His Majesty who considers her sensible and wise. It was during this period that Safiye also built her own all-intertwined relationship system and began to immerse herself in every corner of politics. With the support of the chief eunuch, Gazanfer Aga, she influenced Murad's decisions more and easier, and gained more power which made some Grand Viziers very uncomfortable. Of course, Koca Sinan Pasha, who was Grand Vizier for three terms during Murad's reign, was her supporter. As much as Safiye could hate her mother-in-law, she continued her pro-Venice policy. She also stood openly in front of Murad for the sake of interests the Venice as Haseki. Although she was able to influence the sultan in many ways, she did not always manage to shape the events according to her own taste. Thus, for example, in 1593 she tried to convince Murad, in favor of the English ambassador she had favored. However, Murad hardly listened, already rejecting Safiye’s offer. Thus, although her power and influence grew during Murad’s reign and she achieves many of her interests, and she more or less took Murad's place in ruling the empire, but the Sultan also set serious boundaries for her. Issue It is believed that Safiye Sultan had monogamous relationship with Murad and that she was his only concubine between 1562 and 1582. From Murad, Safiye had at least five children, two sons and three daughters: Hümaşah Sultan (Manisa, c. 1564 – Constantinople, after 1606) Ayşe Sultan (Manisa, 1565 – Constantinople, May 15, 1605). Mehmed III (Manisa, May 16 or 26, 1566 – Constantinople, December 21 or 22, 1603); he succeeded his father as Ottoman sultan. Şehzade Mahmud (Manisa, 1568 – Constantinople, 1580/1581). Fatma Sultan (Manisa, before 1574 – Constantinople, 1620). Also, since they were born during Murad's years of monogamy, she was also probably, but not certainly, mother of: Şehzade Selim (Manisa, 1567? – Constantinople, 28 January 1595, executed by Mehmed III) Mihrimah Sultan (Constantinople, 1579? – Constantinople, after 1625) Fahriye Sultan (died in 1656, buried in Murad III Mausoleum, Hagia Sophia Mosque), called also Fahri Sultan. Possibly daughter with Safiye, perhaps born after her mother's return from exile in Old Palace. She married firstly to Cuhadar Ahmed Pasha, Governor of Mosul, married secondly to Damad Sofu Bayram Pasha, sometime Governor of Bosnia. In addition to these, a European braggart, Alexander of Montenegro, claimed to be the lost son of Murad III