(0–1) || Colomé (2) || 32,723 || 7–2 || L1 |-style=background:#bfb ||10|| April 6 || @ White Sox || 9–2 || Leake (2–0) || Giolito (1–1) || — || 31,286 || 8–2 || W1 |-style=background:#bfb ||11|| April 7 || @ White Sox || 12–5 || LeBlanc (2–0) || Nova (0–1) || — || 12,509 || 9–2 || W2 |-style=background:#bfb ||12|| April 8 || @ Royals || 13–5 || Elías (1–0) || Bailey (0–1) || — || 10,259 || 10–2 || W3 |-style=background:#bfb ||13|| April 9 || @ Royals || 6–3 || Gonzales (4–0) || Junis (1–1) || Swarzak (2) || 10,366 || 11–2 || W4 |-style=background:#bfb ||14|| April 10 || @ Royals || 6–5 || Swarzak (1–0) || Boxberger (0–2) || Elías (2) || 12,775 || 12–2 || W5 |-style=background:#bfb ||15|| April 11 || @ Royals || 7–6 (10) || Brennan (1–0) || Sparkman (0–1) || Sadzeck (1) || 10,231 || 13–2 || W6 |- style=background:#fbb ||16|| April 12 || Astros || 6–10 || Peacock (2–0) || Armstrong (0–1) || Osuna (5) || 30,969 || 13–3 || L1 |- style="text-align:center; background:#fbb ||17|| April 13 || Astros || 1–3 || Verlander (2–0) || Hernández (1–1)|| Osuna (6) || 30,533 || 13–4 || L2 |-style=background:#fbb ||18|| April 14 || Astros || 2–3 || Cole (1–2) ||Brennan (0–1) || Osuna (7) || 29,237 || 13–5 || L3 |-style=background:#fbb ||19|| April 15 || Indians || 4–6 || Bauer (2–1) || Kikuchi (0–1) || Hand (5) || 11,214 || 13–6 || L4 |-style=background:#fbb ||20|| April 16 || Indians || 2–4 || Bieber (2–0) || Leake (2–1) || Hand (6) || 11,826 || 13–7 || L5 |-style=background:#fbb ||21|| April 17 || Indians || 0–1 || Carrasco (2–2) || Swanson (0–1) || Wittgren (1) || 13,325 || 13–8 || L6 |-style=background:#bfb ||22|| April 18 || @ Angels || 11–10 || Swarzak (2–0) || Allen (0–1) || Elias (3) || 33,592 || 14–8 || W1 |-style=background:#bfb ||23|| April 19 || @ Angels || 5–3 || Rosscup (2–0) || Allen (0–2) || Elias (4) || 41,021 || 15–8 || W2 |-style=background:#bfb ||24|| April 20 || @ Angels || 6–5 || Kikuchi (1–1) || Cahill (1–2) || Swarzak (3) || 41,147 || 16–8 || W3 |-style=background:#fbb ||25|| April 21 || @ Angels || 6–8 || Barria (2–1) || Leake (2–2) || García (1) || 34,155 || 16–9 || L1 |-style=background:#fbb ||26|| April 23 || @ Padres || 3–6 || Margevicius