triethylamine are structurally very similar, with both compounds considered hindered organic bases. Due to their structural similarity, DIPEA and triethylamine can be used interchangeably in most applications. The nitrogen atom in DIPEA is more shielded than the nitrogen atom in triethylamine. However, triethylamine is a slightly stronger base than DIPEA; the pKas of the respective conjugate acids in dimethyl sulfoxide are 9.0 and 8.5, respectively. References Alkylamines Non-nucleophilic bases Diisopropylamino compounds Tertiary amines