Red Sox tied the series 2–2 (27–21 runs) August 12–14, at Cleveland Indians In the series' opening game, Boston trailed, 5–1, after three innings. Two runs by the Red Sox in the fourth, one in the seventh, and one in the ninth resulted in a 5–5 tie. In the bottom of the ninth, Cleveland's Carlos Santana hit a walk-off home run, giving Boston their third loss in a row. Boston built a 6–1 lead midway through the sixth inning of the second game of the series, only to have Cleveland tie the game and force extra innings. A home run by Jackie Bradley Jr. in the top of the 10th inning proved to be the difference in a 7–6 Red Sox win. Andrew Cashner was used in relief and got the save, the first of his MLB career. Chris Sale recorded the 2,000th strikeout of his MLB career. Rafael Devers became the latest MLB player to record six hits in a game; he was 5-for-5 in the first nine innings, and had his sixth hit in the 10th inning. The Red Sox won the third and final game of the series, 5–1. Devers homered, and Xander Bogaerts hit two home runs. Red Sox won the series 2–1 (17–13 runs) August 16–18, vs. Baltimore Orioles The opening game of the series was a 9–1 Boston win, as the Red Sox outhit the Orioles, 12–5. Mookie Betts hit his 21st home run of the season. Boston extended their winning streak to four games with a 4–0 win in the middle game of the series. Eduardo Rodríguez improved his record on the season to 14–5, while Brock Holt and Rafael Devers each homered. Boston completed the sweep on Sunday, coming back from a 6–0 deficit to record a 13–7 win. Devers and Sam Travis each homered, as Boston used seven pitchers, with Marcus Walden getting the win. Devers became the first MLB players to reach 100 RBIs on the season. Red Sox won the series 3–0 (26–8 runs) August 20–21, vs. Philadelphia Phillies Boston lost the opening inter-league game against Philadelphia, 3–2. All three Phillies runs came in the first inning, from a walk, two doubles, and a single. Both Red Sox runs came in the third inning, as Jackie Bradley Jr. hit a two-run homer. Boston's five-game winning streak ended as the team fell to 67–60 on the season. Philadelphia then swept