At his Pro Day on February 28, he measured in at 5-foot-11⅜ and 226 pounds. He ran the short shuttle in 4.44 seconds, short cone drill in 6.95 second, and had a 41½-inch vertical leap. On April 15, Parmele met with the Miami Dolphins for a pre-draft visit. Miami Dolphins Parmele was drafted by the Miami Dolphins in the sixth round (176th overall) of the 2008 NFL Draft. The pick used to select Parmele was acquired from the Detroit Lions. Shortly after the draft, Dolphins general manager Jeff Ireland labeled Parmele the third running back on the depth chart and said he would also be a given a chance to return kickoffs. During June workouts, Parmele worked with the second-team offense and also returned punts. After spending the first three games of the 2008 regular season inactive, Parmele was waived by the Dolphins on September 24 to make room for tight end Joey Haynos on the roster. Parmele was re-signed to the team's practice squad the following day. Baltimore Ravens Parmele was signed by the Baltimore Ravens off the Dolphins' practice squad on December 9, 2008. He made his NFL debut against the Jacksonville Jaguars in the regular season finale on December 28, rushing twice for 27 yards. They were his only stats that year. In his second season with the Ravens in 2009, he made a much bigger impact as he became the team's starting kick returner after rookie Lardarius Webb tore his ACL in Week 15. On only nine kick-off returns, Parmele racked up 283 yards for a 31.4 average with his longest return being 53 yards. He also added five carries for 17 yards as the team's #4 runningback and six special teams tackles. He had by this time developed a reputation has a hard worker. In 2010, Parmele did not rush once but continued his role as a backup returner. Parmele was released by Baltimore during final cuts on September 3, 2011. Jacksonville Jaguars Parmele was signed by the Jacksonville Jaguars on May 1, 2012. He began the season as a special teams player, including returning kicks. When Maurice Jones-Drew and two other running backs were injured, Parmele became the starting running back. He played in the Jaguars first 11 games before incurring a partially torn groin on November 27. Parmele was placed on injured reserve and surgery ended his season with 40 carries for 143