her arrival at Saint Mary-of-the-Woods in July 1840 to January 1849, Mother Théodore worked with Catholic parishes to establish parish schools at several sites within the Diocese of Vincennes. Guérin personally directed the establishment of Saint Joseph School (1842) in Jasper; Saint Anne's Academy (1844) in Madison; Saint Augustine's (1846) in Fort Wayne; and Saint Vincent's Academy (1849) in Terre Haute, Indiana; as well as a school in Saint Francisville, Illinois. After her return to the United States from a fundraising trip to France, Guérin and the Sisters of Providence established six other schools in Indiana: two in Evansville, Saint Joseph's Academy (1853) and Assumption (1853); Saint Patrick's (1853) in North Madison; Saint Mary's (1853) at Fort Wayne; Saint Mary's (1854) at Lanesville; and Saint Bartholomew (1855) at Columbus. Bishop Hailandière established two additional schools in Indiana while Guérin was traveling in France and assigned them to the Sisters of Providence to operate: St. Peter-Montgomery (1843) and Saint Mary Female School-Vincennes (1843). In addition to establishing schools, Mother Théodore and the Sisters of Providence cooperated with Bishop John Stephen Bazin, Hailandière's successor, and Bishop Jacques-Maurice de Saint-Palais, Bazin's successor, in the establishment of two orphanages in Vincennes and free pharmacies at Vincennes and Saint Mary-of-the-Woods. Business and congregation leader Guérin proved to be a skilled businesswoman and leader and a beloved general superior and spiritual leader of the Sisters of Providence of Saint Mary-of-the-Woods. She arranged to purchase a local farmhouse belonging to the Thralls family to serve as the congregation's first convent at Saint Mary-of-the-Woods. She oversaw the construction of a new Providence convent, which was formally dedicated on 7 August 1854. During the final years, Guerin was planning to build a new chapel at the convent in honor of the Blessed Virgin; however, she did not live to see it completed. The Church of the Immaculate Conception (Saint Mary-of-the-Woods, Indiana), her last major project, was completed in 1886. Despite numerous challenges and hardships during the congregation's early years, which included rebuilding after destructive fires and crop failures, prudent use of limited finances, and negotiating disagreements with Catholic leaders, Guérin remained devoted to her work and the Sisters of Providence of Saint Mary-of-the-Woods endured. By the time of her death in May 1856, the Sisters of Providence congregation in Indiana had grown from its original six sisters and four postulants to sixty-seven professed members, nine novices, and seven postulants.