Torment storyline) for her own purposes, reducing him to a mindless, savage state. After a series of bloody battles, the Lizard and Calypso were defeated by Spider-Man, and Spider-Man assumed that he perished under Calypso's spell. Connors once again gained control of the Lizard's mind and body, although it was very weak. Curt carried out a plan to cure himself temporarily, after which he voluntarily submitted to incarceration in the supervillain prison the Vault. When Calypso forced the transformation and attempted to control the Lizard once again, the creature killed her and escaped from the Vault. After this escape, the Lizard fell and sank into a quicksand pit during a battle in the Everglades with Spider-Man and the bounty hunter Warrant and was believed to have died. Later, a huge bestial Lizard appeared, shortly after Connors was called in to investigate Peter Parker's sudden sickness (the result of Peter's recently lost spider-powers returning). Spider-Man (Ben Reilly) realized that not only had the Lizard survived, but revealed later his new monstrous transformation seemed to be permanent and the personality of Curt Connors appeared completely lost. However, when this savage mindless Lizard later unexpectedly encountered Dr. Connors himself while Connors was helping Peter, Curt became the true Lizard once again and saved his family by killing the "Lizard-clone". It was revealed that the Lizard-clone was a scientific accident resulting from an experimental formula being tested on a piece of the original Lizard's tail, which had then grown into a fully formed second creature. Although reunited after Curt's apparent death, Martha and Billy were diagnosed with cancer after being exposed to carcinogens from living near an industrial lab in Florida. Spider-Man assisted Curt in successfully forcing Monnano, the lab's owner, to admit culpability, but Martha died from her cancer. Billy recovered but remained bitter towards his father. Curt's guilt and internalized anger led him to become the Lizard once again, and once human, Curt attempted a bank robbery so that he would be sent to prison. After a short-lived term, Connors was released and changed into the Lizard once more, this time due to a scheme by Norman Osborn to form the Sinister Twelve to kill Spider-Man. The Sinister Twelve were defeated and captured by the combined forces of Daredevil, the Fantastic Four, and the Avengers. The Lizard resurfaced to face Spider-Man with the aid of Billy Connors, who was changed into an