August 5 || @ Tigers || 6:10pm || 7–4 || Giolito (12–5) || Soto (0–5) || — || 16,942 || 49–61 || W2 |-style=background:#bfb || 111 || August 6 || @ Tigers || 12:10pm || 5–3 || Cease (2–4) || Norris (3–9) || Colomé (22) || 18,455 || 50–61 || W3 |-style=background:#fbb || 112 || August 6 || @ Tigers || 6:10pm || 6–10 || VerHagen (2–2) || Santiago (1–1) || — || 16,367 || 50–62 || L1 |-style=background:#bfb || 113 || August 7 || @ Tigers || 12:10pm || 8–1 || Nova (7–9) || Alexander (0–3) || — || 17,444 || 51–62 || W1 |-style=background:#fbb || 114 || August 9 || Athletics || 2:10pm || 0–7 || Fiers (11–3) || Detwiler (1–3) || — || 18,318 || 51–63 || L1 |-style=background:#bfb || 115 || August 10 || Athletics || 6:10pm || 3–2 || López (7–9) || Roark (7–8) || Colomé (23) || 27,026 || 52–63 || W1 |-style=background:#fbb || 116 || August 11 || Athletics || 1:10pm || 0–2 || Bassitt (8–5) || Giolito (12–6) || Hendriks (12) || 30,951 || 52–64 || L1 |-style=background:#bbb || — || August 12 || Astros || 7:10pm || colspan=7| Postponed (Inclement Weather, makeup date on August 13) |-style=background:#fbb || 117 || August 13 || Astros || 3:40pm || 2–6 || Greinke (12–4) || Cease (2–5) || — || N/A || 52–65 || L2 |-style=background:#bfb || 118 || August 13 || Astros || 7:10pm || 4–1 || Nova (8–9) || Devenski (2–1) || — || 19,559 || 53–65 || W1 |-style=background:#bfb || 119 || August 14 || Astros || 1:10pm || 13–9 || Colomé (4–2) || Pressly (2–3) || — || 18,899 || 54–65 || W2 |-style=background:#fbb || 120 || August 15 || @ Angels || 9:07pm || 7–8 || Heaney (2–3) || López (7–10) || Robles (17) || 33,533 || 54–66 || L1 |-style=background:#bfb || 121 || August 16 || @ Angels || 9:07pm || 7–2 || Giolito (13–6) || Sandoval (0–1) || — || 39,206 || 55–66 || W1 |-style=background:#fbb || 122 || August 17 || @ Angels || 8:07pm || 5–6 || Cole (3–4) || Marshall (3–2) || Robles (18) || 39,419 || 55–67 || L1 |-style=background:#fbb || 123 || August 18 || @ Angels || 3:07pm || 2–9 || Canning (5–6) || Cease (2–6) || — || 35,436 || 55–68 || L2 |-style=background:#bfb || 124 || August 19 ||