| Neris (4) | 37,868 | 8–19 | L2 |-style="background:#fbb;" | 28 | April 28 | @ Phillies | 1–5 | Eflin (3–3) | López (2–4) | — | 39,168 | 8–20 | L3 |-style="background:#fbb;" | 29 | April 30 | Indians | 4–7 | Bauer (4–1) | Alcántara (1–3) | Hand (9) | 7,247 | 8–21 | L4 |- |-style="background:#bfb;" | 30 | May 1 | Indians | 4–2 | Smith (3–0) | Kluber (2–3) | Romo (5) | 7,262 | 9–21 | W1 |-style="background:#fbb;" | 31 | May 3 | Braves | 2–7 | Toussaint (2–0) | Ureña (1–5) | — | 7,198 | 9–22 | L1 |-style="background:#fbb;" | 32 | May 4 | Braves | 2–9 | Soroka (3–1) | Anderson (0–1) | — | 10,229 | 9–23 | L2 |-style="background:#fbb;" | 33 | May 5 | Braves | 1–3 (10) | Tomlin (1–0) | Guerrero (1–1) | Jackson (2) | 11,885 | 9–24 | L3 |-style="background:#bfb;" | 34 | May 6 | @ Cubs | 6–5 | Conley (1–3) | Strop (1–2) | Romo (6) | 34,555 | 10–24 | W1 |-style="background:#fbb;" | 35 | May 7 | @ Cubs | 2–5 | Cishek (1–1) | Conley (1–4) | — | 35,274 | 10–25 | L1 |-style="background:#fbb;" | 36 | May 8 | @ Cubs | 2–3 (11) | Edwards Jr. (1–1) | Quijada (0–1) | — | 37,241 | 10–26 | L2 |-style="background:#fbb;" | 37 | May 9 | @ Cubs | 1–4 | Montgomery (1–0) | Richards (0–5) | — | 32,301 | 10–27 | L3 |-style="background:#fbb;" | 38 | May 10 | @ Mets | 2–11 | Wheeler (3–2) | López (2–5) | — | 25,194 | 10–28 | L4 |-style="background:#fbb;" | 39 | May 11 | @ Mets | 1–4 | deGrom (3–4) | Alcántara (1–4) | Díaz (10) | 32,501 | 10–29 | L5 |-style="background:#bbb;" | — | May 12 | @ Mets | colspan="7"|Postponed (Inclement weather) (Makeup date: August 5) |-style="background:#fbb;" | 40 | May 14 | Rays | 0–4 | Morton (4–0) | Smith (3–1) | — | 6,306 | 10–30 | L6 |-style="background:#fbb;" | 41 | May 15 | Rays | 0–1 | Beeks (3–0) | Ureña (1–6) | Castillo (3) | 5,947 | 10–31 | L7 |-style="background:#bfb;" | 42 | May 17 | Mets | 8–6 | Richards (1–5) | deGrom (3–5) | Romo (7) | 9,870