Father and Tuttle as Mother "what I consider 22 carat casting with two all-Americans." Heaven Only Knows (1947) was her first film. She went on to appear in such films as Orson Welles's Macbeth (1948, as one of the Three Witches), Mr. Blandings Builds His Dream House (1948, as Mr. Blandings' secretary, Mary), and Alfred Hitchcock's Psycho (1960, as the wife of Sheriff Chambers). In Don't Bother to Knock (1952), she portrayed a mother who unknowingly lets a disturbed woman (played by Marilyn Monroe) babysit her daughter. The next year she appeared again with Monroe in Niagara, as Mrs. Kettering. She had a rare starring role in Ma Barker's Killer Brood (1960). She played Grandma Pusser in the original Walking Tall film trilogy, and also appeared in horror films such as The Manitou (1978), starring Tony Curtis. Her final film role was in the 1983 film Testament. She guest-starred twice on Edmond O'Brien's 1960 crime drama Johnny Midnight. She then played a supporting role in the 1961 Father of the Bride television situation comedy. She made six guest appearances on Perry Mason, with Raymond Burr, during the nine-year run of the show from 1957 to 1966. She usually played the role of the defendant, such as Anna Houser in "The Case of the Substitute Face" in 1958, Sarette Winslow in "The Case of the Artful Dodger" in 1959, Sarah Breel in "The Case of the Shoplifter's Shoe" in 1963, and Josephine Kempton in "The Case of the Grinning Gorilla" in 1965. However, in 1966, she played the murderess, Henny McLeod, in "The Case of the Avenging Angel". In 1958 and 1959, she was cast in two episodes as Gladys Purvis, the mother of series character Kate McCoy, played by Kathleen Nolan, in the sitcom The Real McCoys, with Walter Brennan and Richard Crenna. She appeared twice on the NBC western series The Californians, once as Belle Calhoun in "Skeleton in the Closet" (1958) and then as Maude Sorel in "The Painted Lady" (1959). She guest-starred with Andrew Duggan in his crime series Bourbon Street Beat. Tuttle appeared three times each on sitcoms The Danny Thomas Show and Petticoat Junction and twice on the following: Leave It to Beaver, The Bob Cummings Show, The Ann Sothern Show, Pete and Gladys, The Andy Griffith Show, Hazel, General Electric Theater, Switch, and Fantasy Island; she appeared as Lee Meriwether's aunt in the final