Gainesville. Newnansville began to lose influence and, when the Savannah, Florida and Western Railroad bypassed the city by about 1.5 miles to the southwest in the early 1880s, citizens began to relocate along the new rail line (eventually abandoning Newnansville and turning it into a ghost town) and established the City of Alachua.Alachua was founded in 1884, with its post office opening in 1887. It was incorporated as a city on 12 April 1905, at which time it had a population of 526 people. A third rail line passed through the new city, and a booming cotton industry helped support the building of several lavish Queen Anne-style homes and brick businesses along Main Street at the turn of the century. Alachua stagnated when the boll weevil nearly destroyed the American cotton industry in 1919-1920, then through the Great Depression in the 1930s. The main industries through the middle of the Twentieth Century were lumber and food processing, notably through Duke Lumber Company and Copeland Sausage Company, respectively. Interstate 75 passed slightly to the west of Downtown Alachua when it was built in the 1960s, providing new access and economic opportunity. Alachua faced another downturn with the closing of Copeland Sausage in 1976, and by the 1980s the buildings and businesses on Main Street were in poor shape. A concerted effort by the citizens and local government of Alachua focused on rehabilitating Downtown, and the construction of Progress Corporate Park with the University of Florida led to the creation of the UF Innovate Sid Martin Biotech Incubator which has resulted in the formation of one of the State's largest bio and life science business sectors. Geography Alachua is located at (29.779286, –82.479849). According to the United States Census Bureau, the city has a total area of , of which is land and (1.08%) is water. Cityscape Alachua's Main Street runs along a North-South direction and is the heart of the City of Alachua Downtown Historic District, which is listed on the National Register of Historic Places. The rest of the Historic District lies mainly to the west of Main Street and consists of residential structures built primarily in the early 20th Century. Main Street is bisected by US Highway 441, which runs East-West along the old Atlantic Coast Line railway. The Historic District lies south of US 441.Selected historic structures of note that are listed in the Register: Main Street Businesses