States can only be done with the approval of the United States Department of Agriculture and the appropriate state veterinarian. Disinfection Caliciviruses are stable in the environment and difficult to inactivate. Products commonly used for household disinfection such as Clorox® and Lysol® disinfecting wipes do not work against these viruses. One effective option is to wipe down surfaces with a 10% bleach solution, allowing 10 minutes of contact time before rinsing. Other disinfectants shown to work include 10% sodium hydroxide, 2% One-Stroke Environ®, Virkon® S, Clorox® Healthcare Bleach Germicidal Wipes, Trifectant®, Rescue®, and hydrogen peroxide cleaners. Surface debris must always be mechanically removed prior to disinfection. A list of disinfectants that are effective against calicivirus (in this case norovirus) can be found on the Environmental Protection Agency's website. Studies have show that many quaternary ammonium compound based disinfectants do not inactivate caliciviruses. Quarantine and other measures Because of the highly infectious nature of the disease, strict quarantine is necessary when outbreaks occur. Depopulation, disinfection, vaccination, surveillance, and quarantine are the only way to properly and effectively eradicate the disease. Deceased rabbits must be removed immediately and discarded in a safe manner. Surviving rabbits should be quarantined or humanely euthanized. Test rabbits may be used to monitor the virus on vaccinated farms. Geographic distribution RHD is primarily a disease affecting European rabbits, which are native to the Iberian Peninsula and are found in the wild in much of Western Europe. Domesticated breeds are farmed throughout the world for meat and fur, and are becoming increasingly popular pets. European rabbits have been introduced to and become feral and sometimes invasive in Australia, New Zealand, Chile, Argentina, and various islands. RHD was first reported in 1984 in the People's Republic of China. Since then, RHD has spread to over 40 countries in Africa, the Americas, Asia, Europe, and Oceania, and is endemic in most parts of the world. Asia The first reported outbreak of RHD caused by RHDVa occurred in 1984 in the Jiangsu Province of the Mainland China. The outbreak occurred in a group of Angora rabbits that had been imported from Germany. The cause of the disease was determined to be a small, nonenveloped RNA virus. An inactivated vaccine was developed that proved effective in preventing disease. In less than a year, the disease spread over an area of 50,000 km2 in China and killed 140 million domestic rabbits. South Korea