Mederos is a Spanish-language surname. Notable people with the surname include: Enrique Mederos (1967–2004), Mexican voice actor Manuel de Mederos (1539 – c. 1613), Portuguese explorer Rene Mederos (1933–1996), Cuban artist Rodolfo Mederos (born 1940), Argentine musician Rogel Lazaro Aguilera-Mederos, a truck driver responsible for the 2019 Lakewood semi-truck crash See also Medeiros (disambiguation), the Portuguese-language variant Medero Spanish-language surnames