Semantides (or semantophoretic molecules) are biological macromolecules that carry genetic information or a transcript thereof. Three different categories or semantides are distinguished: primary, secondary and tertiary. Primary Semantides are genes, which consist of DNA. Secondary semantides are chains of messenger RNA, which are transcribed from DNA. Tertiary semantides are polypeptides, which are translated from messenger RNA. In eukaryotic organisms, primary semantides may consist of nuclear, mitochondrial or plastid DNA. Not all primary semantides ultimately form tertiary semantides. Some primary semantides are not transcribed into mRNA (non-coding DNA) and some secondary semantides are not translated into polypeptides (non-coding RNA). The complexity of semantides varies greatly. For tertiary semantides, large globular polypeptide chains are most complex while structural proteins, consisting of repeating simple sequences, are least complex. The term semantide and related terms were coined by Linus Pauling and Emile Zuckerkandl. Although semantides are the major type of data used in modern phylogenetics, the term itself is not commonly used. Related terms Isosemantic DNA or RNA that differs in base sequence, but translate into identical polypeptide chains are referred to as being isosemantic. Episemantic Molecules that are synthesized by enzymes (tertiary semantides) are referred to as episemantic molecules. Episemantic molecules have a larger variety in types than semantides, which only consist of three types (DNA, RNA or polypeptides). Not all polypeptides are tertiary semantides. Some, mainly small polypeptides, can also be episemantic molecules. Asemantic Molecules that are not produced by an organism are referred to as asemantic molecules, because they do not contain any genetic information. Asementic molecules may be changed into episemantic molecules by anabolic processes. Asemantic molecules may also become semantic molecules when they integrate into a genome. Certain viruses and episomes have this ability. When referring to a molecule as being semantic, episemantic or asemantic, then this only applies to a specific organism. A semantic molecule for one organism may be asemantic for another organism. Research applications Semantides are used as phylogenetic information for studying the evolutionary history of organisms. Primary semantides are also used in comparative biodiversity analyses. However, since extracellular DNA can persist for some time, these types of analysis cannot discern active from inactive and or dead organisms. The extent to which biological macromolecules are informative for studying evolutionary history differs. The more complex a molecule, the more informative it is in for phylogenetics. Primary and secondary semantides contain the most information. In tertiary semantides, some