|| 10–8 |-style=background:#bfb |19|| April 19||@ Cardinals || 5–4 || Lugo (1–0) || Wainwright (1–2) || Díaz (7) || Busch Stadium || 40,413 || 11–8 |-style=background:#fbb |20|| April 20||@ Cardinals || 2–10 || Mikolas (2–1)|| Flexen (0–1) || — || Busch Stadium || 47,059 || 11–9 |-style=background:#fbb |21|| April 21||@ Cardinals || 4–6 || Hudson (1–1) || Syndergaard (1–2) || Hicks (5) || Busch Stadium || 42,765 || 11–10 |-style=background:#bfb |22|| April 22||Phillies || 5–1 || Matz (2–1) || Arrieta (3–2) || — || Citi Field || 25,293 || 12–10 |-style=background:#bfb |23|| April 23||Phillies || 9–0 || Wheeler (2–2) || Eflin (2–3) || — || Citi Field || 26,049 || 13–10 |-style=background:#fbb |24|| April 24||Phillies || 0–6 || Valasquez (1–0) || Vargas (1–1) || — || Citi Field || 27,685 || 13–11 |-style=background:#fbb |25|| April 26||Brewers || 2–10 || Albers (2–1) || deGrom (2–3) || — || Citi Field || 28,131 || 13–12 |-style=background:#fbb |26|| April 27||Brewers || 6–8 || Woodruff (3–1) || Syndergaard (1–3) || Hader (6) || Citi Field || 40,610 || 13–13 |-style=background:#bfb |27|| April 28||Brewers || 5–2 || Matz (3–1)|| Barnes (1–1) || Díaz (8) || Citi Field || 25,756 || 14–13 |-style=background:#fbb |28|| April 29||Reds || 4–5 || Iglesias (1–3) || Díaz (0–1) || — || Citi Field || 20,766 || 14–14 |-style=background:#bfb |29|| April 30||Reds || 5–4 || Gagnon (1–0) || Iglesias (1–4) || — || Citi Field|| 20,836 || 15–14 |- |-style=background:#fbb |30|| May 1 ||Reds || 0–1 || Duke (2–1) || Díaz (0–2) || Lorenzen (2) || Citi Field|| 22,119 || 15–15 |-style=background:#bfb |31|| May 2 ||Reds || 1–0 || Syndergaard (2–3) || Mahle (0–4) || — || Citi Field|| 21,445 || 16–15 |-style=background:#fbb |32|| May 3 ||@ Brewers || 1–3 || Woodruff (4–1) || Matz (3–2) || Hader (8) || Miller Park || 32,550 || 16–16 |-style=background:#fbb |33|| May 4 ||@ Brewers || 3–4 || Williams (1–1) || Flexen (0–2) || — || Miller Park || 39,565 || 16–17 |-style=background:#fbb |34|| May 5 ||@ Brewers || 2–3 || Davies (4–0) || Vargas (1–2) || Hader (9) || Miller Park || 36,016 || 16–18 |-style=background:#fbb |35|| May 6 ||@ Padres || 0–4 || Paddack (3–1) || deGrom (2–4) || Stammen (1) || Petco Park || 20,176 || 16–19 |-style=background:#bfb |36|| May 7 ||@ Padres || 7–6 || Lugo (2–0) || Warren (2–1) || Díaz (9) || Petco Park || 23,129 || 17–19