|| L1 |-style="background:#fbb" | 152 || September 17 || @ Dodgers || 5–7 || Maeda (10–8) || Fairbanks (1–3) || Jansen (30) || 48,663 || 89–63 || L2 |-style="background:#bfb" | 153 || September 18 || @ Dodgers || 8–7 (11) || Poche (5–5) || Sborz (0–1) || Fairbanks (2) || 48,253 || 90–63 || W1 |-style="background:#bfb" | 154 || September 20 || Red Sox || 5–4 (11) || Castillo (4–8) || Kelley (0–3) || — || 17,117 || 91–63 || W2 |-style="background:#bfb" | 155 || September 21 || Red Sox || 5–4 (11) || Castillo (5–8) || Smith (0–3) || — || 18,179 || 92–63 || W3 |-style="background:#fbb" | 156 || September 22 || Red Sox || 4–7 || Eovaldi (2–0) || Yarbrough (11–5) || — || 17,946 || 92–64 || L1 |-style="background:#bfb" | 157 || September 23 || Red Sox || 7–4 || Pruitt (3–0) || Poyner (0–1) || Poche (2) || 8,779 || 93–64 || W1 |-style="background:#bfb" | 158 || September 24 || Yankees || 2–1 (12) || Fairbanks (2–3) || Gearrin (1–3) || — || 16,699 || 94–64 || W2 |-style="background:#bfb" | 159 || September 25 || Yankees || 4–0 || Morton (16–6) || Loáisiga (2–2) || — || 20,390 || 95–64 || W3 |-style="background:#bfb" | 160 || September 27 || @ Blue Jays || 6–2 || Drake (5–2) || Zeuch (1–2) || — || 16,348 || 96–64 || W4 |-style="background:#fbb" | 161 || September 28 || @ Blue Jays || 1–4 || Thornton (6–9) || Yarbrough (11–6) || Giles (23) || 20,293 || 96–65 || L1 |-style="background:#fbb" | 162 || September 29 || @ Blue Jays || 3–8 || Buchholz (2–5) || Snell (6–8) || — || 25,738 || 96–66 || L2 |- |- style="text-align:center;" | Legend: = Win = Loss = PostponementBold = Rays team member Postseason |- style="background:#bfb" | October 2 || @ Athletics || 5–1 || Morton (1–0) || Manaea (0–1) || — || RingCentral Coliseum54,005 || 1–0 ||W1 |- |- style="background:#fbb" | 1 || October 4 || @ Astros || 2–6 || Verlander (1–0) || Glasnow (0–1) || — || Minute Maid Park43,360 || 0–1 |- style="background:#fbb" | 2 || October 5 || @ Astros || 1–3 || Cole (1–0) || Snell (0–1) || Harris (1) || Minute Maid Park43,378 || 0–2 |- style="background:#bfb" | 3 || October 7 || Astros || 10–3 || Morton (2–0) || Greinke (0–1) || — ||