15 interchange, US 6 heads into Mansfield and becomes West Wellsboro Street, heading through developed areas and crossing the Tioga River. The route continues into the downtown area, where it crosses US 15 Bus. and becomes West Wellsboro Street. US 6 becomes Sullivan Street and curves northeast and then southeast as it heads north of the Mansfield University of Pennsylvania campus. The route leaves Mansfield and becomes Roosevelt Highway, continuing southeast through wooded areas with some fields and reaching a junction with the southern terminus of PA 549. The road heads east through a mix of farmland and woodland with occasional development, passing through the community of Mainesburg. US 6 enters Bradford County and heads into the Endless Mountains region, continuing through hilly areas of farms and woods. A short distance past the county line, the road runs south of a rest area accessible from both directions. The route passes through the borough of Sylvania on Sylvania Road before running through more rural land as Roosevelt Highway. The road turns southeast and passes to the southwest of the Guthrie Troy Community Hospital before it enters the borough of Troy. Here, US 6 becomes West Main Street and runs through developed areas, curving to the east and intersecting PA 14 in the downtown area. At this point, PA 14 becomes concurrent with US 6 and the two route head northeast along Elmira Street. The road leaves Troy and turns east, with PA 14 splitting to the north. US 6 continues southeast along Roosevelt Highway through a mix of farmfields and woodland with occasional development, curving back to the east. The route continues through rural land and bends to the northeast, passing through the borough of Burlington on Main Street. The road becomes Roosevelt Highway again and winds east through more farms and woods, turning northeast. US 6 comes to an interchange with US 220, at which point it heads through developed areas in North Towanda. The route turns south-southeast and becomes Reuter Boulevard before it heads into the borough of Towanda, where it becomes York Avenue and runs past development. US 6 turns south onto Main Street and passes through the downtown area before turning east and crossing over a Reading Blue Mountain and Northern Railroad line, the Susquehanna River, and the Lehigh Secondary railroad line that is owned by Norfolk Southern Railway and operated by the Lehigh Railway to leave