There were no side effects or complications reported from the treatment. A recent study found that transcranial magnetic stimulation is more clinically effective treating depression when targeted specifically to Brodmann area 46, because this area has intrinsic functional connectivity (negative correlation) with area 25. Another recent study has found that the responses of area 25 to viewing sad stimuli are affected by cortisol. This suggests that depression related changes in the activity in area 25 could be due to hypothalamic–pituitary–adrenal axis dysregulation. Image See also Brodmann area List of regions in the human brain Biology of depression Notes and references 25 Serotonin Neuroscience of depression Medial surface of cerebral hemisphere