@ Athletics || 0–7 || Brooks (1–0) || Price (0–1) || — || Oakland Coliseum || 12,417 || 1–4 || L3 |- style="text-align:center; background-color:#fbb" | 6 || Apr 2 || @ Athletics || 0–1 || Fiers (2–1) || Sale (0–2) || Treinen (3) || Oakland Coliseum || 12,721 || 1–5 || L4 |- style="text-align:center; background-color:#bfb" | 7 || Apr 3 || @ Athletics || 6–3 || Barnes (1–0) || Rodney (0–1) || Brasier (1) || Oakland Coliseum || 14,207 || 2–5 || W1 |- style="text-align:center; background-color:#fbb" | 8 || Apr 4 || @ Athletics || 3–7 || Anderson (2–0) || Rodríguez (0–2) || — || Oakland Coliseum || 15,095 || 2–6 || L1 |- style="text-align:center; background-color:#fbb" | 9 || Apr 5 || @ Diamondbacks || 8–15 || Godley (1–1) || Porcello (0–2) || — || Chase Field || 48,338 || 2–7 || L2 |- style="text-align:center; background-color:#fbb" | 10 || Apr 6 || @ Diamondbacks || 4–5 || Holland (1–0) || Brewer (0–1) || — || Chase Field || 35,969 || 2–8 || L3 |- style="text-align:center; background-color:#bfb" | 11 || Apr 7 || @ Diamondbacks || 1–0 || Walden (1–0) || Kelly (1–1) || Brasier (2) || Chase Field || 31,565 || 3–8 || W1 |- style="text-align:center; background-color:#fbb" | 12 || Apr 9 || Blue Jays || 5–7 || Shoemaker (3–0) || Sale (0–3) || Giles (3) || Fenway Park || 36,179 || 3–9 || L1 |- style="text-align:center; background-color:#bfb" | 13 || Apr 11 || Blue Jays || 7–6 || Walden (2–0) || Giles (0–1) || — || Fenway Park || 36,510 || 4–9 || W1 |- style="text-align:center; background-color:#bfb" | 14 || Apr 12 || Orioles || 6–4 || Rodríguez (1–2) || Hess (1–2) || Brasier (3) || Fenway Park || 33,664 || 5–9 || W2 |- style="text-align:center; background-color:#fbb" | 15 || Apr 13 || Orioles || 5–9 || Cashner (3–1) || Porcello (0–3) || — || Fenway Park || 35,823 || 5–10 || L1 |- style="text-align:center; background-color:#bfb" | 16 || Apr 14 || Orioles || 4–0 || Price (1–1) || Means (1–2) || — || Fenway Park || 36,023 || 6–10 || W1 |- style="text-align:center; background-color:#fbb" | 17 || Apr 15 || Orioles || 1–8 || Straily (1–1) || Velázquez (0–1) || — || Fenway Park || 35,860 || 6–11 || L1 |- style="text-align:center; background-color:#fbb" | 18 || Apr 16 || @ Yankees || 0–8 || Paxton (2–2) || Sale