Sertindole, sold under the brand name Serdolect among others, is an antipsychotic medication. Sertindole was developed by the Danish pharmaceutical company Lundbeck and marketed under license by Abbott Labs. Like other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative. Sertindole is not approved for use in the United States and was discontinued in Australia in January 2014. Medical Uses Sertindole appears effective as an antipsychotic in schizophrenia. In a 2013 study in a comparison of 15 antipsychotic drugs in effectivity in treating schizophrenic symptoms, sertindole was found to be slightly less effective than haloperidol, quetiapine, and aripiprazole, as effective as ziprasidone, approximately as effective as chlorpromazine and asenapine, and slightly more effective than lurasidone and iloperidone. Adverse effects Very common (>10% incidence) adverse effects include: Headache Ejaculation failure Insomnia Dizziness Common (1–10% incidence) adverse effects include: Urine that tests positive for red and/or white blood cells Sedation (causes less sedation than most antipsychotic drugs according to a recent meta-analysis of the efficacy and tolerability of 15 antipsychotic drugs. Causes only slightly [and non-significantly] more sedation than amisulpride and paliperidone) Ejaculation disorder Erectile dysfunction Orthostatic hypotension Weight gain (which it seems to possess a similar propensity for causing as quetiapine) Uncommon (0.1–1% incidence) adverse effects include: Substernal chest pain Face oedema Influenza-like illness Neck rigidity Pallor Peripheral vascular disorder syncope Torsades de pointes Vasodilation Suicide attempt Amnesia Anxiety Ataxia Confusion Incoordination Libido decreased Libido increased Miosis Nystagmus Personality disorder Psychosis Reflexes decreased Reflexes increased Stupor Suicidal tendency Urinary retention Vertigo Diabetes mellitus Abnormal stools Gastritis Gingivitis Glossitis Increased appetite Mouth ulceration Rectal disorder Rectal haemorrhage Stomatitis Tongue disorder Ulcerative stomatitis Anaemia Ecchymosis Hypochromic anaemia Leukopenia Hyperglycaemia Hyperlipemia Oedema Bone pain Myasthenia Twitching Bronchitis Hyperventilation Pneumonia Sinusitis Furunculosis Herpes simplex Nail disorder Psoriasis Pustular Rash Skin discolouration Skin hypertrophy Skin ulcer Abnormal vision Keratoconjunctivitis Lacrimation disorder Otitis externa Pupillary disorder Taste perversion Anorgasmia Penis disorder (gs) Urinary urgency Hyperprolactinaemia (which it seems to cause with a higher propensity than most other atypical antipsychotics do) Seizures Galactorrhoea Rare (<0.1% incidence) adverse effects include: Neuroleptic malignant syndrome Tardive dyskinesia Unknown frequency adverse events include: Extrapyramidal side effects (EPSE; e.g. dystonia, akathisia, muscle rigidity, parkinsonism, etc. These adverse effects are probably uncommon/rare according to a recent meta-analysis of the efficacy and tolerability of 15