|| 2–4 |-style=background:#bfb | 7 || April 4 || @ Orioles || 8–4 || Paxton (1–1) || Wright (0–1) || — || Oriole Park at Camden Yards || 44,182 || 3–4 |-style=background:#bfb | 8 || April 6 || @ Orioles || 6–4 || Ottavino (1–0) || Castro (0–1) || Chapman (2) || Oriole Park at Camden Yards || 27,504 || 4–4 |-style=background:#bfb | 9 || April 7 || @ Orioles || 15–3 || Germán (2–0) || Hess (1–1) || — || Oriole Park at Camden Yards || 33,102 || 5–4 |-style=background:#fbb | 10 || April 8 || @ Astros || 3–4 || Pressly (1–0) || Ottavino (1–1) || Osuna (3) || Minute Maid Park || 27,631 || 5–5 |-style=background:#fbb | 11 || April 9 || @ Astros || 3–6 || Rondón (1–0) || Green (0–2) || Osuna (4) || Minute Maid Park || 31,009 || 5–6 |-style=background:#fbb | 12 || April 10 || @ Astros || 6–8 || McHugh (2–1) || Paxton (1–2) || Pressly (1) || Minute Maid Park ||27,685 || 5–7 |-style=background:#fbb | 13 || April 12 || White Sox || 6–9 || Giolito (2–1) || Happ (0–2) || Jones (1) || Yankee Stadium || 40,913 || 5–8 |-style=background:#bfb | 14 || April 13 || White Sox || 4–0 || Germán (3–0) || Nova (0–2) || — || Yankee Stadium || 41,176 || 6–8 |-style=background:#fbb | 15 || April 14 || White Sox || 2–5 || Rodón (2–2) || Tanaka (1–1) || Colomé (3) || Yankee Stadium || 40,104 || 6–9 |-style=background:#bfb | 16 || April 16 || Red Sox || 8–0 || Paxton (2–2) || Sale (0–4) || — || Yankee Stadium || 45,008 || 7–9 |-style=background:#bfb | 17 || April 17 || Red Sox || 5–3 || Kahnle (1–0) || Workman (0–1) || Chapman (3) || Yankee Stadium || 44,106 || 8–9 |-style=background:#fbb | 18 || April 18 || Royals || 1–6 || Bailey (2–1) || Germán (3–1) || — || Yankee Stadium || 39,106 || 8–10 |-style=background:#bfb | 19 || April 19 || Royals || 6–2 || Sabathia (1–0) || Junis (1–2) || — || Yankee Stadium || 39,668 || 9–10 |-style=background:#bfb | 20 || April 20 || Royals || 9–2 ||Tanaka (2–1) || Fillmyer (0–1) || — || Yankee Stadium || 42,013 || 10–10 |-style=background:#bfb | 21 || April 21 || Royals || 7–6 || Britton (1–0) || Diekman (0–1) || — || Yankee