style="text-align:center; background-color:#bfb" | 135 || Aug 30 || @ Angels || 7–6 || Cashner (11–7) || Cahill (3–9) || — || Angel Stadium || 39,788 || 73–62 || W3 |- style="text-align:center; background-color:#fbb" | 136 || Aug 31 || @ Angels || 4–10 || García (2–1) || Brasier (2–4) || — || Angel Stadium || 43,036 || 73–63 || L1 |- | colspan=11 | |- |- style="text-align:center; background-color:#bfb" | 137 || Sep 1 || @ Angels || 4–3 || Weber (2–2) || Heaney (3–4) || Workman (10) || Angel Stadium || 39,382 || 74–63 || W1 |- style="text-align:center; background-color:#fbb" | 138 || Sep 3 || Twins || 5–6 || Thorpe (2–1) || Porcello (12–11) || Rogers (23) || Fenway Park || 35,129 || 74–64 || L1 |- style="text-align:center; background-color:#bfb" | 139 || Sep 4 || Twins || 6–2 || Rodríguez (17–5) || Berríos (11–8) || Workman (11) || Fenway Park || 35,218 || 75–64 || W1 |- style="text-align:center; background-color:#fbb" | 140 || Sep 5 || Twins || 1–2 || Pérez (10–6) || Cashner (11–8) || Rogers (24) || Fenway Park || 32,632 || 75–65 || L1 |- style="text-align:center; background-color:#bfb" | 141 || Sep 6 || Yankees || 6–1 || Walden (9–2) || Germán (17–4) || — || Fenway Park || 36,162 || 76–65 || W1 |- style="text-align:center; background-color:#fbb" | 142 || Sep 7 || Yankees || 1–5 || Happ (12–8) || Weber (2–3) || — || Fenway Park || 36,619 || 76–66 || L1 |- style="text-align:center; background-color:#fbb" | 143 || Sep 8 || Yankees || 5–10 || Green (3–4) || Porcello (12–12) || — || Fenway Park || 35,681 || 76–67 || L2 |- style="text-align:center; background-color:#fbb" | 144 || Sep 9 || Yankees || 0–5 || Paxton (13–6) || Rodríguez (17–6) || — || Fenway Park || 35,884 || 76–68 || L3 |- style="text-align:center; background-color:#fbb" | 145 || Sep 10 || @ Blue Jays || 3–4 || Shafer (2–1) || Taylor (1–2) || Giles (19) || Rogers Centre || 17,819 || 76–69 || L4 |- style="text-align:center; background-color:#fbb" | 146 || Sep 11 || @ Blue Jays || 0–8 || Thornton (5–9) || Kelley (0–1) || — || Rogers Centre || 14,463 || 76–70 || L5 |- style="text-align:center; background-color:#bfb" | 147 || Sep 12 || @ Blue Jays || 7–4 || Taylor (2–2) || Buchholz (1–5) || Workman (12) || Rogers Centre || 17,420 || 77–70 || W1 |- style="text-align:center; background-color:#bfb" |