Scombroid food poisoning, also known as simply scombroid, is a foodborne illness that typically results from eating spoiled fish. Symptoms may include flushed skin, headache, itchiness, blurred vision, abdominal cramps, and diarrhea. Onset of symptoms is typically 10 to 60 minutes after eating and can last for up to two days. Rarely, breathing problems or an irregular heartbeat may occur. Scombroid occurs from eating fish high in histamine due to inappropriate storage or processing. Fish commonly implicated include tuna, mackerel, mahi mahi, sardine, anchovy, herring, bluefish, amberjack, and marlin. These fish naturally have high levels of histidine, which is converted to histamine when bacterial growth occurs during improper storage. Subsequent cooking, smoking, or freezing does not eliminate the histamine. Diagnosis is typically based on the symptoms and may be supported by a normal blood tryptase. If a number of people who eat the same fish develop symptoms, the diagnosis is more likely. Prevention is by refrigerating or freezing fish right after it is caught. Treatment is generally with antihistamines such as diphenhydramine and ranitidine. Epinephrine may be used for severe symptoms. Along with ciguatera fish poisoning, it is one of the most common type of seafood poisoning. It occurs globally in both temperate and tropical waters. Only one death has been reported. The condition was first described in 1799. Signs and symptoms Symptoms typically occur within 10–30 minutes of ingesting the fish and generally are self-limited. People with asthma are more vulnerable to respiratory problems such as wheezing or bronchospasms. However, symptoms may show over two hours after eating a spoiled dish. They usually last for about 10 to 14 hours, and rarely exceed one to two days. Initial The first signs of poisoning suggest an allergic reaction with these symptoms: facial flushing/sweating burning-peppery taste sensations in the mouth and throat dizziness nausea headache tachycardia cold-like symptoms Additional symptoms The above symptoms can advance to: facial rash (intense itching may accompany the rash) torso or body rash: The rash associated with scombroid poisoning is a form of urticaria, but most commonly does not include wheals (patchy areas of skin-swelling also known as hives) that may be seen in true allergies. edema (generalized if it occurs at all) short-term diarrhea abdominal cramps Severe In the worst cases, the poisoning may cause: blurred vision respiratory distress swelling of the tongue In rare cases, the poisoning may result in death. Causes Unlike many