in Minnesota that Worthington enjoyed his greatest success, working as the team's top relief pitcher for most of the next six seasons," reporter Creg Stephenson wrote. With Minnesota, Worthington was often used at the end of games, accumulating 14 saves in approximately half a season. He gave up no earned runs in his first 20 appearances with the ballclub, though he did allow three unearned runs and take the loss in the first game of a doubleheader against the New York Yankees on July 4. Ultimately, he allowed earned runs in just five of the 41 games he appeared in for Minnesota and had a 1.37 ERA with the Twins in 1964, which Sports Illustrated called "impressive." He had a 5–6 record, struck out 59 batters, walked 27 hitters, and allowed 47 hits in innings. With Minnesota in 1965, Worthington had the lowest ERA of any Twins pitcher (2.13, the lowest of his career) for a team that won 102 games and the American League (AL) pennant. From July 25 through July 31, he won three straight appearances without allowing a run, pitching three scoreless innings against the Washington Senators in the second game of a July 27 doubleheader. On August 30, he entered in the seventh after Jim Kaat had allowed a run and threw three scoreless innings in an eventual 11-inning, 3–2 victory over the Detroit Tigers. In 62 games, he had a 10–7 record, a 2.13 ERA, 59 strikeouts, 41 walks, and 57 hits in innings. He had a career-high 21 saves, which ranked sixth in the AL. The Twins faced the Dodgers in the 1965 World Series, and Worthington was used twice. He relieved Mudcat Grant in the sixth inning of Game 4 with no outs, runners on second and third, and the Twins trailing 3–2. The first batter, Ron Fairly, had an RBI single that scored both runners, and he scored on the next play when Worthington made an errant throw to first base on a Lou Johnson sacrifice bunt. He finished the inning and threw a scoreless seventh, but the Twins lost 7–2. After Kaat allowed three hits and two runs to start the fourth inning of Game 7, Worthington relieved him, this time not allowing any runners to score in his two innings of work. The Twins lost 2–0 as the Dodgers became World Series champions. On April 24, 1966, Worthington struck out