|| 139 || September 4 || @ Indians || 6:10pm || 6–8 || Bieber (13–7) || Nova (9–12) || Wittgren (4) || 25,488 || 61–78 || L1 |-style=background:#bfb || 140 || September 5 || @ Indians || 12:10pm || 7–1 || López (9–12) || Plesac (7–6) || — || 18,913 || 62–78 || W1 |-style=background:#fbb || 141 || September 6 || Angels || 7:10pm || 4–5 || Robles (5–0) || Colomé (4–3) || — || 20,026 || 62–79 || L1 |-style=background:#fbb || 142 || September 7 || Angels || 6:10pm || 7–8 || Heaney (4–4) || Covey (1–8) || Robles (20) || 25,230 || 62–80 || L2 |-style=background:#bfb || 143 || September 8 || Angels || 1:10pm || 5–1 || Osich (2–0) || Barría (4–8) || — || 22,681 || 63–80 || W1 |-style=background:#bfb || 144 || September 10 || Royals || 7:10pm || 7–3 || Nova (10–12) || Junis (9–13) || — || 15,196 || 64–80 || W2 |-style=background:#fbb || 145 || September 11 || Royals || 7:10pm || 6–8 || Sparkman (4–11) || López (9–13) || Kennedy (28) || 14,385 || 64–81 || L1 |-style=background:#fbb || 146 || September 12 || Royals || 1:10pm || 3–6 || López (4–7) || Giolito (14–9) || Kennedy (29) || 13,838 || 64–82 || L2 |-style=background:#bfb || 147 || September 13 || @ Mariners || 9:10pm || 9–7 || Osich (3–0) || Kikuchi (6–10) || Colomé (27) || 17,255 || 65–82 || W1 |-style=background:#fbb || 148 || September 14 || @ Mariners || 8:10pm || 1–2 || Magill (5–2) || Colomé (4–4) || — || 26,063 || 65–83 || L1 |-style=background:#fbb || 149 || September 15 || @ Mariners || 3:10pm || 10–11 || Adams (2–2) || Ruiz (1–3) || — || 17,091 || 65–84 || L2 |-style=background:#fbb || 150 || September 16 || @ Twins || 6:40pm || 3–5 || Berríos (13–8) || López (9–14) || Rogers (27) || 21,850 || 65–85 || L3 |-style=background:#fbb || 151 || September 17 || @ Twins || 6:40pm || 8–9 || Harper (4–2) || Ruiz (1–4) || — || 22,518 || 65–86 || L4 |-style=background:#bfb || 152 || September 18 || @ Twins || 6:40pm || 3–1 || Fry (3–4) || Odorizzi (14–7) || Colomé (28) || 23,759 || 66–86 || W1 |-style=background:#bfb || 153 || September 20 || @ Tigers || 6:10pm || 10–1 || Cease (4–7) || Zimmermann (1–12) || — ||