test-takers. The Z-test tells us that the 55 students of interest have an unusually low mean test score compared to most simple random samples of similar size from the population of test-takers. A deficiency of this analysis is that it does not consider whether the effect size of 4 points is meaningful. If instead of a classroom, we considered a subregion containing 900 students whose mean score was 99, nearly the same z-score and p-value would be observed. This shows that if the sample size is large enough, very small differences from the null value can be highly statistically significant. See statistical hypothesis testing for further discussion of this issue. Z-tests other than location tests Location tests are the most familiar Z-tests. Another class of Z-tests arises in maximum likelihood estimation of the parameters in a parametric statistical model. Maximum likelihood estimates are approximately normal under certain conditions, and their asymptotic variance can be calculated in terms of the Fisher information. The maximum likelihood estimate divided by its standard error can be used as a test statistic for the null hypothesis that the population value of the parameter equals zero. More generally, if is the maximum likelihood estimate of a parameter θ, and θ0 is the value of θ under the null hypothesis, can be used as a Z-test statistic. When using a Z-test for maximum likelihood estimates, it is important to be aware that the normal approximation may be poor if the sample size is not sufficiently large. Although there is no simple, universal rule stating how large the sample size must be to use a Z-test, simulation can give a good idea as to whether a Z-test is appropriate in a given situation. Z-tests are employed whenever it can be argued that a test statistic follows a normal distribution under the null hypothesis of interest. Many non-parametric test statistics, such as U statistics, are approximately normal for large enough sample sizes, and hence are often performed as Z-tests. See also Normal distribution Standard normal table Standard score Student's t-test References Casella, G., Berger, R. L. (2002). Statistical Inference. Duxbury Press. . Douglas C.Montgomery, George C.Runger.(2014). Applied Statistics And Probability For Engineers.(6th ed.). John Wiley & Sons, inc. . Statistical tests Normal distribution