in 2009 and 2010. He led the team to a second-place finish in the Dominican Winter League Championships in 2010 and was asked to play shortstop for the Escogido Leones on Team Dominicana in the 2010 Caribbean World Series, which the Dominican won as Santiago hit .316 at the plate. During the Tigers run to the 2011 American League Central Division championship, Santiago played in 101 games, mostly at second base, and hit .260. His season highlights included a walk-off home run on August 30, which gave the Tigers a 2–1 victory over the Kansas City Royals in the bottom of the 10th inning. He also drove in the winning run with a walk-off triple in a June 13 game against the Tampa Bay Rays. On November 30, 2011, the Tigers re-signed Santiago to a two-year extension, which kept him on the team through the 2013 season. With the return of Omar Infante in July 2012, Santiago lost his every day second base position. He still played some games as a pinch hitter and as a late-inning defensive replacement. He also started at second and shortstop when needed. In a July 2013 game versus the Toronto Blue Jays, Colby Rasmus slid into second base, slide-tackling Infante, who was injured and placed on the disabled list. Santiago was called into the game and finished it out, and played several more games at second base until Infante returned. Cincinnati Reds Santiago was a non-roster invitee to the 2014 Cincinnati Reds training camp, and he made the team as a reserve infielder. On September 27, he hit a walk–off grand slam in the 13th inning against Pittsburgh Pirates pitcher Bobby LaFromboise in what would be the last at–bat of Santiago's Major League career. He elected free agency on October 30, 2014. Toronto Blue Jays Santiago signed a minor league deal with the Toronto Blue Jays on January 30, 2015. During a spring training game against the Atlanta Braves on March 15, Santiago broke his left collarbone. He was released on March 30. The Blue Jays re-signed him to a minor league contract on April 6. He started the season on the disabled list of the Triple-A Buffalo Bisons, and was released on July 24. Post-playing career Santiago rejoined the Detroit Tigers organization as a coach and served as the first base coach for the 2018 and 2019 seasons. He shifted to third base