Patricia Anne Wettig (born December 4, 1951) is an American actress and playwright. She is best known for her role as Nancy Weston in the television series Thirtysomething (1987–1991), for which she received a Golden Globe Award and three Primetime Emmy Awards. After her breakthrough role in Thirtysomething, Wettig has appeared in a number of films, including Guilty by Suspicion (1991), City Slickers (1991), City Slickers II: The Legend of Curly's Gold (1994), and The Langoliers (1995). She returned to television playing a leading role in the 1995 short-lived drama Courthouse and later played Caroline Reynolds in the Fox drama Prison Break (2005–2007) and Holly Harper in the ABC family drama Brothers & Sisters (2006–2011). Early life Wettig was born in Milford, Ohio, to Florence (née Morlock) and Clifford Neal Wettig, a high school basketball coach. She has three sisters: Pam, Phyllis, and Peggy. She was raised in Grove City, Pennsylvania and graduated in 1970. She attended Ohio Wesleyan University and graduated from Temple University in 1975. She returned to her studies later in life and received a Master of Fine Arts in playwriting from Smith College in 2001. F2M, a play she authored, was performed in 2011 as part of the New York Stage and Film and Vassar College's 2011 Powerhouse Theater season. Career Wettig began her career on stage and worked as a personal dresser for Shirley MacLaine. On television, she appeared in episodes of 1980s dramas Remington Steele, Hill Street Blues and L.A. Law, before taking a recurring role as Joanne McFadden in the NBC medical drama series St. Elsewhere from 1986 to 1987. Later in 1987, Wettig was cast as Nancy Weston in the ABC drama series thirtysomething. For her role in Thirtysomething, Wettig received critical acclaim. Her portrayal of Nancy's cancer struggle attracted considerable acclaim and attention. She won three Primetime Emmy Awards: for Outstanding Supporting Actress in a Drama Series in 1988, and for Outstanding Lead Actress in a Drama Series in 1990 and 1991. In 1991, she won Golden Globe Award for Best Actress – Television Series Drama. The series ended in 1991 after four seasons. Later that year, she made her big screen debut in the drama film Guilty by Suspicion starring opposite Robert De Niro and Annette Bening. She played Billy Crystal's wife in the comedy films City Slickers (1991) and City Slickers II: The Legend of Curly's Gold (1994). In