1991, a Spacelab Life Sciences 1 flight performed 18 experiments on two men and two women over nine days. In an environment without gravity, it was concluded that the response of white blood cells and muscle mass decreased. Additionally, within the first 24 hours spent in a weightless environment, blood volume decreased by 10%. Long weightless periods can cause brain swelling and eyesight problems. Upon return to Earth, the effects of prolonged weightlessness continue to affect the human body as fluids pool back to the lower body, the heart rate rises, a drop in blood pressure occurs, and there is a reduced tolerance for exercise. Artificial gravity, for its ability to mimic the behavior of gravity on the human body, has been suggested as one of the most encompassing manners of combating the physical effects inherent in weightless environments. Other measures that have been suggested as symptomatic treatments include exercise, diet, and Pingvin suits. However, criticism of those methods lies in the fact that they do not fully eliminate health problems and require a variety of solutions to address all issues. Artificial gravity, in contrast, would remove the weightlessness inherent in space travel. By implementing artificial gravity, space travelers would never have to experience weightlessness or the associated side effects. Especially in a modern-day six-month journey to Mars, exposure to artificial gravity is suggested in either a continuous or intermittent form to prevent extreme debilitation to the astronauts during travel. Proposals Several proposals have incorporated artificial gravity into their design: Discovery II: a 2005 vehicle proposal capable of delivering a 172-metric-ton crew to Jupiter's orbit in 118 days. A very small portion of the 1,690-metric-ton craft would incorporate a centrifugal crew station. Multi-Mission Space Exploration Vehicle (MMSEV): a 2011 NASA proposal for a long-duration crewed space transport vehicle; it included a rotational artificial gravity space habitat intended to promote crew health for a crew of up to six persons on missions of up to two years in duration. The torus-ring centrifuge would utilize both standard metal-frame and inflatable spacecraft structures and would provide 0.11 to 0.69 g if built with the diameter option. ISS Centrifuge Demo: a 2011 NASA proposal for a demonstration project preparatory to the final design of the larger torus centrifuge space habitat for the Multi-Mission Space Exploration Vehicle. The structure would have an outside diameter of with a ring interior cross-section diameter of . It would