|| 99–53 |-style=background:#fbb | 153 || September 18 || Angels || 2–3 || Bard (2–2) || Ottavino (6–5) || Robles (22) || Yankee Stadium || 38,106 || 99–54 |-style=background:#bfb | 154 || September 19 || Angels || 9–1 || Tanaka (11–8) || Heaney (4–6) || — || Yankee Stadium || 42,056 || 100–54 |-style=background:#fbb | 155 || September 20 || Blue Jays || 3–4 || Adam (2–0) || Kahnle (3–2) || Giles (21) || Yankee Stadium || 45,270 || 100–55 |-style=background:#bfb | 156 || September 21 || Blue Jays || 7–2 || Paxton (15–6) || Zeuch (1–1) || — || Yankee Stadium || 43,602 || 101–55 |-style=background:#bfb | 157 || September 22 || Blue Jays || 8–3 || Severino (1–0) || Font (4–5) || — || Yankee Stadium || 44,583 || 102–55 |-style=background:#fbb | 158 || September 24 || @ Rays || 1–2 || Fairbanks (2–3) || Gearrin (1–3) || — || Tropicana Field || 16,669 || 102–56 |-style=background:#fbb | 159 || September 25 || @ Rays || 0–4 || Morton (16–6) || Loáisiga (2–2) || — || Tropicana Field || 20,390 || 102–57 |-style=background:#bfb | 160 || September 27 || @ Rangers || 14–7 || Tarpley (1–0) || Palumbo (0–3) || — || Globe Life Park in Arlington || 35,168 || 103–57 |-style=background:#fbb | 161 || September 28 || @ Rangers || 4–9 || Hernández (2–1) || Severino (1–1) || — || Globe Life Park in Arlington || 42,870 || 103–58 |-style=background:#fbb | 162 || September 29 || @ Rangers || 1–6 || Lynn (16–11) || Tanaka (11–9) || — || Globe Life Park in Arlington || 47,144 || 103–59 |- Postseason |- bgcolor=#ccffcc | 1 || October 4 || Twins || Yankee Stadium || 10–4 || Kanhle (1–0) || Littell (0–1) || — || 49,233 || 1–0 |- bgcolor=#ccffcc | 2 || October 5 || Twins || Yankee Stadium || 8–2 || Tanaka (1–0) || Dobnak (0–1) || — || 49,277 || 2–0 |- bgcolor=#ccffcc | 3 || October 7 || @ Twins || Target Field || 5–1 || Green (1–0) || Odorizzi (0–1) || Chapman (1) || 41,121 || 3–0 |- bgcolor=#ccffcc | 1 || October 12 || @ Astros || Minute Maid Park || 7–0 || Tanaka (1–0) || Greinke (0–1) || — || 43,311 || 1–0 |- bgcolor=#ffbbbb | 2 || October 13 || @ Astros || Minute Maid Park || 2–3 || James (1–0)