is a well conserved signalling pathway that coordinately regulates cell proliferation and apoptosis. Mutations of the NF2 gene cause a human autosomal dominant disease called neurofibromatosis type 2. It is characterized by the development of tumors of the nervous system, most commonly of bilateral vestibular schwannomas (also called acoustic neuromas). NF2 belongs to the tumor suppressor group of genes. Interactions Merlin (protein) has been shown to interact with: CUL4A, DDB1, EZR, HGS, MED28, RIT1, SDCBP, SPTBN1, and VPRBP. References External links GeneReviews/NCBI/NIH/UW entry on Neurofibromatosis 2 FlyBase synopsis of gene Mer Cytoskeleton Peripheral membrane proteins Human proteins Tumor suppressor genes