permanent premolar is deprived of a discernable number of organized principal collagen fibre bundles passing from tooth to alveolar bone. Molecular determinants of tooth eruption Tooth eruption is a closely controlled process which involves the tooth organ, consisting of the dental follicle and the enamel organ, and adjacent alveolar tissues. The balance between tissue formation of bone, periodontal ligament and root, and tissue destruction of bone, connective tissue and epithelium causes tooth movement. Osteoclasts are gathered from circulating monocytes which are chemically drawn to the location where bone resorption takes place during bone remodelling. A growth factor, colony-stimulating factor 1, produced by the dental follicle, encourages the differentiation of monocytes into macrophages and osteoclasts. In addition, as a result of the epidermal growth factor, the enamel organ produces interleukin-1 alpha, a promoter of bone resorption, that induces follicular cells to produce the colony-stimulating factor 1. In the process of tooth eruption, monocyte chemotactic protein-1 may also be involved. Signalling via the receptor-activated Nuclear factor kB or receptor- activated Nuclear factor kB ligand or osteoprotegerin pathway controls osteoclastogenesis. In the apex of the dental follicle, osteoprotegerin prevents osteoclast formation, and its expression is down-regulated. Ultimately, accentuation of the differentiation of osteoblasts at the base of the alveolar crypt is accentuated. A high level of transcription factor Runt-related transcription factor- 2, that is involved in osteoblast differentiation and function, is indicated in the basal portion of the dental follicle. Down-regulation of the expression of the Runt-related transcription factor- 2 in the apex portion of the dental follicle, that supports bone removal along the surface which the tooth erupts, is due to the transforming growth factor b. Acceleration of incisor eruption in rodents has been proven to be affected by the epidermal growth factor which increases the level of expression for the transformation of growth factor b. Role in development of Odontogenic Cysts and Tumours Role in development of odontogenic cysts and tumour The most common pathologies associated with dental follicle are dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma. Carcinomas, such as primary intraosseous carcinoma and the other tumors including sarcoma and bromixoma can also be associated with dental follicle. Dentigerous (follicular) cyst The second most common odontogenic cyst is the follicular cyst. The cyst develops in normal dental follicule surrounding an unerupted tooth. It can also develop from break down of stellate reticulum or collection of fluid between the reduced enamel epithelium