that riluzole may have use in mood and anxiety disorders. A reformulation of riluzole that originated at Yale University and is known by the code name BHV-0223 is under development for the treatment of generalized anxiety disorder and mood disorders by Biohaven Pharmaceuticals. Riluzole, which is neuroprotective and a glutamate modulator could be used for psychiatric problems though it failed in trials of Huntington's disease and Parkinson's disease. See also List of investigational antidepressants List of investigational anxiolytics 4-Aminopyridine References External links National Institute for Health and Clinical Excellence (NICE) guidelines for prescription of riluzole in the UK Benzothiazoles Drugs with unknown mechanisms of action GABA reuptake inhibitors Glycine receptor antagonists Trifluoromethyl ethers