Trauma Center is a series of video games developed by Atlus and published by Atlus (Japan, North America) and Nintendo (Europe). Beginning with Trauma Center: Under the Knife in 2005 for the Nintendo DS, the series released four more entries on the DS and Wii. The gameplay is split between a surgical gameplay simulation, and visual novel storytelling. While mostly dealing with different characters, the games share a common setting of a near-future Earth where advanced medical procedures are used to treat several patients, including outbreaks of deadly viruses. A recurring organisation is Caduceus, a worldwide semi-covert medical foundation. The series was created by Katsura Hashino, who wanted to use the DS's controls to explore a simulation type only previously possible on PCs. Following the first game, a dedicated production team dubbed "CaduceTeam" was created to handle future games. Beginning with the Wii remake Second Opinion, the series was directed by Daisuke Kanada. Titles Trauma Center: Under the Knife is the first entry in the series, released on the Nintendo DS. It was published in Japan and North America in 2005, and in Europe the following year. The game follows protagonist Derek Stiles as he confronts a manmade disease called GUILT. Trauma Center: Second Opinion is the second entry and a remake of the first game. It released as a launch title for the Wii in Japan and North America in 2006, and the following year in Europe and Australia. In addition to revisiting Stiles's battle against GUILT, Second Opinion adds missions for surgeon Naomi Kimishima, and a new chapter closing off both narratives. Trauma Center: New Blood is the third entry in the series, released for the Wii first in North America in 2007, then in Japan and Europe regions in 2008, and Australia in 2009. The narrative follows two new doctors as they are recruited to fight Stigma, a new manmade disease spreading across the world. Trauma Center: Under the Knife 2 is the fourth entry, a direct sequel to the first game developed for the DS. It was released in North America and Japan in 2008. The story features Derek Stiles when he encounters a new GUILT-based threat. Trauma Team, the fifth and to-date final entry and cited as a spin-off title within the series universe, was released in 2010 in Japan and North America. The narrative, split across six different characters working at Resurgam First Care,