Lorient, France, which would remain her home port for the rest of her career. 1941 U-105 left Lorient on her second patrol on 22 February 1941 and underwent a 112-day voyage in the Atlantic Ocean. Along with , she was directed by the Oberkommando der Marine (Supreme naval headquarters), to attack Convoy SL-67. During this attack, U-105 sank the merchant ship Harmodius, on 8 March. Collectively, the two U-boats sank a total of 28,148 tons. U105 then stalked Convoy SL-68, sinking Medjerda on 18 March, Mandalika on 19 March and Clan Ogilvy, Benwyvis and Jhelum, all on the 21st. U-105 went on to score Nazi Germany's first kill off the coast of South America when she sank Ena de Larrinaga on 5 April 1941. Later during the patrol she sank Oakdene, part of Convoy OG-59. On 6 May, Benvrackie, part of Convoy OB 312; on the 13th, Benvenue part of Convoy OB 314 and on the 15th, Rodney Star on 16 May and Scottish Monarch on 1 June as part of Convoy OB 319. This was the second most successful U-boat patrol of the entire Second World War, with 12 ships sunk for a total of . On 5 May 1941, the 105mm deck gun exploded, wounding six crew members. U-105 returned to Lorient on 13 June, and remained there until 3 August, when she departed on her third war patrol. On 5 August she was assigned to wolfpack 'Hammer' and remained with it until it was disbanded on 12 August, when she was reassigned to wolfpack 'Grönland', with which she remained until its disbanding on 27 August. She was then assigned to wolfpack 'Margrave', and sank the Panamanian merchant ship Montana, part of Convoy SC 42, on 11 September. She returned to Lorient nine days later. U-105 left Lorient on her fourth patrol on 8 November 1941 and spent 36 days in the North Atlantic. On 14 November she was assigned to wolfpack 'Steuben' and remained with it until 2 December. Having sunk no ships during the patrol, she returned to Lorient on 13 December 1941. Georg Schewe left the boat shortly after this patrol, and was replaced as commander by Heinrich Schuch. 1942 On 25 January 1942 U-105 left Lorient on her fifth patrol. On 31 January she sank the British warship , part of Convoy SL 98, south-west of Ireland, and, on 5 February 1942, she rescued