|| 5–13 || Gibson (13–6) || Jackson (3–8) || — || 17,273 || 39–93 || L6 |- bgcolor="bbffbb | 133 || August 31 || Twins || 10–7 || Boyd (7–10) || Pérez (9–6) || — || 16,713 || 40–93 || W1 |- |- bgcolor="ffbbbb | 134 || September 1 || Twins || 3–8 || Pineda (11–5) || Turnbull (3–14) || — || 13,776 || 40–94 || L1 |- bgcolor="ffbbbb | 135 || September 2 || Twins || 3–4 || Littell (3–0) || Farmer (5–6) || Rogers (22) || 14,614 || 40–95 || L2 |- bgcolor="ffbbbb | 136 || September 3 || @ Royals || 5–6 || Kennedy (2–2) ||Reininger (0–1) || — || 12,644 || 40–96 || L3 |- bgcolor="ffbbbb | 137 || September 4 || @ Royals || 4–5 || Junis (9–12) || Jackson (3–9) || Kennedy (26) || 15,308 || 40–97 || L4 |- bgcolor="bbffbb | 138 || September 5 || @ Royals || 6–4 || Boyd (8–10) || Sparkman (3–11) || Jiménez (5) || 14,736 || 41–97 || W1 |- bgcolor="ffbbbb | 139 || September 6 || @ Athletics || 3–7 || Fiers (4–3) || Reininger (0–2) || — || 15,680 || 41–98 || L1 |- bgcolor="bbffbb | 140 || September 6 || @ Athletics || 5–4 (11) || Schreiber (1–0) || Blackburn (0–2) || Jiménez (6) || 16,080 || 42–98 || W1 |- bgcolor="ffbbbb | 141 || September 7 || @ Athletics || 2–10 || Bassitt (10–5) || Zimmermann (1–10) || — || 32,626 || 42–99 || L1 |- bgcolor="ffbbbb | 142 || September 8 || @ Athletics || 1–3 || Manaea (1–0) || Norris (3–12) || Hendriks (19) || 24,550 || 42–100 || L2 |- bgcolor="bbffbb | 143 || September 10 || Yankees || 12–11 || Jiménez (4–7) || Adams (1–1) || — || 16,733 || 43–100 || W1 |- bgcolor="bbbbbb" | — || September 11 || Yankees ||colspan="9" | Postponed (inclement weather). Rescheduled to September 12. |- bgcolor="ffbbbb | 144 || September 12 || Yankees || 4–10 || Green (4–4) || Boyd (8–11) || — || — || 43–101 || L1 |- bgcolor="ffbbbb | 145 || September 12 || Yankees || 4–6 || Germán (18–4) || Turnbull (3–15) || Chapman (37) || 17,807 || 43–102 || L2 |- bgcolor="ffbbbb | 146 || September 13 || Orioles || 2–6 || Brooks (5–8) || Zimmermann (1–11) || — || 14,722 || 43–103 || L3 |- bgcolor="bbffbb