Mariners || 3–1 || Happ (2–3) || Leake (2–4) || Chapman (8) || Yankee Stadium || 37,016 || 22–15 |-style=background:#bfb | 38 || May 10 || @ Rays || 4–3 || Germán (7–1) || Glasnow (6–1) || Chapman (9) || Tropicana Field || 20,846 || 23–15 |-style=background:#fbb | 39 || May 11 || @ Rays || 2–7 || Chirinos (5–1) || Holder (2–1) || — || Tropicana Field || 25,025 || 23–16 |-style=background:#bfb | 40 || May 12 || @ Rays || 7–1 || Tanaka (3–3) || Snell (3–4) || —|| Tropicana Field || 25,025 || 24–16 |-style=background:#bbb | — || May 13 || Orioles || colspan=7 | Postponed (inclement weather: rain). Makeup date: May 15th (doubleheader) |-style=background:#bbb | — || May 14 || Orioles || colspan=7 | Postponed (inclement weather: rain). Makeup date: August 12th (doubleheader) |-style=background:#bfb | 41 || May 15 || Orioles || 5–3 || Happ (3–3) || Hess (1–5) || Chapman (10) || Yankee Stadium || — || 25–16 |-style=background:#bfb | 42 || May 15 || Orioles || 3–1 || Germán (8–1) || Cashner (4–2) || Chapman (11) || Yankee Stadium || 41,138 || 26–16 |-style=background:#bfb | 43 || May 17 || Rays || 4–3 || Holder (3–1) || Alvarado (0–3) || — || Yankee Stadium || 41,281 || 27–16 |-style=background:#fbb | 44 || May 18 || Rays || 1–2 || Wood (1–0) || Cessa (0–1) || Alvarado (5) || Yankee Stadium || 43,079 || 27–17 |-style=background:#bfb | 45 || May 19 || Rays || 13–5 || Ottavino (2–1) || Castillo (0–3) || Adams (1) || Yankee Stadium || 43,032 || 28–17 |-style=background:#bfb | 46 || May 20 || @ Orioles || 10–7 || Britton (2–0) ||Givens (0–1) || Chapman (12) || Oriole Park at Camden Yards || 16,457 || 29–17 |-style=background:#bfb | 47 || May 21 || @ Orioles || 11–4 || Germán (9–1) || Hess (1–6) || Hale (1) || Oriole Park at Camden Yards || 17,389 || 30–17 |-style=background:#bfb | 48 || May 22 || @ Orioles || 7–5 || Sabathia (3–1) ||Straily (1–4) || Chapman (13) || Oriole Park at Camden Yards || 17,849 || 31–17 |-style=background:#bfb | 49 || May 23 || @ Orioles || 6–5 || Kahnle (2–0) || Givens (0–2) || Britton (2) || Oriole Park at Camden Yards || 30,624 || 32–17 |-style=background:#bbb | — || May 24 || @ Royals || colspan=7 | Postponed (inclement weather: rain).