The high-speed minesweeper again sailed westward on 23 September, departing Mare Island, bound for Pearl Harbor. Reaching Oahu on 30 September, she remained in the Hawaiian operating area for the rest of the year 1943 and through mid-January 1944. 1944 to 1945 Departing Pearl Harbor on 22 January 1944, Zane subsequently took part in Operation Flintlock, the invasion of the Marshall Islands. As part of the Southern Attack Force, Zane was assigned escort duties in the Southern Transport Screen, TU 52.7.1, in company with sistership Perry, four destroyers, and two subchasers (SC's). She screened transports during the Kwajalein phase of "Flintlock" and subsequently served as "sweep" ship and mine disposal vessel during the invasion and occupation of Eniwetok. In that part of the operation, she suffered minor damage from exploding mines, some of which exploded within 100 yards of the ship. After returning to Pearl Harbor in March for availability, Zane during the summer participated in her last major operation, Operation Forager conducted in the Mariana Islands and Palau. Again working as mine disposal vessel, Zane was part of Task Group 12.13, the Minesweeping and Hydrographic Survey Group. Unit 2, to which the ship was attached, included three of her sisterships: , , and . During the landing phases of "Forager", which commenced on 15 June when Vice Admiral Turner's Task Force 52 (the Northern Attack Force) began sending ashore the marines under the command of Lieutenant General H. M. Smith, USMC, Zane laid down buoys and destroyed drifting mines with gunfire, working once more as mine-destruction vessel. She spotted several planes attacking the beachheads, but all were beyond the range of her guns. Subsequently, when marines and Army troops under Major General Roy S. Geiger went ashore on Guam on 22 July under the covering gunfire of Rear Admiral Harry W. Hill's task force, Zane worked as an antisubmarine escort vessel, steaming in the vanguard of a reserve transport group, TG 53.19. Significantly, the Guam operation proved to be the last front-line tour for the veteran high-speed minesweeper; for, after remaining in the Marianas until 8 August, she reported to Commander, Service Squadron (ServRon) 10, at Ulithi, in the Carolines, for duty as a target-towing vessel. Zane performed target-towing and local escort duties for the remainder of the war, touching in the Palaus, Marianas, Carolines, and Philippines before V-J Day in mid-August 1945 found her at anchor in San