Siddique's comedy thriller Sadhu Miranda. His role of a modern-day villain was a huge hit in Mysskin's film Anjathe (2008). His negative role was critically acclaimed and fetched him a nomination at the 56th Filmfare Awards South in the Best Supporting Actor category. Later that year, he starred in G. Marimuthu's Kannum Kannum. Regarding his performance, a critic noted that "Prasanna oozes sincerity and his ability to bring the Sathya and Murthy character to life with all the nuances of love, tenderness, humour and frustrations is one of the highlights of the film". He played the lead in Arun Vaidyanathan's Achchamundu! Achchamundu! (2009) opposite Sneha that dealt with the subject of paedophiles. It received rave reviews, and was very well received internationally, but failed at the domestic box office. Manjal Veyil also failed to be successful. During the period, he also worked as a voice actor, speaking dubbing for Aryan Rajesh in Cheran's Pokkisham on the insistence of the director. Then, alongside Sibiraj as antagonist, he starred in Shakthi Soundar Rajan's Naanayam as a protagonist produced by S.P.B. Charan's Capital Film Works. In Bale Pandiya, directed by Siddharth Chandrasekhar, Prasanna was replaced by Vishnu Vishal. He was seen in a supporting role as a local gangster in Baana Kaathadi. A review from Times of India wrote that "with his eyes-to-die-for and underplayed violence, Prasanna easily steals the show". In 2011, he performed a lead role alongside director-actor Cheran in the thriller film Muran. His character, a "spoiled brat" and son of a millionaire, again had negative shades. He was also approached for Lucky Jokers, which he could not take due to his busy schedule with Muran. He has been approached to play a vital role in the Malayalam Vellaripravinte Changathi, but eventually did not star in the film. In 2013, he played a doctor in the Chennaiyil Oru Naal, a remake of the Malayalam film Traffic (2011). The film featured an ensemble cast and released to positive reviews. That same year, he made his Telugu debut with Bhai and starred in the successful romantic comedy Kalyana Samayal Saadham. Regarding his performance, a critic stated that "Prasanna deserves special credit for playing a role that most actors would hesitate to take up". 2014 saw the release of Pulivaal and the long delayed Netru Indru; both films featured himself and Vimal in the lead. The former was directed by Marimuthu and was