MCAD may refer to: Science and technology ACADM or MCAD, a gene Medium-chain acyl-CoA dehydrogenase, an enzyme used in lipid metabolism Medium-chain acyl-coenzyme A dehydrogenase deficiency (MCAD deficiency or MCADD), caused by mutations in the ACADM gene Mast cell activation disorder, a disease Microsoft Certified Application Developer Mechanical computer-aided design Organizations Massachusetts Commission Against Discrimination, US Minneapolis College of Art and Design, US