few decades after its foundation in the early 13th century, Neustadt was granted town rights on 6 April 1275 based on those given to Speyer. Town quarters In the Late Middle Ages Neustadt was divided into four town quarters, whose names indicate the status and occupations of their inhabitants or give important local information: In the Lauerviertel (from Loheviertel = "Tanbark Quarter") next to the Speyerbach worked the tanners. The Kesselringviertel was named after an influential family of the 14th century. In the Frauenviertel ("Women's Quarter") were ecclesiastical possessions under the patronage of Saint Mary's. The Jewish community lived in the Judenviertel ("Jewish Quarter"). Towards the end of the 15th century, other quarters were established outside the town fortifications: the Stadtgasserviertel, the Kirschgartenviertel and the Ägyptenvorstadt. Reformation In the Peasants' Uprising, rebellious peasant bands entered the town unopposed on 6 May 1525. During the Reformation, Louis the Pacific ruled the Palatinate until 1544 and strove for reconciliation. His 1538 religion edict allowed Lutherans to preach and take communion. Equally even-handed was his brother and successor, Frederick the Wise. Not until his successor were there strict Protestant rulers. When Frederick III died in 1576, he left a clause in his will that his Lutheran son, Louis VI should not inherit the Ämter of Kaiserslautern and Neustadt, but that they should go instead to his Calvinist brother, John Casimir. In 1578, Count Palatine John Casimir founded the Neustadt College that was named after him, the Casimirianum, because his Lutheran brother, Louis had cleared the university in Heidelberg of Calvinists; John Casimir was active as an advocate of the reformed faith and offered the exiled professors and students asylum. When he moved to Heidelberg in 1583 in order to take over the regency for his still under-age son there after the death of the brother's reign, Neustadt's short time as a university seat ended. 17th century Denominational disputes over the following century were no longer pursued purely by argument, but with weapons, and the Palatinate was invaded by one campaign after another. Neustadt was conquered six times during the Thirty Years' War; in 1622 by the Spaniards, in 1631 by Sweden, in 1635 by Imperial troops, in 1638 by troops of Duke Bernard of Weimar, in 1639 by the French under Field Marshal Henri II d'Orleans, Duke of Longueville and 1644 again by the French. After each occasion the occupying forces attempted to