heads northeast before making a turn to the southeast. The route crosses into McKean County and heads southeast through more of the Allegheny National Forest parallel to the railroad tracks. US 6 leaves the national forest and runs through more rural land with some development before it enters the borough of Kane. Here, the route heads south through developed areas on North Fraley Street, passing UPMC Kane hospital before running through the downtown area. Here, US 6 comes to a junction with the northern terminus of PA 66, with PA 66 continuing south on South Fraley Street and US 6 turning east onto Greeves Street. The route soon turns south onto Edgar James Street and east onto Biddle Street, passing more development and forming a short concurrency with PA 321. At this point, the railroad tracks split from paralleling the road. The road leaves Kane and becomes Kane Lantz Corners Road, winding east through a mix of farms and woods with some development. US 6 curves northeast and runs through more rural areas, coming to an intersection with US 219 in Lantz Corners. Past here, the route heads to the east and passes over the Buffalo and Pittsburgh Railroad's B&P Main Line Subdivision line as it enters the borough of Mount Jewett, heading through developed areas of the borough as West Main and East Main streets. East of Mount Jewett, the road heads southeast through forested mountains, passing through Hazel Hurst and turning to the northeast. US 6 reaches a junction with the western terminus of PA 146 in Marvindale and continues northeast through wooded mountains with some fields and development. The road enters the borough of Smethport and becomes Marvin Street, heading north through developed areas and coming to an intersection with the eastern terminus of PA 59. Here, the route turns east onto West Main Street and passes through the downtown area, becoming East Main Street before turning east onto East Street and intersecting PA 46 on the eastern edge of the borough. At this point, PA 46 heads east for a concurrency with US 6, with the two route continuing to East Smethport, where PA 46 splits to the south. US 6 winds east through wooded areas with some farmfields. The road turns southeast and runs through forests before heading east into the borough of Port Allegany, where it crosses the Allegheny River and the Buffalo Line