possible to follow the internalization of cargo molecules and the evolution of a clathrin-coated pit by fluorescence microscopy and immuno electron microscopy. Since the process is non-specific, the ligand can be a carrier for larger molecules. If the target cell has a known specific pinocytotic receptor, drugs can be attached and will be internalized. To achieve internalisation of nanoparticles into cells, such as T cells, antibodies can be used to target the nanoparticles to specific receptors on the cell surface (such as CCR5). This is one method of improving drug delivery to immune cells. The development of photoswitchable peptide inhibitors of protein-protein interactions involved in clathrin-mediated endocytosis (Traffic Lights peptides) and photoswitchable small molecule inhibitors of dynamin (Dynazos) has been reported. These photopharmacological compounds allow spatiotemporal control of the endocytosis with light. Characteristics Induction within minutes of exposure to excess ligand. The formation of these vesicles is sensitive to inhibition by wortmannin The initiation of vesicle formation can be delayed/inhibited by temperature variations See also Non-specific, adsorptive pinocytosis Pinocytosis Phagocytosis Viropexis Bulk endocytosis Endocytosis References External links CytoChemistry.net- A lecture on RME with some nice pictures Cellular processes