|- bgcolor="ffbbbb" | 43 || May 17 || Athletics || 2–7 || Montas (5–2) || Norris (2–2) || — || 18,746 || 18–25 || L5 |- bgcolor="ffbbbb" | 44 || May 18 || Athletics || 1–4 || Mengden (1–1) || Boyd (4–4) || Treinen (7) || 22,913 || 18–26 || L6 |- bgcolor="bbbbbb" | — || May 19 || Athletics || colspan="9" | Suspended (inclement weather). Continuation scheduled for September 6 in Oakland. |- bgcolor="ffbbbb" | 45 || May 21 || Marlins || 4–5 (11) || Anderson (1–1) || Jiménez (2–2) || — || 15,565 || 18–27 || L7 |- bgcolor="ffbbbb" | 46 || May 22 || Marlins || 3–6 || Ureña (2–6) || Farmer (2–3) || Romo (8) || 14,506 || 18–28 || L8 |- bgcolor="ffbbbb" | 47 || May 23 || Marlins || 2–5 || Kinley (1–0) || Greene (0–2) || Romo (9) || 17,214 || 18–29 || L9 |- bgcolor="bbffbb" | 48 || May 24 || @ Mets || 9–8 || Farmer (3–3) || Gagnon (3–1) || Greene (16) || 27,082 || 19–29 || W1 |- bgcolor="ffbbbb" | 49 || May 25 || @ Mets || 4–5 (13) || Santiago (1–0) || Farmer (3–4) || — || 40,691 || 19–30 || L1 |- bgcolor="ffbbbb" | 50 || May 26 || @ Mets || 3–4 || Wheeler (4–3) || Turnbull (2–4) || Díaz (13) || 31,414 || 19–31 || L2 |- bgcolor="ffbbbb | 51 || May 27 || @ Orioles || 3–5 || Straily (2–4) || Norris (2–3) || Armstrong (1) || 18,004 || 19–32 || L3 |- bgcolor="bbffbb" | 52 || May 28 || @ Orioles || 3–0 || Boyd (5–4) || Bundy (2–6) || Greene (17) || 8,106 || 20–32 || W1 |- bgcolor="bbffbb" | 53 || May 29 || @ Orioles || 4–2 || Ramirez (1–0) || Kline (1–2) || Greene (18) || 10,614 || 21–32 || W2 |- bgcolor="bbffbb" | 54 || May 31 || @ Braves || 8–2 || Turnbull (3–4) || Foltynewicz (1–4) || — || 35,524 || 22–32 || W3 |- |- bgcolor="ffbbbb | 55 || June 1 || @ Braves || 5–10 || Soroka (6–1) || Norris (2–4) || Jackson (8) || 37,108 || 22–33 || L1 |- bgcolor="ffbbbb | 56 || June 2 || @ Braves || 4–7 || Toussaint (3–0) || Jiménez (2–3) || — || 28,978 || 22–34 || L2 |- bgcolor="bbffbb | 57 || June 4