March 2007, Reid appeared for a second time in the series Doctor Who in the episode "Smith and Jones". In the episode, she played Florence Finnegan: a shape-shifting, blood-sucking alien known as a Plasmavore, who took on the guise of a human. That same year she appeared in the ITV television adaptation of the novel The Bad Mother's Handbook, co-starring alongside Catherine Tate. In February 2008, Reid appeared as the mother of Monica Gallagher, Joan, who was suffering from Alzheimer's in the Channel 4 drama Shameless. In October 2008, she played the title role in In Love with Barbara on BBC Four, a biographical film of Barbara Cartland. In 2009, Reid appeared in the television series Agatha Christie's Marple in the episode Nemesis. From 2009 to 2010 she starred as Vera alongside Maureen Lipman as Irene in an ITV3 adaptation of the BBC Radio 4 series Ladies of Letters. In 2010, she began playing Mrs Thackeray, the cook, in the BBC's short-lived revival series of Upstairs Downstairs, and also appeared in Five Days, New Tricks and Moving On. In 2011 Reid had a major part in Marchlands, a five-part ITV supernatural drama, made a guest appearance in Doc Martin and played a supporting role in The Jury II. In 2012 Reid began starring as Celia alongside Sir Derek Jacobi as Alan in the BBC romantic comedy-drama series, Last Tango in Halifax. Reid was nominated for the 2013 British Academy Television Award for Best Actress for this role. In 2013, she appeared in the second series of the BBC drama Prisoners' Wives as Margaret. She also starred with Katherine Kelly in The Last Witch, part of a series of original dramas for Sky Living and appeared in the final Agatha Christie's Poirot mystery, Curtain: Poirot’s Last Case as Daisy Luttrell. The following year, she guest-starred in "Sardines", the first episode of the BBC anthology series Inside No. 9. She also starred alongside Lee Ingleby and Ralf Little in the six-part BBC drama series Our Zoo. Reid took part in an episode of the BBC genealogy series Who Do You Think You Are? in September 2015. In 2017, Reid starred alongside Timothy Spall in "The Commuter", an episode of the Channel 4/Amazon Video anthology series Electric Dreams. In 2018 and 2019, she starred alongside Alison Steadman and John Cleese in a new BBC comedy series, Hold the Sunset. In 2019 Reid co-starred