Magazine named him an All-American and a member of its Dream Team Top 100 players, and Calhisports.com voted him the 2004 Mr. Football State Player of the Year. He committed to the football program at the University of California, Berkeley under Coach Jeff Tedford, making his announcement on Southern California's FSN West. Jackson waited until the deadline to choose between scholarship offers for California and the University of Southern California. College career Jackson attended the University of California, where he played for the California Golden Bears football team from 2005 to 2007. Wearing the number 1, in his first collegiate game against Sacramento State in 2005, he scored both an offensive and special teams touchdown, returning a punt 49 yards for a score. Throughout his freshman season, Jackson picked up 38 receptions for 601 yards along with seven touchdowns, eclipsing the 100-yard mark three times. In the 2005 Las Vegas Bowl game against BYU, Jackson tallied 130 yards and two scores. Jackson was also expected to play for Cal's baseball team but, due to the success of his freshman football season, he chose to focus exclusively on football. Coming into his sophomore year with high expectations, Jackson displayed more of his talent and playmaking ability, tallying 1,060 receiving yards and nine touchdowns. Jackson also returned four punts for touchdowns. He earned first-team All-Pac-10 honors as both a punt returner and a wide receiver. Jackson garnered national recognition with selections to first-team All-America by the Associated Press, Walter Camp Football Foundation, the Football Writers Association of America, the Sporting News, and Rivals.com as a punt returner. Jackson also captured the inaugural Randy Moss Award as the top returner in the nation. In one of only two California losses in Pac-10 play, Jackson had a 95-yard punt return for a touchdown against Arizona. Jackson entered his junior season being considered a Heisman Trophy candidate. His season began promisingly, with a 77-yard punt return for a touchdown against Tennessee in the opening game of the season. Against eleventh-ranked Oregon, he caught 11 passes for 161 yards and two touchdowns to lead the Bears to their first victory in Autzen Stadium since 1987. Jackson finished the 2007 season with 65 catches for 762 yards, and scored six touchdowns as a receiver. Jackson was named an All-American as a return specialist. Jackson suffered several minor injuries that limited his effectiveness at times during the season,