Makeup date: May 25th (doubleheader) |-style=background:#bfb | 50 || May 25 || @ Royals || 7–3 || Happ (4–3)|| Barlow (1–1)|| || Kauffman Stadium || 25,243 || 33–17 |-style=background:#bfb | 51 || May 25 || @ Royals || 6–5 || Adams (1–0) || López (0–6) || Chapman (14) || Kauffman Stadium || 18,599 || 34–17 |-style=background:#fbb | 52 || May 26 || @ Royals || 7–8 || McCarthy (1–1) || Holder (3–2) || — || Kauffman Stadium || 21,499 || 34–18 |-style=background:#bfb | 53 || May 27 || Padres || 5–2 || Hale (1–0) || Strahm (2–4) || Chapman (15) || Yankee Stadium || 46,254 || 35–18 |-style=background:#fbb | 54 || May 28 || Padres || 4–5 || Lauer (4–4) || Tanaka (3–4) || Yates (21) || Yankee Stadium || 37,028 || 35–19 |-style=background:#bfb | 55 || May 29 || Padres || 7–0 || Holder (4–2) || Paddack (4–3) || — || Yankee Stadium || 40,918 || 36–19 |-style=background:#bbb | — || May 30 || Red Sox || colspan=7 | Postponed (inclement weather: rain). Makeup date: August 3rd (doubleheader) |-style=background:#bfb | 56 || May 31 || Red Sox || 4–1 || Happ (5–3) || Sale (1–7) || Chapman (16) || Yankee Stadium || 45,556 || 37–19 |- |-style=background:#bfb | 57 || June 1 || Red Sox || 5–3 || Green (1–2) || Porcello (4–5) || Chapman (17)|| Yankee Stadium || 46,307 || 38–19 |-style=background:#fbb | 58 || June 2 || Red Sox || 5–8 || Price (3–2) || Sabathia (3–2) || Workman (2) || Yankee Stadium || 40,068 || 38–20 |-style=background:#fbb | 59 || June 4 || @ Blue Jays || 3–4 || Pannone (2–3) || Tanaka (3–5) || Giles (11) || Rogers Centre || 20,671 || 38–21 |-style=background:#fbb | 60 || June 5 || @ Blue Jays || 7–11 || Gaviglio (4–1) || Britton (2–1) || — || Rogers Centre || 16,609 || 38–22 |-style=background:#bfb | 61 || June 6 || @ Blue Jays || 6–2 || Happ (6–3) || Jackson (0–4) || Chapman (18) || Rogers Centre || 25,657 || 39–22 |-style=background:#fbb | 62 || June 7 || @ Indians || 2–5 || Plesac (1–1) || Germán (9–2) || Hand (19) || Progressive Field || 31,531 || 39–23 |-style=background:#fbb | 63 || June 8 || @ Indians || 4–8 || Plutko (2–1) || Sabathia (3–3) || — || Progressive Field || 32,329 || 39–24 |-style=background:#bfb | 64 ||