to the top of the smaller-diameter body half. After capping, some ullage volume (air space) remains in the finished capsule. Standard sizes of two-piece capsules Drug-embedded empty capsule shells A new class of capsules has been developed whereby drugs can be embedded in the capsule shell matrix. This allows different drugs to be delivered using the same capsule. The drug might be in a solubilized form, suspended form or chemically bound form in the capsule shell matrix. The drug can be in the cap of the capsule, the body of the capsule or in both body and cap of the capsule. One can embed more than one drug in the capsule shell matrix. The drug can be in the dissolved and suspended form in the capsule shell matrix. Thus, one can create various types of variations in these "drug-embedded capsules". The rate of release of drug can vary based on the way the drug is embedded in the capsule shell matrix and drug properties. See also Capsule endoscopy OROS Pharmacy Automation - The Tablet Counter Pharmaceutical formulation Pill splitting Tablet Oblaat References Hemant N. Joshi, US Patent #8,728,521 (May 20, 2014). Hemant N. Joshi, US Patent # 9,884,024 (February 6, 2018). Hemant N. Joshi, US Patent # 10,357,461 (July 23, 2019). Harshada Sant, MS, "Joshi Capsules" US Patent Numbers # 8,728,521 and # 9,884,024, American Pharmaceutical Review, Page 60, April 2018. Pharmaceutical industry Drug delivery devices Dosage forms Articles containing video clips