to AMMI and GGE, especially when the yield improvement implies multiple yield variables. Seven genetically distinct yarrow plants were collected and three cuttings taken from each plant. One cutting of each genotype was planted at low, medium, and high elevations, respectively. When the plants matured, no one genotype grew best at all altitudes, and at each altitude the seven genotypes fared differently. For example, one genotype grew the tallest at the medium elevation but attained only middling height at the other two elevations. The best growers at low and high elevation grew poorly at medium elevation. The medium altitude produced the worst overall results, but still yielded one tall and two medium-tall samples. Altitude had an effect on each genotype, but not to the same degree nor in the same way. A sorghum bi-parental population was repeatedly grown in seven diverse geographic locations across years. A group of genotypes requires similar growing degree-day (GDD) to flower across all environments, while another group of genotypes need less GDD in certain environments, but higher GDD in different environments to flower. The complex flowering time patterns is attributed to the interaction of major flowering time genes (Ma1, Ma6, FT, ELF3) and an explicit environmental factor, photothermal time (PTT) capturing the interaction between temperature and photoperiod. Phenylketonuria (PKU) is a human genetic condition caused by mutations to a gene coding for a particular liver enzyme. In the absence of this enzyme, an amino acid known as phenylalanine does not get converted into the next amino acid in a biochemical pathway, and therefore too much phenylalanine passes into the blood and other tissues. This disturbs brain development leading to mental retardation and other problems. PKU affects approximately 1 out of every 15,000 infants in the U.S. However, most affected infants do not grow up impaired because of a standard screening program used in the U.S. and other industrialized societies. Newborns found to have high levels of phenylalanine in their blood can be put on a special, phenylalanine-free diet. If they are put on this diet right away and stay on it, these children avoid the severe effects of PKU. This example shows that a change in environment (lowering Phenylalanine consumption) can affect the phenotype of a particular trait, demonstrating a gene–environment interaction. A single nucleotide polymorphism rs1800566 in NAD(P)H Quinone Dehydrogenase 1 (NQO1) alters the risk of asthma and general lung injury upon interaction with