the left ring forming a tetrahydrofuranone species. The newly formed grisan skeleton with a spiro center is then O-methylated by SAM to generate dehydrogriseofulvin. Ultimately, a stereoselective reduction of the olefin on dehydrogriseofulvin by NADPH affords griseofulvin. Toxicology Mice Griseofulvin is found to alter the bile metabolism of mice by Yokoo et al. 1979. The same team went on to find a similar effect on mice by a chemically unrelated substance, 3,5-diethoxycarbonyl-1,4-dihydrocollidine, in Yokoo et al. 1982 and Tsunoo et al. 1987. References External links Antifungals Aromatic ketones Benzofuran ethers at the benzene ring Chloroarenes Cyclohexenes Disulfiram-like drugs Halogen-containing natural products IARC Group 2B carcinogens Mutagens Resorcinol ethers Wikipedia medicine articles ready to translate Spiro compounds World Health Organization essential medicines