diabetics. Methylglyoxal binds directly to the nerve endings and by that increases the chronic extremity soreness in diabetic neuropathy. Occurrence, other Methylglyoxal is a component of some kinds of honey, including mānuka honey; it appears to have activity against E. coli and S. aureus and may help prevent formation of biofilms formed by P. aeruginosa . Research suggests that Methylglyoxal contained in honey does not cause an increased formation of advanced glycation end products (AGEs) in healthy persons. References Aldehydes Endogenous aldehydes GABAA receptor agonists Metabolism Conjugated ketones