Andriese (1–0) || García (0–1) || Holland (1) || 42,266 || 1–1 || W1 |- align="center" bgcolor=ffbbbb | 3 || March 30 || @ Dodgers || 5–18 || Maeda (1–0) || Godley (0–1) || — || 50,626 || 1–2 || L1 |- align="center" bgcolor=ffbbbb | 4 || March 31 || @ Dodgers || 7–8 || Floro (1–0) || Hirano (0–1) || — || 43,815 || 1–3 || L2 |- align="center" bgcolor=ccffcc | 5 || April 1 || @ Padres || 10–3 || Kelly (1–0) || Strahm (0–1) || — || 18,683 || 2–3 || W1 |- align="center" bgcolor=ccffcc | 6 || April 2 || @ Padres || 8–5 || Greinke (1–1) || Lauer (1–1) || Holland (2) || 22,504 || 3–3 || W2 |- align="center" bgcolor=ffbbbb | 7 || April 3 || @ Padres || 1–4 || Lucchesi (2–0) || Ray (0–1) || — || 19,376 || 3–4 || L1 |- align="center" bgcolor=ccffcc | 8 || April 5 || Red Sox || 15–8 || Godley (1–1) || Porcello (0–2) || — || 48,338 || 4–4 || W1 |- align="center" bgcolor=ccffcc | 9 || April 6 || Red Sox || 5–4 || Holland (1–0) || Brewer (0–1) || — || 35,969 || 5–4 || W2 |- align="center" bgcolor=ffbbbb | 10 || April 7 || Red Sox || 0–1 || Walden (1–0) || Kelly (1–1) || Brasier (2) || 31,565 || 5–5 || L1 |- align="center" bgcolor=ccffcc | 11 || April 9 || Rangers || 5–4 || Andriese (2–0) || Leclerc (1–1) || — || 16,620 || 6–5 || W1 |- align="center" bgcolor=ffbbbb | 12 || April 10 || Rangers || 2–5 || Lynn (1–1) || Chafin (0–1) || Bird (1) || 15,871 || 6–6 || L1 |- align="center" bgcolor=ffbbbb | 13 || April 11 || Padres || 6–7 || Stammen (1–0) || Bradley (0–1) || Wingenter (1) || 15,449 || 6–7 || L2 |- align="center" bgcolor=ffbbbb | 14 || April 12 || Padres || 1–2 || Reyes (1–0) || Weaver (0–1) || Yates (8) || 22,209 || 6–8 || L3 |- align="center" bgcolor=ffbbbb | 15 || April 13 || Padres || 4–5 || Stammen (2–0) || Andriese (2–1) || Yates (9) || 27,256 || 6–9 || L4 |- align="center" bgcolor=ccffcc | 16 || April 14 || Padres || 8–4 || Greinke (2–1) || Lauer (2–2) || — || 25.489 || 7–9 || W1 |- align="center" bgcolor=ccffcc | 17 || April 16