founded Genetics Institute, Inc. in 1980. The company produced several FDA approved drugs “protein biologics” including blood clotting factors for the treatment of hemophilia, and erythropoietin for the treatment of anemia. The company was acquired by Wyeth Pharmaceuticals. In 1994, Maniatis, Fred Goldeberg, and others from the Harvard Medical School founded ProScript. The company invented the proteasome inhibitor Velcade (Bortezomid) approved by the FDA for the treatment of Multiple Myeloma. ProScript was acquired by Millennium/Takeda Pharma. In 2004 Maniatis cofounded Acceleron Pharma, a TGF-b company that produced “ligand trap” drugs, including REBLOZYL® for the treatment of Myodysplastic Syndrome (MDS) and b-thalassaemia. Kallyope was founded by Maniatis, Charles Zuker, and Richard Axel in 2006. It focused on the development of drugs to treat metabolic and inflammatory disorders of the gut. Maniatis, David Goeddel, and William Rudder won the Brandeis University Jacob and Louise Gabbay Award in Biotechnology and Medicine in 1999. Service Maniatis has served on the board of trustees of the Cold Spring Harbor Laboratory, the Jackson Laboratory, and the Rockefeller University. Maniatis led the ALS Association's initiative TREAT ALS (Translational Research Advancing Therapy for ALS) that combines drug discovery with priorities set for existing drug candidates, to accelerate clinical testing of compounds with promise for treating the disease. He also served on the scientific advisory board of “Prize for Life” founded by Avichai Kremer. Maniatis’ won the Jacob F. Javits Lifetime Achievement Award in ALS research from the ALS Association. Maniatis was a cofounder of the New York Genome Center, headed its scientific steering committee, and has served as a member of its board of directors from its founding in 2011. Maniatis is founding director of the university-wide Columbia University Precision Medicine Initiative (CPMI), which is dedicated to the application of genomic technology to the advancement of basic and medical science, directed towards the practice of precision medicine (the use of genetic and genomic information to diagnose and treat human diseases). Awards Rita Allen Foundation Career Development Award, 1978. The Eli Lilly Research Award in Microbiology and Immunology from the American Society of Microbiology, 1981. The Richard Lounsbery Award for Biology presented jointly by the French and U.S. National Academies of Sciences, 1985. The American Medical Association Scientific Achievement Award, 2000. The Pasarow Award in Cancer Research, 2001. The Lasker-Koshland Special Achievement Award in Medical Science, 2012. Maniatis has received Honorary PhD degrees from the University of Athens, the