San Diego area, Agerholm sailed to the western Pacific on her 12th deployment. She returned to her home port in June 1963 and commenced overhaul at the Naval Repair Facility, San Diego, to update and improve the electronic and weapons systems on board. Following completion of the overhaul in January 1964, Agerholm continued her routine of local operations and preparations for deployment. Vietnam In August, the destroyer got underway for the western Pacific where she spent six months patrolling off the coast of Vietnam and in the Taiwan Strait. Upon her return to her home port early in 1965, Agerholm underwent a brief overhaul and in August embarked midshipmen for a cruise to Hawaii. With the escalation of American involvement in Vietnam, the destroyer prepared for another cruise to that area. Agerholm began her next deployment in January 1966 when she departed San Diego for Vietnam. There, her assigned duties included Naval Gunfire Support (NGFS), anti-submarine warfare (ASW), carrier escort, and search and rescue (SAR). In May during NGFS off the South Vietnamese coast, Agerholm provided call fire for a Marine Corps air spotter who was drawing heavy gunfire. The destroyer silenced the Viet Cong machine gun nest with just four rounds from her guns. On 17 June Agerholm aided a South Vietnamese patrol boat and took off 12 badly wounded men while on a SAR mission in the Gulf of Tonkin. The ship visited Subic Bay, Yokosuka, Kaohsiung, Hong Kong and Pearl Harbor before returning to San Diego in July. While in Yokosuka, Angerholm was filmed and subsequently made a cameo appearance in the 1968 movie Nobody's Perfect. Agerholm began another modernization overhaul at the Long Beach Naval Shipyard in August. She received new 5-inch gun mounts, and advanced radar and sonar gear, as well as communications systems and engineering plant alterations. The destroyer left the shipyard in December to spend the holiday season in her home port. With the advent of 1967, Agerholm once again prepared for deployment to the Far East. On 15 May, she departed for the Gulf of Tonkin, joining the aircraft carrier at Subic Bay. The ships sailed to "Yankee Station" where they arrived on 20 June. For the next four months, Agerholm provided plane guard assistance for the carriers Intrepid, , and . When a major fire broke out on the aircraft carrier on 29 July all ships in the area, including Agerholm,