Route 46 is a highway in northern Missouri. Its eastern terminus is at U.S. Route 69 north of Eagleville; its western terminus is at U.S. Route 59 east of Fairfax. History Route 46 is one of the original state highways from 1922. Its original termini were the east and west county lines of Worth which it ran completely across. Major intersections References 046 Transportation in Atchison County, Missouri Transportation in Nodaway County, Missouri Transportation in Worth County, Missouri Transportation in Harrison County, Missouri