(0–4) || — || Yankee Stadium || 45,008 || 6–12 || L2 |- style="text-align:center; background-color:#fbb" | 19 || Apr 17 || @ Yankees || 3–5 || Kahnle (1–0) || Workman (0–1) || Chapman (3) || Yankee Stadium || 44,106 || 6–13 || L3 |- style="text-align:center; background-color:#bfb" | 20 || Apr 19 || @ Rays || 6–4 || Workman (1–1) || Castillo (0–2) || Brasier (4) || Tropicana Field || 21,343 || 7–13 || W1 |- style="text-align:center; background-color:#bfb" | 21 || Apr 20 || @ Rays || 6–5 || Barnes (2–0) || Alvarado (0–1) || Brasier (5) || Tropicana Field || 22,940 || 8–13 || W2 |- style="text-align:center; background-color:#bfb" | 22 || Apr 21 || @ Rays || 4–3 (11) || Walden (3–0) || Alvarado (0–2) || Brasier (6) || Tropicana Field || 18,740 || 9–13 || W3 |- style="text-align:center; background-color:#bbb" | — || Apr 22 || Tigers || colspan=8|Postponed (rain). Makeup date April 23. |- style="text-align:center; background-color:#fbb" | 23 || Apr 23 (1) || Tigers || 4–7 || Boyd (2–1) || Brewer (0–2) || — || Fenway Park || 30,015 || 9–14 || L1 |- style="text-align:center; background-color:#fbb" | 24 || Apr 23 (2)|| Tigers || 2–4 || Turnbull (1–2) || Velázquez (0–2) || Greene (11) || Fenway Park || 30,578 || 9–15 || L2 |- style="text-align:center; background-color:#bfb" | 25 || Apr 24 || Tigers || 11–4 || Rodríguez (2–2) || Ross (1–3) || — || Fenway Park || 31,763 || 10–15 || W1 |- style="text-align:center; background-color:#bfb" | 26 || Apr 25 || Tigers || 7–3 || Porcello (1–3) || Zimmermann (0–4) || — || Fenway Park || 34,165 || 11–15 || W2 |- style="text-align:center; background-color:#bbb" | — || Apr 26 || Rays || colspan=8|Postponed (rain). Makeup date June 8. |- style="text-align:center; background-color:#fbb" | 27 || Apr 27 || Rays || 1–2 ||Morton (3–0) || Price (1–2) || Pagán (3) || Fenway Park || 34,773 || 11–16 || L1 |- style="text-align:center; background-color:#fbb" | 28 || Apr 28 || Rays || 2–5 || Glasnow (5–0) || Sale (0–5) || Castillo (3) || Fenway Park || 33,823 || 11–17 || L2 |- style="text-align:center; background-color:#bfb" | 29 || Apr 29 || Athletics || 9–4 || Brasier (1–0) || Montas (4–2) || Barnes (2) || Fenway Park || 30,866 || 12–17 || W1 |- style="text-align:center; background-color:#bfb" | 30 || Apr 30 || Athletics || 5–1 || Porcello (2–3) || Brooks (2–3) || — || Fenway