tissue sarcomas of diverse histological subtypes and 28 breast cancers. Additional features of the syndrome included an excess of brain tumors (14 cases), leukemia (9 cases), and adrenocortical carcinoma (4 cases) before age 45 years. These neoplasms also accounted for 73% of the multiple primary cancers occurring in 15 family members. Six of these patients had second cancers linked to radiotherapy. The diversity of tumor types in this syndrome suggests pathogenetic mechanisms which differ from hereditary cancers arising in single organs or tissues. The syndrome is presently diagnosed on clinical grounds; laboratory markers are needed to identify high-risk individuals and families and to provide insights into susceptibility mechanisms that may be shared by a wide variety of cancers." Following these families for twenty years along with the 1990 discovery of inherited (germline) p53 gene mutations led to these mutations as being linked to causing Li-Fraumeni Syndrome. The p53 gene is known as the tumor suppressor gene. Awards 1999 Medal of Honor for Clinical Research, American Cancer Society 1998 Harry and Elsa Jiler Clinical Research Professorship, American Cancer Society 1995 Award for Research Excellence in Cancer Epidemiology and Prevention, American Association for Cancer Research/American Cancer Society 1995 Charles S. Mott Prize, General Motors Cancer Research Foundation References External links Biography of Frederick Pei Li on Who Named It? Dana–Farber Cancer Institute Researcher Profile - Frederick P. Li, MD 1940 births 2015 deaths American oncologists New York University alumni University of Rochester alumni Harvard School of Public Health faculty Harvard Medical School faculty Georgetown University alumni Chinese emigrants to the United States Physicians from New York City 20th-century American physicians 21st-century American physicians Fellows of the AACR Academy Deaths from dementia in Massachusetts Deaths from Alzheimer's disease