Senate Minority Whip in 1915 because the Democrats held the majority of Senate seats. He was re-elected in 1920 but defeated by Democrat Robert F. Wagner in 1926. In 1921, Wadsworth was considered for the post of Secretary of War by President Warren G. Harding but was ultimately passed over in favor of John W. Weeks. Wadsworth was a proponent of individual rights and feared what he considered the threat of federal intervention into the private lives of Americans. He believed that the only purpose of the United States Constitution is to limit the powers of government and to protect the rights of citizens. For this reason, he voted against the Eighteenth Amendment when it was before the Senate. Before Prohibition went into effect, Wadsworth predicted that there would be widespread violations and contempt for the law. By the mid-1920s, Wadsworth was one of a handful of congressmen who spoke out forcefully and frequently against prohibition. He was especially concerned that citizens could be prosecuted by both state and federal officials for a single violation of prohibition law. This seemed to him to constitute double jeopardy, inconsistent with the spirit if not the letter of the Fifth Amendment. The Fifth Amendment in criminal cases prevents two trials for the same offense in the same level of court, not two trials for the same charge in separate state and national jurisdictions. In 1926, he joined the Association Against the Prohibition Amendment and made 131 speeches across the country for the organization between then and repeal. His political acumen and contacts proved valuable in overturning prohibition. He served in the U.S. House from 1933 to 1951, and, like Alton Lennon, Garrett Withers, Claude Pepper, Hugh Mitchell, Matthew M. Neely, and Magnus Johnson, is one of the few modern Senators to serve later in the House of Representatives. In the House of Representatives, he opposed the isolationism of many of his conservative Republican colleagues, opposed anti-lynching legislation on state's rights grounds, rejected minimum wage laws and most of FDR's domestic policy. Although Wadsworth never ran for president, his name was mentioned as a possible candidate in 1936 and 1944. A confidential 1943 analysis of the House Foreign Affairs Committee by Isaiah Berlin for the British Foreign Office described Wadsworth as He was a hereditary companion of Military Order of the Loyal Legion of the United States and was also a member of the