hands of world No. 14, Garbiñe Muguruza, in straight sets. She ended her trip in Australia with another successful qualifying campaign at the Adelaide International, reaching the main draw and challenging sixth seed Martić to three sets. Samsonova returned to the tour at the Miami Open, where she qualified for the main draw with consecutive wins. In the first round, she then beat fellow hard-hitting Camila Giorgi, in straight sets. She earned the biggest win of her career over world No. 11, Kiki Bertens, after losing just three games, reaching the third round of a WTA 1000 event for the first time in her career. Samsonova lost to Maria Sakkari eventually. Samsonova then began her clay-court campaign at the Charleston Open and MUSC Health Women's Open, held at the same venue in consecutive weeks. She suffered early losses to Coco Gauff and Clara Tauson in both tournaments, respectively. As a lucky loser, Samsonova reached the second round of the Emilia-Romagna Open, before being defeated by Martic once again. She then suffered a shock loss in the first round of qualifying at the French Open, losing to Aleksandra Krunić in three sets. Beginning her first career grass-court season at the German Open in Berlin, starting as a qualifier, she reached her first WTA Tour final. Her campaign began with a tight win over Ana Konjuh in a final-set tiebreak to qualify for the main draw, before stunning Markéta Vondroušová in the first round. Samsonova then reached her first WTA 500 quarterfinal with a straight-sets defeat of compatriot Veronika Kudermetova, not facing a break point throughout the encounter. Samsonova then prevailed 7–6, 2–6, 7–6 over former top-10 player Madison Keys, saving 8/11 break points in the match, and followed it up with a bigger upset over two-time Grand Slam champion Victoria Azarenka in the semifinal. In the final, she upset world No. 12, Belinda Bencic, from a set down to win her maiden WTA tournament title. With this run she climbed 43 spots to reach a career-high ranking of world No. 63, on 21 June 2021. By virtue of her Berlin run, she also received a wildcard into the main draw of Wimbledon, making her debut in the main draw. There, she rode on her momentum and reached the fourth round of a Grand Slam for the first time in her career after defeating the giant-killing Kaia Kanepi, 22nd seed Jessica Pegula