musical The Life. The New York Times said that "Isaacs's voice has the suppleness of Lena Horne's and a purity that is never sabotaged by its range. It's an instrument to cause goose bumps of pleasure. She rivets attention from her first appearance until the ambitious finale. As sung by Ms. Isaacs, Queen has backbone that only a good score can express with such immediacy." Isaacs was nominated for the 1997 Tony and Drama Desk Award as Best Actress in a Musical for The Life. Ben Brantley also praised Isaac's performance when the play opened in 1997. "Most of the ballads go to Ms. Isaacs, who has a husky, vibrato-shaded voice, somewhere between Tina Turner and Helen Morgan, which resonates affectingly with pain and longing," said Brantley. "She delivers absolutely everything (including some clunky sung recitative) with commanding sincerity and polish." The Life played for 466 performances on Broadway at the Ethel Barrymore Theatre. In 1999 Isaacs played a plastic-molding machine worker in the revival of Working, based on Studs Terkel's identically titled book. In 2001 Isaacs portrayed a Starbucks counter girl who kept yuppies waiting in Newyorkers. Isaacs sings "No Hurry at All," "a bluesy solo powerfully sung and amusingly acted" said Bruce Weber in the New York Times. In 2001, Isaacs won an Obie Award for her performance as the Starbucks barista in the off-Broadway play. Thoroughly Modern Millie In 2003 Isaacs won raves for her performance of Muzzie Van Hossmere, a madcap Manhattan cabaret singer and heiress with a zest for the high life and a glamorous penthouse, in the national tour of the Broadway musical Thoroughly Modern Millie. Donna Bailey-Thompson said of Isaac's performance at the Bushnell Center for the Performing Arts in Hartford, Connecticut that "Pamela Isaacs almost stops the show when she wraps her powerful, throaty voice around an okay sound and transforms it into a throbbing paean to New York." D. Aviva Rothschild wrote of her performance: "Pamela Isaacs as Muzzy proved right from the get-go why she'd been a Tony nominee for The Life. Damn, her voice was thrilling!" Les Spindle wrote that "As bon-vivant millionaire Muzzy van Hossmere – a role created for Carol Channing – the vivacious Pamela Isaacs pulls off a tour-de-force triumph, bolstered by her lively new songs." Isaacs has performed in Regional Theatre at Long Wharf Theatre, Baltimore Center Stage, Yale Repertory Theatre, and Goodspeed Opera House.