|-style="background:#bfb" | 121 || August 13 || @ Padres || 7–5 || Anderson (4–4) || Báez (0–1) || Pagán (13) || 25,261 || 71–50 || W5 |-style="background:#fbb" | 122 || August 14 || @ Padres || 2–7 || Quantrill (6–6) || Beeks (5–2) || — || 22,886 || 71–51 || L1 |-style="background:#fbb" | 123 || August 16 || Tigers || 0–2 || VerHagen (3–2) || Morton (13–5) || Jiménez (3) || 13,717 || 71–52 || L2 |-style="background:#bfb" | 124 || August 17 || Tigers || 1–0 (13) || Poche (3–4) || Hall (0–1) || — || 17,228 || 72–52 || W1 |-style="background:#bfb" | 125 || August 18 || Tigers || 5–4 || Alvarado (1–5) || Jiménez (3–7) || — || 16,634 || 73–52 || W2 |-style="background:#fbb" | 126 || August 19 || Mariners || 3–9 || Gonzales (13–10) || McKay (2–3) || — || 9,152 || 73–53 || L1 |-style="background:#fbb" | 127 || August 20 || Mariners || 4–7 || Milone (3–7) || Beeks (5–3) || Magill (2) || 7,455 || 73–54 || L2 |-style="background:#bfb" | 128 || August 21 || Mariners || 7–6 || Pagán (3–2) || Magill (3–1) || — || 7,827 || 74–54 || W1 |-style="background:#bfb" | 129 || August 22 || @ Orioles || 5–2 || Drake (2–1) || Castro (1–2) || Pagán (14) || 8,153 || 75–54 || W2 |-style="background:#bfb" | 130 || August 23 || @ Orioles || 7–1 || Richards (4–12) || Blach (0–2) || Slegers (1) || 14,762 || 76–54 || W3 |-style="background:#fbb" | 131 || August 24 || @ Orioles || 1–7 || Means (9–9) || Alvarado (1–6) || — || 11,409 || 76–55 || L1 |-style="background:#fbb" | 132 || August 25 || @ Orioles || 3–8 || Bundy (6–13) || Castillo (2–7) || — || 13,287 || 76–56 || L2 |-style="background:#fbb" | 133 || August 27 || @ Astros || 1–15 || Verlander (16–5) || Morton (13–6) || — || 28,454 || 76–57 || L3 |-style="background:#fbb" | 134 || August 28 || @ Astros || 6–8 || Harris (4–1) || Castillo (2–8) || — || 25,539 || 76–58 || L4 |-style="background:#bfb" | 135 || August 29 || @ Astros || 9–8 || De León (1–0) || Devenski (2–3) || Pagán (15) || 33,051 || 77–58 || W1 |-style="background:#bfb" | 136 || August 30 || Indians || 4–0 || Drake (3–1) || Bieber (12–7) || — || 15,294 || 78–58 ||