7 || Indians || 5–3 || Littell (4–0) || Cimber (5–3) || Rogers (25) || 39,573 || 88–54 || W1 |-style=background:#fbb ||143|| September 8 || Indians || 2–5 || Clevinger (11–2) || Dobnak (0–1) || Hand (34) || 31,380 || 88–55 || L1 |-style=background:#bfb ||144|| September 10 || Nationals || 5–0 || Berríos (12–8) || Sánchez (8–8) || — || 24,813 || 89–55 || W1 |-style=background:#fbb ||145|| September 11 || Nationals || 2–6 || Strasburg (17–6) || Pérez (10–7) || — || 20,062 || 89–56 || L1 |-style=background:#fbb ||146|| September 12 || Nationals || 6–12 || Corbin (12–7) || Gibson (13–7) || — || 19,167 || 89–57 || L2 |-style=background:#bbb ||—|| September 13 || @ Indians || – || Colspan=7| Postponed (rain) (Makeup date: September 14.) |-style=background:#bfb ||147|| September 14 || @ Indians || 2–0 || Littell (5–0) || Clevinger (11–3) || Rogers (26) || 24,258 || 90–57 || W1 |-style=background:#bfb ||148|| September 14 || @ Indians || 9–5 || Graterol (1–0) || Pérez (2–3) || — || 31,841 || 91–57 || W2 |-style=background:#fbb ||149|| September 15 || @ Indians || 5–7 || Wittgren (5–1) || Romero (0–1) || Pérez (1) || 26,414 || 91–58 || L1 |-style=background:#bfb ||150|| September 16 || White Sox || 5–3 || Berríos (13–8) || López (9–14) || Rogers (27) || 21,850 || 92–58 || W1 |-style=background:#bfb ||151|| September 17 || White Sox || 9–8 (12) || Harper (4–2) || Ruiz (1–4) || — || 22,518 || 93–58 || W2 |-style=background:#fbb ||152|| September 18 || White Sox || 1–3 || Fry (3–4) || Odorizzi (14–7) || Colomé (28) || 23,759 || 93–59 || L1 |-style=background:#bfb ||153|| September 19 || Royals || 8–5 || Thorpe (3–2) || Barnes (1–3) || Rogers (28) || 24,565 || 94–59 || W1 |-style=background:#bfb ||154|| September 20 || Royals || 4–3 || Dobnak (1–1) || Skoglund (0–2) || May (2) || 29,468 || 95–59 || W2 |-style=background:#fbb ||155|| September 21 || Royals || 5–12 || Rosario (2–0) || Rogers (2–4) || — || 37,750 || 95–60 || L1 |-style=background:#bfb ||156|| September 22 || Royals || 12–8 || Littell (6–0) || López (4–9) || — || 31,628 || 96–60 || W1 |-style=background:#bfb ||157|| September 24 || @ Tigers || 4–2 || Odorizzi (15–7) || Turnbull (3–16) || Rogers (29) || 16,174 || 97–60 || W2 |-style=background:#bfb ||158|| September 25 || @ Tigers || 5–1 || Dobnak (2–1) || VerHagen (4–3) || —