soluble and transmembrane proteins often works, as it is only necessary to find out if a protein has such a domain at all. Of course, membrane proteins which don't have transmembrane α helices (e.g. porins) or which are fixed with a covalent bond cannot be found by SOSUI. Results The result page first shows general information (length, average hydrophobicity). If the protein in question is a transmembrane protein, the number of transmembrane domains and their localization is noted. A "hydropathy-profile" with colored accents of hydrophobic parts; the helical wheel diagrams of potential transmembrane domains are shown as well. The last image shows a schematic overview of the transmembrane protein's location. Sources Hirokawa, Boon-Chieng, Mitaku, SOSUI: Classification and secondary structure prediction for membrane proteins, Bioinformatics Vol.14 S.378-379 (1998) Masami Ikeda, Masafumi Arai, Toshio Shimizu, Evaluation of transmembrane topology prediction methods by using an experimentally characterized topology dataset, Genome Informatics 11: 426–427 (2000) External links SOSUI-homepage Bioinformatics software