Tsunematsu Takemoto, who worked on it the early 1980s in Japan (later Takemoto decided to concentrate on the similar sweet plant, jiaogulan). The development of luo han guo products in China has continued ever since, focusing in particular on the development of concentrated extracts. Description The vine attains a length of 3 to 5 m, climbing over other plants by means of tendrils which twine around anything they touch. The narrow, heart-shaped leaves are 10–20 cm long. The fruit is round, 5–7 cm in diameter, smooth, yellow-brownish or green-brownish in color, containing striations from the fruit stem end of the furrows with a hard but thin skin covered by fine hairs. The inside of the fruit contains an edible pulp, which, when dried, forms a thin, light brown, brittle shell about 1 mm in thickness. The seeds are elongated and almost spherical. The interior fruit is eaten fresh, and the rind is used to make tea. The monk fruit is notable for its sweetness, which can be concentrated from its juice. The fruit contains 25 to 38% of various carbohydrates, mainly fructose and glucose. The sweetness of the fruit is increased by the mogrosides, a group of triterpene glycosides (saponins). The five different mogrosides are numbered from I to V; the main component is mogroside V, which is also known as esgoside. Mogroside biosynthesis One analysis of 200 candidate genes of Siraitia grosvenorii revealed five enzyme families involved in the synthesis of mogroside V: squalene epoxidases, triterpenoid synthases, epoxide hydrolases, cytochrome P450s, and UDP-glucosyltransferases. The metabolic pathway for mogroside biosynthesis involves an initial stage of fruit development when squalene is metabolized to di-glucosylated, tetra-hydroxycucurbitadienols, then during fruit maturation, branched glucosyl groups are added and catalyzed, leading to the sweet M4, M5, and M6 mogrosides. Cultivation Germination of seeds is slow and may take several months. It is grown primarily in the far southern Chinese province of Guangxi (mostly in the mountains near Guilin), as well as in Guangdong, Guizhou, Hunan, and Jiangxi. These mountains lend the plants shade and often are surrounded by mists which protect the plants from the sun. Nonetheless, the climate in this southern province is warm. The plant is rarely found in the wild, so it has been cultivated for hundreds of years. Records as early as 1813 mention the cultivation of this plant in the Guangxi province. Most of the plantations are located in Yongfu