Orioles || 7–5 || Barlow (3–3) || Fry (1–6) || Kennedy (24) || 18,385 || 48–89 || W1 |- |-style=background:#bfb ||138|| September 1 || Orioles || 6–4 || McCarthy (3–2) || Fry (1–7) || Kennedy (25) || 18,208 || 49–89 || W2 |-style=background:#bfb ||139|| September 3 || Tigers || 6–5 || Kennedy (2–2) || Reininger (0–1) ||-|| 12,644 || 50–89 || W3 |-style=background:#bfb ||140|| September 4 || Tigers || 5–4 || Junis (9–12) || Jackson (3–9) || Kennedy (26) || 15,308 || 51–89 || W4 |-style=background:#fbb ||141|| September 5 || Tigers || 4–6 || Boyd (8–10) || Sparkman (3–11) || Jiménez (5) || 14,736 || 51–90 || L1 |-style=background:#bfb ||142|| September 6 || @ Marlins || 3–0 || López (3–7) || López (5–7) || Kennedy (27) || 8,915 || 52–90 || W1 |-style=background:#bfb ||143|| September 7 || @ Marlins || 7–2 || Duffy (6–6) || Conley (2–8) || Hill (1) || 13,112 || 53–90 || W2 |-style=background:#fbb ||144|| September 8 || @ Marlins || 0–9 || Alcántara (5–12) || Montgomery (3–8) ||-|| 10,934 || 53–91 || L1 |-style=background:#fbb ||145|| September 10 || @ White Sox || 3–7 || Nova (10–12) || Junis (9–13) ||-|| 15,196 || 53–92 || L2 |-style=background:#bfb ||146|| September 11 || @ White Sox || 8–6 || Sparkman (4–11) || López (9–13) || Kennedy (28) || 14,385 || 54–92 || W1 |-style=background:#bfb ||147|| September 12 || @ White Sox || 6–3 || López (4–7) || Giolito (14–9) || Kennedy (29) || 13,838 || 55–92 || W2 |-style=background:#fbb ||148|| September 13 || Astros || 1–4 || Cole (17–5) || Fillmyer (0–2) || Osuna (33) || 20,593 || 55–93 || L1 |-style=background:#fbb ||149|| September 14 || Astros || 1–6 || Greinke (16–5) || Montgomery (3–9) ||-|| 20,716 || 55–94 || L2 |-style=background:#fbb ||150|| September 15 || Astros || 3–12 || Miley (14–5) || Junis (9–14) ||-|| 17,205 || 55–95 || L3 |-style=background:#bfb ||151|| September 16 || @ A's || 6–5 || McCarthy (4–2) || Hendriks (4–3) || Kennedy (30) || 12,902 || 56–95 || W1 |-style=background:#fbb ||152|| September 17 || @ A's || 1–2 || Puk (2–0) || López (4–8) || Hendriks (23) || 14,992 || 56–96 || L1 |-style=background:#fbb ||153|| September 18 || @ A's || 0–1 || Wendelken (3–1) || Hahn (0–1) ||-|| 16,714 || 56–97 || L2 |-style=background:#fbb ||154|| September 19 || @ Twins || 5–8 || Thorpe (3–2) || Barnes (1–3) || Rogers (28) ||