L2 |-style=background:#cfc ||23|| April 26 || Orioles || 6–1 || Pérez (3–0) || Cobb (0–2) || — || 23,658 || 14–9 || W1 |-style=background:#cfc ||24|| April 27 || Orioles || 9–2 || Berríos (4–1) || Fry (0–1) || — || 18,878 || 15–9 || W2 |-style=background:#cfc ||25|| April 28 || Orioles || 4–1 ||Gibson (2–0) || Bundy (0–4) || Parker (5) || 20,034 || 16–9 || W3 |-style=background:#cfc ||26|| April 29 || Astros || 1–0 || Odorizzi (3–2) || Verlander (4–1) || Parker (6) || 12,615 || 17–9 || W4 |-style=background:#fbb ||27|| April 30 || Astros || 0–11 || Cole (2–4)|| Pineda (2–2) || — || 12,181 || 17–10 || L1 |- |-style=background:#cfc ||28|| May 1 || Astros || 6–2 || Pérez (4–0) || McHugh (3–3) || — || 14,115 || 18–10 || W1 |-style=background:#cfc ||29|| May 2 || Astros || 8–2 || Berríos (5–1) || Peacock (2–2) || — || 17,271 || 19–10 || W2 |-style=background:#fbb ||30|| May 3 || @ Yankees || 3–6 || Holder (2–0) || Gibson (2–1) ||Chapman (6)|| 35,911 || 19–11 || L1 |-style=background:#cfc ||31|| May 4 || @ Yankees || 7–3 || Odorizzi (4–2) || Happ (1–3) || — || 43,123 || 20–11 || W1 |-style=background:#fbb ||32|| May 5 || @ Yankees || 1–4 || Germán (6–1) || Pineda (2–3) || Chapman (7) || 38,603 || 20–12 || L1 |-style=background:#cfc ||33|| May 6 || @ Blue Jays || 8–0 || Pérez (5–0) || Stroman (1–5) || – || 12,292 || 21–12 || W1 |-style=background:#cfc ||34|| May 7 || @ Blue Jays || 3–0 || Berríos (6–1) || Sanchez (3–3) || Rogers (4) || 14,039 || 22–12 || W2 |-style=background:#cfc ||35|| May 8 || @ Blue Jays || 9–1 || Gibson (3–1) || Thornton (0–4) || — || 14,372 || 23–12 || W3 |-style=background:#cfc ||36|| May 10 || Tigers || 6–0 || Odorizzi (5–2) || Ross (1–5) || — || 26,789 || 24–12 || W4 |-style=background:#fbb ||37|| May 11 || Tigers || 3–5 || Jiménez (2–1) || Hildenberger (2–2) || Greene (14) || 28,840 || 24–13 || L1 |-style=background:#cfc ||38|| May 11 || Tigers || 8–3 || Stewart (1–1) || Soto (0–1) || || 20,724 || 25–13 || W1 |-style=background:#fbb ||39|| May 12 || Tigers || 3–5 || Norris (2–1) || Pérez (5–1) || Greene (15) || 27,373 || 25–14 || L1 |-style=background:#fbb ||40|| May 13 || Angels || 4–5 || Skaggs (4–3) || Berríos