metabolism to the highly toxic formate via formaldehyde coincides with the rate of appearance of hangover symptoms. As both ethanol and methanol are metabolized by alcohol dehydrogenase – and ethanol has a greater binding affinity for this enzyme than methanol – drinking more of the former effectively prevents (or delays) the metabolism of the latter. In popular culture In the videogame The Curse of Monkey Island, the main character Guybrush Threepwood needs to make a hangover remedy, which includes "the hair of the dog that bit you" as an ingredient. In the videogame Kingdom Come: Deliverance, the "Hair o' the dog" potion is a consumable and craftable item used to cure the effects of a hangover on the player character. In the videogame “Ponos’s The Battle Cats”, the playable character, Doctor Cat description reads “His medical philosophy is “Hair of the Dog”. If it doesn’t kill ya, it must be working right?!” In the MMORPGs RuneScape and Old School RuneScape, there is a tavern in the werewolf-populated town of Canifis called Hair of the Dog. In the spinoff series Cells at Work! Code Black Chapter 2, the body receives more alcohol when the human takes the hair of the dog during hangover, much to the cells' dismay. This was also portrayed in the anime. In Stanley Kubricks film The Shining (1980), the character Jack Torrance (played by Jack Nicholson) stands by the hotel bar and is asked by Lloyd the bartender (played by Joe Turkel): "What will it be, Sir?", whereby Jack answers "Hair of the dog that bit me". Lloyd follows up by saying "Bourbon on the rocks", and Jack answers "That'll do her!". See also Corpse Reviver Hangover food References External links "Early Modern Whale: Langley Marish: Milton, and the hair of the dog" a compilation of early uses of the expression "hair of the dog". Alcohol and health Drinking culture Substance-related disorders