|| 37,137 || 8–12 || W3 |-style="background:#fbb" |21||April 21|| @ Padres || 3–4 || Lucchesi (3–2) || Mahle (0–2) || Yates (10) || 25,932 || 8–13 || L1 |-style="background:#bfb" |22||April 23|| Braves || 7–6 || Stephenson (2–0) || Gausman (1–2) || Iglesias (5) || 12,789 || 9–13 || W1 |-style="background:#fbb" |23||April 24|| Braves || 3–1 || Soroka (1–1) || Roark (1–1) || Minter (3) || 12,949 || 9–14 || L1 |-style="background:#bfb" |24||April 25|| Braves || 4–2 || Castillo (3–1) || Teherán (2–3) || Iglesias (6) || 14,792 || 10–14 || W1 |-style="background:#bfb |25||April 26|| || 12–1 || DeSclafani (1–1) || Mikolas (2–2) || — || 45,087 || 11–14 || W2 |-style="background:#fbb |26||April 27|| @ Cardinals || 3–6 || Hudson (2–1) || Mahle (0–3) || Hicks (8) || 44,197 || 11–15 || L1 |-style="background:#fbb" |27||April 28|| @ Cardinals || 2–5 || Flaherty (3–1) || Gray (0–4) || Gant (2) || 45,701 || 11–16 || L2 |-style="background:#bfb" |28||April 29|| @ Mets || 5–4 || Iglesias (1–3) || Díaz (0–1) || — || 20,766 || 12–16 || W1 |-style="background:#fbb |29||April 30|| @ Mets || 3–4 (10) || Gagnon (1–0) || Iglesias (1–4) || — || 20,836 || 12–17 || L1 |- |colspan="10"|*April 13 and 14 games played in Monterrey, Mexico |- |-style="background:#bfb |30|| May 1|| @ Mets || 1–0 || Duke (2–1) || Díaz (0–2) || Lorenzen (2) || 22,119 || 13–17 || W1 |-style="background:#fbb |31||May 2|| @ Mets || 0–1 || Syndergaard (2–3) || Mahle (0–4) || — || 21,445 || 13–18 || L1 |-style="background:#fbb |32||May 3|| Giants || 11–12 || Moronta (1–2) || Hughes (2–1) || Smith (8) || 23,478 || 13–19 || L2 |-style="background:#bfb |33||May 4|| Giants || 9–2 || Roark (2–1) || Rodríguez (3–4) || — || 24,104 || 14–19 || W1 |-style="background:#fbb |34||May 5|| Giants || 5–6 || Watson (1–0) || Iglesias (1–5) || Smith (9) || 23,654 || 14–20 || L1 |-style="background:#bfb |35||May 6|| Giants || 12–4 || DeSclafani (2–1) || Pomeranz (1–4) || — || 19,476 || 15–20 || W1 |-style="background:#fbb |36||May 7|| @ Athletics || 0–2 || Fiers (3–3) || Mahle (0–4) || — || 11,794 || 15–21 || L1 |-style="background:#fbb |37||May 8|| @ Athletics || 4–5 (13) || Hendriks (1–0) || Stephenson (2–1) || — || 9,096 || 15–22 || L2 |-style="background:#bfb |38||May 9|| @ Athletics || 3–0 || Roark (3–1) || Bassitt (1–1) || Iglesias (7) || 19,694 || 16–22 || W1 |-style="background:#bfb