Cardinals agreed to a four-year, $15.5 million deal with a club option for a fifth, cementing his position as their starting catcher. He reported to spring training having lost 15 pounds and in improved physical shape from rehabilitating following knee surgery. He started the season with an Opening Day home run and seven-game hitting streak. After a home plate collision with Eric Bruntlett on June 15 against the Philadelphia Phillies in the ninth inning, Molina sustained head and neck injuries and was removed from the field on a stretcher. There were no indications of a concussion. He held on to the ball to help the Cardinals win. He missed the next four games. To that point, Molina was batting .295 with three home runs and 24 RBIs. He also had thrown out 10 of 32 baserunners (31.3%) – well below his career average of 45% – but an Associated Press reporter attributed the decline to an inexperienced pitching staff. Molina returned to the field against Boston at Fenway Park as the designated hitter. In that game, his solo home run provided the difference in a 5–4 Cardinals victory. It was also the first game of the first of two 13-game hitting streaks for the season. His first career start at first base, also against Boston, occurred two days later. During that streak, he collected 17 hits in 47 at-bats for a .362 batting average. The second hitting streak spanned from August 16 to September 2, where he successfully hit 19 times in 50 at bats for a .380 average. On September 2, he and Felipe López hit consecutive home runs against the Arizona Diamondbacks en route to an 8–2 victory. Overall, Molina enjoyed a breakout offensive season, finishing with new career highs with a .304 batting average – his first over .300 – and in hits (135), OBP (.349), SLG (.392), runs (37) and RBIs (56). Of all catchers in franchise history with at least 450 PA in a season, he became just the second ever, after Simmons, to bat over .300; it was then the fourth-best season batting average; and, his 29 strikeouts were the fewest since Simmons fanned 20 times in 1976. Molina led the team and was sixth in the NL with a .340 batting average with runners in scoring position. For the season, he successfully caught 35% of opposing baserunners, still higher than the league average