B16 or B-16 may refer to: B16 (New York City bus) serving Brooklyn HLA-B16, an HLA - B serotype Honda B16 engine Volvo B16 engine LNER Class B16, a class of British steam locomotives Martin XB-16, a proposed bomber aircraft B16 Melanoma, a cell line Boron-16 (B-16 or 16B), an isotope of boron One of the ECO codes for the Caro–Kann Defence in chess Pope Benedict XVI Bundesstraße 16, federal highway in Germany 16 amp, type B – a standard circuit breaker current rating