6 || @ Phillies || 6–2 || Pineda (1–0) || Arrieta (1–1) || — || 44,693 || 5–2 || W1 |-style=background:#fbb ||8|| April 7 || @ Phillies || 1–2 || Eflin (2–0) || Berríos (1–1) || Neris (1) || 39,735 || 5–3 || L1 |-style=background:#cfc ||9|| April 9 || @ Mets || 14–8 || Hildenberger (2–0) || deGrom (2–1) || — || 22,126 || 6–3 || W1 |-style=background:#fbb ||10|| April 10 || @ Mets || 6–9 || Syndergaard (1–1) || Odorizzi (0–2) || — || 20,946 || 6–4 || L1 |-style=background:#bbb ||—|| April 12 || Tigers || Colspan=7| Postponed (snow) (Makeup date: May 11.) |-style=background:#cfc ||11|| April 13 || Tigers || 4–3 || Pineda (2–0) || Ross (1–2) || Parker (3) || 16,484 || 7–4 || W1 |-style=background:#cfc ||12|| April 14 || Tigers || 6–4 || Berríos (2–1) || Zimmermann (0–2) || Hildenberger (1) || 14,774 || 8–4 || W2 |-style=background:#fbb ||13|| April 15 || Blue Jays || 3–5 || Gaviglio (1–0) || Mejía (0–1) || Biagini (1) || 11,727 || 8–5 || L1 |-style=background:#fbb ||14|| April 16 || Blue Jays || 5–6 || Sanchez (2–1) || May (1–1) || Giles (5) || 13,365 || 8–6 || L2 |-style=background:#cfc ||15|| April 17 || Blue Jays || 4–1 || Odorizzi (1–2) || Thornton (0–2) || Parker (4) || 11,465 || 9–6 || W1 |-style=background:#fbb ||16|| April 18 || Blue Jays || 4–7 || Biagini (1–1) || Pineda (2–1) || Giles (6) || 12,523 || 9–7 || L1 |-style=background:#bbb ||-|| April 19 || @ Orioles || Colspan=7| Postponed (rain) (Makeup date: April 20.) |-style=background:#cfc ||17|| April 20 || @ Orioles || 6–5 || Berríos (3–1) || Yacabonis (1–1) || Rogers (2) || — || 10–7 || W1 |-style=background:#cfc ||18|| April 20 || @ Orioles || 16–7 || Pérez (2–0) || Cobb (0–1) || — || 28,409 || 11–7 || W2 |-style=background:#cfc ||19|| April 21 || @ Orioles || 4–3 || Gibson (1–0) || Bundy (0–3) || Rogers (3) || 11,018 || 12–7 || W3 |-style=background:#cfc ||20|| April 22 || @ Astros || 9–5 || Odorizzi (2–2) || Peacock (2–1) || — || 34,518 || 13–7 || W4 |-style=background:#fbb ||21|| April 23 || @ Astros || 4–10 || Rondón (2–0) || Hildenberger (2–1) || — || 29,409 || 13–8 || L1 |-style=background:#fbb ||22|| April 24 || @ Astros || 1–7 || Verlander (2–0) || Stewart (0–1) || — || 26,582 || 13–9 ||