| 147 || September 14 || Orioles || 8–4 (12) || Schreiber (2–0) || Fry (1–9) || — || 17,760 || 44–103 || W1 |- bgcolor="ffbbbb | 148 || September 15 || Orioles || 2–8 || Wojciechowski (3–8) || Jackson (3–10) || — || 15,688 || 44–104 || L1 |- bgcolor="bbffbb | 149 || September 16 || Orioles || 5–2 || Alexander (1–3) || Means (10–11) || Jiménez (7) || 14,142 || 45–104 || W1 |- bgcolor="ffbbbb | 150 || September 17 || @ Indians || 2–7 || Plutko (7–4) || Reininger (0–3) || — || 19,108 || 45–105 || L1 |- bgcolor="ffbbbb | 151 || September 18 || @ Indians || 1–2 (10) || Cimber (6–3) || Cisnero (0–4) || — || 15,828 || 45–106 || L2 |- bgcolor="ffbbbb | 152 || September 19 || @ Indians || 0–7 || Clevinger (12–3) || Norris (3–13) || — || 19,432 || 45–107 || L3 |- bgcolor="ffbbbb | 153 || September 20 || White Sox || 1–10 || Cease (4–7) || Zimmermann (1–12) || — || 15,265 || 45–108 || L4 |- bgcolor="ffbbbb | 154 || September 21 || White Sox || 3–5 || Nova (11–12) || Alexander (1–4) || Colomé (29) || 16,891 || 45–109 || L5 |- bgcolor="bbffbb | 155 || September 22 || White Sox || 6–3 || Boyd (9–11) || López (9–15) || Jiménez (8) || 16,157 || 46–109 || W1 |- bgcolor="ffbbbb | 156 || September 24 || Twins || 2–4 || Odorizzi (15–7) || Turnbull (3–16) || Rogers (29) || 16,174 || 46–110 || L1 |- bgcolor="ffbbbb | 157 || September 25 || Twins || 1–5 || Dobnak (2–1) || VerHagen (4–3) || — || 16,242 || 46–111 || L2 |- bgcolor="ffbbbb | 158 || September 26 || Twins || 4–10 || Smeltzer (2–2) || Zimmermann (1–13) || — || 17,557 || 46–112 || L3 |- bgcolor="bbbbbb" | — || September 27 || @ White Sox || colspan="9" | Postponed (rain). Rescheduled to September 28. |- bgcolor="bbbbbb" | — || September 27 || @ White Sox || colspan="9" | Cancelled (rain). Due to both teams being eliminated from playoff contention. |- bgcolor="ffbbbb | 159 || September 28 || @ White Sox || 1–7 || López (10–15) || Boyd (9–12) || — || — || 46–113 || L4 |- bgcolor="bbffbb | 160 || September 28 || @ White Sox || 4–3 || Farmer (6–6) || Colomé