background:#bfb;" | 12 || April 9 || @ Red Sox || 7–5 || Shoemaker (3–0) || Sale (0–3) || Giles (3) || 36,179 || 4–8 || 5 |- style="text-align:center; background:#fbb;" | 13 || April 11 || @ Red Sox || 6–7 || Walden (2–0) || Giles (0–1) || — || 36,510 || 4–9 || 6 |- style="text-align:center; background:#fbb;" | 14 || April 12 || Rays || 7–11 || Yarbrough (2–1) || Thornton (0–1) || — || 17,326 || 4–10 || 7 |- style="text-align:center; background:#bfb;" | 15 || April 13 || Rays || 3–1 || Pannone (1–2) || Roe (0–2) || Giles (4) || 20,771 || 5–10 || 6 |- style="text-align:center; background:#fbb;" | 16 || April 14 || Rays || 4–8 || Kolarek (1–0) || Stroman (0–3) || — || 20,512 || 5–11 || 7 |- style="text-align:center; background:#bfb;" | 17 || April 15 || @ Twins || 5–3 || Gaviglio (1–0) || Mejía (0–1) || Biagini (1) || 11,727 || 6–11 || 6½ |- style="text-align:center; background:#bfb;" | 18 || April 16 || @ Twins || 6–5 || Sanchez (2–1) || May (1–1) || Giles (5) || 13,365 || 7–11 || 6½ |- style="text-align:center; background:#fbb;" | 19 || April 17 || @ Twins || 1–4 || Odorizzi (1–2) || Thornton (0–2) || Parker (4) || 11,465 || 7–12 || 7½ |- style="text-align:center; background:#bfb;" | 20 || April 18 || @ Twins || 7–4 || Biagini (1–1) || Pineda (2–1) || Giles (6) || 12,523 || 8–12 || 6½ |- style="text-align:center; background:#bfb;" | 21 || April 19 || @ Athletics || 5–1 || Stroman (1–3) || Brooks (2–2) || — || 15,128 || 9–12 || 5½ |- style="text-align:center; background:#bfb;" | 22 || April 20 || @ Athletics || 10–1 || Gaviglio (2–0) || Fiers (2–2) || — || 31,140 || 10–12 || 4½ |- style="text-align:center; background:#bfb;" | 23 || April 21 || @ Athletics || 5–4 || Hudson (1–1) || Anderson (3–1) || Giles (7) || 16,015 || 11–12 || 3½ |- style="text-align:center; background:#fbb;" | 24 || April 23 || Giants || 6–7 || Samardzija (2–1) || Thornton (0–3) || Smith (6) || 20,384 || 11–13 || 5 |- style="text-align:center; background:#fbb;" | 25 || April 24 || Giants || 0–4 || Pomeranz (1–2) || Buchholz (0–1) || — || 19,652 || 11–14 || 5 |- style="text-align:center; background:#bfb;" | 26 || April 26 || Athletics || 4–2 || Giles (1–1) || Petit (0–1) ||