March 4 | @ New Jersey | | Paul Pierce (31) | Kendrick Perkins (13) | Paul Pierce, Rajon Rondo (5) | Izod Center15,791 | 48–14 |- bgcolor="#bbffbb" | 63 | March 6 | Cleveland | | Paul Pierce (29) | Leon Powe (11) | Rajon Rondo (10) | TD Banknorth Garden18,624 | 49–14 |- bgcolor="#ffcccc" | 64 | March 8 | Orlando | | Ray Allen (32) | Ray Allen (9) | Paul Pierce (3) | TD Banknorth Garden18,624 | 49–15 |- bgcolor="#ffcccc" | 65 | March 11 | @ Miami | | Ray Allen (27) | Leon Powe (13) | Stephon Marbury (4) | American Airlines Arena19,600 | 49–16 |- bgcolor="#bbffbb" | 66 | March 13 | Memphis | | Leon Powe (30) | Leon Powe (11) | Rajon Rondo (8) | TD Banknorth Garden18,624 | 50–16 |- bgcolor="#ffcccc" | 67 | March 15 | @ Milwaukee | | Kendrick Perkins (26) | Kendrick Perkins (12) | Rajon Rondo (8) | Bradley Center18,134 | 50–17 |- bgcolor="#ffcccc" | 68 | March 17 | @ Chicago | | Paul Pierce (37) | Kendrick Perkins, Mikki Moore (10) | Rajon Rondo (10) | United Center22,107 | 50–18 |- bgcolor="#bbffbb" | 69 | March 18 | Miami | | Paul Pierce (36) | Paul Pierce (11) | Rajon Rondo (10) | TD Banknorth Garden18,624 | 51–18 |- bgcolor="#bbffbb" | 70 | March 20 | @ San Antonio | | Ray Allen (19) | Paul Pierce (12) | Rajon Rondo (12) | AT&T Center18,797 | 52–18 |- bgcolor="#bbffbb" | 71 | March 21 | @ Memphis | | Glen Davis (24) | Rajon Rondo (7) | Rajon Rondo (10) | FedExForum18,119 | 53–18 |- bgcolor="#bbffbb" | 72 | March 23 | L. A. Clippers | | Ray Allen (20) | Kendrick Perkins (13) | Rajon Rondo (7) | TD Banknorth Garden18,624 | 54–18 |- bgcolor="#ffcccc" | 73 | March 25 | @ Orlando | | Paul Pierce (26) | Kendrick Perkins (11) | Ray Allen, Rajon Rondo (5) | Amway Arena17,461 | 54–19 |- bgcolor="#bbffbb" | 74 | March 27 | @ Atlanta | | Ray Allen (22) | Glen Davis (12) | Paul Pierce, Rajon Rondo (5) | Philips Arena20,054 | 55–19 |- bgcolor="#bbffbb" | 75 | March 29 | Oklahoma City | | Paul Pierce (27) | Mikki Moore (11) | Rajon Rondo (12) | TD Banknorth Garden18,624 | 56–19