with four RBIs. The third game of the series saw David Price hold the Orioles to three hits and no runs through seven innings, as the Red Sox won, 4–0. Benintendi had to leave the game shortly after fouling a pitch off of his right foot in the bottom of the third inning, while Bogaerts had three RBIs on an eighth inning home run. The closing game of the series was an 8–1 Orioles win on the day of the Boston Marathon, with the Red Sox using a total of six pitchers. Red Sox tied the series 2–2 (16–21 runs) April 16–April 17, at New York Yankees The first game of the season between the longtime rivals was an 8–0 shutout by the Yankees, as Chris Sale took the loss to fall to 0–4 on the season. Boston's record fell to 6–12, the team's worst start since the 1996 Red Sox started 3–15. In the second game of this two-game series, Boston starter Nathan Eovaldi held New York to three hits and one run through six innings, with the Red Sox leading, 3–1. However, after the Yankees loaded the bases in the bottom of the seventh inning off of Red Sox reliever Brandon Workman, Brett Gardner hit a grand slam off of Ryan Brasier, giving New York a 5–3 lead and ultimately the win by that score. J. D. Martinez and Christian Vázquez homered for Boston, while Dustin Pedroia left the game in the middle of the second inning due to left knee discomfort. Boston's record of 6–13 was the worst for a defending World Series champion through 19 games since the 1998 Florida Marlins started 5–14. Boston's run differential of -42 set a new MLB-worst for a defending champion through 19 games, surpassing the -37 of the 1988 Minnesota Twins. Red Sox lost the series 0–2 (3–13 runs) April 19–April 21, at Tampa Bay Rays The opening game against the AL East leading Rays was a 6–4 Red Sox win. Tied 4–4 in the eighth inning, Mookie Betts and Mitch Moreland hit back-to-back home runs, and Ryan Brasier pitched a scoreless ninth inning for his fourth save of the season. In the second game of the series, the Red Sox jumped out to an early 5–0 lead, with four runs coming on a grand slam by Andrew Benintendi in the second inning. The Rays came back to tie the