17 || @Rangers || 3–7 || Sampson (1–3) || Mikolas (4–4) || || 34,398 || 23–22 || L3 |- style="background:#cfc;" | 46 || May 18 || @Rangers || 8–2 || Hudson (3– 3) || Jurado (1– 2) || || 30,967 || 24–22 || W1 |- style="background:#fbb;" | 47 || May 19 || @Rangers || 4–5 (10) || Gómez (1–0) || Hicks (1–2) || || 32,112 || 24–23 || L1 |- style="background:#bbb;" | – || May 21 || Royals || colspan=8;|Postponed (rain) Makeup: May 22 |- style="background:#fbb;" | 48 || May 22 || Royals || 2–8 || Keller (3–5) || Wacha (3– 2) || || 42,725 || 24–24 || L2 |- style="background:#cfc;" | 49 || May 22 || Royals || 10–3 || Wainwright (4–4) || Bailey (4–5) || || 42,529 || 25–24 || W1 |- style="background:#fbb;" | 50 || May 24 || Braves || 2–5 || Foltynewicz (1–3) || Mikolas (4–5) || || 44,630 || 25–25 || L1 |- style="background:#cfc;" | 51 || May 25 || Braves || 6–3 || Miller (2–2) || Winkler (1–1) || Hicks (10) || 45,760 || 26–25 || W1 |- style="background:#fbb;" | 52 || May 26 || Braves || 3–4 || Webb (3–0) || Webb (0–1) || Jackson (7) || 45,152 || 26–26 || L1 |- style="background:#fbb;" | 53 || May 28 || @Phillies || 3–4 || Pivetta (3–1) || Wainwright (4–5) || Neris (10) || 29,084 || 26–27 || L2 |- style="background:#fbb;" | 54 || May 29 || @Phillies || 4–11 || Nola (6–0) || Cabrera (0–1) || || 30,486 || 26–28 || L3 |- style="background:#cfc;" | 55 || May 30 || @Phillies || 5–3 || Hudson (4–3) || Eickhoff (2–3) || Hicks (11) || 31,206 || 27–28 || W1 |- style="background:#cfc;" | 56 || May 31 || Cubs || 2–1 (10) || Hicks (2–2) || Montgomery (1–1) || || 45,321 || 28–28 || W2 |- |- style="background:#cfc;" | 57 || June 1 || Cubs || 7–4 || Gant (4–0) || Chatwood (3–1) || Martínez (1) || 46,297 || 29–28 || W3 |- style="background:#cfc;" | 58 || June 2 || Cubs || 2–1 || Wainwright (5–5) || Hamels (4–2) || Gant (3) || 46,053 || 30–28 || W4 |- style="background:#fbb;" | 59 || June 4 || Reds || 1–4 || Castillo (6–1) || Cabrera (0–2) || Iglesias (12) || 40,649 || 30–29 || L1 |- style="background:#bbb;" | – || June 5 || Reds || colspan=8;|Postponed