May 17 || @ Tigers || 7–2 || Montas (5–2) || Norris (2–2) || — || 18,746 || 21–25 || W2 |-style=background:#cfc ||47|| May 18 || @ Tigers || 4–1 || Mengden (1–1) || Boyd (4–4) || Treinen (7) || 22,913 || 22–25 || W3 |-style=background:#bbb || – || May 19 || @ Tigers || colspan="9" | Suspended (inclement weather). Continuation scheduled for September 6 in Oakland. |-style=background:#cfc ||49|| May 20 || @ Indians || 6–4 || Anderson (5–3) || Carrasco (4–4) || Treinen (8) || 12,563 || 23–25 || W5 |-style=background:#cfc |50|| May 21 || @ Indians || 5–3 || Hendriks (2–0) || Bauer (4–3) || Treinen (9) || 13,705 || 24–25 || W6 |-style=background:#cfc ||51|| May 22 || @ Indians || 7–2 || Montas (6–2) || Rodríguez (1–4) || — || 17,010 || 25–25 || W7 |-style=background:#cfc ||52|| May 24 || Mariners || 6–2 || Trivino (2–0) || LeBlanc (2–2) || — || 12,902 || 26–25 || W8 |-style=background:#cfc ||53|| May 25 || Mariners || 6–5 || Fiers (4–3) || Kikuchi (3–2) || Treinen (10) || 18,975 || 27–25 || W9 |-style=background:#cfc ||54|| May 26 || Mariners || 7–1 || Anderson (6–3) || Leake (3–6) || — || 14,664 || 28–25 || W10 |-style=background:#cfc ||55|| May 27 || Angels || 8–5 || Bassitt (3–1) || Cahill (2–5) || Treinen (11) || 20,409 || 29–25 || W11 |-style=background:#fbb ||56|| May 28 || Angels || 4–6 || Buttrey (3–2) || Soria (1–4) || Robles (6) || 13,060 || 29–26 || L1 |-style=background:#fbb ||57|| May 29 || Angels || 7–12 (11) || Ramirez (2–0) || Trivino (2–1) || — || 21,185 || 29–27 || L2 |-style=background:#fbb ||58|| May 31 || Astros || 2–3 || Rondón (3–1) || Trivino (2–2) || Osuna (16) || 14,519 || 29–28 || L3 |- |-style=background:#fbb ||59|| June 1 || Astros || 1–5 || Verlander (9–2) || Anderson (6–4) || — || 20,425 || 29–29 || L4 |-style=background:#fbb ||60|| June 2 || Astros || 4–6 (12) || James (3–0) || Trivino (2–3) || — || 23,144 || 29–30 || L5 |-style=background:#bfb ||61|| June 4 || @ Angels || 4–2 || Montas (7–2) || Canning (2–2) || Treinen (12) || 36,009 || 30–30 || W1 |-style=background:#fbb ||62|| June 5 || @ Angels || 9–10 || Robles (3–0) || Trivino (2–4) || — || 36,065 || 30–31 || L1 |-style=background:#cfc ||63|| June 6 || @ Angels || 7–4 ||