3 || @ Astros || 0–9 || Sanchez (4–14) || Gonzales (12–9) || — || 37,059 || 47–66 || L3 |-style=background:#fbb ||114|| August 4 || @ Astros || 1–3 || Verlander (15–4) || Milone (1–6) || Osuna (25) || 39,667 || 47–67 || L4 |-style=background:#fbb ||115|| August 6 || Padres || 4–9 || Lamet (1–2) || LeBlanc (6–5) || — || 24,020 || 47–68 || L5 |-style=background:#bfb ||116|| August 7 || Padres || 3–2 || Magill (3–0) || Muñoz (0–1) || Bass (2) || 20,142 || 48–68 || W1 |-style=background:#fbb ||117|| August 9 || Rays || 3–5 || Drake (1–1) || Bass (1–4) || Pagán (10) || 26,774 || 48–69 || L1 |-style=background:#fbb ||118|| August 10 || Rays || 4–5 || Morton (13–4) || Milone (1–7) || Pagán (11) || 33,895 || 48–70 || L2 |-style=background:#fbb ||119|| August 11 || Rays || 0–1 || Yarbrough (11–3) || LeBlanc (6–6) || Pagán (12) || 24,219 || 48–71 || L3 |-style=background:#bfb ||120|| August 13 || @ Tigers || 11–6 || Grotz (1–0) || Boyd (6–9) || — || 16,195 || 49–71 || W1 |-style=background:#fbb ||121|| August 14 || @ Tigers || 3–2 || Jackson (3–5) || Gonzales (12–10) || Jiménez (2) || 17,132 || 49–72 || L1 |-style=background:#bfb ||122|| August 15 || @ Tigers || 7–2 || Milone (2–7) || Turnbull (3–11) || || 19,440 || 50–72 || W1 |-style=background:#fbb ||123|| August 16 || @ Blue Jays || 3–7 || Waguespack (4–1) || LeBlanc (6–7) || — || 20,844 || 50–73 || L1 |-style=background:#bfb ||124|| August 17 || @ Blue Jays || 4–3 || Bass (2–4) || Mayza (1–2) || Magill (1) || 22,073 || 51–73 || W1 |-style=background:#bfb ||125|| August 18 || @ Blue Jays || 7–0 || Kikuchi (5–8) || Font (3–3) || — || 23,604 || 52–73 || W2 |-style=background:#bfb ||126|| August 19 || @ Rays || 9–3 || Gonzales (13–10) || McKay (2–3) || — || 9,152 || 53–73 || W3 |-style=background:#bfb ||127|| August 20 || @ Rays || 7–4 || Milone (3–7) || Beeks (5–3) || Magill (2) || 7,455 || 54–73 || W4 |-style=background:#fbb ||128|| August 21 || @ Rays || 6–7 || Pagán (3–2) || Magill (3–1) || — || 7,827 || 54–74 || L1 |-style=background:#bfb ||129|| August 23 || Blue Jays || 7–4 || Wisler (3–2) || Gaviglio (4–2) || Magill (3) || 34,706 || 55–74 || W1 |-style=background:#fbb ||130|| August 24 || Blue