— || 28,688 || 12–14 || 4½ |- style="text-align:center; background:#bfb;" | 27 || April 27 || Athletics || 7–1 || Sanchez (3–1) || Anderson (3–2) || — || 22,254 || 13–14 || 4½ |- style="text-align:center; background:#bfb;" | 28 || April 28 || Athletics || 5–4 (11) || Luciano (1–0) || Treinen (1–2) || — || 18,557 || 14–14 || 4½ |- style="text-align:center; background:#fbb;" | 29 || April 30 || @ Angels || 3–4 || Buttrey (2–1) || Tepera (0–1) || Robles (2) || 38,797 || 14–15 || 5½ |- |- style="text-align:center; background:#fbb;" | 30 || May 1 || @ Angels || 3–6 || Peña (1–1) || Stroman (1–4) || Buttrey (1) || 33,082 || 14–16 || 5 |- style="text-align:center; background:#fbb;" | 31 || May 2 || @ Angels || 2–6 || Skaggs (3–2) || Sanchez (3–2) || — || 40,064 || 14–17 || 6 |- style="text-align:center; background:#bfb;" | 32 || May 3 || @ Rangers || 1–0 (12) || Hudson (2–1) || Jurado (0–1) || Giles (8) || 26,179 || 15–17 || 6 |- style="text-align:center; background:#fbb;" | 33 || May 4 || @ Rangers || 5–8 || Lynn (4–2) || Pannone (1–3) || Kelley (2) || 31,787 || 15–18 || 6 |- style="text-align:center; background:#fbb;" | 34 || May 5 || @ Rangers || 2–10 || Dowdy (2–1) || Buchholz (0–2) || — || 30,934 || 15–19 || 6½ |- style="text-align:center; background:#fbb;" | 35 || May 6 || Twins || 0–8 || Pérez (5–0) || Stroman (1–5) || — || 12,292 || 15–20 || 7½ |- style="text-align:center; background:#fbb;" | 36 || May 7 || Twins || 0–3 || Berríos (6–1) || Sanchez (3–3) || Rogers (4) || 14,039 || 15–21 || 8½ |- style="text-align:center; background:#fbb;" | 37 || May 8 || Twins || 1–9 || Gibson (3–1) || Thornton (0–4) || — || 14,372 || 15–22 || 8½ |- style="text-align:center; background:#bfb;" | 38 || May 10 || White Sox || 4–3 || Biagini (2–1) || Covey (0–2) || Giles (9) || 20,402 || 16–22 || 7½ |- style="text-align:center; background:#fbb;" | 39 || May 11 || White Sox || 2–7 || Nova (2–3) || Stroman (1–6) || — || 24,563 || 16–23 || 8½ |- style="text-align:center; background:#fbb;" | 40 || May 12 || White Sox || 1–5 || Giolito (4–1) || Sanchez (3–4) || — || 24,222 || 16–24 || 8½ |- style="text-align:center; background:#bfb;" | 41 || May 14 || @ Giants