years after the Russell–Einstein Manifesto, confronts the humankind in an even more dangerous and more complex form. "Our deep worry that we, as members of the species homo sapiens, are increasingly reducing the living diversity of our earth and of our creative developmental possibilities, thus irreversibly endangering our survival in peace and our mutual exchange gives us the courage, and our awareness that we have to take new paths gives us the occasion, to compose this manifesto." (Potsdam Manifesto & Potsdam Denkschrift) In this spirit it is not adequate just to answer - to give symptom remedies - to the diverse and escalating endangerments for humankind and more over for its carrying biosphere. It is urgent to detect the deeper causes covert behind these various crises syndromes. They have to be searched in the grave failures of the dominant strategies in our thinking and actions. It is obviously that the existence threatening problems of humankind are human-made too. Re-orientations for Sustainable Development In accordance Potsdam Denkschrift & Potsdam Manifesto enquire for the deeper sub-structures of the diverse crises symptoms. They show radical and deep going re-orientations for the sustainable development of humankind and for our thinking. "This wide variety of crises today confronting us and threatening to exceed our ability to cope are the expression of a mental crisis in the relation between us humans and our living world. They are symptoms of deeper causes that we have thus far neglected to seek and reveal. They are closely connected with the materialistic-mechanistic worldview favored all over the world today and with its prior history." (Potsdam Manifesto & Potsdam Denkschrift) Potsdam Denkschrift & Potsdam Manifesto charge a unidirectional narrow-minded western-European-North American modelled way of thinking to stall the living co-action between humans and creatures and to hinder their viability via centralisation trends and averaging of living complexes from biosphere to anthroposphere. Bridging Quantum Physics, Ecology and Philosophy Via the linking up between quantum physics, ecology and philosophy Potsdam Denkschrift & Potsdam Manifesto are highlighting plurality, diversity and alteration as genuine in a living cosmos, as fundamental for a concerted evolution. The idea of a separated, fragmented reality dissolves in the micro physics and dynamically transforming and differentiating relations are taking the place of substantial segregations. The image of a world assembled from dead matter is superseded by a cosmology, what is based on an immaterial omni-connectedness and what is inherently “alive”.