Tum Kab Jaoge opposite Ajay Devgan and Paresh Rawal. and Neeraj Pathak's Right Yaa Wrong where she played a lawyer. She has completed shooting for Rituparno Ghosh's comedy film Sunglass and Vinay Shukla's Mirch. In 2011, Sen Sharma played the leading role in Aparna Sen's Iti Mrinalini, reportedly a semi-autobiographical film directed by the acclaimed Indian director Aparna Sen, also Konkona's mother. She will also appear in Amitabh Verma's Jackpot opposite Ranvir Shorey, in Suman Mukherjee's adaptation of Shesher Kobita and Goutam Ghose's Shunyo Awnko. In 2013, Sen Sharma starred in Balaji Telefilms' Ek Thi Daayan, directed by newcomer Kannan Iyer and produced by Vishal Bhardwaj and Ekta Kapoor. The film also starred Emraan Hashmi, Kalki Koechlin and Huma Qureshi, and the film itself is inspired by the short story written by her father Mukul Sharma. She has also played a lead role in Aparna Sen's Goynar Baksho. In 2015, Sharma starred in the Bengali film Kadombori as Tagore's sister-in-law and also played Lakshmi Das, the wife of Gour Hari Das – an Odisha freedom fighter who spent 32 years attempting to convince the government of his patriotism. In October, she played a character based on Nupur Talwar in Vishal Bhardwaj's film Talvar, regarding the 2008 Noida Double Murder case. The film premiered at the Toronto Film Festival to extensive critical acclaim for Sharma and her co-stars Irrfan Khan and Neeraj Kabi, and also became a sleeper hit in India. In the same year she played Nayantara in a short film, Nayantara's Necklace. In 2016, Sharma worked on A.R. Murgadoss' film entitled Akira, where she was portrayed a cop alongside Sonakshi Sinha. In 2017, her directorial debut A Death in the Gunj was released on 2 June 2017, which starred Vikrant Massey and Kalki Koechlin in pivotal roles. The film was critically acclaimed and won her the Best Director award in the New York Indian film festival and also in the MAMI film festival. In July, her long-awaited Lipstick Under My Burkha released, directed by Alankrita Srivastava. The film garnered positive reviews and did well at the box office too. Her next project, titled Scholarship, alongside Kalki Koechlin is in pre-production. In 2021, Sen Sharma stars in the Amazon Prime web series Mumbai Diaries 26/11. Directed by Nikkhil Advani and produced by Emmay Entertainment, it also stars Mohit Raina, Tina Desai, and Shreya Dhanwanthary. In 2022, Sen Sharma and actor