the 2016 Indian Wells Masters he lost to 9th seed John Isner and in the 2016 Miami Open he lost to 27th seed Alexandr Dolgopolov. In the Italian Open he lost to Richard Gasquet in the second round. Seppi crashed out of the 2016 French Open in the first round to Ernest Gulbis. In 2016 Wimbledon Championships, Seppi smashed Guillermo García López in straight sets before losing to eventual finalist Milos Raonic in the second round. In the US Open, Seppi beat Frenchman Stéphane Robert before falling to 4 seed Rafa Nadal. Seppi finished the year ranked World No. 87 in singles. 2017: Third Australian Open fourth round Seppi's first ATP tournament of the year was the Australian Open. After beating Paul-Henri Mathieu in the first round, he upset No.14 Nick Kyrgios, despite losing the first 2 sets of the match. He then took down Steve Darcis in 4 sets before falling to Stan Wawrinka in a tight 3-set, 3-tiebreak match. This matched Seppi's best result in singles at a Major. He then played the Sofia Open where he lost to Steve Darcis in the Round of 16. He lost in the first round of a challenger in Bergamo. He then lost in the first round of the Dubai Duty Free Tennis Championships to an in-form Fernando Verdasco. 2018: Fourth Australian Open fourth round At the Australian Open 2018 he again reached the round of 16 for the fourth time in his career before losing to Kyle Edmund in 4 sets. At the 2018 ABN AMRO World Tennis Tournament, he entered in the qualifying draw, but lost in qualifying competition to Martin Kližan. Seppi then gained a spot in the main draw as lucky loser, where he defeated João Sousa in three sets at first round. In the second round, he upset No.3 seed, Alexander Zverev in straights sets. In the quarterfinals, he defeated Daniil Medvedev to reach the semifinals, but lost to the newly returned to the No.1 position in the ATP rankings, Roger Federer in straight sets, failing to get the spot in the final. 2019–2020: Tenth ATP final Seppi reached the final in 2019 in Sydney, where he lost to Alex de Minaur. He also reached the final of the 2020 New York Open where he was defeated by Kyle Edmund. 2021: Back to Top 100, Fourth US Open third round He won his tenth title at