chemerin may play an important role in the pathogenesis of obesity and insulin resistance. Studies in mice found that feeding mice a high-fat diet, resulted in increased expression of both chemerin and CMKLR1. In humans, chemerin levels are significantly different between individuals with normal glucose tolerance and individuals with type II diabetes and first degree relatives. Moreover, chemerin levels show a significant correlation with body mass index, plasma triglyceride levels and blood pressure. It was found incubation of 3T3-L1 cells with recombinant human chemerin protein facilitated insulin-stimulated glucose uptake. This suggests chemerin plays a role in insulin sensitivity and may be a potential therapeutic target for treating type II diabetes. References Further reading Proteins