Umbrella Corporation and a head of its personnel training facility, personally appointed by Oswell E. Spencer to work with the Progenitor virus. In this capacity, Marcus played an integral role in developing the T-virus (Tyrant virus), and the Tyrant and Nemesis programs, also conducting extensive research on leeches that led to the development of the G-virus, up until his death in 1988. Spencer betrayed him by sending Marcus' direct subordinates, Albert Wesker and William Birkin, to murder him and steal his research. They dumped his body away along with the Queen Leech that Marcus created, the creature consuming his body and ended up absorbing his genetic memory as consequence. This resulted in the Queen Leech believing itself to be Marcus reborn. Serving as the antagonist of Resident Evil Zero, The Queen Leech avenges the real Marcus by triggering the events of the first Resident Evil game by causing a T-virus outbreak in the Arklay Mansion before being destroyed by Rebecca Chambers and Billy Coen. Marcus also appears in The Umbrella Chronicles. In the film Resident Evil: The Final Chapter (2016), James is played by Mark Simpson. In the film, it is revealed that Alice is a clone of James's daughter, Alicia Marcus. In the Netflix's live-action series (2022), set in its own universe but featuring the game series storyline as its backstory, James Marcus has a daughter named Evelyn, played by Paola Núñez, who inherited control of Umbrella. William Birkin Voiced by (English): Diego Matamoros (RE2), T.J. Rotolo (The Umbrella Chronicles, The Darkside Chronicles, Operation Raccoon City, REmake 2), Misha Standjofski (Dead by Daylight) Voiced by (Japanese): Toshihiko Seki (Operation Raccoon City, 0, REmake 2) Motion capture: T.J. Rotolo (REmake 2) Played by: Jason Isaacs (RE), Neal McDonough (Welcome to Raccoon City) is one of the main antagonists in the Resident Evil series, specifically Resident Evil 2. After completing his G-virus project (Golgotha virus), he is mortally wounded by agents of the Umbrella Special Forces and his work is stolen. Left for dead, he injects himself with the G-virus, thus turning himself into a monster known as "G". He then kills his attackers, causing a T-virus vial to be leaked into the city's drainage system, resulting in the zombie outbreak in Raccoon City. During the course of the game, he encounters the main characters, Claire Redfield and Leon S. Kennedy, as he undergoes gradual mutation and begins losing any resemblance