|| 33,069 || 20–23 || L4 |-style=background:#bfb ||44|| May 13 || Athletics || 6–5 (10) || Brennan (2–2) || Soria (1–3) || — || 12,250 || 21–23 || W1 |-style=background:#bfb ||45|| May 14 || Athletics || 4–3 || Leake (3–4) || Anderson (4–3) || Elias (5) || 11,365 || 22–23 || W2 |-style=background:#fbb ||46|| May 16 || Twins || 6–11 || Pineda (3–3) || Swanson (1–5) || — || 16,397 || 22–24 || L1 |-style=background:#fbb ||47|| May 17 || Twins || 1–7 || Pérez (6–1) || Gonzales (5–3) || — || 20,268 || 22–25 || L2 |-style=background:#fbb ||48|| May 18 || Twins || 4–18 || Duffey (1–0) || LeBlanc (2–1) || — || 34,433 || 22–26 || L3 |-style=background:#bfb ||49|| May 19 || Twins || 7–4 || Kikuchi (3–1) || Gibson (4–2)|| — || 31,068 || 23–26 || W1 |-style=background:#fbb ||50|| May 20 || @ Rangers || 9–10 || Minor (5-3) || Leake (3-5) || — || 18,796 || 23–27 || L1 |-style=background:#fbb ||51|| May 21 || @ Rangers || 3–5 || Lynn (6–3) || Milone (0–1) || Kelley (3) || 19,157 || 23–28 || L2 |-style=background:#fbb ||52|| May 22 || @ Rangers || 1–2 || Sampson (2-3) || Gonzales (5-4) || Kelley (4) || 22,400 || 23–29 || L3 |-style=background:#fbb ||53|| May 24 || @ Athletics || 2–6 || Trivino (2-0) || LeBlanc (2-2) || — || 12,902 || 23–30 || L4 |-style=background:#fbb ||54|| May 25 || @ Athletics || 5–6 || Fiers (4–3) || Kikuchi (3–2) || Treinen (10) || 18,975 || 23–31 || L5 |-style=background:#fbb ||55|| May 26 || @ Athletics || 1–7 || Anderson (6–3) || Leake (3-6) || — || 14,664 || 23–32 || L6 |-style=background:#bfb ||56|| May 27 || Rangers || 6–2 || Milone (1–1) || Lynn (6–4) || — || 14,135 || 24–32 || W1 |-style=background:#fbb ||57|| May 28 || Rangers || 4–11 || Sampson (3-3) || Gonzales (5-5) || — || 12,452 || 24–33 || L1 |-style=background:#fbb ||58|| May 29 || Rangers || 7–8 || Chavez (1–1) || Bass (0–1) || Kelley (6) || 16,059 || 24–34 || L2 |-style=background:#fbb ||59|| May 30 || Angels || 3–9 || Peña (3–1) || Kikuchi (3–3) || — || 13,972 || 24–35 || L3 |-style=background:#bfb ||60|| May 31 || Angels || 4–3 || Leake (4-6) || Skaggs (4–5) || Bass (1) || 32,164 || 25–35 || W1 |- |-style=background:#fbb ||61|| June 1 || Angels ||