in addition have new fusions that potentially increase metabolic flux. Detection In recent years, next generation sequencing technology has already become available to screen known and novel gene fusion events on a genome wide scale. However, the precondition for large scale detection is a paired-end sequencing of the cell's transcriptome. The direction of fusion gene detection is mainly towards data analysis and visualization. Some researchers already developed a new tool called Transcriptome Viewer (TViewer) to directly visualize detected gene fusions on the transcript level. Research applications Biologists may also deliberately create fusion genes for research purposes. The fusion of reporter genes to the regulatory elements of genes of interest allows researches to study gene expression. Reporter gene fusions can be used to measure activity levels of gene regulators, identify the regulatory sites of genes (including the signals required), identify various genes that are regulated in response to the same stimulus, and artificially control the expression of desired genes in particular cells. For example, by creating a fusion gene of a protein of interest and green fluorescent protein, the protein of interest may be observed in cells or tissue using fluorescence microscopy. The protein synthesized when a fusion gene is expressed is called a fusion protein. See also Chimeric gene De novo gene birth ETV6-NTRK3 gene fusion Exon shuffling Gene duplication Horizontal gene transfer List of RNA-Seq bioinformatics tools Mobile genetic elements References External links ChiTaRS 5.0: The Improved Database of Chimeric Ttanscripts and RNA-seq Data. ChiPPI: The Server Protein-Protein Interaction of Chimeric Proteins. ChimerDB 2.0: a knowledgebase for fusion genes updated. dbCRID: a new, comprehensive database of human CR events and associated diseases (both tumor and non-tumor) with detailed documentation of the CR events. Mitelman Database : a database relates chromosomal aberrations to tumor characteristics, based either on individual cases or associations. Mutation Modification of genetic information