to treat malaria, that resulted in a "ten fold" increase in sales. Lilly products gained a reputation for quality and became popular in the city. At the end of 1876, his first year of business, sales reached $4,470 ($ in 2020 chained dollars), and by 1879 they had grown to $48,000 ($ in 2020 chained dollars). As sales expanded rapidly he began to acquire customers outside of Indiana. Lilly hired his brother, James, as his first full-time salesman in 1878. James, and the subsequent sales team that developed, marketed the company's drugs nationally. Other family members were also employed by the growing company; Lilly's cousin Evan Lilly was hired as a bookkeeper and his grandsons, Eli and Josiah (Joe), were hired to run errands and perform other odd jobs. In 1881 Lilly formally incorporated the firm as Eli Lilly and Company, elected a board of directors, and issued stock to family members and close associates. By the late 1880s Colonel Lilly had become one of the Indianapolis area's leading businessmen, with a company of more than one hundred employees and $200,000 ($ in 2020 chained dollars) in annual sales. To accommodate his growing business, Lilly acquired additional facilities for research and production. Lilly's business remained at the Pearl Street location from 1876 to 1878, then moved to larger quarters at 36 South Meridian. In 1881 he purchased a complex of buildings at McCarty and Alabama Streets, south of downtown Indianapolis, and moved the company to its new headquarters. Other businesses followed and the area developed into a major industrial and manufacturing district of the city. In the early 1880s the company also began making its first, widely-successful product, called Succus Alteran (a treatment for venereal disease, types of rheumatism, and skin diseases). Sales of the product provided funds for company research and additional expansion. Believing that it would be an advantage for his son to gain a greater technical knowledge, Lilly sent Josiah to the Philadelphia College of Pharmacy in 1880. Upon returning to the family business in 1882, Josiah was named superintendent of the laboratory. In 1890, Lilly turned over the day-to day management of the business to Josiah, who ran the company for thirty-four years. The company flourished despite the tumultuous economic conditions in the 1890s. In 1894, Lilly purchased a manufacturing plant to be used solely for creating capsules. The company made several technological advances in the