In medicine, Goodell's sign is an indication of pregnancy. It is a significant softening of the vaginal portion of the cervix from increased vascularization. This vascularization is a result of hypertrophy and engorgement of the vessels below the growing uterus. This sign occurs at approximately six weeks' gestation. The sign is named after William Goodell (gynecologist) (1829-1874). See also Chadwick's sign Hegar's sign Ladin's sign References Medical signs Obstetrics Midwifery