(4–3) || Barlow (1–1) ||-|| 25,243 || 17–33 || L2 |-style=background:#fbb ||51|| May 25 || Yankees || 5–6 || Adams (1–0) || López (0–6) || Chapman (14) || 18,599 || 17–34 || L3 |-style=background:#bfb ||52|| May 26 || Yankees || 8–7 (10) || McCarthy (1–1) || Holder (3–2) || — || 21,499 || 18–34 || W1 |-style=background:#bbb ||53|| May 27 || @ White Sox || colspan=8|Suspended (inclement weather); Continuation scheduled for May 28 |-style=background:#fbb ||53|| May 28 || @ White Sox || 1–2 || Colomé (2–0) || Diekman (0–2) || — || 13,842 || 18–35 || L1 |-style=background:#fbb ||54|| May 28 || @ White Sox || 3–4 || Giolito (7–1) || Keller (3–6) || Colomé (10) || 13,842 || 18–36 || L2 |-style=background:#fbb ||55|| May 29 || @ White Sox || 7–8 || Herrera (2–3) || Kennedy (0–2) || Colomé (11) || 16,167 || 18–37 || L3 |-style=background:#bfb ||56|| May 30 || @ Rangers || 4–2 || Junis (4–5) || Minor (5–4) || Kennedy (3) || 26,202 || 19–37 || W1 |-style=background:#fbb ||57|| May 31 || @ Rangers || 2–6 || Jurado (2–2) || Duffy (3–2) ||-|| 31,183 || 19–38 || L1 |- |-style=background:#fbb ||58|| June 1 || @ Rangers || 2–6 || Lynn (7–4) || Bailey (4–6) ||-|| 27,133 || 19–39 || L2 |-style=background:#fbb ||59|| June 2 || @ Rangers || 1–5 || Sampson (4–3) || Keller (3–7) ||-|| 21,891 || 19–40 || L3 |-style=background:#fbb ||60|| June 4 || Red Sox || 3–8 || Rodríguez (6–3) || Barlow (1–2) ||-|| 13,184 || 19–41 || L4 |-style=background:#fbb ||61|| June 5 || Red Sox || 0–8 || Sale (2–7) || Junis (4–6) ||-|| 15,523 || 19–42 || L5 |-style=background:#fbb ||62|| June 6 || Red Sox || 5–7 || Brewer (1–2) || Duffy (3–3) || Barnes (4) || 19,928 || 19–43 || L6 |-style=background:#bfb ||63|| June 7 || White Sox || 6–4 || Boxberger (1–3) || Fry (1–2) || Kennedy (4) || 24,744 || 20–43 || W1 |-style=background:#fbb ||64|| June 8 || White Sox || 0–2 || Giolito (9–1) || Keller (3–8) || Colomé (13) || 20,889 || 20–44 || L1 |-style=background:#fbb ||65|| June 9 || White Sox || 2–5 || López (4–6) || Sparkman (1–2) ||-|| 22,501 || 20–45 || L2 |-style=background:#bfb ||66|| June 11 || Tigers || 3–2 || Barlow (2–2) || Alcántara (2–1) || Kennedy (5) || 20,776 || 21–45|| W1 |-style=background:#fbb ||67|| June 12 || Tigers || 2–3