outbreak of COVID-19, causing a global pandemic. These studies have shown that approximately 20% of people with COVID-19 can present with mucosal manifestations in their oral cavities, including geographic tongue. Geographic tongue may appear alongside the onset of the regular symptoms of COVID-19. Interleukin-6 (IL-6) is known to be an important biomarker in people with COVID-19 in relation to a cytokine storm where too many inflammatory cells which have a detrimental effect on organ systems throughout the body. Geographic tongue is associated with elevated levels of IL-6, which possibly helps explain the presentation in confirmed COVID-19 cases. This evidence is minimal and requires more studies and research to confirm these claims. Notes References External links Ailments of unknown cause Tongue disorders Conditions of the mucous membranes