acetate is of about 15% higher molecular weight than estradiol due to the presence of its C3 acetate ester. Because estradiol acetate is a prodrug of estradiol, it is considered to be a natural and bioidentical form of estrogen. Pharmacokinetics Estradiol acetate is converted into estradiol in the body. Chemistry Estradiol acetate is a synthetic estrane steroid and the C3 acetate ester of estradiol. It is also known as estradiol 3-acetate or as estra-1,3,5(10)-triene-3,17β-diol 3-acetate. Another common ester of estradiol in use for oral administration is estradiol valerate, which is a C17β ester of estradiol. The experimental octanol/water partition coefficient (logP) of estradiol acetate is 4.2. History Estradiol acetate is relatively recent to the market, having been first approved in a vaginal ring formulation as Menoring in the United Kingdom in 2001, followed by a vaginal ring formulation as Femring in the United States in 2002, and finally as an oral preparation as Femtrace in the United States in 2004. Society and culture Generic names Estradiol acetate is the generic name of the drug and its . Brand names Estradiol acetate is marketed under the brand names Femtrace, Femring, and Menoring. Availability Estradiol acetate is available in the United States and the United Kingdom. References Acetate esters Estradiol esters Prodrugs Secondary alcohols Synthetic estrogens