Pharmacist Jules Brissonet had synthesized this compound in the hopes of treating pulmonary phthisis (tuberculosis), but soon after administration all 6 patients developed polyneuropathy. The original paper ads described this phosphocresote to be:A bland, limpid liquid, nearly tasteless and odourless, which is not irritating to the gastric mucous membranes. When creosote is combined with phosphoric acid the metabolic action produced is much more marked, and Phosote can be tolerated in larger doses and for a longer continuance than Creosote or Guaiacol. Dose of the preparation, one to two grammes three times a day. The greatest mass poisoning by TOCP occurred in 1930 when it was added as an adulterant into the popular drink "Ginger Jake" (or Jamaica "Jake") during the United States Prohibition era. Although the drink was a primary substitute for alcohol during that period, when all alcoholic drinks had been outlawed, under the Eighteenth Amendment to the United States Constitution, it was also listed as a cure for "assorted ailments" in the U.S. Pharmocopoeia and thus easy to acquire. Up to 100,000 people were poisoned and 5,000 paralyzed when a manufacturer of Ginger Jake added Lindol—a compound that consisted mainly of TOCP— to their product. The exact reason for why TOCP was found in Ginger Jake is disputed; some sources claim it was to further extract the Jamaica root, others to water the drink down, and another as a result of contamination from lubricating oils. Binges of Ginger Jake resulted in what was known to be a "Jake walk," in which patients experienced a highly irregular gait caused by numbness in the legs that followed with eventual paralysis of the wrists and feet. In medical journals it was described to have produced an organophosphate-induced delayed neuropathy (OPIDN) neurodegenerative syndrome, "characterized by distal axonal lesions, ataxia, and neuronal degeneration in the spinal cord and peripheral nervous systems." In 1932, 60 European women experienced TOCP poisoning by means of the abortion-inducing (abortifacient) drug Apiol. This drug, formed by the phenylpropanoid compound extracted from parsley leaves, was exploited throughout history—and even known to Hippocrates himself—as an agent to terminate pregnancies. The contamination of the modern drug in 1932 was not accidental, but rather included as an "additional stimulus." Those who took the pill experienced comas, convulsions, paralysis of the lower body (paraplegia) and often death Apiol was subsequently criticized by doctors, journalists, and activists alike until its discontinuation, citing that the