|| Keller (2-5) || Robles (5) || 43,444 || 21–23 || W1 |-style=background:#bfb | 45 || May 18 || Royals || 6–3 || Canning (2-1) || Junis (3-5) || Buttrey (2) || 43,415 || 22–23 || W2 |-style=background:#fbb | 46 || May 19 || Royals || 1–5 || Duffy (3-1) || Skaggs (4-4) || — || 43,329 || 22–24 || L1 |-style=background:#fbb | 47 || May 20 || Twins || 1–3 || Rogers (1-0) || Buttrey (2-2) || Parker (8) || 34,177 || 22–25 || L2 |-style=background:#fbb | 48 || May 21 || Twins || 3–8 || Pineda (4-3) || Bard (1-2) || — || 32,316 || 22–26 || L3 |-style=background:#bbb | 49 || May 22 || Twins || colspan=7 | Postponed (rain) Makeup date: May 23 |-style=background:#fbb | 49 || May 23 || Twins || 7–16 || Pérez (7-1) || Harvey (2-4) || — || 30,992 || 22–27 || L4 |-style=background:#fbb | 50 || May 24 || Rangers || 3–4 || Smyly (1-3) || Smyly (1-3) || Kelley (5) || 43,806 || 22–28 || L5 |-style=background:#bfb | 51 || May 25 || Rangers || 3–2 || Robles (2–0) || Kelley (3–1) || — || 36,392 || 23–28 || W1 |-style=background:#bfb | 52 || May 26 || Rangers || 7–6 || García (1–1) || Springs (2–1) || Anderson (1) || 39,406 || 24–28 || W2 |-style=background:#fbb | 53 || May 27 || @ Athletics || 5–8 || Bassitt (3–1) || Cahill (2–5) || Treinen (11) || 20,409 || 24–29 || L1 |-style=background:#bfb | 54 || May 28 || @ Athletics || 6–4 || Buttrey (3–2) || Soria (1–4) || Robles (6) || 13,060 || 25–29 || W1 |-style=background:#bfb | 55 || May 29 || @ Athletics || 12–7 (11) || Ramirez (2–0) || Trivino (2–1) || — || 21,185 || 26–29 || W2 |-style=background:#bfb | 56 || May 30 || @ Mariners || 9–3 || Peña (3–1) || Kikuchi (3–3) || — || 13,972 || 27–29 || W3 |-style=background:#fbb | 57 || May 31 || @ Mariners || 3–4 || Leake (4–6) || Skaggs (4–5) || Bass (1) || 32,164 || 27–30 || L1 |- |-style=background:#bfb | 58 || June 1 || @ Mariners || 6–3 || Bedrosian (2–3) || Brennan (2–3) || Robles (7) || 28,128 || 28–30 || W1 |-style=background:#bfb | 59 || June 2 || @ Mariners || 13–3 || Suárez (1–0) || Gonzales (5–6) || —