117 || August 14 || Mariners || 3–2 || Jackson (3–5) || Gonzales (12–10) || Jiménez (2) || 17,132 || 36–81 || W1 |- bgcolor="ffbbbb | 118 || August 15 || Mariners || 2–7 || Milone (2–7) || Turnbull (3–11) || — || 19,440 || 36–82 || L1 |- bgcolor="bbffbb | 119 || August 16 || @ Rays || 2–0 || VerHagen (3–2) || Morton (13–5) || Jiménez (3) || 13,717 || 37–82 || W1 |- bgcolor="ffbbbb | 120 || August 17 || @ Rays || 0–1 (13) || Poche (3–4) || Hall (0–1) || — || 17,228 || 37–83 || L1 |- bgcolor="ffbbbb | 121 || August 18 || @ Rays || 4–5 || Alvarado (1–5) || Jiménez (3–7) || — || 16,634 || 37–84 || L2 |- bgcolor="ffbbbb | 122 || August 19 || @ Astros || 4–5 || Miley (12–4) || Jackson (3–6) || Osuna (28) || 40,499 || 37–85 || L3 |- bgcolor="ffbbbb | 123 || August 20 || @ Astros || 3–6 || Peacock (7–6) || Turnbull (3–12) || Osuna (29) || 30,143 || 37–86 || L4 |- bgcolor="bbffbb | 124 || August 21 || @ Astros || 2–1 || Farmer (5–4) || Verlander (15–5) || Jiménez (4) || 29,567 || 38–86 || W1 |- bgcolor="ffbbbb | 125 || August 22 || @ Astros || 3–6 || Cole (15–5) || Zimmermann (1–9) || Osuna (30) || 27,220 || 38–87 || L1 |- bgcolor="bbffbb | 126 || August 23 || @ Twins || 9–6 || VerHagen (4–2) ||Berríos (10–7) || — || 31,238 || 39–87 || W1 |- bgcolor="ffbbbb | 127 || August 24 || @ Twins || 5–8 || Gibson (12–6) || Jackson (3–7) || Rogers (20) || 39,429 || 39–88 || L1 |- bgcolor="ffbbbb | 128 || August 25 || @ Twins || 4–7 || Pérez (9–5) || Boyd (6–10) || — || 32,892 || 39–89 || L2 |- bgcolor="ffbbbb | 129 || August 27 || Indians || 1–10 || Plutko (6–3) || Turnbull (3–13) || — || 15,715 || 39–90 || L3 |- bgcolor="ffbbbb | 130 || August 28 || Indians || 2–4 || Civale (2–3) || Farmer (5–5) || Hand (32) || 15,834 || 39–91 || L4 |- bgcolor="ffbbbb | 131 || August 29 || Indians || 0–2 || Clevinger (10–2) || Norris (3–11) || Hand (33) || 16,855 || 39–92 || L5 |- bgcolor="ffbbbb | 132 || August 30 || Twins