– || April 27 || Tigers || 6:10pm ||colspan=7| Postponed (Inclement Weather, makeup date on July 3) |-style=background:#bfb || 25 || April 28 || Tigers || 1:10pm || 4–1 || López (2–3) || Boyd (2–2) || Colomé (5) || 14,539 || 11–14 || W2 |-style=background:#bfb || 26 || April 29 || Orioles || 7:10pm || 5–3 || Bañuelos (2–0) || Means (3–3) || Colomé (6) || 14,717 || 12–14 ||W3 |-style=background:#bbb || – || April 30 || Orioles || 7:10pm ||colspan=7| Postponed (Inclement Weather, makeup date on May 1) |- |-style=background:#fbb || 27 || May 1 || Orioles || 3:10pm || 4–5 || Kline (1–0) || Herrera (0–1) || Givens (2) || TBA G2 || 12–15 || L1 |-style=background:#bfb || 28 || May 1 || Orioles || 7:30pm || 7–6 || Vieira (1–0) || Phillips (0–1) || — || 14,781 || 13–15 || W1 |-style=background:#bfb || 29 || May 2 || Red Sox || 7:10pm || 6–4 || Fulmer (1–1) || Brasier (1–1) || — || 15,118 || 14–15 || W1 |-style=background:#fbb || 30 || May 3 || Red Sox || 7:10pm || 1–6 || Sale (1–5) || López (2–4) || — || 17,504 || 14–16 || L1 |-style=background:#fbb || 31 || May 4 || Red Sox || 6:10pm || 2–15 || Rodríguez (3–2) || Bañuelos (2–1) || — || 30,068 || 14–17 || L2 |-style=background:#fbb || 32 || May 5 || Red Sox || 1:10pm || 2–9 || Workman (2–1) || Herrera (0–2) || — || 36,553 || 14–18 || L3 |-style=background:#bfb || 33 || May 6 || @ Indians || 5:10pm || 9–1 || Nova (1–3) || Bauer (4–2) || — || 12,745 || 15–18 || W1 |-style=background:#bfb || 34 || May 7 || @ Indians || 5:10pm || 2–0 || Giolito (3–1) || Rodríguez (0–2) || Colomé (7) || 12,961 || 16–18 || W2 |-style=background:#fbb || 35 || May 8 || @ Indians || 5:10pm || 3–5 || Hand (2–1) || Fry (1–1) || — || 12,519 || 16–19 || L1 |-style=background:#fbb || 36 || May 9 || @ Indians || 12:10pm || 0–5 (6) || Carrasco (3–3) || Bañuelos (2–2) || — || 13,247 || 16–20 || L2 |-style=background:#fbb || 37 || May 10 || @ Blue Jays || 6:07pm || 3–4 || Biagini (2–1) || Covey (0–2) || Giles (9) || 20,402 || 16–21 || L3 |-style=background:#bfb || 38 || May 11 || @ Blue