Mississippi Highway 12 (MS 12) is a state highway in northern Mississippi that runs west–east from MS 1 west of Hollandale at the Mississippi River to State Route 18 (SR 18) at the Alabama state line northeast of Columbus. MS 12 traverses three major regions of the state, the Mississippi Delta, the North Central Hills, and the Golden Triangle. Route description MS 12 begins the Mississippi Delta region in Washington County at an intersection with MS 1 (part of the Great River Road) thirteen miles south of Greenville, not even a mile from the banks of the Mississippi River, and only five miles north of Lake Washington. The highway heads east through flat farmland as a two-lane highway to travel through Leroy Percy State Park, where it crosses Silver Creek Bayou, before entering Hollandale. MS 12 enters town along W Washington Street, makes a right in downtown onto East Avenue S, then left onto E Crouch Street to cross Deer Creek and come to an intersection with US 61. The highway now leaves Hollandale and continues east through rural farmland for several miles to cross the Sunflower River into Humphreys County. MS 12 continues east through farmland for several miles to enter Belzoni and immediately come to an intersection between US 49W (unsigned MS 3) and MS 7 just west of downtown. The road continues as MS 7 (1st Street) into downtown while MS 12 becomes concurrent with US 49W/MS 3 and they head south as a four-lane to bypass downtown. MS 12 breaks off as a two-lane shortly thereafter and goes east to cross the Yazoo River to leave Belzoni. The highway continues east through rural farmland and woodlands for several miles to enter Holmes County. MS 12 crosses Tchula Lake before traveling along the southern edge of Marcella and coming to an intersection and becoming concurrent with US 49E. They head northeast for a few miles to travel through Mileston before entering Tchula, with MS 12 splitting off and heading east just south of downtown. MS 12 climbs some Loess bluffs onto the North Central Hills region, passing in between the Morgan Brake National Wildlife Refuge and the Hillside National Wildlife Refuge. It now travels southeast through woodlands for several miles to enter Lexington. The highway passes through neighborhoods before turning south and becoming concurrent with MS 17 at a Y-Intersection. MS 12/MS 17 continue along Carrollton Street