown, turning north along Main Street for a couple blocks before turning right onto River Road and heading east through neighborhoods. MS 4 now enters a business district and becoming concurrent with US 61. They head southward as a four-lane highway to leave Tunica and pass through rural areas for a few miles to the community of Evansville, where MS 4 splits off and heads east. MS 4 passes through White Oak as a two-lane to have an interchange and become concurrent with MS 3. The highway now crosses the Coldwater River into Tate County. MS 3/MS 4 now pass through Savage before turning southward, with MS 4 breaking off and heading east shortly thereafter. MS 4 now climbs onto a plateau as it passes through Strayhorn before entering Senatobia. It enters some neighborhoods and turns left onto a two-lane northern bypass of the city, known as Wilson Drive. The highway heads through outskirts to a business district, where it has an intersection with US 51. MS 4 turns south through a mix of neighborhoods and businesses for a few blocks (along Norfleet Drive) before making a sharp left onto Main Street and immediately having an interchange with I-55 (Exit 265). The highway leaves Senatobia and passes through the communities of New Town and Looxahoma before having an intersection with MS 305. MS 4 passes through Thyatira and Wyatte before crossing into Marshall County. MS 4 almost immediately has an intersection with MS 309 before passing through Chulahoma and turning northeast through wooded areas for several miles to an intersection with MS 7. They become concurrent and head north to enter Holly Springs and immediately have an interchange with I-22/US 78 (Exit 30). MS 4/MS 7 become S Craft Street as