New Orleans to meet Faust LaChapelle (a goat), a failed musician who found success signing more talented yet less fortunate musicians to record labels. They learn that LaChapelle has terminal cancer, and is being treated by Ms. Gibraltar, a vodou priestess. LaChapelle begs Blacksad to find Sebastian "Little Hand" Fletcher (a Boxer), who – despite having one arm smaller than the other – was the most successful musician he ever signed. Fletcher has gone missing, and LaChapelle is concerned that his addiction to heroin has something to do with it. Blacksad and Weekly accept the case. The pair soon meet Leeman (a hippopotamus), the last detective who was hired to find Fletcher. He proposes they all work together, but Blacksad is put off by his reckless driving and alcoholism. Blacksad tracks down and roughs up Fletcher's drug dealer, who admits that a masked individual paid him to sell poisoned heroin to Fletcher. Later, Blacksad meets LaChapelle's son, Thomas, who has formed a friendship with Fletcher's pregnant wife, Hannah. The two get on well until Thomas asks Blacksad to give up the case for his father's sake; he believes Fletcher is a bad influence, and his father is wasting his money trying to find him when he could be saving it for his cancer treatment. Disappointed, Blacksad walks out. The conversation does lead him to ponder if Thomas cares for Hannah more than a friend and may be jealous of Fletcher's attentions. Later, Blacksad finds Thomas and Hannah as she gives birth to Fletcher's son. Despite Thomas' insistence that he leave her alone, he questions her as to her husband's whereabouts. Hannah states that Fletcher was supposed to perform his newest song that night, but that LaChapelle had been enraged when he found out. Meanwhile, Weekly discovers that some of Fletcher's friends seem to have been mysteriously murdered in staged suicides, causing Blacksad to fear that someone might be after Sebastian's life as well. At a nightclub, Fletcher performs his new song, detailing how he had become congenitally deformed and many others had died due to a carcinogenic flu balm that was being sold in his hometown by the mysterious "Dr. Dupre", and how bureaucratic payoffs kept Dupre from prison once he was found out. LaChapelle saved them from poverty by signing them all to a successful band. However, the conditions eventually caught up with them, leading them to lives full