Jays || 5–7 || Stewart (3–0) || McClain (0–1) || Law (4) || 34,590 || 55–75 || L1 |-style=background:#bfb ||131|| August 25 || Blue Jays || 3–1 || Gonzales (14–10) || Buchholz (0–3) || Magill (4) || 29,698 || 56–75 || W1 |-style=background:#fbb ||132|| August 26 || Yankees || 4–5 || Happ (11–8) || Milone (3–8) || Chapman (36) || 23,030 || 56–76 || L1 |-style=background:#fbb ||133|| August 27 || Yankees || 0–7 || Tanaka (10–7) || Kikuchi (5–9) || — || 23,129 || 56–77 || L2 |-style=background:#fbb ||134|| August 28 || Yankees || 3–7 || Paxton (11–6) || Sheffield (0–1) || — || 32,013 || 56–78 || L3 |-style=background:#bfb ||135|| August 29 || @ Rangers || 5–3 || Magill (4–1) || Leclerc (2–4) || — || 16,591 || 57–78 || W1 |-style=background:#fbb ||136|| August 30 || @ Rangers || 3–6 || Allard (3–0) || Gonzales (14–11) || Clase (1) || 23,563 || 57–79 || L1 |-style=background:#fbb ||137|| August 31 || @ Rangers || 2–3 || Clase (2–2) || Magill (4–2) || — || 33,668 || 57–80 || L2 |- |-style=background:#bfb ||138|| September 1 || @ Rangers || 11–3 || Kikuchi (6–9) || Martin (1–3) || — || 22,116 || 58–80 || W1 |-style=background:#fbb ||139|| September 2 || @ Cubs || 1–5 || Phelps (2–0) || Wisler (3–3) || — || 39,133 || 58–81 || L1 |-style=background:#fbb ||140|| September 3 || @ Cubs || 1–6 || Lester (12–9) || Hernández (1–5) || — || 33,958 || 58–82 || L2 |-style=background:#fbb ||141|| September 5 || @ Astros || 9–11 || James (5–0) || Wisler (3–4) || — || 27,822 || 58–83 || L3 |-style=background:#fbb ||142|| September 6 || @ Astros || 4–7 || Smith (1–0) || Milone (3–9) || Osuna (32) || 33,149 || 58–84 || L4 |-style=background:#fbb ||143|| September 7 || @ Astros || 1–2 || Verlander (18–5) || Adams (1–2) || Harris (2) || 41,938 || 58–85 || L5 |-style=background:#fbb ||144|| September 8 || @ Astros || 1–21 || Cole (16–5) || Hernández (1–6) || — || 35,569 || 58–86 || L6 |-style=background:#bfb ||145|| September 10 || Reds || 4–3 || Altavilla (1–0) || Garrett (4–3) || Bass (3) || 12,230 || 59–86 || W1 |-style=background:#bfb ||146|| September 11 || Reds || 5–3 || Gonzales (15–11) || Gray (10–7) || Bass (4) || 10,152 || 60–86 || W2 |-style=background:#fbb ||147|| September 12 || Reds || 5–11 || Romano (1–0)