Strain 121 (Geogemma barossii) is a single-celled microbe of the domain Archaea. First discovered off Puget Sound near a hydrothermal vent, it is a hyperthermophile, able to reproduce at , hence its name. It was (at the time of its discovery) the only known form of life that could tolerate such high temperatures. A temperature of is biostatic for Strain 121, meaning that although growth is halted, the archaeon remains viable, and can resume reproducing once it has been transferred to a cooler medium. The ability to grow at is significant because medical equipment is exposed to this temperature for sterilization in an autoclave. Prior to the 2003 discovery of Strain 121, a fifteen-minute exposure to autoclave temperatures was believed to kill all living organisms. However, Strain 121 is not infectious in humans, because it cannot grow at temperatures near . Strain 121 metabolizes by reducing iron oxide. The maximum growth temperature of strain 121 is 8 °C higher than the previous record holder, Pyrolobus fumarii (Tmax=113 °C). However, it appears highly improbable that strain 121 marks the upper limit of viable growth temperature. It may very well be the case that the true upper limit lies somewhere in the vicinity of 140 to 150 °C, the temperature range where molecular repair and resynthesis becomes unsustainable. See also Methanopyrus kandleri Strain 116 References Cowan, D. (2004). “The Upper Temperature for Life – Where Do We Draw the Line?” Trends in Microbiology (Regular Ed.), vol. 12, no. 2, Elsevier Ltd, pp. 58–60, https://doi.org/10.1016/j.tim.2003.12.002. External links Guardian News Science Daily article NSF "Microbe from Depths Takes Life to Hottest Known Limit" How Hot is Too Hot for Earth-Style Life? Thermoproteota Thermophiles Archaea described in the 21st century