2–1 || Fiers (13–3) || Montgomery (3–7) || Hendriks (16) || 13,669 || 76–55 || W2 |-style=background:#fbb ||133|| August 28 || @ Royals || 4–6 || Hill (2–0) || Treinen (6–5) || Kennedy (23) || 15,049 || 76–56 || L1 |-style=background:#cfc ||134|| August 29 || @ Royals || 9–8 || Petit (4–3) || Sparkman (3–10) || Hendriks (17) || 13,844 || 77–56 || W1 |-style=background:#cfc ||135|| August 30 || @ Yankees || 8–2 || Anderson (11–9) || Kahnle (3–1) || — || 47,265 || 78–56 || W2 |-style=background:#fbb ||136|| August 31 || @ Yankees || 3–4 || Gearrin (1–2) || Trivino (4–6) || — || 44,462 || 78–57 || L1 |- |-style=background:#fbb ||137|| September 1 || @ Yankees || 4–5 || Ottavino (6–4) || Hendriks (4–2) || — || 42,860 || 78–58 || L2 |-style=background:#cfc ||138|| September 3 || Angels || 7–5 || Petit (5–3) || Ramirez (4–3) || Hendriks (18) || 14,031 || 79–58 || W1 |-style=background:#cfc ||139|| September 4 || Angels || 4–0 || Roark (9–8) || Sandoval (0–2) || — || 12,597 || 80–58 || W2 |-style=background:#cfc ||140|| September 5 || Angels || 10–6 || Puk (1–0) || Buttrey (6–7) || — || 14,013 || 81–58 || W3 |-style=background:#cfc ||48|| September 6 || @ Tigers || 7–3 || Fiers (14–3) || Reininger (0–2) || — || 15,680 || 82–58 || W4 |-style=background:#fbb ||141|| September 6 || Tigers || 4–5 (11) || Schreiber (1–0) || Blackburn (0–2) || Jiménez (6) || 16,080 || 82–59 || L1 |-style=background:#cfc ||142|| September 7 || Tigers || 10–2 || Bassitt (10–5) || Zimmermann (1–10) || — || 32,623 || 83–59 || W1 |-style=background:#cfc ||143|| September 8 || Tigers || 3–1 || Manaea (1–0) || Norris (3–12) || Hendriks (19) || 24,550 || 84–59 || W2 |-style=background:#fbb ||144|| September 9 || @ Astros || 0–15 || Greinke (15–5) || Fiers (14–4) || — || 38,289 || 84–60 || L1 |-style=background:#cfc ||145|| September 10 || @ Astros || 21–7 || Roark (10–8) || Miley (13–5) || Mengden (1) || 32,100 || 85–60 || W1 |-style=background:#cfc ||146|| September 11 || @ Astros || 5–3 ||Anderson (12–9) || James (5–1) || Hendriks (20) || 32,938 || 86–60 || W2 |-style=background:#cfc ||147|| September 12 || @ Astros || 3–2 || Bailey (13–8) || Verlander (18–6) || Hendriks (21) || 34,024 || 87–60 || W3 |-style=background:#cfc ||148|| September 13 || @ Rangers || 14–9 || Wendelken (2–1) ||