(6–2) || Robles (4) || 21,359 || 25–15 || L2 |-style=background:#cfc | 41 || May 14 || Angels || 4–3 || Gibson (4–1) || Bedrosian (1–2) || Parker (7) || 26,747 || 26–15 || W1 |-style=background:#CFC | 42 || May 15 || Angels || 8–7 || Odorizzi (6–2) || Cahill (2–4) || Morin (1) || 31,919 || 27–15 || W2 |-style=background:#cfc ||43|| May 16 || @ Mariners || 11–6 || Pineda (3–3) || Swanson (1–5) || — || 16,397 || 28–15 || W3 |-style=background:#cfc ||44|| May 17 || @ Mariners || 7–1 || Pérez (6–1) || Gonzales (5–3) || — || 20,268 || 29–15 || W4 |-style=background:#cfc ||45|| May 18 || @ Mariners || 18–4 || Duffey (1–0) || LeBlanc (2–1) || — || 34,433 || 30–15 || W5 |-style=background:#fbb ||46|| May 19 || @ Mariners || 4–7 || Kikuchi (3–1) || Gibson (4–2) || — || 31,068 || 30–16 || L1 |-style=background:#cfc ||47|| May 20 || @ Angels || 3–1 || Rogers (1–0) || Buttrey (2–2) || Parker (8) || 34,177 || 31–16 || W1 |-style=background:#cfc ||48|| May 21 || @ Angels || 8–3 || Pineda (4–3) || Bard (1–2) || — || 32,316 || 32–16 || W2 |-style=background:#bbb ||49|| May 22 || @ Angels || – || Colspan=7| Postponed (rain) (Makeup date: May 23.) |-style=background:#cfc ||49|| May 23 || @ Angels || 16–7 || Pérez (7–1) || Harvey (2–4) || — || 30,992 || 33–16 || W3 |-style=background:#cfc ||50|| May 24 || White Sox || 11–4 || Berríos (7–2) || López (3–5) || — || 29,638 || 34–16 || W4 |-style=background:#cfc ||51|| May 25 ||White Sox|| 8–1 || Gibson (5–2) || Bañuelos (2–4) || — || 39,139 || 35–16 || W5 |-style=background:#cfc ||52|| May 26 || White Sox || 7–0 || Odorizzi (7–2) || Covey (0–4) || — || 39,913 || 36–16 ||W6 |-style=background:#fbb ||53|| May 27 || Brewers || 4–5 || Burnes (1–3) || Rogers (1–1) || Hader (13) || 29,167 || 36–17 || L1 |-style=background:#cfc ||54|| May 28 || Brewers || 5–3 || Magill (1–0) || Claudio (1–2) || Harper (1) || 27,120 || 37–17 || W1 |-style=background:#fbb ||55|| May 30 || @ Rays || 3–14 || Morton (6–0) || Pérez (7–2) || — || 8,076 || 37–18 || L1 |-style=background:#cfc ||56|| May 31 || @ Rays || 5–3 || Rogers (2–1) || Castillo (1–4) || — || 14,375 || 38–18 || W1 |- |-style=background:#cfc ||57||