— || 11,744 || 19–9 || W3 |-style="background:#bbb" | — || April 30 || @ Royals || colspan=7|Postponed (rain); Makeup: May 1 |- |-style="background:#fbb" | 29 || May 1 || @ Royals || 2–3 || Junis (3–2) || Stanek (0–1) || Ian Kennedy (2) || 11,141 || 19–10 || L1 |-style="background:#fbb" | 30 || May 1 || @ Royals || 2–8 || Sparkman (1–1) || Snell (2–3) || — || 11,141 || 19–11 || L2 |-style="background:#bfb" | 31 || May 2 || @ Royals || 3–1 || Kolarek (2–0) || Peralta (2–2) || Castillo (4) || 23,343 || 20–11 || W1 |-style="background:#bfb" | 32 || May 3 || @ Orioles || 7–0 || Glasnow (6–0) || Straily (1–2) || — || 10,034 || 21–11 || W2 |-style="background:#fbb" | 33 || May 4 || @ Orioles || 0–3 || Bundy (1–4) || Chirinos (4–1) || Givens (3) || 15,241 || 21–12 || L1 |-style="background:#bbb" | – || May 5 || @ Orioles || colspan=7|Postponed (rain); Makeup: July 13 |-style="background:#bfb" | 34 || May 6 || Diamondbacks || 12–1 || Snell (3–3) || Kelly (3–3) || — || 8,124 || 22–12 || W1 |-style="background:#bfb" | 35 || May 7 || Diamondbacks || 6–3 || Beeks (2–0) || Clarke (0–1) || — || 8,059 || 23–12 || W2 |-style="background:#fbb" | 36 || May 8 || Diamondbacks || 2–3 (13) || Bradley (2–3) || Kolarek (2–1) || Godley (1) || 8,663 || 23–13 || L1 |-style="background:#fbb" | 37 || May 10 || Yankees || 3–4 || Germán (7–1) || Glasnow (6–1) || Chapman (9) || 20,846 || 23–14 || L2 |-style="background:#bfb" | 38 || May 11 || Yankees || 7–2 || Chirinos (5–1) || Holder (2–1) || — || 25,025 || 24–14 || W1 |-style="background:#fbb" | 39 || May 12 || Yankees || 1–7 || Tanaka (3–3) || Snell (3–4) || — || 25,025 || 24–15 || L1 |-style="background:#bfb" | 40 || May 14 || @ Marlins || 4–0 || Morton (4–0) || Smith (3–1) || — || 6,306 || 25–15 || W1 |-style="background:#bfb" | 41 || May 15 || @ Marlins || 1–0 || Beeks (3–0) || Ureña (1–6) || Castillo (5) || 5,947 || 26–15 || W2 |-style="background:#fbb" | 42 || May 17 || @ Yankees || 3–4 || Holder (3–1) || Alvarado (0–3) || — || 41,281 || 26–16 || L1 |-style="background:#bfb" | 43 || May 18 || @ Yankees ||