5–6 || L4 |- style="background:#cfc;" | 12 || April 10 || @ Dbacks || 5–2 || Lynn (1–1) || Chafin (0–1) || Bird (1) || 15,871 || 6–6 || W1 |- style="background:#fbb;" | 13 || April 12 || Athletics || 6–8 || Trivino (1–0) || Martin (0–1) || Treinen (5) || 24,817 || 6–7 || L1 |- style="background:#bbb;" | – || April 13 || Athletics || colspan="9"| Postponed (rain); Rescheduled for June 8 as part of a doubleheader. |- style="background:#cfc;" | 14 || April 14 || Athletics || 8–7 || Springs (2–0) || Soria (0–2) || Leclerc (3) || 26,350 || 7–7 || W1 |- style="background:#cfc;" | 15 || April 15 || Angels || 12–7 || Dowdy (1–0) || Bedrosian (1–1) || Leclerc (4) || 18,265 || 8–7 || W2 |- style="background:#cfc;" | 16 || April 16 || Angels || 5–0 || Minor (2–1) || Barría (1–1) || — || 17,704 || 9–7 || W3 |- style="background:#cfc;" | 17 || April 17 || Angels || 5–4 || Lynn (2–1) || Harvey (0–2) || Leclerc (5) || 16,691 || 10–7 || W4 |- style="background:#fbb;" | 18 || April 19 || Astros || 2–7 || Verlander (3–0) || Smyly (0–2) || — || 35,649 || 10–8 || L1 |- style="background:#cfc;" | 19 || April 20 || Astros || 9–4 || Kelley (3–0) || Cole (1–3) || — || 39,636 || 11–8 || W1 |- style="background:#cfc;" | 20 || April 21 || Astros || 11–10 || Miller (1–1) || McHugh (3–2) || Kelley (1) || 26,225 || 12–8 || W2 |- style="background:#fbb" | 21 || April 22 || @ Athletics || 1–6 || Bassitt (1–0) || Minor (2–2) || — || 8,073 || 12–9 || L1 |- style="background:#fbb" | 22 || April 23 || @ Athletics || 5–11 || Montas (4–1) || Lynn (2–2) || — || 10,496 || 12–10 || L2 |- style="background:#fbb" | 23 || April 24 || @ Athletics || 5–6 || Treinen (1–1) || Martin (0–2) || — || 18,610|| 12–11 || L3 |- style="background:#fbb" | 24 || April 25 || @ Mariners || 2–14 || Gonzales (5–0) || Hearn (0–1) || — || 12,644 || 12–12 || L4 |- style="background:#fbb" | 25 || April 26 || @ Mariners || 4–5 (11) || Elías (2–0) || Dowdy (1–1) || — || 21,721 || 12–13 || L5 |- style="background:#cfc" | 26 || April 27 || @ Mariners || 15–1 ||