multi-agent) chemotherapy and regional radiotherapy, also surgery may be an option in specific situations. Meningococcal group C conjugate vaccine are also used in some cases. In primary biliary cirrhosis ursodeoxycholic acid helps the bloodstream remove bile which may increase survival in some affected individuals. See also Hepatosplenomegaly Liver function tests References Further reading External links Merck Manual: Hepatomegaly Hepatology Symptoms and signs: Digestive system and abdomen