|| 7–3 || Thornton (1–4) || Vincent (0–2) || — || 31,230 || 17–24 || 8½ |- style="text-align:center; background:#fbb;" | 42 || May 15 || @ Giants || 3–4 || Melancon (1–0) || Tepera (0–2) || Smith (11) || 31,028 || 17–25 || 9½ |- style="text-align:center; background:#fbb;" | 43 || May 16 || @ White Sox || 2–4 || Herrera (1–2) || Law (0–1) || Colomé (9) || 20,119 || 17–26 || 10 |- style="text-align:center; background:#bfb;" | 44 || May 17 || @ White Sox || 10–2 || Gaviglio (3–0) || Nova (2–4) || Guerra (1) || 17,078 || 18–26 || 9½ |- style="text-align:center; background:#fbb;" | 45 || May 18 || @ White Sox || 1–4 (5) || Giolito (5–1) || Feierabend (0–1) || — || 22,908 || 18–27 || 10 |- style="text-align:center; background:#bfb;" | 46 || May 19 || @ White Sox || 5–2 || Hudson (3–1) || Herrera (1–3) || Giles (10) || 18,605 || 19–27 || 9½ |- style="text-align:center; background:#fbb;" | 47 || May 20 || Red Sox || 2–12 || Price (2–2) || Jackson (0–1) || — || 26,794 || 19–28 || 10½ |- style="text-align:center; background:#bfb;" | 48 || May 21 || Red Sox || 10–3 || Stroman (2–6) || Rodríguez (4–3) || — || 14,407 || 20–28 || 10½ |- style="text-align:center; background:#fbb;" | 49 || May 22 || Red Sox || 5–6 (13) || Hembree (1–0) || Cordero (0–1) || — || 18,285 || 20–29 || 11½ |- style="text-align:center; background:#fbb;" | 50 || May 23 || Red Sox || 2–8 || Weber (1–0) || Gaviglio (3–1) || — || 36,526 || 20–30 || 12½ |- style="text-align:center; background:#fbb;" | 51 || May 24 || Padres || 3–6 || Wisler (2–1) || Hudson (3–2) || Stammen (2) || 19,480 || 20–31 || 13 |- style="text-align:center; background:#fbb;" | 52 || May 25 || Padres || 4–19 || Quantrill (1–2) || Jackson (0–2) || — || 24,212 || 20–32 || 14½ |- style="text-align:center; background:#bfb;" | 53 || May 26 || Padres || 10–1 || Stroman (3–6) || Erlin (0–1) || — || 24,462 || 21–32 || 13½ |- style="text-align:center; background:#fbb;" | 54 || May 27 || @ Rays || 3–8 || Chirinos (6–1) || Sanchez (3–5) || || 15,883 || 21–33 || 14½ |- style="text-align:center; background:#fbb;" | 55 || May 28 || @ Rays || 1–3 || Yarbrough (4–1) || Richard (0–1) || Castillo (6) || 5,786 || 21–34