Atropates refused to pay allegiance to Seleucus, and made Media Atropatene an independent kingdom. In 223 BCE, Antiochus III came to power in the Seleucid Empire, one of the Hellenistic states that had emerged following the death of Alexander. Antiochus attacked Atropatene, resulting in a victory. Consequently, the king of Atropatene, Artabazan, accepted the ascendency of Seleucids and became dependent on it; on the other hand, interior independence was preserved. At the same time, the Roman Empire came into sight in the Mediterranean basin and was trying to spread its power in the East, and in 190 B.C., its army met and defeated the Seleucids' army in the battle of Magnesia. Parthia and Atropatene subsequently considered Rome a threat to their independence and allied themselves in the struggle against Rome. After the battle between Rome and the Parthians in 38 BC, the Romans won and the Roman general Antony attacked Fraaspa (36 BC), one of the central cities of Atropatene. The city was surrounded by strong defenses. After a long blockade, Antony receded, losing approximately thirty-five thousand soldiers. In the face of Parthian attempts to annex Atropatene, Atropatene began to draw closer to Rome, thus, Ariobarzan II, who came to power in Atropatene in 20 BC, lived in Rome for about ten years. The dynasty Atropates founded would rule the kingdom for several centuries, first independently, then as vassals of the Arsacids (who called it 'Aturpatakan'). It was later supplanted by a line of the Arsacids. During the late Parthian era, the empire was declining, resulting in the weakening of hold over western Iran. The Iranologist Touraj Daryaee argues that the reign of the Parthian monarch Vologases V () was "the turning point in Arsacid history, in that the dynasty lost much of its prestige." The people of Atropatene (both nobility and peasantry) allied themselves with the Persian Sasanian prince Ardashir I () during his wars against Vologases V's son and second successor Artabanus IV (). In 226, Atropatene submitted with little resistance to Ardashir I after he had defeated and killed Artabanus IV at the Battle of Hormozdgan. Ardashir I and his son and heir Shapur I () are depicted in a rock relief near Salmas, possibly a testimonial to the Sasanian conquest of Atropatene. The nobility of Atropatene most likely allied themselves the Sasanians due to a desire for a strong state capable of maintaining order. The priesthood,