(0–3) | — | 10,058 | 3–8 | L2 |-style="background:#fbb;" | 12 | April 10 | @ Reds | 1–2 | Garrett (1–0) | Steckenrider (0–2) | Iglesias (1) | 11,375 | 3–9 | L3 |-style="background:#fbb;" | 13 | April 11 | @ Reds | 0–5 | Stephenson (1–0) | López (1–2) | — | 11,192 | 3–10 | L4 |-style="background:#fbb;" | 14 | April 12 | Phillies | 1–9 | Arrieta (2–1) | Alcántara (1–1) | — | 9,322 | 3–11 | L5 |-style="background:#bfb;" | 15 | April 13 | Phillies | 10–3 | Smith (1–0) | Eflin (2–1) | — | 13,828 | 4–11 | W1 |-style="background:#fbb;" | 16 | April 14 | Phillies | 1–3 (14) | Arano (1–0) | Chen (0–1) | Álvarez (1) | 15,238 | 4–12 | L1 |-style="background:#fbb;" | 17 | April 15 | Cubs | 2–7 | Darvish (1–2) | Richards (0–2) | — | 9,888 | 4–13 | L2 |-style="background:#fbb;" | 18 | April 16 | Cubs | 0–4 | Quintana (2–1) | López (1–3) | — | 8,137 | 4–14 | L3 |-style="background:#fbb;" | 19 | April 17 | Cubs | 0–6 | Hamels (3–0) | Alcántara (1–2) | — | 10,247 | 4–15 | L4 |- |-style="background:#bfb;" | 20 | April 19 | Nationals | 3–2 | Smith (2–0) | Sánchez (0–2) | Romo (2) | 8,199 | 5–15 | W1 |-style="background:#bfb;" | 21 | April 20 | Nationals | 9–3 | Ureña (1–3) | Scherzer (1–3) | — | 9,910 | 6–15 | W2 |-style="background:#fbb;" | 22 | April 21 | Nationals | 0–5 | Strasburg (2–1) | Richards (0–3) | — | 7,412 | 6–16 | L1 |-style="background:#bfb;" | 23 | April 23 | @ Indians | 3–1 | López (2–3) | Ramírez (0–1) | Romo (3) | 12,963 | 7–16 | W1 |-style="background:#fbb;" | 24 | April 24 | @ Indians | 2–6 | Wittgren (1–0) | Conley (0–3) | — | 13,046 | 7–17 | L1 |-style="background:#bfb;" | 25 | April 25 | @ Phillies | 3–1 (10) | Guerrero (1–0) | Neris (0–1) | Romo (4) | 32,060 | 8–17 | W1 |-style="background:#fbb;" | 26 | April 26 | @ Phillies | 0–4 | Eickhoff (1–1) | Ureña (1–4) | — | 31,159 | 8–18 | L1 |-style="background:#fbb;" | 27 | April 27 | @ Phillies | 9–12 | Arrieta (4–2) | Richards (0–4)