Automatic extraction of protein interactions and associations of proteins to functional concepts (e.g. gene ontology terms) has been explored. The search engine PIE was developed to identify and return protein-protein interaction mentions from MEDLINE-indexed articles. The extraction of kinetic parameters from text or the subcellular location of proteins have also been addressed by information extraction and text mining technology. Gene-disease associations Text mining can aid in gene prioritization, or identification of genes most likely to contribute to genetic disease. One group compared several vocabularies, representations and ranking algorithms to develop gene prioritization benchmarks. Gene-trait associations An agricultural genomics group identified genes related to bovine reproductive traits using text mining, among other approaches. Protein-disease associations Text mining enables an unbiased evaluation of protein-disease relationships within a vast quantity of unstructured textual data. Applications of phrase mining to disease associations A text mining study assembled a collection of 709 core extracellular matrix proteins and associated proteins based on two databases: MatrixDB (matrixdb.univ-lyon1.fr) and UniProt. This set of proteins had a manageable size and a rich body of associated information, making it a suitable for the application of text mining tools. The researchers conducted phrase-mining analysis to cross-examine individual extracellular matrix proteins across the biomedical literature concerned with six categories of cardiovascular diseases. They used a phrase-mining pipeline, Context-aware Semantic Online Analytical Processing (CaseOLAP), then semantically scored all 709 proteins according to their Integrity, Popularity, and Distinctiveness using the CaseOLAP pipeline. The text mining study validated existing relationships and informed previously unrecognized biological processes in cardiovascular pathophysiology. Software tools Search engines Search engines designed to retrieve biomedical literature relevant to a user-provided query frequently rely upon text mining approaches. Publicly available tools specific for research literature include PubMed search, Europe PubMed Central search, GeneView, and APSE Similarly, search engines and indexing systems specific for biomedical data have been developed, including DataMed and OmicsDI. Some search engines, such as Essie, OncoSearch, PubGene, and GoPubMed were previously public but have since been discontinued, rendered obsolete, or integrated into commercial products. Medical record analysis systems Electronic medical records (EMRs) and electronic health records (EHRs) are collected by clinical staff in the course of diagnosis and treatment. Though these records generally include structured components with predictable formats and data types, the remainder of the reports are often free-text and difficult to search, leading to challenges with patient care. Numerous complete systems and tools have been developed to