|| W2 |-style=background:#bfb ||15|| April 14 || Indians || 9–8 || Peralta (1–1) || Hand (0–1) ||-|| 14,303 || 5–10 || W3 |-style=background:#fbb ||16|| April 15 || @ White Sox || 4–5 || Bañuelos (1–0) || Boxberger (0–3) || Colomé (4) || 12,553 || 5–11 || L1 |-style=background:#fbb ||17|| April 16 || @ White Sox || 1–5 || López (1–2) || López (0–2) ||-|| 13,583 || 5–12 || L2 |-style=background:#bfb ||18|| April 17 || @ White Sox || 4–3(10) || Peralta (2–1) || Jones (0–1) || Barlow (1) || 14,358 || 6–12 || W1 |-style=background:#bfb ||19|| April 18 || @ Yankees || 6–1 || Bailey (2–1) || Germán (3–1) ||-|| 39,106 || 7–12 || W2 |-style=background:#fbb ||20|| April 19 || @ Yankees || 2–6 || Sabathia (1–0) || Junis (1–2) ||-|| 39,668 || 7–13 || L1 |-style=background:#fbb ||21|| April 20 || @ Yankees || 2–9 || Tanaka (2–1) || Fillmyer (0–1) ||-|| 42,013 || 7–14 || L2 |-style=background:#fbb ||22|| April 21 || @ Yankees || 6–7(10) || Britton (1–0) || Diekman (0–1) ||-|| 40,523 || 7–15 || L3 |-style=background:#fbb ||23|| April 22 || @ Rays || 3–6|| Font (1–0) || Keller (2–2) || Pagan (1) || 9,914 || 7–16 || L4 |-style=background:#fbb ||24|| April 23 || @ Rays || 2–5 || Beeks (1–0) || Bailey (2–2) || Pagan (2) || 8,298 || 7–17 || L5 |-style=background:#bfb ||25|| April 24 || @ Rays || 10–2 || Junis (2–2) || Snell (2–2) ||-|| 9,502 || 8–17 || W1 |-style=background:#fbb ||26|| April 26 || Angels || 1–5 || Skaggs (2–2) || Duffy (0–1) ||-|| 23,186 || 8–18 || L1 |-style=background:#bfb ||27|| April 27 || Angels || 9–4 || Barlow (1–0) || Barría (2–2) ||-|| 18,755 || 9–18 || W1 |-style=background:#fbb ||28|| April 28 || Angels || 3–7 || Harvey (1–2) || Bailey (2–3) ||-|| 21,549 || 9–19 || L1 |-style=background:#fbb ||29|| April 29 || Rays || 5–8 || Chirinos (4–0) || Keller (2–3) ||-|| 11,744 || 9–20 || L2 |-style=background:#bbb ||—|| April 30 || Rays || colspan=7|Postponed (Rain); Makeup: May 1 |- |-style=background:#bfb ||30|| May 1 || Rays || 3–2 || Junis (3–2) || Stanek (0–1) || Kennedy (2) || - || 10–20 || W1 |-style=background:#bfb ||31|| May 1 || Rays || 8–2 || Sparkman (1–1) || Snell (2–3) ||-|| 11,411 || 11–20 || W2 |-style=background:#fbb ||32|| May 2 || Rays || 1–3 || Kolarek (2–0) || Peralta (2–2) || Castillo (4) ||