of Francesco II Sforza, the duke of Milan. When Charles' son Philip inherited the duchy, Francis invaded Italy, capturing Turin, but failed to take Milan. In response, Charles invaded Provence, advancing to Aix-en-Provence, but withdrew to Spain rather than attacking the heavily fortified Avignon. The Truce of Nice ended the war, leaving Turin in French hands but effecting no significant change in the map of Italy. Francis, allying himself with Suleiman I of the Ottoman Empire, launched a final invasion of Italy. A Franco-Ottoman fleet captured the city of Nice in August 1543, and laid siege to the citadel. The defenders were relieved within a month. The French, under François, Count d'Enghien, defeated an Imperial army at the Battle of Ceresole in 1544, but the French failed to penetrate further into Lombardy. Charles and Henry VIII of England then proceeded to invade northern France, seizing Boulogne and Soissons. A lack of cooperation between the Spanish and English armies, coupled with increasingly aggressive Ottoman attacks, led Charles to abandon these conquests, restoring the status quo once again. In 1547, Henry II of France, who had succeeded Francis to the throne, declared war against Charles with the intent of recapturing Italy and ensuring French, rather than Habsburg, domination of European affairs. An early offensive against Lorraine was successful, but the attempted French invasion of Tuscany in 1553 was defeated at the Battle of Marciano. Charles's abdication in 1556 split the Habsburg empire between Philip II of Spain and Ferdinand I, and shifted the focus of the war to Flanders, where Philip, in conjunction with Emmanuel Philibert, Duke of Savoy, defeated the French at St. Quentin. England's entry into the war later that year led to the French capture of Calais, England's last possession on the French mainland, and French armies plundered Spanish possessions in the Low Countries; but Henry was nonetheless forced to accept the Peace of Cateau-Cambrésis, in which he renounced any further claims to Italy. The Wars of Religion Barely were the Italian Wars over, when France was plunged into a domestic crisis with far-reaching consequences. Despite the conclusion of a Concordat between France and the Papacy (1516), granting the crown unrivalled power in senior ecclesiastical appointments, France was deeply affected by the Protestant Reformation's attempt to break the unity of Roman Catholic Europe. A growing urban-based Protestant minority (later dubbed Huguenots) faced ever harsher repression under the rule of