3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale. It and its parent compound indole-3-carbinol are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms. DIM is sold as a dietary supplement. Properties In vitro, DIM has action as a histone deacetylase inhibitor, specifically against HDAC1, HDAC2, and HDAC3. DIM is a metabolite of indole-3-carbinol. DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2. See also Glucobrassicin, precursor to indole-3-carbinol Phytochemicals References External links Diindolylmethane Information Resource Center, University of California-Berkeley Indoles Antineoplastic drugs Histone deacetylase inhibitors