treatment of choice for indolent lymphoma (a less aggressive subset of non-Hodgkin lymphoma). [R]-CHOEP modification In order to develop more effective first-line chemotherapy regimen for aggressive lymphomas, some researchers tried to add to the standard [R]-CHOP regimen. There were also attempts to further improve the efficacy of the [R]-CHOEP regimen with escalating the chemotherapy doses. This mode was called [R]-High-CHOEP. However, it did not show more effectiveness than standard-dose [R]-CHOEP while adding more toxicity and cost. In order to try improving efficacy of the [R]-CHOEP, some researchers tried to escalate chemotherapy to very high doses, requiring autologous stem cell support in each cycle. Doses in that regimen were increased from cycle to cycle. This regimen was called [R]-MegaCHOEP. But again, such escalation seemed to not improve effectiveness while adding toxicity. See also Chemotherapy regimens EPOCH chemotherapy References Chemotherapy regimens used in lymphoma