available over-the-counter in many countries. They work to very quickly open up nasal passages by constricting blood vessels in the lining of the nose. Prolonged use of these types of sprays can damage the delicate mucous membranes in the nose. This causes increased inflammation, an effect known as rhinitis medicamentosa or the rebound effect. Decongestant nasal sprays are advised for short-term use only, preferably 5 to 7 days at maximum. Some doctors advise to use them 3 days at maximum. A recent clinical trial has shown that a corticosteroid nasal spray may be useful in reversing this condition. Topical nasal decongestants include: Oxymetazoline Phenylephrine Xylometazoline Allergy combinations Combination use of two medications as nasal spray preparation has been frequently prescribed by doctors. List of combination nasal sprays: Azelastine together with fluticasone propionate (trade names including Dymista) Xylometazoline together with cromoglicic acid See also Olopatadine/mometasone References External links Dosage forms Drug delivery devices Medical treatments Nose