B61 may refer to: B61 nuclear bomb B61 (New York City bus) in Brooklyn HLA-B61, an HLA serotype Sicilian, Richter-Rauzer, Encyclopaedia of Chess Openings code Alternative name for the ephrin A1, human gene B-61 may refer to: B-61 Matador, the first operational surface-to-surface cruise missile built by the United States