(2–2) || Swanson (0–2) || Yates (11) || 25,154 || 16–10 || L2 |-style=background:#fbb ||27|| April 24 || @ Padres || 0–1 || Paddack (1–1) || Hernández (1–2) || Yates (12) || 23,417 || 16–11 || L3 |-style=background:#bfb ||28|| April 25 || Rangers || 14–2 || Gonzales (5–0) || Hearn (0–1) || — || 12,644 || 17–11 || W1 |-style=background:#bfb ||29|| April 26 || Rangers || 5–4 (11) || Elias (2–0) || Dowdy (1–1) || — || 21,721 || 18–11 || W2 |-style=background:#fbb ||30|| April 27 || Rangers || 1–15 || Minor (3–2) || Leake (2–3) || — || 26,493 || 18–12 || L1 |-style=background:#fbb ||31|| April 28 || Rangers || 1–14 || Lynn (3–2) || Swanson (0–3) || — || 21,503 || 18–13 || L2 |-style=background:#fbb ||32|| April 30 || Cubs || 5–6 || Brach (3–0)|| Brennan (1–1) || Cishek (1) || 27,545 || 18–14 || L3 |- |-style=background:#fbb ||33|| May 1 || Cubs || 0–11 || Lester (2–1) || Gonzales (5–1) || — || 29,471 || 18–15 || L4 |-style=background:#fbb ||34|| May 3 || @ Indians || 1–2 || Hand (1–1) || Swarzak (2–1) || — || 16,334 || 18–16 || L5 |-style=background:#fbb ||35|| May 4 || @ Indians || 4–5 || Olson (1–0) || Sadzeck (0–1) || Hand (10) || 18.420 || 18–17 || L6 |-style=background:#bfb ||36|| May 5 || @ Indians || 10–0 || Swanson (1–3) || Anderson (0–1) || — || 19,665 || 19–17 || W1 |-style=background:#fbb ||37|| May 6 || @ Yankees || 3–7 || Sabathia (2–1) || Hernández (1–3) || — || 37,423 || 19–18 || L1 |-style=background:#fbb ||38|| May 7 || @ Yankees || 4–5 || Harvey (1–0) || Swarzak (2–2) || — || 36,851 || 19–19 || L2 |-style=background:#bfb ||39|| May 8 || @ Yankees || 10–1 || Kikuchi (2–1) || Loáisiga (1–1) || — || 38,774 || 20–19 || W1 |-style=background:#fbb ||40|| May 9 || @ Yankees || 1–3 || Happ (2–3) || Leake (2–4) || Chapman (8) || 37,016 || 20–20 || L1 |-style=background:#fbb ||41|| May 10 || @ Red Sox || 1–14 || Rodríguez (4–2) || Swanson (1–4) || — || 33,731 || 20–21 || L2 |-style=background:#fbb ||42|| May 11 || @ Red Sox || 5–9 || Porcello (3–3) || Hernández (1–4) || — || 36,024 || 20–22 || L3 |-style=background:#fbb ||43|| May 12 || @ Red Sox || 2–11 || Velázquez (1–2) || Gonzales (5–2) || —