North America. Large-scale Jewish immigration commenced in the 19th century, when, by mid-century, many German Jews had arrived, migrating to the United States in large numbers due to antisemitic laws and restrictions in their countries of birth. They primarily became merchants and shop-owners. Gradually early Jewish arrivals from the east coast would travel westward, and in the fall of 1819 the first Jewish religious services west of the Appalachian Range were conducted during the High Holidays in Cincinnati, the oldest Jewish community in the Midwest. Gradually the Cincinnati Jewish community would adopt novel practices under the leadership Rabbi Isaac Meyer Wise, the father of Reform Judaism in the United States, such as the inclusion of women in minyan. A large community grew in the region with the arrival of German and Lithuanian Jews in the latter half of the 1800s, leading to the establishment of Manischewitz, one of the largest producers of American Kosher products and now based in New Jersey, and the oldest continuously published Jewish newspaper in the United States, and second-oldest continuous published in the world, The American Israelite, established in 1854 and still extant in Cincinnati. By 1880 there were approximately 250,000 Jews in the United States, many of them being the educated, and largely secular, German Jews, although a minority population of the older Sephardi Jewish families remained influential. Jewish migration to the United States increased dramatically in the early 1880s, as a result of persecution and economic difficulties in parts of Eastern Europe. Most of these new immigrants were Yiddish-speaking Ashkenazi Jews, most of whom arrived from poor diaspora communities of the Russian Empire and the Pale of Settlement, located in modern-day Poland, Lithuania, Belarus, Ukraine, and Moldova. During the same period, great numbers of Ashkenazic Jews also arrived from Galicia, at that time the most impoverished region of the Austro-Hungarian Empire with a heavy Jewish urban population, driven out mainly by economic reasons. Many Jews also emigrated from Romania. Over 2,000,000 Jews landed between the late 19th century and 1924, when the Immigration Act of 1924 restricted immigration. Most settled in the New York metropolitan area, establishing the world's major concentrations of Jewish population. In 1915, the circulation of the daily Yiddish newspapers was half a million in New York City alone, and 600,000 nationally. In addition thousands more subscribed to the numerous weekly papers and the many magazines in Yiddish. At the