The Sanctum Sanctorum is a fictional building appearing in American comic books published by Marvel Comics, as the residence and headquarters of Doctor Strange. Created by Stan Lee and Steve Ditko, the building first appeared in Strange Tales #110 (July 1963). It is located at 177A Bleecker Street in New York City's Greenwich Village neighborhood. This is a reference to the address of an apartment once shared by writers Roy Thomas and Gary Friedrich. The Sanctum Sanctorum has appeared in various media adaptations, including animated television series, video games, and in numerous media within the Marvel Cinematic Universe. Publication history The Sanctum Sanctorum first appeared with Doctor Strange in his debut in Strange Tales #110 (July 1963), drawn by Steve Ditko. The details of the building have varied by artist, with one reviewer noting, for example, of Marvel Premiere #3 (July 1972) that "[n]ot since the heady days of Ditko for instance, did the doctor's sanctum sanctorum appear in such scrumptious detail, laden it seemed, with the heavy odor of burning incense". In a comical turn in Strange Tales #147, a building inspector informs Strange that he has six months to get the Sanctum Sanctorum repainted and make other repairs, or the building will be condemned. It has been described as "an integral part of the Doctor Strange mythos". Characterization Location The Sanctum Sanctorum is a three-story townhouse located at 177A Bleecker Street. It is "in the heart of New York City's Greenwich Village." Contrary to fan theories that this address was meant to invoke 221B Baker Street, the fictional domicile of Sherlock Holmes, it was actually a reference to the address of an apartment shared in the 1960s by Roy Thomas and Gary Friedrich. In the comics, the building was said to have been built upon the site of pagan sacrifices, and before that Native American rituals, and is a focal point for supernatural energies. It was noted that as of 2016, the location could be found on Google Maps. Architecture The building's depiction has varied over the years but some elements remain consistent. "The outside looks like a townhouse, while past a veil of magical force on the inside are various rooms with various mystical artifacts", as one source put it. There seems to be more space inside than there would seem to be from outside. Some corridors form labyrinths, and the arrangement of rooms seems to change