Rays || 5–8 || Yarbrough (10–3) || Porcello (9–8) || Roe (1) || Fenway Park || 33,046 || 59–50 || L3 |- |- style="text-align:center; background-color:#fbb" | 110 || Aug 1 || Rays || 4–9 || McKay (2–1) || Cashner (10–6) || — || Fenway Park || 37,225 || 59–51 || L4 |- style="text-align:center; background-color:#fbb" | 111 || Aug 2 || @ Yankees || 2–4 || Paxton (6–6) || Rodríguez (13–5) || Chapman (28) || Yankee Stadium || 46,932 || 59–52 || L5 |- style="text-align:center; background-color:#fbb" | 112 || Aug 3 (1) || @ Yankees || 2–9 || Germán (14–2) || Sale (5–11) || — || Yankee Stadium || 46,625 || 59–53 || L6 |- style="text-align:center; background-color:#fbb" | 113 || Aug 3 (2) || @ Yankees || 4–6 || Kahnle (3–0) || Barnes (3–4) || Chapman (29) || Yankee Stadium || 48,101 || 59–54 || L7 |- style="text-align:center; background-color:#fbb" | 114 || Aug 4 || @ Yankees || 4–7 || Happ (9–6) || Price (7–5) || Green (2) || Yankee Stadium || 47,267 || 59–55 || L8 |- style="text-align:center; background-color:#bfb" | 115 || Aug 5 || Royals || 7–5 || Porcello (10–8) || Montgomery (1–5) || Workman (6) || Fenway Park || 33,636 || 60–55 || W1 |- style="text-align:center; background-color:#fbb" | 116 || Aug 6 || Royals || 2–6 || Junis (7–10) || Cashner (10–7) || — || Fenway Park || 36,360 || 60–56 || L1 |- style="text-align:center; background-color:#bfb" | 117 || Aug 7 || Royals || 5–4 || Taylor (1–1) || Lovelady (0–2) || — || Fenway Park || 32,453 || 61–56 || W1 |- style="text-align:center; background-color:#bfb" | 118 || Aug 8 || Angels || 3–0 || Sale (6–11) || Peters (2–1) || Workman (7) || Fenway Park || 34,744 || 62–56 || W2 |- style="text-align:center; background-color:#bfb" | 119 || Aug 9 || Angels || 16–4 || Walden (7–1) || Barría (4–6) || — || Fenway Park || 36,650 || 63–56 || W3 |- style="text-align:center; background-color:#fbb" | 120 || Aug 10 || Angels || 4–12 || Cole (2–3) || Porcello (10–9) || — || Fenway Park || 36,390 || 63–57 || L1 |- style="text-align:center; background-color:#fbb" | 121 || Aug 11 || Angels || 4–5 || Robles (4–0) || Weber (1–2) || — || Fenway Park || 36,709 || 63–58 || L2 |- style="text-align:center; background-color:#fbb" | 122 || Aug 12 || @ Indians || 5–6 || Hand (6–3) || Walden (7–2)