over her younger daughter Isabelle's (Allie Grant) "weight problem," and disapproves of her being a lesbian. At the end of the first season, Celia is diagnosed with breast cancer and cured with chemotherapy. When interrogated by the police over Nancy's grow house in Celia's home burning down the city, Dean, Doug, and other characters falsely allege that Celia coordinated it, which leads to her arrest. Following her release from prison, she becomes addicted to cocaine, so Isabelle arranges a rehab home intervention. Celia later becomes envious of Nancy; therefore, she dresses like her. After the fifth season, the actress left to pursue other projects. Doug Wilson (Kevin Nealon) begins the series as an accountant and city councilman for the town of Agrestic. Doug is friends with many characters in the series including Andy, Dean, and Sanjay Patel (Maulik Pancholy); all four aid Nancy's career as a marijuana dealer. Doug makes mistakes and loses his position; his wife Dana leaves him. He becomes a drifter who follows the Botwins during seasons four through eight. He and the Botwins move to New York City, where he becomes the chief accountant for a Ponzi scheme posing as a hedge fund. The show has a changing cast of supporting characters. Heylia James (Tonye Patano) and her family — Conrad and Vaneeta, portrayed by Romany Malco and Indigo, respectively — play key roles during the first three seasons. They are wholesalers who supply marijuana to Nancy. Conrad later develops his own strain of marijuana, called MILF weed, which Nancy sells. Season three features Sullivan Groff (Matthew Modine), an unethical, womanizing real estate developer with big plans for Agrestic. When Nancy moves to Ren Mar, the characters in Esteban's drug cartel—primarily Cesar (Enrique Castillo), Ignacio (Hemky Madera), and Guillermo (Guillermo Díaz), the latter first appearing in the third season—take a leading role. Other key characters include Nancy's housekeeper Lupita (Renée Victor); rival drug dealers; countless law enforcement officials; the romantic interests of Andy, Silas, and Shane; and the residents of Agrestic and Ren Mar. In the sixth season, Nancy is on the run, and the new characters only have minor roles and appear for only a few episodes. An exception to this is Warren Schiff (Richard Dreyfuss), who she first met when teaching her math in high school; he becomes infatuated with Nancy. When the Botwins and Doug settle in New York City, new supporting characters