| Brandon Roy (10) | Rose Garden20,638 | 11–6 |- bgcolor="#bbffbb" | 18 | November 30 | @ Detroit | | LaMarcus Aldridge (27) | Greg Oden (13) | Steve Blake (7) | The Palace of Auburn Hills22,076 | 12–6 |- bgcolor="#bbffbb" | 19 | December 2 | @ New York | | Brandon Roy (23) | Joel Przybilla (14) | Steve Blake (6) | Madison Square Garden18,664 | 13–6 |- bgcolor="#bbffbb" | 20 | December 3 | @ Washington | | Brandon Roy (22) | Greg Oden (10) | Sergio Rodríguez (7) | Verizon Center12,802 | 14–6 |- bgcolor="#ffcccc" | 21 | December 5 | @ Boston | | Travis Outlaw, LaMarcus Aldridge (13) | Joel Przybilla (8) | Steve Blake (4) | TD Banknorth Garden18,624 | 14–7 |- bgcolor="#bbffbb" | 22 | December 7 | @ Toronto | | LaMarcus Aldridge (20) | Greg Oden (10) | Brandon Roy (7) | Air Canada Centre17,671 | 15–7 |- bgcolor="#ffcccc" | 23 | December 9 | Orlando | | Brandon Roy (30) | LaMarcus Aldridge (13) | Sergio Rodríguez (7) | Rose Garden20,642 | 15–8 |- bgcolor="#ffcccc" | 24 | December 11 | @ Utah | | Brandon Roy (33) | Greg Oden (9) | Steve Blake (5) | EnergySolutions Arena19,911 | 15–9 |- bgcolor="#ffcccc" | 25 | December 12 | L.A. Clippers | | Brandon Roy (38) | Greg Oden (15) | Brandon Roy (9) | Rose Garden20,558 | 15–10 |- bgcolor="#bbffbb" | 26 | December 16 | Sacramento | | Brandon Roy (29) | Joel Przybilla (14) | Sergio Rodríguez, Brandon Roy (5) | Rose Garden20,005 | 16–10 |- bgcolor="#bbffbb" | 27 | December 18 | Phoenix | | Brandon Roy (52) | Travis Outlaw, Joel Przybilla (6) | Steve Blake (10) | Rose Garden20,650 | 17–10 |- bgcolor="#ffcccc" | 28 | December 22 | @ Denver | | LaMarcus Aldridge (20) | Joel Przybilla (8) | Brandon Roy (5) | Pepsi Center18,611 | 17–11 |- bgcolor="#bbffbb" | 29 | December 23 | Denver | | LaMarcus Aldridge (22) | Joel Przybilla (19) | Brandon Roy (6) | Rose Garden20,007 | 18–11 |- bgcolor="#ffcccc" | 30 | December 25 | Dallas | | Brandon Roy (22) | Brandon Roy, Joel Przybilla, Greg Oden (5) | Steve Blake (7) | Rose Garden20,643 | 18–12 |- bgcolor="#bbffbb" | 31 | December 27 | Toronto | | Brandon Roy (32) |