below). Only some Schedule 3 medicines may be advertised to the public. Examples: Orlistat (trade name Xenical) Pseudoephedrine (marketed in Cold and Flu preparations) Salbutamol (Ventolin/Asmol) Schedule 4: Prescription Only Medicine Schedule 4 (S4) drugs and poisons, otherwise known as prescription only medicines, are substances and preparations for therapeutic use that – require professional medical, dental, or veterinary management or monitoring; are for ailments or symptoms that require professional medical, dental, or veterinary diagnosis or management; may require further evaluation for safety or efficacy; are new therapeutic substances. cost of the drug is high, or when there is a risk of dependence The price of many Schedule 4 substances are subsidized by the Australian Government through the Pharmaceutical Benefits Scheme (PBS), when prescribed by an authorized prescriber. Certain medications may require an authority from the PBS. Situations that may require an authority include where the drug may only have benefit in limited conditions, the true cost of the drug is high, or when there is a risk of dependence. Some states have subsets of Schedule 4 with additional requirements (see below). Schedule 4 medicines cannot be advertised directly to the public. Examples: Amoxicillin Anabolic steroids Apomorphine Cannabidiol in preparations for therapeutic use containing 2 percent or less of other cannabinoids found in cannabis (since June 2015) Cisplatin Co-codamol preparations comprising codeine and paracetamol Ephedrine Ergotamine Oestradiol Fluticasone Ibogaine Isotretinoin Methoxyflurane Pseudoephedrine in large doses Salmeterol Tramadol Tretinoin Trimethoprim All benzodiazepines except flunitrazepam and alprazolam All: SSRIs (e.g. fluoxetine, citalopram), SNRIs (e.g. duloxetine, milnacipran), TCAs (e.g. amitriptyline, imipramine) MAOIs (e.g. selegiline, moclobemide). Antipsychotic drugs (e.g. aripiprazole, quetiapine) Schedule 5: Caution Schedule 5 (S5) drugs and poisons are substances and preparations that must have appropriate packaging and simple warning labels to display that these poisons: have low toxicity or a low concentration; have a low to moderate hazard; can cause only minor adverse effects to the human being in normal use; require caution in handling, storage, or use. Examples: Ammonia Acetic acid (>30%) Boric acid Chlorinating compounds Clove oil Ivermectin (for use in animals) Lidocaine Methylated Spirits Petrol Some of the above examples are subject to exceptions dependant on the specific preparation, concentration, or inclusion in other schedules. Schedule 6: Poison Must use distinctive packaging and strong warnings to display the potential for: moderate to high toxicity; that may cause death or severe injury if ingested, inhaled, or in contact with the