|| 34,487 || 6–6 || L2 |-style=background:#fbb ||13|| April 7 || @ Astros || 8–9 || Osuna (1–0) || Treinen (0–1) || — || 34,902 || 6–7 || L3 |-style=background:#fbb ||14|| April 8 || @ Orioles || 4–12 || Cashner (2–1) || Estrada (0–1) || — || 6,585 || 6–8 || L4 |-style=background:#cfc ||15|| April 9 || @ Orioles || 13–2 || Anderson (3–0) || Means (1–1) || — || 7,738 || 7–8 || W1 |-style=background:#cfc ||16|| April 10 || @ Orioles || 10–3 || Montas (2–1) || Straily (0–1) || — || 7,974 || 8–8 || W2 |-style=background:#cfc ||17|| April 11 || @ Orioles || 8–5 || Brooks (2–1) || Bundy (0–1) || Treinen (4) || 8,374 || 9–8 || W3 |-style=background:#cfc ||18|| April 12 || @ Rangers || 8–6 || Trivino (1–0) || Martin (0–1) || Treinen (5) || 24,817 || 10–8 || W4 |-style=background:#bbb || – || April 13 || @ Rangers || colspan="9"| Postponed (rain); Rescheduled for June 8 as part of a doubleheader. |-style=background:#fbb ||19|| April 14 || @ Rangers || 7–8 || Springs (2–0) || Soria (0–2) || Leclerc (3) || 26,350 || 10–9 || L1 |-style=background:#fbb ||20|| April 16 || Astros || 1–9 || McHugh (3–1) || Estrada (0–2) || — || 12,270 || 10–10 || L2 |-style=background:#cfc ||21|| April 17 || Astros || 2–1 || Montas (3–1) || Miley (1–2) || Treinen (6) || 11,323 || 11–10 || W1 |-style=background:#fbb ||22|| April 19 || Blue Jays || 1–5 || Stroman (1–3) || Brooks (2–2) || — || 15,128 || 11–11 || L1 |-style=background:#fbb ||23|| April 20 || Blue Jays || 1–10 || Gaviglio (2–0) || Fiers (2–2) || — || 31,140 || 11–12 || L2 |-style=background:#fbb ||24|| April 21 || Blue Jays || 4–5 || Hudson (1–1 || Anderson (3–1) || Giles (7) || 16,015 || 11–13 || L3 |-style=background:#cfc ||25|| April 22 || Rangers || 6–1 || Bassitt (1–0) || Minor (2–2) || — || 8,073 || 12–13 || W1 |-style=background:#cfc ||26|| April 23 || Rangers || 11–5 || Montas (4–1) || Lynn (2–2) || — || 10,496 || 13–13 || W2 |-style=background:#cfc ||27|| April 24 || Rangers || 6–5 || Treinen (1–1) || Martin (0–2) || — || 18,610 || 14–13 || W3 |-style=background:#fbb ||28|| April 26 || @ Blue Jays || 2–4 || Giles (1–1) || Petit (0–1) || — || 28,688 || 14–14 || L1 |-style=background:#fbb ||29|| April