copper gluconate was even more effective. A cream containing copper gluconate has been produced, to be applied to inhibit the injected venom; although it is used by U.S. military divers, evidence that it is effective in humans is only anecdotal. In April 2019, a team of researchers at the University of Sydney announced that they had found a possible antidote to Chironex fleckeri venom that would stop pain and skin necrosis if administered within 15 minutes of being stung. The research was the result of work done with CRISPR whole genome editing in which the researchers selectively deactivated skin-cell genes until they were able to identify ATP2B1, a calcium transporting ATPase, as a host factor supporting cytotoxicity. The research showed the therapeutic use of existing drugs targeting cholesterol in mice, although the efficacy of the approach had not been demonstrated in humans. References External links Cubozoa classification Medusozoa Venomous animals Cnidarians of the Pacific Ocean Cnidarians of the Indian Ocean