in a hyperspace with as many dimensions as there are critical variables. This is a more or less direct adaptation of Ashby's "homeostat", first adopted into PCT in the 1960 paper and then changed to use E. coli's method of navigating up gradients of nutrients, as described by Koshland (1980). Reorganization may occur at any level when loss of control at that level causes intrinsic (essential) variables to deviate from genetically determined set points. This is the basic mechanism that is involved in trial-and-error learning, which leads to the acquisition of more systematic kinds of learning processes. Psychotherapy: the method of levels (MOL) The reorganization concept has led to a method of psychotherapy called the method of levels (MOL). Using MOL, the therapist aims to help the patient shift his or her awareness to higher levels of perception in order to resolve conflicts and allow reorganization to take place. Neuroscience Learning Currently, no one theory has been agreed upon to explain the synaptic, neuronal or systemic basis of learning. Prominent since 1973, however, is the idea that long-term potentiation (LTP) of populations of synapses induces learning through both pre- and postsynaptic mechanisms. LTP is a form of Hebbian learning, which proposed that high-frequency, tonic activation of a circuit of neurones increases the efficacy with which they are activated and the size of their response to a given stimulus as compared to the standard neurone (Hebb, 1949). These mechanisms are the principles behind Hebb's famously simple explanation: "Those that fire together, wire together". LTP has received much support since it was first observed by Terje Lømo in 1966 and is still the subject of many modern studies and clinical research. However, there are possible alternative mechanisms underlying LTP, as presented by Enoki, Hu, Hamilton and Fine in 2009, published in the journal Neuron. They concede that LTP is the basis of learning. However, they firstly propose that LTP occurs in individual synapses, and this plasticity is graded (as opposed to in a binary mode) and bidirectional. Secondly, the group suggest that the synaptic changes are expressed solely presynaptically, via changes in the probability of transmitter release. Finally, the team predict that the occurrence of LTP could be age-dependent, as the plasticity of a neonatal brain would be higher than that of a mature one. Therefore, the theories differ, as one proposes an on/off occurrence of LTP by pre- and postsynaptic mechanisms