the Fifth BWC Review Conference in 2001, the United States charged four BWC States Parties—Iran, Iraq, Libya, and North Korea—and one signatory, Syria, with operating covert biological weapons programs. Moreover, a 2019 report from the U.S. Department of State raises concerns regarding BWC compliance in China, Russia, North Korea, and Iran. The report concluded that North Korea "has an offensive biological weapons program and is in violation of its obligations under Articles I and II of the BWC" and that Iran "has not abandoned its (...) development of biological agents and toxins for offensive purposes". In recent years, Russia has repeatedly alleged that the United States is supporting and operating biological weapons facilities in the Caucasus and Central Asia, in particular the Richard Lugar Center for Public Health Research in the Republic of Georgia. The U.S. Department of State called these allegations "groundless" and reaffirmed that "all U.S. activities (...) [were] consistent with the obligations set forth in the Biological Weapons Convention". Biological weapons expert Filippa Lentzos agreed that the Russian allegations are "unfounded" and commented that they are "part of a disinformation campaign". Similarly, Swedish biodefense specialists Roger Roffey and Anna-Karin Tunemalm called the allegations "a Russian propaganda tool". Implementation Support Unit After a decade of negotiations, the major effort to institutionally strengthen the BWC failed in 2001, which would have resulted in a legally binding protocol to establish an Organization for the Prohibition of Biological Weapons (OPBW). Against this background, the Sixth Review Conference in 2006 created an Implementation Support Unit (ISU) funded by the States Parties to the BWC and housed in the Geneva Branch of the United Nations Office for Disarmament Affairs. The unit's mandate is to provide administrative support, assist the national implementation of the BWC, encourage the treaty's universal adoption, pair assistance requests and offers, and oversee the confidence-building measures process. With a staff size of only three and a budget smaller than the average McDonald's restaurant, the ISU does not compare with the institutions established to deal with chemical or nuclear weapons. For example, the Organisation for the Prohibition of Chemical Weapons (OPCW) has about 500 employees, the International Atomic Energy Agency employs around 2,600 people, and the CTBTO Preparatory Commission employs around 280 staff. Review Conferences States Parties have formally reviewed the operation of the BWC at periodic Review Conferences held every five years; the first took place in 1980. The objective