Turnbull (2–2) || Velasquez (1–1) || Greene (12) || 31,759 || 13–14 || W1 |- |- bgcolor="ffbbbb" | 28 || May 1 || @ Phillies || 3–7 || Domínguez (2–0) || Farmer (1–2) || — || 28,103 || 13–15 || L1 |- bgcolor="bbffbb" | 29 || May 3 || Royals || 4–3 || Boyd (3–2) || López (0–3) || Greene (13) || 14,020 || 14–15 || W1 |- bgcolor="ffbbbb" | 30 || May 4 || Royals || 3–15 || Bailey (3–3) || Ross (1–4) || — || 19,500 || 14–16 || L1 |- bgcolor="bbffbb" | 31 || May 5 || Royals || 5–2 (10) || Farmer (2–2) || Kennedy (0–1) || — || 16,369 || 15–16 || W1 |- bgcolor="ffbbbb" | 32 || May 7 || Angels || 2–5 || Canning (1–0) || Norris (1–1) || Robles (3) || 14,169 || 15–17 || L1 |- bgcolor="bbffbb" | 33 || May 8 || Angels || 10–3 || Boyd (4–2) || Skaggs (3–3) || — || 13,224 || 16–17 || W1 |- bgcolor="ffbbbb" | 34 || May 9 || Angels || 0–13 || Peña (2–1) || Carpenter (0–1) || — || 16,404 || 16–18 || L1 |- bgcolor="ffbbbb" | 35 || May 10 || @ Twins || 0–6 || Odorizzi (5–2) || Ross (1–5) || — || 26,789 || 16–19 || L2 |- bgcolor="bbffbb" | 36 || May 11 || @ Twins || 5–3 || Jiménez (2–1) || Hildenberger (2–2) || Greene (14) || 28,840 || 17–19 || W1 |- bgcolor="ffbbbb" | 37 || May 11 || @ Twins || 3–8 || Stewart (1–1) || Soto (0–1) || — || 20,724 || 17–20 || L1 |- bgcolor="bbffbb" | 38 || May 12 || @ Twins || 5–3 || Norris (2–1) || Pérez (5–1) || Greene (15) || 27,373 || 18–20 || W1 |- bgcolor="ffbbbb" | 39 || May 13 || Astros || 1–8 || Peacock (4–2) || Boyd (4–3) || — || 15,086 || 18–21 || L1 |- bgcolor="ffbbbb" | 40 || May 14 || Astros || 4–11 || Miley (4–2) || Carpenter (0–2) || — || 14,261 || 18–22 || L2 |- bgcolor="ffbbbb" | 41 || May 15 || Astros || 1–5 || Verlander (7–1) || Soto (0–2) || — || 15,940 || 18–23 || L3 |- bgcolor="ffbbbb" | 42 || May 16 || Athletics || 3–17 || Bassitt (2–1) || Turnbull (2–3) || — || 18,527 || 18–24 || L4