Greenville is a town in Madison County, Florida, United States. The population was 746 at the 2020 census, down from 843 at the 2010 census. Geography Greenville is located in western Madison County at (30.467, –83.635). U.S. Route 90 passes through the north side of the town, leading east to Madison, the county seat, and northwest to Monticello. U.S. Route 221 passes through the center of town, leading south to Perry and north to Quitman, Georgia. Interstate 10 passes south of the town, with access to US-221 at Exit 241. I-10 leads west to Tallahassee, the state capital, and east to Lake City. According to the United States Census Bureau, the town of Greenville has a total area of , all land. Demographics 2020 census Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos can be of any race. As of the 2020 United States census, there were 746 people, 329 households, and 199 families residing in the town. 2000 census As of the census of 2000, there were 837 people, 331 households, and 220 families residing in the town. The population density was . There were 394 housing units at an average density of . The racial makeup of the town was 27.36% White, 72.04% African American, 0.12% Native American, 0.12% Asian, 0.12% from other races, and 0.24% from two or more races. Hispanic or Latino of any race were 0.24% of the population. There were 331 households, out of which 33.8% had children under the age of 18 living with them, 33.8% were married couples living together, 27.5% had a female householder with no husband present, and 33.5% were non-families. 31.4% of all households were made up of individuals, and 16.9% had someone living alone who was 65 years of age or older. The average household size was 2.53 and the average family size was 3.16. In the town, the population was spread out, with 31.3% under the age of 18, 7.2% from 18 to 24, 24.4% from 25 to 44, 19.0% from 45 to 64, and 18.2% who were 65 years of age or older. The median age was 35 years. For every 100 females, there were 83.2 males. For every 100 females age 18 and over, there were 70.1 males. The median income for a household in the town