las Cacerías, and Manzote. During the Reconquista, Moguer was conquered by the Order of Santiago around 1239–1240, along with other enclaves of historic Algarve, and annexed to Castile. Señorío de Moguer In 1333, the village of Moguer became the first seigneury in the area, granted by Alfonso XI of Castile to Alonso Jofré Tenorio, Staff Admiral (Almirante Mayor) of Castile. Under this nobleman, Moguer became a prosperous town. Besides the existing Almohad castle, Moguer acquired the Monastery of Santa Clara and a Franciscan convent. On his death, the seigneury passed to his daughter María Tenorio, wife of Martín Femández Portocarrero, and later to their son Alonso Femández Portocarrero, to whose lineage it would remain connected. The Casa de Portocarrero enlarged the town with the construction of the 15th-century San Francisco Convent; the old Franciscan convent became the Corpus Christi Hospital, a hospital for the poor. The House of Portocarrero were Grandees, wealthy upper nobility, with close connections to the royal court. In 1375 the Señorío de Moguer became a majorat (). Like any feudal lords, the lords of Moguer exercised control over the municipal government. Moguer soon became a prominent Andalusian fishing town, thanks mainly to the Portocarrero's policy of attracting additional settlement. The town of Moguer gained distinction for various services provided to the Crown by its successive lords. In 1369, Henry II of Castile granted it the title of Muy Leal ("Very Loyal"); in 1642, Philip IV of Spain designated Moguer a city, and gave its council the right to use the coat of arms of the Portocarrero; and in 1779, Charles III distinguished it again with the titles of Muy Noble and Muy Leal ("Very Noble" and "Very Loyal"). Because of this, Moguer is known as the "Very Noble and twice Very Loyal City" of Moguer. Moguer and Columbus's first voyage The economy of Moguer in the 15th century was based in agriculture, fishing, and mercantile activities. in 1489 the Catholic Monarchs Isabella and Ferdinand granted a seguro (?) to ships arriving at the river port of Moguer from the Canary Islands, North Africa and Atlantic European countries. Beginning in the 15th century, Moguer had a loading wharf for loading and discharging merchandise, a carriageway, shipyards, and an alota that was, together with Huelva and Palos, among the most active on the Huelva coast. Toward the end of the 15th century, the town had a population of