are pathogenic. In 2016, Filges et al. followed up with Strømme's original two siblings and found using whole exome sequencing that they both had mutations in both of their copies of CENPF, establishing mutations in CENPF as the cause of Strømme syndrome. Notable cases In May 2017, Ruby Ardolf (born November 11, 2004), from Minnesota, United States and diagnosed with Strømme syndrome, appeared in an Instagram video answering questions from her mother Angela which went viral, gaining over 500,000 views in a week. Angela manages a website, online store and YouTube channel for her daughter, with over 170,000 subscribers . See also Ciliopathy Seckel syndrome References External links Ciliopathy Rare syndromes Syndromes affecting the eye Syndromes affecting the kidneys Syndromes affecting the gastrointestinal tract Syndromes affecting head size Syndromes affecting the heart