Park || 31,754 || 13–17 || W2 |- |- style="text-align:center; background-color:#bfb" | 31 || May 1 || Athletics || 7–3 || Walden (4–0) || Fiers (2–3) || — || Fenway Park || 33,708 || 14–17 || W3 |- style="text-align:center; background-color:#fbb" | 32 || May 2 || @ White Sox || 4–6 || Fulmer (1–1) || Brasier (1–1) || — || Guaranteed Rate Field || 15,118 || 14–18 || L1 |- style="text-align:center; background-color:#bfb" | 33 || May 3 || @ White Sox || 6–1 || Sale (1–5) || López (2–4) || — || Guaranteed Rate Field || 17,504 || 15–18 || W1 |- style="text-align:center; background-color:#bfb" | 34 || May 4 || @ White Sox || 15–2 || Rodríguez (3–2) || Bañuelos (2–1) || — || Guaranteed Rate Field || 30,068 || 16–18 || W2 |- style="text-align:center; background-color:#bfb" | 35 || May 5 || @ White Sox || 9–2 || Workman (2–1) || Herrera (0–2) || — || Guaranteed Rate Field || 36,553 || 17–18 || W3 |- style="text-align:center; background-color:#fbb" | 36 || May 6 || @ Orioles || 1–4 || Means (4–3) || Smith (0–1) || Givens (4) || Camden Yards || 11,042 || 17–19 || L1 |- style="text-align:center; background-color:#bfb" | 37 || May 7 || @ Orioles || 8–5 || Walden (5–0) || Kline (1–1) || Barnes (3) || Camden Yards || 10,703 || 18–19 || W1 |- style="text-align:center; background-color:#bfb" | 38 || May 8 || @ Orioles || 2–1 (12) || Brasier (2–1) || Ramírez (0–1) || Hembree (1) || Camden Yards || 12,451 || 19–19 || W2 |- style="text-align:center; background-color:#bfb" | 39 || May 10 || Mariners || 14–1 || Rodríguez (4–2) || Swanson (1–4) || — || Fenway Park || 33,731 || 20–19 || W3 |- style="text-align:center; background-color:#bfb" | 40 || May 11 || Mariners || 9–5 || Porcello (3–3) || Hernández (1–4) || — || Fenway Park || 36,024 || 21–19 || W4 |- style="text-align:center; background-color:#bfb" | 41 || May 12 || Mariners || 11–2 || Velázquez (1–2) || Gonzales (5–2) || — || Fenway Park || 33,069 || 22–19 || W5 |- style="text-align:center; background-color:#fbb" | 42 || May 14 || Rockies || 4–5 (11) || Dunn (1–0) || Brasier (2–2) || Davis (7) || Fenway Park || 35,804 || 22–20 || L1 |- style="text-align:center; background-color:#bfb" | 43 || May 15 || Rockies || 6–5 (10) || Workman (3–1) || Bettis (1–3) || — || Fenway