|| — || Progressive Field || 24,770 || 63–59 || L3 |- style="text-align:center; background-color:#bfb" | 123 || Aug 13 || @ Indians || 7–6 || Workman (9–1) || Wittgren (4–1) || Cashner (1) || Progressive Field || 26,662 || 64–59 || W1 |- style="text-align:center; background-color:#bfb" | 124 || Aug 14 || @ Indians || 5–1 || Eovaldi (1–0) || Bieber (12–5) || — || Progressive Field || 29,535 || 65–59 || W2 |- style="text-align:center; background-color:#bfb" | 125 || Aug 16 || Orioles || 9–1 || Porcello (11–9) || Brooks (2–7) || — || Fenway Park || 37,213 || 66–59 || W3 |- style="text-align:center; background-color:#bfb" | 126 || Aug 17 || Orioles || 4–0 || Rodríguez (14–5) || Wojciechowski (2–6) || — || Fenway Park || 36,744 || 67–59 || W4 |- style="text-align:center; background-color:#bfb" | 127 || Aug 18 || Orioles || 13–7 || Walden (8–2) || Fry (1–5) || — || Fenway Park || 36,350 || 68–59 || W5 |- style="text-align:center; background-color:#fbb" | 128 || Aug 20 || Phillies || 2–3 || Nola (12–3) || Johnson (1–2) || Neris (22) || Fenway Park || 37,712 || 68–60 || L1 |- style="text-align:center; background-color:#fbb" | 129 || Aug 21 || Phillies || 2–5 || Hughes (4–5) || Porcello (11–10) || Neris (23) || Fenway Park || 37,077 || 68–61 || L2 |- style="text-align:center; background-color:#bbb" | — || Aug 22 || Royals || colspan=4|Completion of suspended game from August 7 || Fenway Park || 16,441 || — || — |- style="text-align:center; background-color:#bfb" | 130 || Aug 23 || @ Padres || 11–0 || Rodríguez (15–5) || Paddack (7–7) || — || Petco Park || 42,904 || 69–61 || W1 |- style="text-align:center; background-color:#bfb" | 131 || Aug 24 || @ Padres || 5–4 || Barnes (4–4) || Yates (0–4) || Workman (8) || Petco Park || 42,625 || 70–61 || W2 |- style="text-align:center; background-color:#fbb" | 132 || Aug 25 || @ Padres || 1–3 || Lucchesi (9–7) || Johnson (1–3) || Yates (37) || Petco Park || 38,026 || 70–62 || L1 |- style="text-align:center; background-color:#bfb" | 133 || Aug 27 || @ Rockies || 10–6 || Porcello (12–10) || Garcia (0–1) || — || Coors Field || 44,101 || 71–62 || W1 |- style="text-align:center; background-color:#bfb" | 134 || Aug 28 || @ Rockies || 7–4 || Rodríguez (16–5) || Lambert (2–5) || Workman (9) || Coors Field || 40,801 || 72–62 || W2 |-