a further development of SPDM the so-called SPDMphymod technology which makes it possible to detect and count two different fluorescent molecule types at the molecular level (this technology is referred to as two-color localization microscopy or 2CLM). Alternatively, the advent of photoactivated localization microscopy could achieve similar results by relying on blinking or switching of single molecules, where the fraction of fluorescing molecules is very small at each time. This stochastic response of molecules on the applied light corresponds also to a highly nonlinear interaction, leading to subdiffraction resolution. Fluorescence micrograph gallery See also Fluorescence imaging Fluorescence in the life sciences Correlative Light-Electron Microscopy Elizabeth Harry, pioneer of fluorescence microscopy techniques for visualization of bacterial subcellular proteins Green fluorescent protein (GFP) Mercury-vapor lamp Microscope Scanning electron microscope#Cathodoluminescence Stokes shift Xenon arc lamp References External links Fluorophores.org, the database of fluorescent dyes Microscopy Resource Center animations and explanations on various types of microscopes including fluorescent and confocal microscopes (Université Paris Sud) Fluorescence Cell imaging Laboratory equipment Optical microscopy techniques Microscopes