|| April 10 || Rays || 1:10pm || 1–9 || Glasnow (3–0) || López (0–2) || Beeks (1) || 11,107 || 3–8 || L5 |-style=background:#bfb || 12 || April 12 || @ Yankees || 6:05pm || 9–6 (7) || Giolito (2–1) || Happ (0–2) || Jones (1) || 40,913 || 4–8 || W1 |-style=background:#fbb || 13 || April 13 || @ Yankees || 12:05pm || 0–4 || Germán (3–0) || Nova (0–2) || — || 41,176 || 4–9 || L1 |-style=background:#bfb || 14 || April 14 || @ Yankees || 12:05pm || 5–2 || Rodón (2–2) || Tanaka (1–1) || Colomé (3) || 40,104 || 5–9 || W1 |-style=background:#bfb || 15 || April 15 || Royals || 7:10pm || 5–4 || Bañuelos (1–0) || Boxberger (0–3) || Colomé (4) || 12,553 || 6–9 || W2 |-style=background:#bfb || 16 || April 16 || Royals || 7:10pm || 5–1 || López (1–2) || López (0–2) || — || 13,583 || 7–9 || W3 |-style=background:#fbb || 17 || April 17 || Royals || 1:10pm || 3–4 (10) || Peralta (2–1) || Jones (0–1) || Barlow (1) || 14,358 || 7–10 || L1 |-style=background:#fbb || 18 || April 18 || @ Tigers || 12:10pm || 7–9 || VerHagen (1–0) || Fulmer (0–1) || Greene (9) || 14,320 || 7–11 || L2 |-style=background:#bfb || 19 || April 19 || @ Tigers || 6:10pm || 7–3 || Rodón (3–2) || Zimmermann (0–3) || — || 14,568 || 8–11 || W1 |-style=background:#bbb || – || April 20 || @ Tigers || 12:10pm ||colspan=7| Postponed (Rain, makeup date on August 6) |-style=background:#fbb || 20 || April 21 || @ Tigers || 12:10pm || 3–4 || Norris (1–0) || López (1–3) || Greene (10) || 15,686 || 8–12 || L1 |-style=background:#bfb || 21 || April 22 || @ Orioles || 6:05pm || 12–2 || Fry (1–0) || Hess (1–4) || — || 8,555 || 9–12 || W1 |-style=background:#fbb || 22 || April 23 || @ Orioles || 6:05pm || 1–9 || Cashner (4-1) || Nova (0-3) || — || 8,953 || 9–13 || L1 |-style=background:#fbb || 23 || April 24 || @ Orioles || 6:05pm || 3–4 || Means (3-2) || Santana (0-2) || Givens (1) || 10,555 || 9–14 || L2 |-style=background:#bfb || 24 || April 26 || Tigers || 7:10pm || 12–11 || Colomé (1–0) || Jiménez (1–1) || — || 18,016 || 10–14 ||W1 |-style=background:#bbb ||