his father's notes and visits Connors to continue what he and Richard started. The two successfully formulate a serum together, which Connors, after being fired from Oscorp for refusing to rush into human trials, injects himself with. The serum regenerates Connors' lost arm, but eventually mutates him into the Lizard, who goes on a rampage until Spider-Man intervenes. Escaping into the sewer, Connors reverts, develops an obsession with his new abilities, builds a makeshift off-site lab, and experiments on himself further due to the chemicals affecting his mind. After the Lizard discovers Spider-Man's secret identity on his first encounter, he develops a mind of his own and asserts himself as the dominant personality, seeking to mutate all of New York into lizards like himself. However, Spider-Man foils his plan with Captain George Stacy's help, who is killed by the Lizard in the process, and cures Connors. With the Lizard's personality gone and his sanity restored, Connors saves Peter from plummeting off of Oscorp Tower and surrenders to the authorities. In the film's mid-credits scene, Connors is remanded to Beloit Psychiatric Hospital, where he speaks with a mysterious man regarding the Parkers' knowledge of him, who vanishes from the room. Ifans reprised his role in the Marvel Cinematic Universe (MCU) film Spider-Man: No Way Home (2021). Sometime after learning Peter's secret identity, Connors is transported to another universe, where he is found and imprisoned by Doctor Strange alongside other alternate universe-displaced supervillains and encounters its version of Peter Parker, who offers to cure them and avert their original fates upon returning to their respective universes, although Connors is the most skeptical, believing there would be consequences and chooses to stay behind at a F.E.AS.T. truck rather than accompany Parker to Happy Hogan's apartment. However as Connors predicted, the Green Goblin convinces most of the villains to fight back instead. The Lizard joins Sandman and Electro in fighting Spider-Man and two alternate universe versions of himself, including the Lizard's version, before he is eventually defeated and cured by the second Parker. After reverting to his human form, Doctor Strange returns Connors and the other displaced individuals to their respective home universes. The Peter Parker incarnation of the Lizard makes a cameo appearance in a flashback in Spider-Man: Into the Spider-Verse. Spider-Woman defeats him, who reverts to Peter Parker and dies in her arms. Video games The Lizard appeared in Questprobe featuring Spider-Man.