La Jolla Institute for Immunology is a non-profit research organization located in La Jolla, California. It is located in UC San Diego’s Research Park. The institute researches immunology and immune system diseases. The institute employs 220 M.D.s and Ph.D.s, including 23 faculty members and more than 450 employees. Dr. Mitchell Kronenberg has served as its president and scientific director since 2003. The institute was founded in 1988. La Jolla Institute for Immunology is a collaborative research organization that has forged many partnerships within the research community in San Diego, across the United States, and abroad. The institute's biomedical research facility covers 145,000 square feet inclusive of specialized research rooms suited for all aspects of molecular and cellular biology. History La Jolla Institute for Immunology was established in 1988 by a coalition that included Makoto Nonaka, the institute's founding president, and Kimishige Ishizaka, the institute's first scientific director. In 1989 the institute began its laboratory operations with the arrival of two immunologists, Kimishige Ishizaka and Teruko Ishizaka, from Johns Hopkins University in Baltimore, Maryland. The Ishizakas were co-discoverers in 1966 of the IgE (immunoglobulin E) protein, a molecule that induces allergic reactions in the human body. In 1991, Kimishige Ishizaka was appointed president and scientific director of the institute and served in the role until his retirement in 1995. In 1995, Howard Grey joined La Jolla Institute of Immunology as president and scientific director. During the next several years, the institute recruited prominent faculty members and formulated a program to accelerate the commercial development of LJI's research and drug discoveries. In 1996, the institute moved from its initial location on Torrey Pines Road in La Jolla to a new purpose-built facility on Science Center Drive on the Torrey Pines Mesa. In 2003, Mitchell Kronenberg was appointed president and scientific director. That same year, the Immune Epitope Database (IEDB) was established and launched. The database was designed and developed by the La Jolla Institute under a competitive contract from the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH. In 2012, the NIH renewed their contract with the institute for a further seven years. In 2006 the institute opened a new research facility located in the new UC San Diego Science Research Park. In 2011, the institute opened the RNAi Center for Identifying Genetic Triggers of Disease. The center's goal is to propel scientific efforts to pinpoint the specific