8–6 || L2 |- bgcolor="ffbbbb" | 15 || April 14 || @ Twins || 4–6 || Berríos (2–1) || Zimmermann (0–2) || Hildenberger (1) || 14,774 || 8–7 || L3 |- bgcolor="ffbbbb" | 16 || April 16 || Pirates || 3–5 (10) || Kela (1–0) || Greene (0–1) || Kingham (1) || 13,251 || 8–8 || L4 |- bgcolor="ffbbbb" | 17 || April 17 || Pirates || 2–3 (10) || Burdi (2–1) || Farmer (1–1) || Vázquez (5) || 12,994 || 8–9 || L5 |- bgcolor="bbffbb" | 18 || April 18 || White Sox || 9–7 || VerHagen (1–0) || Fulmer (0–1) || Greene (9) || 14,320 || 9–9 || W1 |- bgcolor="ffbbbb" | 19 || April 19 || White Sox || 3–7 || Rodón (3–2) || Zimmermann (0–3) || — || 14,568 || 9–10 || L1 |- bgcolor="bbbbbb" | — || April 20 || White Sox ||colspan="9" | Postponed (inclement weather). Rescheduled to August 6. |- bgcolor="bbffbb" | 20 || April 21 || White Sox || 4–3 || Norris (1–0) || López (1–3) || Greene (10) || 15,686 || 10–10 || W1 |- bgcolor="bbbbbb" | — || April 22 || @ Red Sox ||colspan="9" | Postponed (inclement weather). Rescheduled to April 23. |- bgcolor="bbffbb" | 21 || April 23 || @ Red Sox || 7–4 || Boyd (2–1) || Brewer (0–2) || — || 30,015 || 11–10 || W2 |- bgcolor="bbffbb" | 22 || April 23 || @ Red Sox || 4–2 || Turnbull (1–2) || Velázquez (0–2) || Greene (11) || 30,578 || 12–10 || W3 |- bgcolor="ffbbbb" | 23 || April 24 || @ Red Sox || 4–11 || Rodríguez (2–2) || Ross (1–3) || — || 31,763 || 12–11 || L1 |- bgcolor="ffbbbb" | 24 || April 25 || @ Red Sox || 3–7 || Porcello (1–3) || Zimmermann (0–4) || — || 34,165 || 12–12 || L2 |- bgcolor="ffbbbb" | 25 || April 26 || @ White Sox || 11–12 || Colomé (1–0) || Jiménez (1–1) || — || 18,016 || 12–13 || L3 |- bgcolor="bbbbbb" | — || April 27 || @ White Sox ||colspan="9" | Postponed (inclement weather). Rescheduled to July 3. |- bgcolor="ffbbbb" | 26 || April 28 || @ White Sox || 1–4 || López (2–3) || Boyd (2–2) || Colomé (5) || 14,539 || 12–14 || L4 |- bgcolor="bbffbb" | 27 || April 30 || @ Phillies || 3–1 ||