Mesoamerica is a historical region and cultural area that begins in the southern part of North America and extends to most of Central America, thus comprising the lands of central Mexico, Belize, and Guatemala, El Salvador, Honduras, and Nicaragua, and northern Costa Rica. In the pre-Columbian era many societies flourished in Mesoamerica for more than 3,000 years before the Spanish colonization of the Americas, begun at Hispaniola island in 1493. In world history, Mesoamerica was the site of two historical transformations: (i) primary urban generation, and (ii) the formation of New World cultures from the mixtures of the indigenous Mesoamerican peoples with the European, African, and Asian peoples who were introduced by the Spanish colonization of the Americas. In the 16th century, Eurasian diseases such as smallpox and measles, which were endemic among the colonists but new to North America, caused the deaths of upwards of 90% of the indigenous people, resulting in great losses to their societies and cultures. Mesoamerica is one of the five areas in the world where ancient civilization arose independently (see cradle of civilization), and the second in the Americas. Norte Chico (Caral-Supe) in present-day Peru, arose as an independent civilization in the northern coastal region. As a cultural area, Mesoamerica is defined by a mosaic of cultural traits developed and shared by its indigenous cultures. Beginning as early as 7000 BCE, the domestication of cacao, maize, beans, tomato, avocado, vanilla, squash and chili, as well as the turkey and dog, resulted in a transition from paleo-Indian hunter-gatherer tribal groupings to the organization of sedentary agricultural villages. In the subsequent Formative period, agriculture and cultural traits such as a complex mythological and religious tradition, a vigesimal numeric system, a complex calendric system, a tradition of ball playing, and a distinct architectural style, were diffused through the area. Also in this period, villages began to become socially stratified and develop into chiefdoms. Large ceremonial centers were built, interconnected by a network of trade routes for the exchange of luxury goods, such as obsidian, jade, cacao, cinnabar, Spondylus shells, hematite, and ceramics. While Mesoamerican civilization knew of the wheel and basic metallurgy, neither of these became technologically relevant. Among the earliest complex civilizations was the Olmec culture, which inhabited the Gulf Coast of Mexico and extended inland and southwards across the Isthmus of Tehuantepec. Frequent contact and cultural interchange between the early Olmec and other cultures in