as it was being abused by soldiers and physicians alike. This caused much debate in the medical field, and eventually led to his removal as Surgeon-General. Calomel continued to be used well into the 1890s and even into the early 20th century. Eventually calomel’s popularity began to wane as more research was done, and scientists discovered that the mercury in the compound was poisoning patients. Calomel was the main of the three components of the pill number 9 of the British army during the First World War. Electrochemistry Calomel is used as the interface between metallic mercury and a chloride solution in a saturated calomel electrode, which is used in electrochemistry to measure pH and electrical potentials in solutions. In most electrochemical measurements, it is necessary to keep one of the electrodes in an electrochemical cell at a constant potential. This so-called reference electrode allows control of the potential of a working electrode. Chemical properties Calomel is a powder that is white when pure. When it is exposed to light or contains impurities it takes on a darker tint. Calomel is made up of mercury and chlorine with the chemical formula Hg2Cl2. Depending on how calomel was administered, it affected the body in different ways. Taken orally, calomel damaged mainly the lining of the gastrointestinal tract. Mercury salts (such as calomel) are insoluble in water and therefore do not absorb well through the wall of the small intestine. Some of the calomel in the digestive system will likely be oxidized into a form of mercury that can be absorbed through the intestine, but most of it will not. Oral calomel was actually the safest form of the drug to take, especially in low doses. Most of the calomel ingested will be excreted through urine and stool. Powdered forms of calomel were much more toxic, as their vapors damaged the brain. Once inhaled, the calomel enters the bloodstream and the mercury binds with the amino acids methionine, cysteine, homocysteine and taurine. This is because of the sulfur group these amino acids contain, which mercury has a high affinity for. It is able to pass through the blood brain barrier and builds up in the brain. Mercury also has the ability to pass through the placenta, causing damage to unborn babies if a pregnant mother is taking calomel. Calomel was manufactured in two ways - sublimation and precipitation. When calomel first started