(1) || 34,446 || 7–6 || W6 |-style=background:#fbb | 14 || April 12 || @ Cubs || 1–5 || Hamels (2–0) || Skaggs (1–2) || — || 30,102 || 7–7 || L1 |-style=background:#bfb | 15 || April 13 || @ Cubs || 6–5 || Buttrey (1–0)|| Hendricks (0–3) || Allen (4) || 38,755 || 8–7 || W1 |-style=background:#bbb | — || April 14 || @ Cubs ||colspan="8"|Postponed (inclement weather) (Makeup date: June 3) |-style=background:#fbb | 16 || April 15 || @ Rangers || 7–12 || Dowdy (1–0) || Bedrosian (1–1) || Leclerc (4) || 18,265 || 8–8 || L1 |-style=background:#fbb | 17 || April 16 || @ Rangers || 0–5 || Minor (2–1) || Barría (1–1) || — || 17,704 || 8–9 || L2 |-style=background:#fbb | 18 || April 17 || @ Rangers || 4–5 || Lynn (2–1) || Harvey (0–2) || Leclerc (5) || 16,691 || 8–10 || L3 |-style=background:#fbb | 19 || April 18 || Mariners || 10–11 || Swarzak (2–0) || Allen (0–1) || Elías (3) || 33,592 || 8–11 || L4 |-style=background:#fbb | 20 || April 19 || Mariners || 3–5 || Rosscup (2–0) || Allen (0–2) || Elías (4) || 41,021 || 8–12 || L5 |-style=background:#fbb | 21 || April 20 || Mariners || 5–6 || Kikuchi (1–1) || Cahill (1–2) || Swarzak (3) || 41,147 || 8–13 || L6 |-style=background:#bfb | 22 || April 21 || Mariners || 8–6 || Barría (2–1) || Leake (2–2) || García (1) || 34,155 || 9–13 || W1 |-style=background:#fbb | 23 || April 22 || Yankees || 3–4 (14) || Holder (1–0) || Bard (0–1) || — || 35,403 || 9–14 || L1 |-style=background:#fbb | 24 || April 23 || Yankees || 5–7 || Germán (4–1)|| Stratton (0–2) || Britton (1) || 38,016 || 9–15 || L2 |-style=background:#fbb | 25 || April 24 || Yankees || 5–6 || Loáisiga (1–0) || Buttrey (1–1) || Chapman (4) || 37,928 || 9–16 || L3 |-style=background:#bfb | 26 || April 25 || Yankees || 11–5 || Ramirez (1–0)|| Tanaka (2–2) || — || 39,584 || 10–16 || W1 |-style=background:#bfb | 27 || April 26 || @ Royals || 5–1 || Skaggs (2–2) || Duffy (0–1) || — || 23,186 || 11–16 || W2 |-style=background:#fbb | 28 || April 27 || @ Royals || 4–9 || Barlow (1–0) || Barría (2–2) || — || 18,755 || 11–17 || L1 |-style=background:#bfb | 29