impressed when he forcefully articulated his brilliant concepts. His obituary in The Physiologist journal, and Memoriam in the 11th edition of his book, are largely verbatim of each other, including as below: Arthur Guyton's research contributions, which include more than 600 papers and 40 books, are legendary and place him among the greatest figures in the history of cardiovascular physiology. His research covered virtually all areas of cardiovascular regulation and led to many seminal concepts that are now an integral part of the understanding of cardiovascular disorders such as hypertension, heart failure, and edema. It is difficult to discuss cardiovascular regulation without including his concepts of cardiac output and venous return, negative interstitial fluid pressure and regulation of tissue fluid volume and edema, regulation of tissue blood flow and whole body blood flow auto-regulation, renal-pressure natriuresis, and long-term blood pressure regulation.Guyton, Arthur C., & Hall, John E (2006) p.vii The Textbook Memoriam continues: "Indeed, his concepts of cardiovascular regulation are found in virtually every major textbook of physiology. They have become so familiar that their origin is sometimes forgotten". Notes References Reference to Guyton's biographical details in the above text comes primarily from the obituary published in Physiologist magazine, and John E. Hall's memoriam and preface to the 11th edition of Textbook of Medical Physiology both of which contain overlapping statements, sometimes verbatim, sometimes almost verbatim. Further reading The pioneering use of systems analysis to study cardiac output regulation, John E. Hall Brinson C, Quinn J. Arthur C. Guyton—His Life, His Family, His Achievements. Jackson, MS, Hederman Brothers Press, 1989. Bode R. "A Doctor Who's Dad to Seven Doctors—So Far!" Reader's Digest, December, 1982, pp. 141–145. 1919 births 2003 deaths University of Mississippi faculty American physiologists Road incident deaths in Mississippi University of Mississippi alumni Harvard Medical School alumni