above ground. It occasionally preys upon small birds, mammals, frogs, lizards, and insects. Steve Angeli and Robert Applegate, noted captive breeders of the beaded lizard, have remarked that captive specimens do best on a diet of small vertebrates such as mice and rats. Confiscated wild-caught specimens can be made to feed by using egg on the prey item. Venom The venom glands of the beaded lizard are modified salivary glands located in the reptile's lower jaw. Each gland has a separate duct leading to the base of its grooved teeth. When biting, the beaded lizard hangs on its victim and chews to get its venomous saliva into the wound. Although its jaw grip is strong, its unsocketed teeth are easily broken off at their bases. The beaded lizard's venom is a weak hemotoxin, and although human deaths are rare, it can cause respiratory failure. It consists of a number of components, including L-amino acid oxidase, hyaluronidase, phospholipase A, serotonin, and highly active kallikreins that release vasoactive kinins. The venom contains no enzymes that significantly affect coagulation. Almost all documented human bites (eight in the past century) have resulted from prodding captive lizards with a finger or bare foot. While invertebrates are essentially immune to the effects of this venom, effects on vertebrates are more severe and varied. In mammals such as rats, major effects include a rapid reduction in carotid blood flow followed by a marked fall in blood pressure, respiratory irregularities, tachycardia, and other cardiac anomalies, as well as hypothermia, edema, and internal hemorrhage in the gastrointestinal tract, lungs, eyes, liver, and kidneys. In humans, the effects of bites are associated with excruciating pain that may extend well beyond the area bitten and persist up to 24 hours. Other common effects of bites on humans include local edema (swelling), weakness, sweating, and a rapid fall in blood pressure. Beaded lizards are immune to the effects of their own venom. Some compounds in its venom have been shown to have pharmacological properties relating to the possible treatment of diabetes, Alzheimer's disease, and even HIV. One compound, a hormone named exendin-3, is marketed by Amylin Pharmaceuticals as the drug exenatide. A study in 1996 revealed that it binds to cell receptors in breast cancer cells and may stop the growth of lung cancer cells. Reproduction The beaded lizard becomes sexually mature at 6–8 years, and mates between September and October. Males