Jays || 2:07pm || 7–2 || Nova (2–3) || Stroman (1–6) || — || 24,563 || 17–21 || W1 |-style=background:#bfb || 39 || May 12 || @ Blue Jays || 12:07pm || 5–1 || Giolito (4–1) || Sanchez (3–4) || — || 24,222 || 18–21 || W2 |-style=background:#bfb || 40 || May 13 || Indians || 7:10pm || 5–2 || López (3–4) || Bieber (2–2) || Colomé (8) || 16,471 || 19–21 || W3 |-style=background:#fbb || 41 || May 14 || Indians || 1:10pm || 0–9 || Carrasco (4–3) || Bañuelos (2–3) || — || 18,823 || 19–22 || L1 |-style=background:#bfb || 42 || May 16 || Blue Jays || 7:10pm || 4–2 || Herrera (1–2) || Law (0–1) || Colomé (9) || 20,119 || 20–22 || W1 |-style=background:#fbb | 43 || May 17 || Blue Jays || 7:10pm || 2–10 || Gaviglio (3–0) || Nova (2–4) || Guerra (1) || 17,078 || 20–23 || L1 |-style=background:#bfb || 44 || May 18 || Blue Jays || 1:10pm || 4–1 (5) || Giolito (5–1) || Feierabend (0–1) || — || 22,908 || 21–23 || W1 |-style=background:#fbb || 45 || May 19 || Blue Jays || 1:10pm || 2–5 || Hudson (3–1) || Herrera (1–3) || Giles (10) || 18,605 || 21–24 || L1 |-style=background:#fbb || 46 || May 20 || @ Astros || 7:10pm || 0–3 || Peacock (5–2) || Burr (1–1) || Osuna (12) || 24,364 || 21–25 || L2 |-style=background:#fbb || 47 || May 21 || @ Astros || 7:10pm || 1–5 || Verlander (8–1) || Covey (0–3) || — || 31,392 || 21–26 || L3 |-style=background:#bfb || 48 || May 22 || @ Astros || 7:10pm || 9–4 || Nova (3–4) || Cole (4–5) || — || 30,237 || 22–26 || W1 |-style=background:#bfb || 49 || May 23 || @ Astros || 7:10pm || 4–0 || Giolito (6–1) || Martin (1–1) || — || 26,073 || 23–26 || W2 |-style=background:#fbb || 50 || May 24 || @ Twins || 7:10pm || 4–11 || Berríos (7–2) || López (3–5) || — || 29,638 || 23–27 || L1 |-style=background:#fbb || 51 || May 25 || @ Twins || 1:10pm || 1–8 || Gibson (5–2) || Bañuelos (2–4) || — || 39,139 || 23–28 || L2 |-style=background:#fbb || 52 || May 26 || @ Twins || 1:10pm || 0–7 || Odorizzi (7–2) || Covey (0–4) || — || 39,913 || 23–29