of Vassy on 1 March 1562, when dozens (some sources say hundreds) of Huguenots were killed, and about 200 were wounded. It was in this year that some Huguenots destroyed the tomb and remains of Saint Irenaeus (d. 202), an early Church father and bishop who was a disciple of Polycarp. The Michelade by Huguenotes against Catholics was later on 29 September 1567. St. Bartholomew's Day massacre In what became known as the St. Bartholomew's Day Massacre of 24 August – 3 October 1572, Catholics killed thousands of Huguenots in Paris and similar massacres took place in other towns in the following weeks. The main provincial towns and cities experiencing massacres were Aix, Bordeaux, Bourges, Lyons, Meaux, Orléans, Rouen, Toulouse, and Troyes. Although the exact number of fatalities throughout the country is not known, on 23–24 August, between 2,000 and 3,000 Protestants were killed in Paris and a further 3,000 to 7,000 more in the French provinces. By 17 September, almost 25,000 Protestants had been massacred in Paris alone. Beyond Paris, the killings continued until 3 October. An amnesty granted in 1573 pardoned the perpetrators. Edict of Nantes The pattern of warfare, followed by brief periods of peace, continued for nearly another quarter-century. The warfare was definitively quelled in 1598, when Henry of Navarre, having succeeded to the French throne as Henry IV, and having recanted Protestantism in favour of Roman Catholicism in order to obtain the French crown, issued the Edict of Nantes. The Edict reaffirmed Roman Catholicism as the state religion of France, but granted the Protestants equality with Catholics under the throne and a degree of religious and political freedom within their domains. The Edict simultaneously protected Catholic interests by discouraging the founding of new Protestant churches in Catholic-controlled regions. With the proclamation of the Edict of Nantes, and the subsequent protection of Huguenot rights, pressures to leave France abated. However, enforcement of the Edict grew increasingly irregular over time, making life so intolerable that many fled the country. The Huguenot population of France dropped to 856,000 by the mid-1660s, of which a plurality lived in rural areas. The greatest concentrations of Huguenots at this time resided in the regions of Guienne, Saintonge-Aunis-Angoumois and Poitou. Montpellier was among the most important of the 66 ('cities of protection' or 'protected cities') that the Edict of 1598 granted to the Huguenots. The city's political institutions and the university were