Chavez (2–2) || — || Fenway Park || 34,330 || 35–34 || W1 |- style="text-align:center; background-color:#bfb" | 70 || Jun 13 || Rangers || 7–6 || Workman (4–1) || Fairbanks (0–1) || Smith (1) || Fenway Park || 35,841 || 36–34 || W2 |- style="text-align:center; background-color:#bfb" | 71 || Jun 14 || @ Orioles || 13–2 || Rodríguez (7–4) || Ortiz (0–1) || — || Camden Yards || 19,383 || 37–34 || W3 |- style="text-align:center; background-color:#bfb" | 72 || Jun 15 || @ Orioles || 7–2 || Sale (3–7) || Bundy (3–8) || — || Camden Yards || 30,050 || 38–34 || W4 |- style="text-align:center; background-color:#bfb" | 73 || Jun 16 || @ Orioles || 8–6 (10) || Workman (5–1) || Givens (0–4) || — || Camden Yards || 27,964 || 39–34 || W5 |- style="text-align:center; background-color:#bfb" | 74 || Jun 17 || @ Twins || 2–0 || Porcello (5–6) || Berríos (8–3) || Brasier (7) || Target Field || 27,970 || 40–34 || W6 |- style="text-align:center; background-color:#fbb" | 75 || Jun 18 || @ Twins || 3–4 || Littell (1–0) || Johnson (1–1) || — || Target Field || 25,741 || 40–35 || L1 |- style="text-align:center; background-color:#bfb" | 76 || Jun 19 || @ Twins || 9–4 || Rodríguez (8–4) || Gibson (7–4) || — || Target Field || 31,835 || 41–35 || W1 |- style="text-align:center; background-color:#bfb" | 77 || Jun 21 || Blue Jays || 7–5 || Workman (6–1) || Romano (0–1) || — || Fenway Park || 36,911 || 42–35 || W2 |- style="text-align:center; background-color:#fbb" | 78 || Jun 22 || Blue Jays || 7–8 || Kingham (3–1) || Barnes (3–2) || Giles (12) || Fenway Park || 36,712 || 42–36 || L1 |- style="text-align:center; background-color:#fbb" | 79 || Jun 23 || Blue Jays || 1–6 || Stroman (5–9) || Porcello (5–7) || — || Fenway Park || 36,495 || 42–37 || L2 |- style="text-align:center; background-color:#bfb" | 80 || Jun 24 || White Sox || 6–5 || Workman (7–1) || Fry (1–3) || — || Fenway Park || 36,117 || 43–37 || W1 |- style="text-align:center; background-color:#bfb" | 81 || Jun 25 || White Sox || 6–3 || Price (5–2) || Ruiz (0–1) || Workman (3) || Fenway Park || 34,740 || 44–37 || W2 |- style="text-align:center; background-color:#fbb" | 82 || Jun 26 || White Sox || 7–8 || Colomé (3–1) || Barnes (3–3) || — || Fenway