of warfarin or similar anticoagulants decreases hepatic synthesis of FVII. A coagulation enzyme cascade may begin with a few molecules of factor XII and culminate in the activation of millions of times more fibrin molecules. Structure Factor VII shares a common domain architecture with factors IX and X. Genetics The gene for factor VII is located on chromosome 13 (13q34). Role in disease Factor VII deficiency (congenital proconvertin deficiency) is rare and inherited recessively. It presents as a hemophilia-like bleeding disorder. It is treated with recombinant factor VIIa (NovoSeven or AryoSeven). Gene therapy approaches for treating FVII deficiency are very promising () Medical uses Recombinant factor VIIa, marketed under the trade names AryoSeven and NovoSeven, is used for people with hemophilia (with Factor VIII or IX deficiency) who have developed antibodies against replacement coagulation factor. It has also been used in the setting of uncontrollable hemorrhage, but its role in this setting is controversial with insufficient evidence to support its use outside of clinical trials. The first report of its use in hemorrhage was in an Israeli soldier with uncontrollable bleeding in 1999. Risks of its use include an increase in arterial thrombosis. However, animal studies have not shown complications as seen in humans, in fact same of the studies show a better prognosis. In the military settings it is used as an off label intervention in complications related to disseminated intravascular coagulation related haemorrhage caused by penetrating trauma. Recombinant human factor VII while initially looking promising in intracerebral hemorrhage failed to show benefit following further study and this is no longer recommended. Interactions Factor VII has been shown to interact with tissue factor and protein kinase C. References Further reading External links Official website The MEROPS online database for peptidases and their inhibitors: S01.215 CHES - Comprehensive Health Education Services LLC - Factor VII treatment and awareness Coagulation system EC 3.4.21 Peripheral membrane proteins