Ossetia; the son of this one, Andronicus Paleologus Comnenoducas is known as gambrox (gamma alpha mu beta rho o x) of Isaac II. Isaac's wife was possibly daughter of Andronikos I Komnenos, Byzantine Emperor (died 1185). A potential foreign origin is also given to her due to having the same name as her daughter, contrary to long-standing Greek custom. Their third child was born in 1182 or 1183 and she was dead or divorced by 1185, when Isaac remarried. Their children were: Anna-Euphrosyne Angelina, married to Roman the Great. Irene Angelina (c. 1181-1208), married first to Roger III of Sicily and secondly to Philip of Swabia. Isaac is the ancestor of all European monarchs now reigning through Irene's children by Philip. Alexios IV Angelos (c. 1182 - 1204). By his second wife, Margaret of Hungary (who took the baptismal name "Maria"), Isaac II had two sons: Manuel Angelos (b. after 1195 – d. 1212), he was evidently the elder son, being contemplated in 1205 to ascend the Byzantine throne John Angelos (b. ca. 1193 – d. 1259). He migrated to Hungary and ruled over Syrmia and Bacs (1227–42) as a vassal of king Béla IV of Hungary. See also List of Roman emperors References Sources Angold, Michael, The Byzantine Empire: A Political History, 1025–1204, 2nd edition (London and New York, 1997) Harris, Jonathan, Byzantium and the Crusades (London: Bloomsbury, 2nd ed., 2014). Harris, Jonathan, 'Collusion with the infidel as a pretext for military action against Byzantium', in Clash of Cultures: the Languages of Love and Hate, ed. Sarah Lambert and Helen Nicholson (Turnhout, 2012), pp. 99–117 Head, C. (1980) Physical Descriptions of the Emperors in Byzantine Historical Writing, Byzantion, Vol. 50, No. 1 (1980), Peeters Publishers, pp. 226–240 Hiestand, Rudolf, 'Die Erste Ehe Isaaks II Angelus und Seine Kinder', Jahrbuch der Osterreichischen Byzantinistik, 47 (1997). External links Foreign policy of the Angeli from A History of the Byzantine Empire by Al. Vasilief Isaac 02 Isaac 02 13th-century Byzantine emperors Isaac Angelos Isaac Angelos Christians of the Third Crusade Isaac Angelos Eastern Orthodox monarchs Byzantine people of the Byzantine–Bulgarian Wars