confirmatory diagnostic testing is necessary Extrapulmonary cryptococcosis including meningitis Disseminated non-tuberculous mycobacteria infection Progressive multifocal leukoencephalopathy Candida of trachea, bronchi or lungs Cryptosporidiosis Isosporiasis Visceral herpes simplex infection Cytomegalovirus (CMV) infection (retinitis or of an organ other than liver, spleen or lymph nodes) Any disseminated mycosis (e.g. histoplasmosis, coccidiomycosis, penicilliosis) Recurrent non-typhoidal salmonella septicaemia Lymphoma (cerebral or B cell non-Hodgkin) Invasive cervical carcinoma Visceral leishmaniasis Original proposal in 1990 Clinical Stage I Asymptomatic Generalised lymphadenopathy In some cases symptoms similar to those of cold flue would be manifested. Performance scale: 1: asymptomatic, normal activity. Clinical Stage II Weight loss, < 10% of body weight Minor mucocutaneous manifestations (seborrheic dermatitis, prurigo, fungal nail infections, recurrent oral ulcerations, angular cheilitis) Herpes zoster within the last five years Recurrent upper respiratory tract infections (i.e. bacterial sinusitis) And/or performance scale 2: symptomatic, normal activity. Clinical Stage III Weight loss, > 10% of body weight Unexplained chronic diarrhoea > 1 month Unexplained prolonged fever (intermittent or constant), > 1 month Oral [candidiasis] ([thrush]) Oral hairy leucoplakia Pulmonary tuberculosis Severe bacterial infections (i.e. pneumonia, pyomyositis) And/or performance scale 3: bedridden < 50% of the day during last month. Clinical Stage IV The declaration of AIDS HIV wasting syndrome * Pneumocystis carinii pneumonia Toxoplasmosis of the brain Cryptosporidiosis with diarrhoea > 1 month Cryptococcosis, extrapulmonary Cytomegalovirus disease of an organ other than liver, spleen or lymph node (ex: retinitis) Herpes simplex virus infection, mucocutaneous (>1 month) or visceral Progressive multifocal leucoencephalopathy Any disseminated endemic mycosis Candidiasis of esophagus, trachea, bronchi Atypical mycobacteriosis, disseminated or lungs Non-typhoid Salmonella septicemia Extrapulmonary tuberculosis Lymphoma Kaposi's sarcoma HIV encephalopathy ** And/or performance scale 4: bedridden > 50% of the day during last month. (*) HIV wasting syndrome: weight loss of > 10% of body weight, plus either unexplained chronic diarrhoea (> 1 month) or chronic weakness and unexplained prolonged fever (> 1 month). (**) HIV encephalopathy: clinical findings of disabling cognitive and/or motor dysfunction interfering with activities of daily living, progressing over weeks to months, in the absence of a concurrent illness or condition other than HIV infection which could explain the findings. References HIV/AIDS World Health Organization