|| 11,107 || 10–3 || W4 |-style="background:#bfb" | 14 || April 12 || @ Blue Jays || 11–7 || Yarbrough (2–1) || Thornton (0–1) || — || 17,326 || 11–3 || W5 |-style="background:#fbb" | 15 || April 13 || @ Blue Jays || 1–3 || Pannone (1–2) || Roe (0–2) || Giles (4) || 20,771 || 11–4 || L1 |-style="background:#bfb" | 16 || April 14 || @ Blue Jays || 8–4 || Kolarek (1–0) || Stroman (0–3) || — || 20,512 || 12–4 || W1 |-style="background:#bfb" | 17 || April 16 || Orioles || 4–2 || Glasnow (4–0) || Bundy (0–2) || Castillo (2) || 9,842 || 13–4 || W2 |-style="background:#bfb" | 18 || April 17 || Orioles || 8–1 || Chirinos (3–0) || Hess (1–3) || — || 9,028 || 14–4 || W3 |-style="background:#fbb" | 19 || April 18 || Orioles || 5–6 (11) || Means (2–2) || Castillo (0–1) || — || 9,081 || 14–5 || L1 |-style="background:#fbb" | 20 || April 19 || Red Sox || 4–6 || Workman (1–1) || Castillo (0–2) || Brasier (4) || 21,343 || 14–6 || L2 |-style="background:#fbb" | 21 || April 20 || Red Sox || 5–6 || Barnes (2–0) || Alvarado (0–1) || Brasier (5) || 22,940 || 14–7 || L3 |-style="background:#fbb" | 22 || April 21 || Red Sox || 3–4 (11) || Walden (3–0) || Alvarado (0–2) || Brasier (6) || 18,740 || 14–8 || L4 |-style="background:#bfb" | 23 || April 22 || Royals || 6–3 || Font (1–0) || Keller (2–2) || Pagán (1) || 9,914 || 15–8 || W1 |-style="background:#bfb" | 24 || April 23 || Royals || 5–2 || Beeks (1–0) || Bailey (2–2) || Pagán (2) || 8,298 || 16–8 || W2 |-style="background:#fbb" | 25 || April 24 || Royals || 2–10 || Junis (2–2) || Snell (2–2) || — || 9,502 || 16–9 || L1 |-style="background:#bbb" | — || April 26 || @ Red Sox || colspan=7|Postponed (rain); Makeup: June 8 |-style="background:#bfb" | 26 || April 27 || @ Red Sox || 2–1 || Morton (3–0) || Price (1–2) || Pagán (3) || 34,733 || 17–9 || W1 |-style="background:#bfb" | 27 || April 28 || @ Red Sox || 5–2 || Glasnow (5–0) || Sale (0–5) || Castillo (3) || 33,823 || 18–9 || W2 |-style="background:#bfb" | 28 || April 29 || @ Royals || 8–5 || Chirinos (4–0) || Keller (2–3) ||