However, the "one-step" catalytic disk systems are not effective against Acanthamoeba due to insufficient exposure time. Enzymatic cleaner Used for cleaning protein deposits off lenses, usually weekly, if the daily cleaner is not sufficient. Typically, this cleaner is in tablet form. Ultraviolet, vibration, or ultrasonic devices These devices intend to disinfect and clean contact lenses. The lenses are inserted inside the portable device (running on batteries and/or plug-in) for 2 to 6 minutes during which both the microorganisms and protein build-up are supposed to be cleaned. However these devices can not be used to replace the manual rub and rinse method because vibration and ultrasound can not create relative motion between contact lens and solution, which is required for proper cleaning of the lens. These devices are not usually available in optic retailers but are in other stores. Rub and rinse method Contact lenses can be mechanically cleaned of more substantial protein, lipid and debris build up by rubbing them between the clean pad of a finger and the palm of a hand, using a small amount of cleaning fluid as a lubricant; and by rinsing thereafter. This "rub and rinse" method is thought to be the most effective method for multipurpose solutions, and is the method indicated by the American Academy of Ophthalmology regardless of cleaning solution used. In 2010, the FDA recommended that manufacturers removed the "no rub" from product labeling, "because rub-and-rinse regimens help prevent microbial adhesion to the contact lens, help prevent formation of biofilms, and generally reduce the microbial load on the lens and the lens case." Physical rubbing devices This type of devices mimic digital rubbing. The lenses are sandwiched by silicone parts inside the portable device. The device applies a gentle yet high speed rubbing action on the lens surface and remove debris. Saline solution Sterile saline is used for rinsing the lens after cleaning and preparing it for insertion. Saline solutions do not disinfect, so it must be used in conjunction with some type of disinfection system. One advantage to saline is that it cannot cause an allergic response, so it is well suited for individuals with sensitive eyes or strong allergies. Daily cleaner Used to clean lenses on a daily basis. A few drops of cleaner are applied to the lens while it rests in the palm of the hand; the lens is rubbed for about 20 seconds with a clean