1989 and 1997 she held various administrative positions with the San Pedro Garza García municipality such as direction of human affairs, assistant to the secretary of primary services and the director of tourism, education and sports. From 1997 to 2001, she was the coordinator of junior high education and social services with the Secretariat of Education of the state of Nuevo León. Initially, Clouthier followed her father into the National Action Party (PAN) and was a member from 1991 to 2005. With this party, she served as a federal deputy from 1991 to 1994, then again from 2003 to 2005. However, she became disillusioned with this party, and left even though she was criticized for betraying her father. Today, she says that it is a “bad copy of the Institutional Revolutionary Party,” the party that her father was so against. In 2009, she was a candidate for municipal president for San Pedro with Nueva Alianza. Manager of the campaign of Andrés Manuel López Obrador Clouthier has come to national attention as the campaign manager for the 2018 presidential campaign of Andrés Manuel López Obrador. She articulated and promoted the potential benefits of electing Andrés Manuel López Obrador to the Presidency of Mexico. Despite her history, her choice to support López Obrador came as a surprise to her family. However, she states that many of the candidate's political positions are similar to those of her father, who was also called a populist. Despite her close association with López Obrador, she is not a member of his party. She states she has disagreements with López Obrador but will not say what they are publicly. Clouthier's main success has been managing the candidate's and campaign's online presence, especially in social media and particularly in a Twitter account called Abre Más Los Ojos (Open Your Eyes Wider). One of her sisters once told her that if Twitter did not exist, Clouthier would have invented it. She discovered Twitter during her work with various civic organizations, as a way to reach the public quickly. Then she began using it for lower-level political campaigns, especially for recruiting. She likes the platform because it is immediate, short and direct, considering it a natural ally for the campaign. She directs a team responsible for social media messaging, focused on pushing the campaign's narrative and defending against attacks by other candidates. In particular, she has been successful in communicating