need for interpretation, lectures, and scholarship to make those works more accessible to scholars in monasteries and urban centers. During the twelfth century universities emerged from these clusters of scholars in Italy at Bologna; in Spain at Salamanca, in France at Paris and in England at Oxford. By 1500 there were at least sixty universities throughout Europe enrolling at least three quarters of a million students. Each of the four faculties (Liberal Arts, Theology, Law, and Medicine) was devoted to the transmission of classic texts rather than the production of fresh knowledge beyond lectures and commentaries. This form of scholastic education continued well into the seventeenth century and beyond in some locations and disciplines. Printing and the growth of knowledge in Europe Johannes Gutenberg’s European introduction of the moveable type printing press around 1450 created new opportunities for the production and widespread distribution of books, fostering much new writing, with particular consequences for the development of knowledge, as documented by Elizabeth Eisenstein. The production and distribution of knowledge was no longer tied to monasteries or universities with their libraries and collections of scribal copies. In the ensuing centuries a politically and increasingly religiously divided Europe, no single authority was able to censor or control the production of books. While universities remained attached to disseminating traditional texts, publishing houses became the new centers of knowledge production, and publishing houses in different jurisdictions led to a diversity of ideas becoming available as books moved across borders and scholars came to see themselves as citizens of the Republic of Letters. The comparison of multiple editions of traditional texts led to improved textual scholarship. The ability to share and compare results from many regions and enlist more people into the production of science soon led to the development of early modern science. Books of medicine began to incorporate observations from contemporary surgery and dissections, including printed plates providing graphic displays, to improve knowledge of anatomy. With many copies of traditional books and new books appearing, debates arose over the value of each in what became known as the battle of the books. Maps and discoveries of exploration and colonization also were recorded in books and governmental records, often with the purpose of economic exploitation as in the Archives of the Indies in Seville but also to satisfy curiosity about the world. Printing also made possible the invention and development of scientific journals, with the