it is known that major signature of asexuality in metazoan genomes appears to be genome wide LOH, a sort of anti-meselson effect. See also Inbreeding depression Microsatellite instability Tumor suppressor gene Virtual Karyotype Knudson hypothesis Deletion (genetics) References External links "Long-term study of the clinical significance of loss of heterozygosity in childhood acute lymphoblastic leukemia" – Leukemia "Loss of heterozygosity identifies genetic changes in chronic myeloid disorders, including myeloproliferative disorders, myelodysplastic syndromes and chronic myelomonocytic leukemia" – Modern Pathology "Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers" – BJC "Loss of Heterozygosity Studies on Chromosome 12q in Disseminated Superficial Actinic Porokeratosis: Lessons to be Learned" – Journal of Investigative Dermatology Genetics concepts Modification of genetic information Mutation de:Heterozygotie#Verlust der Heterozygotie