for impairment of the eye(s). Pilocarpine drops may be administered as a treatment as well as a diagnostic measure. Thoracic sympathectomy is the definitive treatment of diaphoresis, if the condition is not treatable by drug therapy. Prognosis Adie's syndrome is not life-threatening or disabling. As such, there is no mortality rate relating to the condition; however, loss of deep tendon reflexes is permanent and may progress over time. Epidemiology It most commonly affects younger women (2.6:1 female preponderance) and is unilateral in 80% of cases. Average age of onset is 32 years. Culture Modern analysis of Leonardo da Vinci's Mona Lisa suggests that the subject had Adie syndrome. See also Ciliary ganglion Ross' syndrome References Further reading de Campos, D., Coutinho Rodrigues, D., & Buso, L. (2021). The Holmes-Adie Syndrome in the Mona Lisa of Leonardo da Vinci (1452-1519) [JB]. Acta Biomedica Atenei Parmensis, 92(5), e2021305. https://doi.org/10.23750/abm.v92i5.10355 External links Neurological disorders Syndromes affecting the eye Syndromes affecting the nervous system Human pupil