Issus may refer to: Issus (Cilicia), an ancient settlement in the modern Turkish province of Hatay Battle of Issus, in 333 BC, in which Alexander the Great defeated Darius III Issus (river), a river near the town and battle site Issus (diocese), a Roman Catholic titular see in the town Gulf of Issus, near the town Issus, Haute-Garonne, a commune in France Issus (planthopper), a genus of planthoppers in the family Issidae Issus, the ostensible Goddess of Death and Eternal Life in the Barsoom series of novels See also Isus (disambiguation)