23,343 || 11–21 || L1 |-style=background:#fbb ||33|| May 3 || @ Tigers || 3–4 || Boyd (3–2) || López (0–3) || Greene (13) || 14,020 || 11–22 || L2 |-style=background:#bfb ||34|| May 4 || @ Tigers || 15–3 || Bailey (3–3) || Ross (1–4) ||-|| 19,500 || 12–22 || W1 |-style=background:#fbb ||35|| May 5 || @ Tigers || 2–5 (10) || Farmer (2–2) || Kennedy (0–1) ||-|| 16,369 || 12–23 || L1 |-style=background:#fbb ||36|| May 6 || @ Astros || 4–6 || Cole (3–4) || Junis (3–3) || Osuna (8) || 27,079 || 12–24 || L2 |-style=background:#bfb ||37|| May 7 || @ Astros || 12–2 || Duffy (1–1) || McHugh (3–4) ||-|| 30,377 || 13–24 || W1 |-style=background:#fbb ||38|| May 8 || @ Astros || 0–9 || Peacock (3–2) || López (0–4) ||-|| 22,698 || 13–25 || L1 |-style=background:#bfb ||39|| May 10 || Phillies || 5–1|| Bailey (4–3) || Arrieta (4–3) ||-|| 20,015 || 14–25 || W1 |-style=background:#fbb ||40|| May 11 || Phillies || 0–7 || Eflin (5–3) || Keller (2–4) ||-|| 24,463 || 14–26 || L1 |-style=background:#fbb ||41|| May 12 || Phillies || 1–6 || Irvin (1–0) || Junis (3–4) ||-|| 19,640 || 14–27 || L2 |-style=background:#bfb ||42|| May 14 || Rangers || 11–5 || Duffy (2–1) || Miller (1–3) ||-|| 19,410 || 15–27 || W1 |-style=background:#fbb ||43|| May 15 || Rangers || 1–6 || Minor (4–3) || López (0–5) ||-|| 14,572 || 15–28 || L1 |-style=background:#fbb ||44|| May 16 || Rangers || 1–16 || Lynn (5–3) || Bailey (4–4) ||-|| 17,469 || 15–29 || L2 |-style=background:#fbb ||45|| May 17 || @ Angels || 2–5 || Harvey (2–3) || Keller (2–5) || Robles (5) || 43,444 || 15–30 || L3 |-style=background:#fbb ||46|| May 18 || @ Angels || 3–6 || Canning (2–1) || Junis (3–5) || Buttrey (2) || 43,415 || 15–31 || L4 |-style=background:#bfb ||47|| May 19 || @ Angels || 5–1 || Duffy (3–1) || Skaggs (4–4) ||-|| 43,329 || 16–31 || W1 |-style=background:#bbb ||48|| May 21 || @ Cardinals || colspan=8|Postponed (rain); Makeup:May 22 |-style=background:#bfb ||48|| May 22 || @ Cardinals || 8–2 || Keller (3–5) || Wacha (3–2) ||-|| 42,275 || 17–31 || W2 |-style=background:#fbb ||49|| May 22 || @ Cardinals || 3–10 || Wainwright (4–4) || Bailey (4–5) ||-|| 42,529 || 17–32 || L1 |-style=background:#bbb ||50|| May 24 || Yankees || colspan=8|Postponed (rain); Makeup:May25 |-style=background:#fbb ||50|| May 25 || Yankees || 3–7 || Happ