one case of developing chronic myelogenous leukemia (CML) and one of AML, indicating it is also a pre-leukemic condition, but the risk is "very low" (1%), and the risk is "correlated with disease severity rather than with occurrence of an ELANE mutation". According to Donadieu et al. (2011), "the cumulative risk of experiencing at least one serious (potentially life-threatening) infection by age 20 years is similar in patients with permanent and cyclic neutropenia, although the former patients tend to have earlier manifestations". History First described in 1910, it was suggested and confirmed to have an autosomal dominant (AD) inheritance in the 1940s and 1960s, but was differentiated from congenital neutropenias until the 1990s when were analyzed pedigrees and identified genetic mutations shared by patients with severe congenital neutropenia. See also Leukopenia Agranulocytosis References External links Severe Chronic Neutropenia International Registry "Understanding Neutropenia: The 20 Year Experience of the Severe Chronic Neutropenia International Registry (SCNIR)" (2014) Congenital defects of phagocyte number, function, or both Conditions of the mucous membranes Rare diseases