White Sox || 4–6 || Nova (9–9) || Gibson (11–6) || Colomé (24) || 25,564 || 76–49 || L1 |-style=background:#bfb ||126|| August 20 || White Sox || 14–4 || Pineda (9–5) || López (7–11) || — || 26,798 || 77–49 || W1 |-style=background:#fbb ||127|| August 21 || White Sox || 0–4 || Giolito (14–6) || Odorizzi (13–6) || — || 31,389 || 77–50 || L1 |-style=background:#fbb ||128|| August 23 || Tigers || 6–9 || VerHagen (4–2) || Berríos (10–7) || — || 31,238 || 77–51 || L2 |-style=background:#bfb ||129|| August 24 || Tigers || 8–5 || Gibson (12–6) || Jackson (3–7) || Rogers (20) || 39,429 || 78–51 || W1 |-style=background:#bfb ||130|| August 25 || Tigers || 7–4 || Pérez (9–5) || Boyd (6–10) || — || 32,892 || 79–51 || W2 |-style=background:#bfb ||131|| August 27 || @ White Sox || 3–1 || Pineda (10–5) || Giolito (14–7) || Rogers (21) || 12,175 || 80–51 || W3 |-style=background:#bfb ||132|| August 28 || @ White Sox || 8–2 || Odorizzi (14–6) || Detwiler (2–4) || — || 16,802 || 81–51 || W4 |-style=background:#bfb ||133|| August 29 || @ White Sox || 10–5 || Berríos (11–7) || Cease (3–7) || Dobnak (1) || 15,886 || 82–51 || W5 |-style=background:#bfb ||134|| August 30 || @ Tigers || 13–5 || Gibson (13–6) || Jackson (3–8) || — || 17,273 || 83–51 || W6 |-style=background:#fbb ||135|| August 31 || @ Tigers || 7–10 || Boyd (7–10) || Pérez (9–6) || — || 16,713 || 83–52 || L1 |- |-style=background:#bfb ||136|| September 1 || @ Tigers || 8–3 || Pineda (11–5) || Turnbull (3–14) || — || 13,776 || 84–52 || W1 |-style=background:#bfb ||137|| September 2 || @ Tigers || 4–3 || Littell (3–0) || Farmer (5–6) || Rogers (22) || 14,614 || 85–52 || W2 |-style=background:#bfb ||138|| September 3 || @ Red Sox || 6–5 || Thorpe (2–1) || Porcello (12–11) || Rogers (23) || 35,429 || 86–52 || W3 |-style=background:#fbb ||139|| September 4 || @ Red Sox || 2–6 || Rodriguez (17–5) || Berríos (11–8) || Workman (11) || 35,218 || 86–53 || L1 |-style=background:#bfb ||140|| September 5 || @ Red Sox || 2–1 || Pérez (10–6) || Cashner (11–8) || Rogers (24) || 32,632 || 87–53 || W1 |-style=background:#fbb ||141|| September 6 || Indians || 2–6 || Clippard (1–0) || Thorpe (2–2) || — || 35,418 || 87–54 || L1 |-style=background:#bfb ||142|| September