– c. 370 BC) and his followers were first to describe many diseases and medical conditions. Galen (129 – c. 200 AD) performed many audacious operations—including brain and eye surgeries— that were not tried again for almost two millennia. The mathematician Euclid laid down the foundations of mathematical rigour and introduced the concepts of definition, axiom, theorem and proof still in use today in his Elements, considered the most influential textbook ever written. Archimedes, considered one of the greatest mathematicians of all time, is credited with using the method of exhaustion to calculate the area under the arc of a parabola with the summation of an infinite series, and gave a remarkably accurate approximation of pi. He is also known in physics for laying the foundations of hydrostatics and the explanation of the principle of the lever. Theophrastus wrote some of the earliest descriptions of plants and animals, establishing the first taxonomy and looking at minerals in terms of their properties such as hardness. Pliny the Elder produced what is one of the largest encyclopedias of the natural world in 77 AD, and must be regarded as the rightful successor to Theophrastus. For example, he accurately describes the octahedral shape of the diamond, and proceeds to mention that diamond dust is used by engravers to cut and polish other gems owing to its great hardness. His recognition of the importance of crystal shape is a precursor to modern crystallography, while mention of numerous other minerals presages mineralogy. He also recognises that other minerals have characteristic crystal shapes, but in one example, confuses the crystal habit with the work of lapidaries. He was also the first to recognise that amber was a fossilized resin from pine trees because he had seen samples with trapped insects within them. India Excavations at Harappa, Mohenjo-daro and other sites of the Indus Valley civilization (IVC) have uncovered evidence of the use of "practical mathematics". The people of the IVC manufactured bricks whose dimensions were in the proportion 4:2:1, considered favourable for the stability of a brick structure. They used a standardised system of weights based on the ratios: 1/20, 1/10, 1/5, 1/2, 1, 2, 5, 10, 20, 50, 100, 200, and 500, with the unit weight equaling approximately 28 grammes (and approximately equal to the English ounce or Greek uncia). They mass-produced weights in regular geometrical shapes, which included hexahedra, barrels, cones, and cylinders, thereby