Systemic fundamental to a predominant social, economic, or political practice. This refers to: In medicine In medicine, systemic means affecting the whole body, or at least multiple organ systems. It is in contrast with topical or local. Systemic administration, a route of administration of medication so that the entire body is affected Systemic circulation, carries oxygenated blood from the heart to the body and then returns deoxygenated blood back to the heart Systemic disease, an illness that affects multiple organs, systems or tissues, or the entire body Systemic effect, an adverse effect of an exposure that affects the body as a whole, rather than one part Systemic inflammatory response syndrome, an inflammatory state affecting the whole body, frequently in response to infection Systemic lupus erythematosus, a chronic autoimmune connective tissue disease that can affect any part of the body Systemic scleroderma, also known as systemic sclerosis, a systemic connective tissue disease Systemic venous system, refers to veins that drain into the right atrium without passing through two vascular beds Systemic exertion intolerance disease, a new name for chronic fatigue syndrome proposed by the Institute of Medicine in 2015 In biology Systemic acquired resistance, a "whole-plant" resistance response that occurs following an earlier localized exposure to a pathogen Systemic pesticide, a pesticide that enters and moves freely within the organism under treatment Other uses Systemic (amateur extrasolar planet search project), a research project to locate extrasolar planets using distributed computing Systemic bias, the inherent tendency of a process to favor particular outcomes Systemic functional grammar, a model of grammar that considers language as a system Systemic functional linguistics, an approach to linguistics that considers language as a system Systemic psychology or systems psychology, a branch of applied psychology based on systems theory and thinking Systemic risk, the risk of collapse of an entire financial system or market, as opposed to risk associated with any one entity Systemic shock, a shock to any system strong enough to drive it out of equilibrium, can refer to a change in many fields Systemic therapy, a school of psychology dealing with the interactions of groups and their interactional patterns and dynamics See also Systematic (disambiguation) Systematics (disambiguation) Systemics de:Systemisch