rare disorder, with 34 cases described in the literature as of 2005. Management Management of ACLS consists mainly of monitoring by a pediatric neuropsychiatrist and supportive therapies or accommodations such as occupational therapy and special education plans. Surgery may be considered in early childhood to remove extra digits in case of polydactyly or resolve orofacial defects such as cleft palate. If present, seizures and renal parenchymal hypertension may be treated with anticonvulsants and antihypertensive drugs, respectively. Patients may be offered genetic and vocational counselling when appropriate. Prognosis Lifespan may range from stillbirth to normal expectancy depending on severity of hypotonia and onset of epilepsy. Severe hypotonia can lead to fatal infant respiratory distress syndrome or apnea within the first days or weeks of life. Conversely, in mild cases, subjects live relatively normal lives with some developmental delays and mild to moderate intellectual disability. References External links Autosomal recessive disorders Rare genetic syndromes Ciliopathy Syndromes with dysmelia Syndromes with intellectual disability Corpus callosum Syndromes with cleft lip and/or palate Syndromes with craniofacial abnormalities