Minor (3–2) || Leake (2–3) || — || 26,493 || 13–13 || W1 |- style="background:#cfc" | 27 || April 28 || @ Mariners || 14–1 || Lynn (3–2) || Swanson (0–3) || — || 21,503 || 14–13 || W2 |- style="background:#fbb" | 28 || April 30 || Pirates || 4–6 (11) || Crick (1–1) || Chavez (0–1) || Vázquez (7) || 18,641 || 14–14 || L1 |- |- style="background:#fbb" | 29 || May 1 || Pirates || 5–7 || Taillon (2–3) || Miller (1–2) || Vázquez (8) || 23,562 || 14–15 || L2 |- style="background:#fbb;" | 30 || May 3 || Blue Jays || 0–1 (12) || Hudson (2–1) || Jurado (0–1) || Giles (8) || 26,179 || 14–16 || L3 |- style="background:#cfc;" | 31 || May 4 || Blue Jays || 8–5 || Lynn (4–2) || Pannone (1–3) || Kelley (2) || 31,787 || 15–16 || W1 |- style="background:#cfc;" | 32 || May 5 || Blue Jays || 10–2 || Dowdy (2–1) || Buchholz (0–2) || — || 30,934 || 16–16 || W2 |- style="background:#fbb;" | 33 || May 7 || @ Pirates || 4–5 || Feliz (2–0) || Sampson (0–2) || Vázquez (10) || 13,032 || 16–17 || L1 |- style="background:#cfc;" | 34 || May 8 || @ Pirates || 9–6 || Jurado (1–1) || Lyons (1–1) || Martin (1) || 13,905 || 17–17 || W1 |- style="background:#fbb;" | 35 || May 9 || @ Astros || 2–4 || Miley (3–2) || Minor (3–3) || Osuna (9) || 26,657 || 17–18 || L1 |- style="background:#fbb;" | 36 || May 10 || @ Astros || 0–3 || Verlander (6–1) || Lynn (4–3) || Osuna (10) || 33,023 || 17–19 || L2 |- style="background:#fbb;" | 37 || May 11 || @ Astros || 4–11 || Cole (4–4) || Smyly (0–3) || — || 35,849 || 17–20 || L3 |- style="background:#fbb;" | 38 || May 12 || @ Astros || 5–15 || Martin (1–0) || Sampson (0–3) || — || 41,027 || 17–21 || L4 |- style="background:#fbb;" | 39 || May 14 || @ Royals || 5–11 || Duffy (2–1) || Miller (1–3) || — || 19,410 || 17–22 || L5 |- style="background:#cfc;" | 40 || May 15 || @ Royals || 6–1 || Minor (4–3) || López (0–5) || — || 14,572 || 18–22 || W1 |- style="background:#cfc;" | 41 || May 16 || @ Royals || 16–1 || Lynn