Mississippi Highway 6 (MS 6) runs east–west from MS 161 in Lyon, east to MS 25 near Amory. It travels approximately , serving Coahoma, Quitman, Panola, Lafayette, Pontotoc, Lee, and Monroe Counties. West of Tupelo, it is concurrent with US 278. Points of interest along the route include the University of Mississippi, Trace State Park, Natchez Trace Parkway, the Elvis Presley Birthplace, and Tombigbee State Park. Route description MS 6 begins in the Mississippi Delta region in Coahoma County at an intersection with MS 161 near the Clarksdale-Lyon city line. It heads east as a two-lane highway for not even a mile to an interchange with US 49/US 61, where it becomes concurrent with US 278. MS 6/US 278 now leave the Clarksdale area and pass through farmland for several miles, where it crosses the same bayou three times, before entering Quitman County. MS 6/US 278 pass through Barksdale before having an intersection with MS 316 at West Marks and entering the town of Marks shortly thereafter. It mostly bypasses the town along its northern outskirts, where it has an intersection with MS 3 and crosses the Coldwater River. The highway now enters Panola County, after passing through Bobo and crossing the Peach Creek. MS 6/US 278 pass through Locke Station before crossing the Tallahatchie River and entering Batesville shortly thereafter. The highway passes through some neighborhoods and business districts as it bypasses downtown along its southern side and has a concurrency with MS 35. It widens to a four-lane undivided highway at an intersection with US 51, where MS 35 splits off, before passing through a major business district to come to an interchange with I-55 (Exit 243). MS 6/US 278 now widen to a divided highway as it leaves Batesville and enters the North Central Hills region. The highway now has an interchange and concurrency with MS 315, which splits off unsigned onto Black Jack Road, providing access to Sardis Lake and John W. Kyle State Park. MS 6/US 278 now cross into Lafayette County. MS 6/US 278 now enter Oxford and bypass that city along a southern freeway bypass, where it passes by the main campus of the University of Mississippi (Ole Miss), as well as having interchanges with MS 7 and MS 334. It has an at-grade intersection with University Avenue (unsigned MS 738) before leaving Oxford. The highway now passes through Lafayette Springs, where it