Yorkville neighborhood, historically a working class German and Hungarian neighborhood, today a wealthy enclave of upper-class residents. In this district, First Avenue is also known as "Bedpan Alley" (a play on "Tin Pan Alley") because of the large number of hospitals located nearby. Crossing 96th Street, First Avenue runs through Spanish Harlem, a historically Puerto Rican neighborhood. Before Puerto Rican migration in the 1950s, much of this district was populated by Italians and known as "Italian Harlem". First Avenue in Italian Harlem was the site of a major open-air pushcart market in the late 19th and early 20th centuries. There is still a small Italian enclave in the Pleasant Valley district of East Harlem, between 114th and 120th Streets. The northern reaches of First Avenue, north of roughly 110th Street have also seen a significant increase in Mexican residents. First Avenue then connects to the Willis Avenue Bridge, which crosses the Harlem River at 125th Street and connects to Willis Avenue in the Bronx. Transportation The M15/M15+ Select Bus runs on the one-way pair of First and Second Avenue between 125th Street and Houston Street. The northbound M9 runs on it between 20th Street and 29th Street, terminating at Bellevue Hospital at 26th Street. The M31, M50, M57, M86+ Select Bus and M116 serve First Avenue for short segments. The BMT Canarsie Line has a station at 14th Street. In popular culture The opening scene of Ghostbusters II was filmed at the intersection of First Avenue and 77th Street. In the Seinfeld TV series, Kramer describes the intersection of First Avenue and 1st Street as the "nexus of the universe". This provided the name for a nightclub called the Nexus Lounge at that location. Gallery References External links New York Songlines: First Avenue, a virtual walking tour 01 East Harlem East Village, Manhattan Kips Bay, Manhattan Midtown Manhattan Murray Hill, Manhattan Upper East Side