19 || April 17 || @ Nationals || 6–9 || Hellickson (2–0) || Samardzija (1–1) || – || 22,611 || 8–11 |-style=background:#fbb;" | 20 || April 18 || @ Nationals || 2–4 || Corbin (1–0) || Pomeranz (0–2) || Doolittle (2) || 26,085 || 8–12 |-style=background:#fbb;” | 21 || April 19 || @ Pirates || 1–4 || Lyles (2–0) || Bumgarner (1–3) || Vázquez (6) || 15,049 || 8–13 |-style=background:#fbb;” | 22 || April 20 || @ Pirates || 1–3 (5) || Taillon (1–2) || Holland (1–3) || – || 17,663 || 8–14 |-style=background:#bfb;" | 23 || April 21 || @ Pirates || 3–2 || Rodríguez (3–2) || Archer (1–1) || Smith (5) || 12,396 || 9–14 |-style=background:#bfb;" | 24 || April 23 || @ Blue Jays || 7–6 || Samardzija (2–1) || Thornton (0–3) || Smith (6) || 20,384 || 10–14 |-style=background:#bfb;" | 25 || April 24 || @ Blue Jays || 4–0 || Pomeranz (1–2) || Buchholz (0–1) || – || 19,652 || 11–14 |-style=background:#fbb;” | 26 || April 26 || Yankees || 3–7 || Paxton (3–2) || Bumgarner (1–4) || – || 34,950 || 11–15 |-style=background:#fbb;” | 27 || April 27 || Yankees || 4–6 || Happ (1–2) || Holland (1–4) || Chapman (5) || 33,971 || 11–16 |-style=background:#fbb;” | 28 || April 28 || Yankees || 5–11 || Germán (5–1) || Rodríguez (3–3) || – || 34,540 || 11–17 |-style=background:#bfb;" | 29 || April 29 || Dodgers || 3–2 || Dyson (1–0) || Stripling (1–2) || Smith (7) || 32,212 || 12–17 |-style=background:#fbb;” | 30 || April 30 || Dodgers || 3–10 || Buehler (3–0) || Pomeranz (1–3) || – || 32,017 || 12–18 |- |-style=background:#bfb;" | 31 || May 1 || Dodgers || 2–1 || Smith (1–0) || Urías (2–2) || – || 31,960 || 13–18 |-style=background:#bfb;" | 32 || May 3 || @ Reds || 12–11 || Moronta (1–2) || Hughes (2–1) || Smith (8) || 23,478 || 14–18 |-style=background:#fbb;” | 33 || May 4 || @ Reds || 2–9 || Roark (2–1) || Rodríguez (3–4) || – || 24,104 || 14–19 |-style=background:#bfb;" | 34 || May 5 || @ Reds || 6–5 || Watson (1–0) || Iglesias (1–5) || Smith (9) || 23,654 || 15–19 |-style=background:#fbb;" | 35 || May 6 || @ Reds || 4–12 || DeSclafani (2–1) || Pomeranz (1–4) || – || 19,476 || 15–20 |-style=background:#bfb;" | 36 || May