|| 0–1 |-style="background-color:#fbb;" | 2 || March 29 || @ Padres || 1–4 || Lucchesi (1–0) || Holland (0–1) || Yates (2) || 33,769 || 0–2 |-style="background-color:#bfb;" | 3 || March 30 || @ Padres || 3–2 || Rodríguez (1–0) || Margevicius (0–1) || Smith (1) || 41,899 || 1–2 |-style="background-color:#fbb;" | 4 || March 31 || @ Padres || 1–3 || Adam Warren (1–0) || Vincent (0–1) || Yates (3) || 38,444 || 1–3 |- |-style=background:#bfb;" | 5 || April 1 || @ Dodgers || 4–2 || Gott (1–0) || Kelly (0–1) || Smith (2) || 40,477 || 2–3 |-style=background:#fbb;" | 6 || April 2 || @ Dodgers || 5–6 || Ryu (2–0) || Bumgarner (0–2) || Jansen (2) || 42,887 || 2–4 |-style=background:#fbb;" | 7 || April 3 || @ Dodgers || 3–5 || Alexander (1–0) || Moronta (0–1) || Jansen (3) || 51,170 || 2–5 |-style=background:#fbb;" | 8 || April 5 || Rays || 2–5 || Glasnow (2–0) || Rodríguez (1–1) || Alvarado (3) || 41,067 || 2–6 |-style=background:#bfb;" | 9 || April 6 || Rays || 6–4 || Bergen (1–0) || Yarbrough (1–1) || Smith (3) || 31,828 || 3–6 |-style=background:#fbb;" | 10 || April 7 || Rays || 0–3 || Chirinos (2–0) || Pomeranz (0–1) || Alvarado (4) || 31,574 || 3–7 |-style=background:#fbb;" | 11 || April 8 || Padres || 5–6 || Lauer (2–1) || Moronta (0–2) || Yates (6) || 28,625 || 3–8 |-style=background:#bfb;" | 12 || April 9 || Padres || 7–2 || Holland (1–1) || Lucchesi (2–1) || – || 28,506 || 4–8 |-style=background:#fbb;" | 13 || April 10 || Padres || 1–3 || Margevicius (1–1) || Rodríguez (1–2) || Yates (7) || 28,584 || 4–9 |-style=background:#bfb;" | 14 || April 11 || Rockies || 1–0 || Samardzija (1–0) || Gray (0–3) || Smith (4) || 29,727 || 5–9 |-style=background:#bfb;" | 15 || April 12 || Rockies || 3–2 || Bergen (2–0) || Johnson (0–1) || – || 33,616 || 6–9 |-style=background:#bfb;" | 16 || April 13 || Rockies || 5–2 || Bumgarner (1–2) || Freeland (1–3) || Dyson (1) || 32,607 || 7–9 |-style=background:#fbb;" | 17 || April 14 || Rockies || 0–4 || Márquez (2–1) || Holland (1–2) || – || 35,513 || 7–10 |-style=background:#bfb;" | 18 || April 16 || @ Nationals || 7–3 || Rodríguez (2–2) || Strasburg (1–1) || – || 22,334 || 8–10 |-style=background:#fbb;" |