Mancuso is an Italian surname derived from a Sicilian noun, related to the Italian mancino, which means "left-handed". An alternate form can be Mancusi. Notable people with the surname include: Alejandro Mancuso, retired Argentine footballer Anna Mancuso, Canadian former politician Ciro Mancuso, Nevada-based drug dealer convicted of running a $140-million marijuana smuggling operation David Mancuso, American DJ Filippo Mancuso, Italian judge and politician Francis Xavier Mancuso, Leader of Tammany Hall and a judge for New York's Court of General Sessions Frank Mancuso Jr., movie producer Gus Mancuso, catcher in Major League Baseball from 1928 to 1945 Julia Mancuso, American alpine skier who won a gold medal at the 2006 Winter Olympics Laurence Mancuso, founding abbot of the New Skete monastery Leonardo Mancuso, Italian footballer Nick Mancuso, Italian-Canadian cinema and stage actor Renee Mancuso, American bridge player Rudy Mancuso, American actor and Internet personality and musician Salvatore Mancuso, Colombian paramilitary warlord The fictional character Nick Mancuso, played by Robert Loggia in Favorite Son (1988) and Mancuso, F.B.I. (1989) The fictional character Angelo Mancuso in the novel A Confederacy of Dunces (1980) The fictional character Bart Mancuso, played by Scott Glenn in The Hunt for Red October (1990) Surnames of Italian origin