|58|| June 1|| Nationals || 2–5 || Rainey (1–1) || Roark (4–4) || Doolittle (11) || 27,748 || 27–31 || L1 |-style="background:#fbb |59||June 2|| Nationals || 1–4 || Scherzer (3–5) || Gray (2–5) || Doolittle (12) || 22,801 || 27–32 || L2 |-style="background:#bfb |60||June 4|| @ Cardinals || 4–1 || Castillo (6–1) || Cabrera (0–1) || Iglesias (12) || 40,649 || 28–32 || W1 |-style="background:#bbb |—||June 5|| @ Cardinals || colspan="8" |Postponed (rain) (Makeup date: August 31) |-style="background:#fbb |61||June 6|| @ Cardinals || 1–3 || Gant (5–0) || Lorenzen (0–1) || Hicks (12) || 44,654 || 28–33 || L1 |-style="background:#fbb |62||June 7|| @ Phillies || 2–4 || Eflin (6–5) || Mahle (2–6) || Neris (13) || 32,058 || 28–34 || L2 |-style="background:#fbb |63||June 8|| @ Phillies || 1–4 || Pivetta (4–1) || Roark (4–5) || — || 44,357 || 28–35 || L3 |-style="background:#bfb |64||June 9|| @ Phillies || 4–3 || Duke (3–1) || Álvarez (0–2) || Iglesias (13) || 42,324 || 29–35 || W1 |-style="background:#fbb |65|| June 11|| @ Indians || 1–2 (10) || Hand (3–2) || Iglesias (1–6) || — || 24,101 || 29–36 || L1 |-style="background:#bfb |66|| June 12|| @ Indians || 7–2 || DeSclafani (3–3) || Plesac (1–2) || — || 24,045 || 30–36 || W1 |-style="background:#fbb |67||June 14|| Rangers || 1–7 || Martin (1–0) || Mahle (2–7) || Smyly (1) || 30,090 || 30–37 || L1 |-style="background:#fbb |68||June 15|| Rangers || 3–4 || Minor (6–4) || Roark (4–6) || Kelley (8) || 25,693 || 30–38 || L2 |-style="background:#bfb |69||June 16|| Rangers || 11–3 || Gray (3–5) || Jurado (4–3) || — || 24,079 || 31–38 || W1 |-style="background:#bfb |70||June 17|| Astros || 3–2 || Castillo (7–1) || Miley (6–4) || Lorenzen (3) || 22,745 || 32–38 || W2 |-style="background:#bfb |71||June 18|| Astros || 4–3 || DeSclafani (4–3) || Verlander (9–3) || Lorenzen (4) || 25,347 || 33–38 || W3 |-style="background:#bfb |72||June 19|| Astros || 3–2 || Bowman (1–0) || Osuna (3–1) || — || 24,777 || 34–38 || W4 |-style="background:#bfb |73||June 20|| @ Brewers || 7–1 || Roark (5–6) || Nelson (0–2) || — || 28,898 || 35–38 || W5 |-style="background:#bfb |74||June 21|| @ Brewers || 11–7 || Hernandez (2–3) || Anderson (3–2) || — || 38,289 || 36–38 || W6 |-style="background:#fbb |75||June 22|| @ Brewers || 5–6 || Albers (4–2) || Castillo (7–2) || Hader (18) || 43,971 || 36–39 || L1 |-style="background:#fbb |76||June 23||