doses of approximately 150 mg/kg body weight. This can be achieved with 1 ml of oil of wintergreen, which equates to 140mg/kg of salicylates for a 10kg child (22lbs). The lowest published lethal dose is 101 mg/kg body weight in adult humans, (or 7.07 grams for a 70 kg adult). It has proven fatal to small children in doses as small as 4 ml. A seventeen-year-old cross-country runner at Notre Dame Academy on Staten Island died in April 2007 after her body absorbed methyl salicylate through excessive use of topical muscle-pain relief products (using multiple patches against the manufacturer's instructions). Most instances of human toxicity due to methyl salicylate are a result of overapplication of topical analgesics, especially involving children. Salicylate, the major metabolite of methyl salicylate, may accumulate in blood, plasma or serum to confirm a diagnosis of poisoning in hospitalized patients or to assist in an autopsy. Compendial status British Pharmacopoeia Japanese Pharmacopoeia See also Trolamine salicylate References External links MedlinePlus – Methyl salicylate overdose MedlinePlus – Sports cream overdose CNN – Medical examiner: Sports cream caused teen's death Wayback machine link to this article NLM Hazardous Substances Databank – Methyl salicylate Commercialization of traditional medicines Flavors Methyl esters Salicylate esters 3-Hydroxypropenals Sweet-smelling chemicals