|| April 28 || @ Royals || 7–3 || Harvey (1–2) || Bailey (2–3) || — || 21,549 || 12–17 || W1 |-style=background:#bfb | 30 || April 30 || Blue Jays || 4–3 || Buttrey (2–1) || Tepera (0–1) || Robles (2) || 38,797 || 13–17 || W2 |- |-style=background:#bfb | 31 || May 1 || Blue Jays || 6–3 || Peña (1-1) || Stroman (1-4) || Buttrey (1) || 33,082 || 14–17 || W3 |-style=background:#bfb | 32 || May 2 || Blue Jays || 6–2 || Skaggs (3-2) || Sanchez (3-2) || — || 40,064 || 15–17 || W4 |-style=background:#fbb | 33 || May 4 @ Estadio de Béisbol Monterrey || Astros || 2–14 || Miley (2-2) || Cahill (1-3) || — || 18,177 || 15–18 || L1 |-style=background:#fbb | 34 || May 5 @ Estadio de Béisbol Monterrey || Astros || 4–10 || Verlander (5-1) || Harvey (1-3) || — || 17,614 || 15–19 || L2 |-style=background:#bfb | 35 || May 7 || @ Tigers || 5–2 || Canning (1-0) || Norris (1–1) || Robles (3) || 14,169 || 16–19 || W1 |-style=background:#fbb | 36 || May 8 || @ Tigers || 3–10 || Boyd (4-2) || Skaggs (3-3) || — || 13,224 || 16–20 || L1 |-style=background:#bfb | 37 || May 9 || @ Tigers || 13–0 || Peña (2-1) || Carpenter (0-1) || — || 16,404 || 17–20 || W1 |-style=background:#bfb | 38 || May 10 || @ Orioles || 8–3 || Cahill (2-3) || Straily (1-3) || — || 14,495 || 18–20 || W2 |-style=background:#bfb | 39 || May 11 || @ Orioles || 7–2 || Bard (1-0) || Bundy (1-5) || — || 21,106 || 19–20 || W3 |-style=background:#fbb | 40 || May 12 || @ Orioles || 1–5 || Means (5-3) || Canning (1-1) || — || 16,387 || 19–21 || L1 |-style=background:#bfb | 41 || May 13 || @ Twins || 5–4 || Skaggs (4-3) || Berríos (6-2) || Robles (4) || 21,359 || 20–21 || W1 |-style=background:#fbb | 42 || May 14 || @ Twins || 3–4 || Gibson (4-1) || Bedrosian (1-2) || Parker (7) || 26,747 || 20-22 || L1 |-style=background:#fbb | 43 || May 15 || @ Twins || 7–8 || Odorizzi (6-2) || Cahill (2-4) || Morin (1) || 31,919 || 20–23 || L2 |-style=background:#bfb | 44 || May 17 || Royals || 5–2 || Harvey (2-3)