April 26, 2019, Twiztid released their 12th full-length studio album Generation Nightmare, a more rock-oriented album than most of their previous releases. Generation Nightmare had featured the most variety of producers on a singular Twiztid album to that point, with seven different producers overall. It peaked at No. 3 on the Billboard Top Independent Albums chart and at No. 51 on the Billboard 200 chart. On April 20, 2020, Twiztid released their 13th full-length studio album Mad Season on their online web store without any prior promotion. A few days later, the album was made available on streaming services. The duo returned to a more horrorcore sound with a hip-hop approach on Mad Season. Due to the lack of promotion, the album had found only minimal success as it peaked at No. 38 on the Billboard Top Independent Albums chart. On November 23, 2020, Twiztid announced their next album would be titled Revelashen. Similar to Mad Season, it received very little promotion or hype, and it was released merely four days after the announcement. In regards to prior albums, Revelashen was not as successful since it only appeared on one chart, the Billboard Top Current Album Sales chart, peaking at No. 57. Revelashen was more straightforward in its content, with the duo shredding the theatrical storylines and moving away from strictly horror themes. Unlikely Prescription, Glyph, and future plans (2021–present) Twiztid released the promotional EP Electric Lettuce on April 20, 2021, as it coincided with a 4:20 livestream event. Twiztid also formed another supergroup in 2021 named East Side Ninjas, which featured the duo, Blaze Ya Dead Homie, and Anybody Killa. Their debut album Pact of the 4 was released on June 5, 2021. Also in early 2021, Twiztid released the single "Rose Petal". It appeared on the Billboard Mainstream Rock chart for over two months, peaking at No. 32. It was the duo's first appearance on a singles chart. Another single was released in May 2021 as a collaboration with Ice Nine Kills titled "Envy". It was the duo's second appearance on the Billboard Mainstream Rock chart, peaking at No. 32 in October 2021 and staying on the chart for 15 weeks overall. The song (and the aforementioned "Rose Petal" single) later appeared on Unlikely Prescription, their rock-oriented album that was released on September 10, 2021. Unlikely Prescription peaked at No. 14 on the Billboard Top Current Album Sales