Alex is spurred by her failing health to instead develop a method to transplant a digital copy of her mind into a host body able to resist fear. Hastening her work after learning of Spencer and Albert's deaths, Alex exploits Neil Fisher with the Uroboros virus she was refining to provide her with candidates from TerraSave, with only Claire Redfield and Moira Burton the sole survivors of her experiments. Alex also captures Natalia Korda as her ideal host, disposing of Fisher before proceeding with her experiment before committing suicide with the expectation to awaken as Natalia within six months. But she is instead mutated by the T-Phobos at the last second from fearing her own demise, suffering an existential crisis with the maddened resolve to kill Natalia before her copy could manifest by releasing the Uroboros virus on the island as Barry arrived. After infecting herself with the Uroboros, Alex is killed during the BSAA's assault on the island. Regardless of Alex's death, her copy starts manifesting as depicted in the bonus episode "Little Miss" and the game's epilogue. Annette Birkin Voiced by (English): Jennifer Dale (RE2), Deborah Sale Butler (DC), Karen Strassman (REmake 2, REmake 3) Voiced by (Japanese): Marika Hayashi (REmake 2, REmake 3) Motion capture: Karen Strassman (REmake 2) Played by: Janet Porter (Welcome to Raccoon City) is a supporting character in Resident Evil 2. She is involved in Bio Organic Weapon research at Umbrella, working with her husband William to create the G-virus. During the Raccoon City outbreak, Annette works to stop Umbrella's experiments from spreading further into the city. She leaves their daughter Sherry at the Raccoon Police Department with a pendant containing the virus, hoping Irons can protect her. During the game's events, Annette helps Claire cure Sherry's G-virus infection and reveals Ada's true motives to Leon. She is fatally injured, forcing them to leave her behind. Annette appears in the game's remake, maintaining the same role as in the original game, and its retelling in The Darkside Chronicles. In the reboot film Resident Evil: Welcome to Raccoon City (2021), Annette is played by Janet Porter. James Marcus Voiced by (English): Ian Downie (RE0) Voiced by (Japanese): Hiroshi Ito (RE0) Played by: Mark Simpson (The Final Chapter) is the main antagonist of Resident Evil Zero. Years before the events of the first Resident Evil, he was one of the top virologist researchers of the