known as aspartame), an artificial sweetener, in 1965. It was released in 1981 by FDA. In 1996, the FDA removed all restrictions on the use of aspartame, which enabled its use in heated and baked goods. G. D. Searle's patent on aspartame was extended in 1981 and ultimately expired in December 1992. References External links The Pill Biotechnology companies of the United States Companies based in Skokie, Illinois History of Chicago Pharmaceutical companies of the United States Pfizer Pharmaceutical companies established in 1888 Health care companies based in New York (state) 1985 mergers and acquisitions 1888 establishments in Nebraska American corporate subsidiaries