Sissons signed a three-year, $1.875 million contract extension to remain with the Predators organization. The following month, Sissons was recalled to the NHL level and changed his jersey number from 84 to 10 because "Eighty-four was a little bit too skilled of a number." On March 8, his first game following his recall, Sissons recorded a goal and an assist in the 4–2 win over the Winnipeg Jets for his first multi-point game. As well, he continued to succeed in the face-off circle and ranked second on the team in face-off wins. Sissons and the Predators qualified for the 2016 Stanley Cup playoffs, where they faced the Anaheim Ducks in the first round. Through 10 post-season games, Sissons remained pointless. Sissons returned to the Predators for their pre-season action, where he played in two exhibition games and logged 12:49 minutes of ice time. In the first year of his new contract, Sissons began the 2016–17 season on the Predators' fourth-line before moving up the lineup. He was eventually teamed up with captain Mike Fisher and Austin Watson for the Predators shutdown line and scored his first career NHL hat-trick in January. His hat-trick came in a 6–1 win over the Tampa Bay Lightning at Amalie Arena. After being scratched for seven games between February 23 and March 7, Sisson returned to the Predators lineup and broke out offensively. During a game against the Calgary Flames on March 27, Sisson scored a goal to help lead the team to a 3–1 win in his 100th career NHL game. As the Predators qualified for the 2017 Stanley Cup playoffs, they met the Chicago Blackhawks in the first round. In Game 2, Sissons was one of four Predators players to score their first career playoff goals and lead the team to a 5–0 win. Sissons continued to produce and scored another goal in Game 4 to lead the Predators to a sweep of the Blackhawks. Following this win, Sissons and the Predators met the St. Louis Blues in Round Two. After tallying two assists in a Game 3 win over the Blues, Sissons had recorded two goals and four assists through seven games. With his assistance, the Predators beat the Blues and met with the Anaheim Ducks in the 2017 Western Conference Final. Due to injuries to top-line forwards Ryan Johansen and Mike Fisher, Sissons was elevated to the first-line role in Game