in Khimki. This version only flew 4 times in 2000; the Fregat upper stage was subsequently flown regularly atop Soyuz-FG and Soyuz-2 boosters. An older variant of Soyuz-U, the Soyuz-U2 launcher, first flown in 1982, had the same hardware as the basic Soyuz-U. Instead of standard RP-1, it used a high energy, synthetic version, Syntin, as the first stage fuel. This variant, mainly used to transport crew and cargo to the Mir space station, last flew in 1995, after production of Syntin ended due to cost reasons. Soyuz-U was the basic platform for the development of the Soyuz-FG variant, which used an all-new first stage and took over crew transport to the ISS in 2002. Since 2013, both Soyuz-U and Soyuz-FG are gradually being replaced by the modernized Soyuz-2 launch vehicle. Human spaceflight The first use of a Soyuz-U to launch a crewed mission took place 2 December 1974, when the Soyuz 16 crew was launched in preparation for the Apollo–Soyuz Test Project (ASTP). Soyuz 19, which as part of the ASTP docked with the last Apollo spacecraft ever flown, was also launched by a Soyuz-U rocket. On 6 July 1976, a Soyuz-U launched Soyuz 21, which took a crew of two to the Salyut 5 space station. Many subsequent space station crews were launched on Soyuz-U launchers. The final crewed mission to use the Soyuz-U was Soyuz TM-34, a Soyuz ferry flight to the International Space Station. A spectacular accident occurred on 26 September 1983, when the launcher for the Soyuz T-10a mission was destroyed by fire on the launch pad. The crew was saved by activation of the launch escape system a few seconds before the explosion. Missions after 2000 From 2000 until its retirement in 2017, Soyuz-U vehicles were used by the Russian Federal Space Agency primarily to launch Progress-M robotic cargo spacecraft on resupply missions to the International Space Station (ISS). Although the Soyuz-U was generally very reliable, occasional failures occurred, such as the October 2002 launch of a Foton satellite which crashed near the pad at Plesetsk after the Blok D strap-on booster suffered an engine malfunction. One person on the ground was killed. A Soyuz-U mission failed to launch Progress M-12M to the ISS on 24 August 2011, when the upper stage experienced a problem and broke up over Siberia. It was the first time a Progress spacecraft had failed to reach orbit. Another