detailed operational information about the populations being affected by a possible crisis. It also includes the project, “Modeling Disease Dynamics on Large, Detailed, Co-Evolving Networks,” which supports work to develop high-performance computer models for the study of very large networks. The Cyberinfrastructure Division develops methods, infrastructure, and resources primarily for infectious disease research. The “Pathosystems Resource Integration Center - Bioinformatics Resource Center for Bacterial Diseases” aims to integrate information on pathogens, provide resources and tools to analyze genomic, proteomic and other data arising from infectious disease research. It is part of the Middle-Atlantic Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research), which focuses on research to enable rapid defense against bioterror and emerging infectious diseases. Specific diseases and disease-causing agents under investigation include anthrax, West Nile virus, smallpox, and cryptosporidiosis The division collaborates with Georgetown University and Social and Scientific Systems on the Administrative Center of the National Institute of Allergy and Infectious Diseases-funded Proteomics Research Resource Center (PRC) for Biodefense Proteomics Research project. The team helps design, develop, and maintain a publicly accessible Web site containing data and technology protocols generated by each PRC, as well as a catalog that lists reagents and products available for public distribution. The Biological Systems Division develops computational methods for studying biochemical networks using experimental data . It developed COPASI (Complex Pathway Simulator), an open-source software package that allows users with limited experience in mathematics to construct models and simulations of biochemical networks. It also developed GenoCAD, a web-based Computer Assisted Design environment for synthetic biology. The Medical Informatics & Systems Division focuses on human genetics and disease, especially cancer and neurological disorders. It collaborates with Carilion Clinics, Virginia Tech Carilion School of Medicine and Research Institute, and other universities and government agencies. Major research laboratories The Network Dynamics and Simulation Science Laboratory at ACDIL pursues programs for interaction-based modeling, simulation, and associated analysis, experimental design, and decision support tools for understanding large and complex systems. Extremely detailed, high-resolution, multi-scale computer simulations allow formal and experimental investigation of these systems. Social and Decision Analytics Laboratory focuses on the use and development of analytical technology in the areas of public health policy, national and international security policy & public and social policy. The Nutritional Immunology and Molecular Medicine Laboratory was founded in 2002 to investigate fundamental mechanisms of gut enteric immunity, and identifying biomarkers and therapeutic targets for inflammatory and immune-mediated