angina. Having formulated a theory of an approach by which the effects of adrenaline might be annulled, he joined ICI Pharmaceuticals in 1958, remaining with the company until 1964, during which time he invented propranolol, which later became the world's best-selling drug. During this time Black pioneered a method of research whereby drug molecules were purposefully built instead of being synthesised first and then investigated for their potential medical uses. The discovery of propranolol was hailed as the greatest breakthrough in the treatment of heart disease since the discovery of digitalis. At the same time, Black was developing a similar method of inventing drugs for treatment of stomach ulcers, but ICI did not wish to pursue the idea so Black resigned in 1964 and joined Smith, Kline and French where he worked for nine years until 1973. While there, Black developed his second major drug, cimetidine, which was launched under the brand name Tagamet in 1975 and soon outsold propranolol to become the world's largest-selling prescription drug. Black was appointed professor, and head of department, of pharmacology at University College London in 1973 where he established a new undergraduate course in medicinal chemistry but he became frustrated by the lack of funding for research and accepted the post of director of therapeutic research at the Wellcome Research Laboratories in 1978. However he did not agree with his immediate boss there, Sir John Vane, and resigned in 1984. Black then became Professor of Analytical Pharmacology at the Rayne Institute of King's College London medical school, where he remained until 1992. He established the James Black Foundation in 1988 with funding from Johnson & Johnson and led a team of 25 scientists in drugs research, including work on gastrin inhibitors which can prevent some stomach cancers. Black contributed to basic scientific and clinical knowledge in cardiology, both as a physician and as a basic scientist. His invention of propranolol, the beta adrenergic receptor antagonist that revolutionised the medical management of angina pectoris, is considered to be one of the most important contributions to clinical medicine and pharmacology of the 20th century. Propranolol has been described as the greatest breakthrough in heart disease treatments since the 18th century discovery of digitalis and has benefited millions of people. Black's method of research, his discoveries about adrenergic pharmacology, and his clarification of the mechanisms of cardiac action are all strengths of his work. He was