Elisabeth of France or Isabella of Bourbon (22 November 1602 – 6 October 1644) was Queen of Spain from 1621 to her death and Queen of Portugal from 1621 to 1640, as the first spouse of King Philip IV & III. She served as regent of Spain during the Catalan Revolt in 1640-42 and 1643–44. Life Childhood Elisabeth, Madame Royale, was born at the Château de Fontainebleau on 22 November 1602. She was the eldest daughter of King Henry IV of France and his second spouse Marie de' Medici. According to the court, her mother showed a cruel indifference to her, because she had believed the prophecy of a nun who assured her that she would give birth to three consecutive sons. Shortly after her birth, she was betrothed to Philip Emmanuel, Prince of Piedmont, son and heir of Charles Emmanuel I, Duke of Savoy, by Catherine Michaela, a daughter of King Philip II of Spain. Philip Emmanuel died in 1605. As a daughter of the King of France, she was born a Fille de France. As the eldest daughter of the king, she was known at court by the traditional honorific of Madame Royale. The early years of Madame Royale were spent under the supervision of the royal governess Françoise de Montglat at the Château de Saint-Germain-en-Laye, a quiet place away from the Parisian court in which she shared education and games with her legitimate siblings and the bastard children that her father had from his constant love affairs. Besides the Dauphin, the other Enfants de France (Henry IV's legitimate children) were Christine Marie, later Duchess of Savoy; Nicholas Henri, Duke of Orléans, who died in infancy; Gaston, Duke of Orléans; and Henrietta Maria, later Queen of England. When King Henry IV was assassinated outside the Palais du Louvre in Paris on 14 May 1610, her brother the Dauphin (with whom Elisabeth had a very close relationship) succeeded him to the throne as King Louis XIII of France under the Regency of their mother Marie de' Medici. When Elisabeth was ten years old, in 1612, negotiations were begun for a double marriage between the royal families of France and Spain; Elisabeth would marry the Prince of Asturias (the future Philip IV of Spain) and her brother Louis the Spanish Infanta Anne. Marriage After her proxy marriage to the Prince of Asturias and Louis's proxy marriage to the Infanta Anne,