Naval District, in Panama Bay. In December 1941, in the face of the growing U-boat campaign in the Caribbean, she replaced as flagship of Destroyer Division 67, which also included and . On 15 June 1942, she rescued survivors of USAT Merrimac, which had been torpedoed. After returning to Philadelphia in November 1942, Borie went to New Orleans for an overhaul and then was reassigned to the Caribbean. During her refit, she had surface search radar installed; four of her .30 cal. (7.62 mm) machine guns were removed, and replaced with two single-mount Oerlikon 20 mm AA guns. For three months beginning in February 1943, Borie, Barry and Goff were attached to Escort Unit 23.2.4 with gunboats and and the patrol craft PC-575 and PC-592, which operated between Trinidad and Recife, Brazil with Admiral Jonas Ingram's South Atlantic Fleet (later Fourth Fleet). The escort unit accompanied convoys from Trinidad to Recife, where it was relieved by Brazilian Navy units who took the convoys to Bahia. Patrols with Task Group 21.14 Returning to Norfolk, Virginia in May, the three destroyers escorted convoy UGS-13 to Casablanca, French Morocco and on their return were assigned to hunter killer Task Group 21.14, escorting the escort carrier under her Captain Arnold J. Isbell. On 26 June 1943, under the command of Lt. Cdr. Charles H. Hutchins, at the time the youngest destroyer commander in the Navy, the destroyer departed the Caribbean and on 30 July put to sea in the North Atlantic as a member of the antisubmarine group built around Card. Borie completed three patrols with Cards group, providing valuable support for sister ships in the pursuit and sinking of German U-boats. The Presidential Unit Citation was awarded to Task Group 21.14 for actions during these three patrols: In late October 1943, TG 21.14 went out for a fourth patrol, searching for a reported refueling concentration of U-boats around a Milchkuhe (Milk Cow) tanker sub in the North Atlantic. The report was the result of the triangulation of bearings taken with high frequency radio direction finders (HFDF, nicknamed "huff-duff"). Final battle with U-405 During her fourth patrol, Borie got a radar contact on shortly after 1943 hours, 31 October and closed in. The U-boat promptly crash-dived. Two depth charge attacks forced her back to the surface, but she again submerged; after a third attack, a large oil slick was observed. Though U-256 made it