Francisco Javier Eugenio de Santa Cruz y Espejo (Royal Audiencia of Quito, February 21, 1747 – December 28, 1795) was a medical pioneer, writer and lawyer of mestizo origin in colonial Ecuador. Although he was a notable scientist and writer, he stands out as a polemicist who inspired the separatist movement in Quito. He is regarded as one of the most important figures in colonial Ecuador. He was Quito's first journalist and hygienist. As a journalist he spread enlightened ideas in the Royal Audiencia, and as a hygienist he composed an important treatise about sanitary conditions in colonial Ecuador that included interesting remarks about microorganisms and the spreading of disease. Espejo was noted in his time for being a satirist. His satirical works, inspired by the philosophy of the Age of Enlightenment, were critical of the lack of education of the Audiencia of Quito, the way the economy was being handled in the Audiencia, the corruption of its authorities, and aspects of its culture in general. Because of these works he was persecuted and finally imprisoned shortly before his death. Historical background The Royal Audiencia of Quito (or Presidency of Quito) was established as part of the Spanish State by Philip II of Spain on August 29, 1563. It was a court of the Spanish Crown with jurisdiction over certain territories of the Viceroyalty of Peru (and later the Viceroyalty of New Granada) that now constitute Ecuador and parts of Peru, Colombia and Brazil. The Royal Audiencia was created to strengthen administrative control over those territories and to rule the relations between whites and the natives. Its capital was the city of Quito. By the 18th century, the Royal Audiencia of Quito began to have economic problems; a lack of roads led to limited communications. Obrajes—a type of textile factory—had provided jobs, but now found themselves in decline, mainly due to a crackdown on smuggled European cloths and a series of natural disasters. Obrajes were replaced by haciendas, and the dominant groups continued to exploit the indigenous population. In the Royal Audiencia, the education situation worsened after of the expulsion of the Jesuit priests; too few learned people lived in Quito to be able to fill the void. The majority of the population neither read nor wrote well. On the other hand, the few who could enter the university were given an education which was heavily theoretical and used memorization