Organic solvent-based coating Organic solvent use in film coating is typically used to incorporate protective coatings to the oral dosage form, which aids in increasing the shelf life of the final drug product. This type of film coating can be dangerous due to its potential for toxicity in the final product and flammability during the film coating process. As such, it is integral to have proper safety measures and ventilation in place when film coating. Aqueous coating Aqueous film coating is the most common film coating method currently used. This type of film coating uses water to aid in the film coating process instead of organic solvents. The result is a safer means of film coating, as it avoids the toxic and flammable properties of organic solvents. Aqueous film coating requires the use of water insoluble polymer mixtures, with the addition of a plasticizer. Despite its widespread popularity, aqueous film coating is more time consuming than organic solvent-based coating, due to the increased time needed for complete evaporation of water. Solvent-free coating Solvent-free film coating is most commonly used in coating heat sensitive drugs due to the benefit of not requiring a drying phase. The end result of this type of film coating is an inert film coating that does not react with the active pharmaceutical ingredients. Some methods to create a solvent-free film coating include injection molding coating, hot-melt coating, and spray congealing. Each method has its own advantages and disadvantages, but the common theme amongst them is the need for very precise conditions that can satisfactorily apply a film coating to the oral dosage form. As such, it is an inefficient type of film coating that has resulted in its lack of widespread use. References Pharmacy Coatings Polymers