activities by bioreductive alkylation. In the bacterium Legionella pneumophila, mitomycin C induces competence, a condition necessary for the process of natural transformation that transfers DNA and promotes recombination between cells. Exposure of the fruitfly Drosophila melanogaster to mitomycin C increases recombination during meiosis, a key stage of the sexual cycle. It has been suggested that during sexual process in prokaryotes (transformation) and eukaryotes (meiosis) DNA cross-links and other damages introduced by mitomycin C may be removed by recombinational repair. See also Aziridine References External links Antineoplastic drugs Aziridines Breakthrough therapy Cancer treatments Carbamates Enones Heterocyclic compounds with 4 rings Mitomycins Nitrogen heterocycles Oncology Orphan drugs Quinones Tetracyclic compounds