|| 3–5 (11) || Pagán (4–2) || Clase (2–3) || Fairbanks (1) || 18,467 || 72–74 || L1 |- style="background:#cfc | 147 || September 11 || Rays || 10–9 || Gibaut (1–0) || Poche (4–5) || Leclerc (12) || 19,746 || 73–74 || W1 |- style="background:#cfc | 148 || September 12 || Rays || 6–4 || Farrell (1–0) || McKay (2–4) || Leclerc (13) || 18,222 || 74–74 || W2 |- style="background:#fbb | 149 || September 13 || Athletics || 9–14 || Wendelken (2–1) || Gibaut (1–1) || — || 27,813 || 74–75 || L1 |- style="background:#fbb | 150 || September 14 || Athletics || 6–8 || Buchter (1–1) || Minor (13–9) || Hendriks (22) || 31,928 || 74–76 || L2 |- style="background:#fbb | 151 || September 15 || Athletics || 1–6 || Manaea (2–0) || Hernández (1–1) || Luzardo (1) || 26,064 || 74–77 || L3 |- style="background:#fbb | 152 || September 17 || @ Astros || 1–4 || Verlander (19–6) || Lynn (14–11) || Osuna (34) || 39,650 || 74–78 || L4 |- style="background:#fbb | 153 || September 18 || @ Astros || 2–3 || Cole (18–5) || Allard (4–1) || Osuna (35) || 38,417 || 74–79 || L5 |- style="background:#fbb | 154 || September 20 || @ Athletics || 0–8 || Fiers (15–4) || Minor (13–10) || — || 29,579 || 74–80 || L6 |- style="background:#fbb | 155 || September 21 || @ Athletics || 3–12 || Manaea (3–0) || Burke (0–2) || — || 29,896 || 74–81 || L7 |- style="background:#cfc | 156 || September 22 || @ Athletics || 8–3 || Lynn (15–11) || Roark (10–9) || — || 38,453 || 75–81 || W1 |- style="background:#fbb | 157 || September 24 || Red Sox || 10–12 || Rodríguez (19–6) || Jurado (7–11) || Workman (16) || 23,341 || 75–82 || L1 |- style="background:#fbb | 158 || September 25 || Red Sox || 3–10 || Porcello (14–12) || Allard (4–2) || — || 29,290 || 75–83 || L2 |- style="background:#cfc | 159 || September 26 || Red Sox || 7–5 || Minor (14–10) || Weber (2–4) || Leclerc (14) || 24,612 || 76–83 || W1 |- style="background:#fbb | 160 || September 27 || Yankees || 7–14 || Tarpley (1–0) || Palumbo (0–3) || — || 35,168 || 76–84 || L1 |- style="background:#cfc | 161 || September 28 || Yankees || 9–4 || Hernández (2–1) || Severino