27 || @ Blue Jays || 1–7 || Sanchez (3–1) || Anderson (3–2) || — || 22,254 || 14–15 || L2 |-style=background:#fbb ||30|| April 28 || @ Blue Jays || 4–5 (11) || Luciano (1–0) || Treinen (1–2) || — || 18,557 || 14–16 || L3 |-style=background:#fbb ||31|| April 29 || @ Red Sox || 4–9 || Brasier (1–0) || Montas (4–2) || Barnes (2) || 30,866 || 14–17 || L4 |-style=background:#fbb ||32|| April 30 || @ Red Sox || 1–5 || Porcello (2–3) || Brooks (2–3) || — || 31,754 || 14–18 || L5 |- |-style=background:#fbb ||33|| May 1 || @ Red Sox || 3–7 || Walden (4–0) || Fiers (2–3) || — || 33,708 || 14–19 || L6 |-style=background:#cfc ||34|| May 3 || @ Pirates || 14–1 || Anderson (4–2) || Musgrove (1–3) || — || 16,428 || 15–19 || W1 |-style=background:#fbb ||35|| May 4 || @ Pirates || 4–6 || Feliz (1–0) || Wendelken (0–1) || Vázquez (9) || 26,447 || 15–20 || L1 |-style=background:#fbb ||36|| May 5 || @ Pirates || 3–5 (13) || Lyons (1–0) || Rodney (0–2) || — || 18,517 || 15–21 || L2 |-style=background:#cfc ||37|| May 7 || Reds || 2–0 || Fiers (3–3) || Mahle (0–5) || — || 11,794 || 16–21 || W1 |-style=background:#cfc ||38|| May 8 || Reds || 5–4 (13) || Hendriks (1–0) || Stephenson (2–1) || — || 9,096 || 17–21 || W2 |-style=background:#fbb ||39|| May 9 || Reds || 0–3 || Roark (3–1) || Bassitt (1–1) || Iglesias (7) || 19,694 || 17–22 || L1 |-style=background:#cfc ||40|| May 10 || Indians || 4–3 (12) || Soria (1–2) || Hand (2–2) || — || 36,913 || 18–22 || W1 |-style=background:#cfc ||41|| May 11 || Indians || 3–2 || Treinen (2–2) || Cole (0–1) || — || 18,278 || 19–22 || W2 |-style=background:#fbb ||42|| May 12 || Indians || 3–5 || Rodríguez (1–2) || Mengden (0–1) || Hand (11) || 18,891 || 19–23 || L1 |-style=background:#fbb ||43|| May 13 || @ Mariners || 5–6 (10) || Brennan (2–2) || Soria (1–3) || — || 12,520 || 19–24 || L2 |-style=background:#fbb ||44|| May 14 || @ Mariners || 3–4 || Leake (3–4) || Anderson (4–3) || Elías (5) || 11,365 || 19–25 || L3 |-style=background:#cfc ||45|| May 16 || @ Tigers || 17–3 || Bassitt (2–1) || Turnbull (2–3) || — || 18,527 || 20–25 || W1 |-style=background:#cfc ||46||