Hendriks (4–2) || — || Yankee Stadium || 42,860 || 90–48 |-style=background:#fbb | 139 || September 2 || Rangers || 0–7 || Minor (12–8) || Tanaka (10–8) || — || Yankee Stadium || 40,015 || 90–49 |-style=background:#bfb | 140 || September 3 || Rangers || 10–1 || Paxton (12–6) || Vólquez (0–1) || — || Yankee Stadium || 33,711 || 91–49 |-style=background:#bfb | 141 || September 4 || Rangers || 4–1 || Cessa (2–1) || Lynn (14–10) || — || Yankee Stadium || 36,082 || 92–49 |-style=background:#fbb | 142 || September 6 || @ Red Sox || 1–6 || Walden (9–2) || Germán (17–4) || — || Fenway Park || 35,162 || 92–50 |-style=background:#bfb | 143 || September 7 || @ Red Sox || 5–1 || Happ (12–8) || Weber (2–3) || — || Fenway Park || 36,619 || 93–50 |-style=background:#bfb | 144 || September 8 || @ Red Sox || 10–5 || Green (3–4) || Porcello (12–12) || — || Fenway Park || 35,681 || 94–50 |-style=background:#bfb | 145 || September 9 || @ Red Sox || 5–0 || Paxton (13–6) || Rodríguez (17–6) || — || Fenway Park || 35,884 || 95–50 |-style=background:#fbb | 146 || September 10 || @ Tigers || 11–12 || Jiménez (4–7) || Adams (1–1) || — || Comerica Park || 16,733 || 95–51 |-style=background:#bbb | — || September 11 || @ Tigers || colspan=7 | Postponed (inclement weather: rain). Makeup date: September 12 (doubleheader) |-style=background:#bfb | 147 || September 12 || @ Tigers || 10–4 || Green (4–4) || Boyd (8–11) || — || Comerica Park || — || 96–51 |-style=background:#bfb | 148 || September 12 || @ Tigers || 6–4 || Germán (18–4) || Turnbull (3–15) || Chapman (37) || Comerica Park || 17,807 || 97–51 |-style=background:#fbb | 149 || September 13 || @ Blue Jays || 5–6 || Font (4–4) || Lyons (1–2) || — || Rogers Centre || 23,915 || 97–52 |-style=background:#bfb | 150 || September 14 || @ Blue Jays || 13–3 || Paxton (14–6) || Waguespack (4–5) || — || Rogers Centre || 26,308 || 98–52 |-style=background:#fbb | 151 || September 15 || @ Blue Jays || 4–6 || Zeuch (1–0) || Cortes Jr. (5–1) || Giles (20) || Rogers Centre || 22,562 || 98–53 |-style=background:#bfb | 152 || September 17 || Angels || 8–0 || Loáisiga (2–1) || Ramirez (5–4) || — || Yankee Stadium || 41,026