|| colspan="8" |Postponed (rain) (Makeup date: May 27) |-style="background:#fbb" |2||March 31|| Pirates || 0–5 || Williams (1–0) || Gray (0–1) || — || 18,737 || 1–1 || L1 |-style="background:#fbb" |3||April 1|| Brewers || 3–4 || Wilson (1–0) || Iglesias (0–1) || Hader (3) || 7,799 || 1–2 || L2 |-style="background:#fbb" |4||April 2|| Brewers || 3–4 || Chacín (2–0) || Duke (1–1) || Hader (4) || 10,195 || 1–3 || L3 |-style="background:#fbb" |5||April 3|| Brewers || 0–1 || Peralta (1–0) || Castillo (0–1) || Wilson (1) || 13,349 || 1–4 || L4 |-style="background:#fbb" |6||April 4|| @ Pirates || 0–2 || Kingham (1–0) || Hernandez (0–1) || Vázquez (1) || 8,523 || 1–5 || L5 |-style="background:#fbb" |7||April 5|| @ Pirates || 0–2 || Musgrove (1–0)|| Gray (0–2) || Vázquez (2) || 12,497 || 1–6 || L6 |-style="background:#fbb" |8||April 6|| @ Pirates || 5–6 (10) || Liriano (1–0) || Iglesias (0–2) || — || 15,798 || 1–7 ||L7 |-style="background:#fbb" |9||April 7|| @ Pirates || 5–7 || Archer (1–0) || DeSclafani (0–1) || Rodríguez (1) || 14,750 || 1–8 ||L8 |-style="background:#bfb" |10||April 9|| Marlins || 14–0 || Castillo (1–1) || Ureña (0–3) || — || 10,058 || 2–8 || W1 |-style="background:#bfb" |11||April 10|| Marlins || 2–1 || Garrett (1–0) || Steckenrider (0–2) || Iglesias (1) || 11,375 || 3–8 || W2 |-style="background:#bfb" |12||April 11|| Marlins || 5–0 || Stephenson (1–0) || López (1–2) || — || 11,192 || 4–8 ||W3 |-style="background:#bfb" |13||April 13|| Cardinals* || 5–2 || Hughes (1–0) || Wainwright (1–1) || Iglesias (2) || 16,886 || 5–8 ||W4 |-style="background:#fbb" |14||April 14|| Cardinals* || 5–9 || Gant (3–0) || Garrett (1–1) || Hicks (3) || 16,793 || 5–9 || L1 |-style="background:#fbb" |15||April 15|| || 3–4 || Jansen (1–0) || Iglesias (0–3) || — || 52,974 || 5–10 || L2 |-style="background:#fbb" |16||April 16|| @ Dodgers || 1–6 || Maeda (3–1) || Mahle (0–1) || — || 45,406 || 5–11 || L3 |-style="background:#fbb" |17||April 17|| @ Dodgers || 2–3 || Buehler (2–0) || Gray (0–3) || Jansen (3) || 42,691 || 5–12 || L4 |-style="background:#bfb" |18||April 18|| @ Padres || 4–1 || Roark (1–0) || Paddack (0–1) || Iglesias (3) || 26,577 || 6–12 || W1 |-style="background:#bfb" |19||April 19|| @ Padres || 3–2 (11) || Hughes (2–0) || Stammen (2–1) || Lorenzen (1) || 33,442 || 7–12 || W2 |-style="background:#bfb" |20||April 20|| @ Padres || 4–2 || Castillo (2–1) || Lauer (2–3) || Iglesias (4)