The history of the Catholic Church is integral to the history of Christianity as a whole. It is also, according to church historian, Mark A. Noll, the "world's oldest continuously functioning international institution." This article covers a period of just under two thousand years. Over time, schisms have disrupted the unity of Christianity. The Catholic Church considers that major divisions occurred in c. 144 with Marcionism, 318 with Arianism, 451 with the Oriental Orthodox, 1054 to 1449 (see East–West Schism) during which time the Orthodox Churches of the East parted ways with the Western Church over doctrinal issues (see the filioque) and papal primacy, and in 1517 with the Protestant Reformation, of which there were many divisions, resulting in over 200 denominations. The Catholic Church has been the driving force behind some of the major events of world history including the Christianization of Western and Central Europe and Latin America, the spreading of literacy and the foundation of the universities, hospitals, the Western tradition of monasticism, the development of art and music, literature, architecture, contributions to the scientific method, just war theory and trial by jury. It has played a powerful role in global affairs, including the Reconquista, the Crusades, the Inquisition, the Investiture Controversy, the establishment of the Holy Roman Empire, and the Fall of Communism in Eastern Europe in the late 20th century. Ministry of Jesus and founding 4 BC: Nativity of Jesus. According to the Gospel of Luke, his birth occurred in the town of Bethlehem during the reigns of King Herod the Great of Judaea and the Roman Emperor Augustus, and he was the son of the Virgin Mary, who conceived him by the power of the Holy Spirit. He is the Divine Son of God incarnate or God the Son. The calculations of Dionysius Exiguus put the birth of Jesus in the year that in consequence is called 1 BC; most historians place his birth between 6 and 4 BC. 28 AD: Jesus' baptism, start of ministry, and selection of the Apostles. The Gospel of Luke indicates that Jesus was baptized during the 15th year of the reign of Tiberius Caesar which is dated in 28 AD (found in Luke 3:1,21,22). Christian Gospels strongly suggest Peter as leader and spokesman of the Apostles of Jesus, being mentioned the most number of times in the Gospels. Peter and the sons of Zebedee, James and John, constitute