Ōtsuka (REmake 4) Motion capture: Kenji Hata (RE4) is the main antagonist of Resident Evil 4. He is the leader of Los Illuminados, the cult responsible for Ashley Graham's kidnapping. Saddler plans on infecting Graham with a sample of Las Plagas, in hope that she will return home and infect higher-ranking members of the U.S. government. Saddler then attempts to control them and seize control of the country, and then the world. He uses samples of Las Plagas to infect and control villagers and even a local castellan Ramon Salazar (ラモン・サラザール) to perform his bidding. However, his plans are foiled by the combined efforts of Kennedy, Wong and Luis Sera. Kennedy, with the assistance of Wong, kills Saddler near the game's conclusion, and destroys his research and production complex. Ramon Salazar Voiced by (English): Rene Mujica (voice actor) (RE4) Voiced by (Japanese): Chō (REmake 4) Motion capture: Tsurugi-Dan (RE4) Ramon Salazar is a secondary antagonist in Resident Evil 4. He is the castellan of the castle affiliated with Los Iluminados. He comes from a noble family, who were responsible for sealing Las Plagas beneath the castle's grounds. Years later, Saddler, a cultist who worships Las Plagas, persuaded Salazar to unearth the parasites, causing them to spread across the local area. Salazar controls the Ganados and orders them to kill Kennedy and apprehend Ashley Graham. He merges with his second Verdugo in a Queen Plaga to become a gigantic abomination in a desperate attempt to defeat Kennedy, but perishes during the ensuing fight. Bitores Mendez Voiced by: Jesse Corti (voice actor) (RE4) Motion capture: Kenji Hata (RE4) Bitorez Mendez is the chief of the unnamed Spanish village, taken over by Osmund Saddler and the Los Illuminados cult. He is given a Dominant Species of the Plaga Parasite, allowing him to command others infected with Las Plagas and granting him incredible strength. Mendez is confronted numerous times throughout the first two chapters of Resident Evil 4 by Leon Kennedy, during the latter's attempt to save the President's daughter from the village. In their last confrontation in a barn, Mendez is forced to mutate after being doused in gasoline and set on fire, eventually detaching the lower part of his body and using the rafters to traverse and attack Leon. He is finally killed by the agent and his glass eye is used to access Salazar's castle. Resident Evil Archives II states that