Clifton is a census-designated place (CDP) and post office in and governed by Mesa County, Colorado, United States. It is part of the Grand Junction, CO Metropolitan Statistical Area. The Clifton post office has the ZIP Code 81520. As of the 2020 census, the population of the Clifton CDP was 20,413. History The Clifton Post Office has been in operation since 1900. The community was named for cliffs near the town site. Geography Clifton is in central Mesa County, bordered to the west by the city of Grand Junction and to the northwest by unincorporated Fruitvale. The Colorado River forms the southern edge of the community. U.S. Route 6 passes through the center of Clifton, leading west to the center of Grand Junction and east the same distance to Palisade. Interstate 70 passes along the northern edge of Clifton, with access from Exit 37 (I-70 Business). Colorado State Highway 141 leads south from US 6, to U.S. Route 50. The Clifton CDP has an area of , of which , or 1.20%, are water. Demographics The United States Census Bureau initially defined the for the See also List of census-designated places in Colorado References External links Clifton @ Colorado.com Clifton @ UncoverColorado.com Mesa County website Census-designated places in Mesa County, Colorado Census-designated places in Colorado