November 8, 1988 || L.A. Clippers || W 117–105 || Charlotte Coliseum || 18,865 || 1–2 |- align="center" bgcolor="edbebf" | 4 || November 11, 1988 || @ Washington || L 87–96 || Capital Centre || 12,731 || 1–3 |- align="center" bgcolor="edbebf" | 5 || November 12, 1988 || @ Atlanta || L 111–132 || The Omni || 16,155 || 1–4 |- align="center" bgcolor="edbebf" | 6 || November 15, 1988 || New Jersey || L 99–106 || Charlotte Coliseum || 21,748 || 1–5 |- align="center" bgcolor="edbebf" | 7 || November 17, 1988 || @ Dallas || L 93–105 || Reunion Arena || 16,512 || 1–6 |- align="center" bgcolor="#bbffbb" | 8 || November 19, 1988 || @ San Antonio || W 107–105 || HemisFair Arena || 10,863 || 2–6 |- align="center" bgcolor="edbebf" | 9 || November 22, 1988 || Detroit || L 93–99 || Charlotte Coliseum || 23,388 || 2–7 |- align="center" bgcolor="edbebf" | 10 || November 23, 1988 || @ Boston || L 109–114 || Boston Garden || 14,890 || 2–8 |- align="center" bgcolor="edbebf" | 11 || November 25, 1988 || @ Philadelphia || L 116–123 || Spectrum || 10,588 || 2–9 |- align="center" bgcolor="edbebf" | 12 || November 26, 1988 || Washington || L 113–120 || Charlotte Coliseum || 23,388 || 2–10 |- align="center" bgcolor="#bbffbb" | 13 || November 29, 1988 || Miami || W 99–84 || Charlotte Coliseum || 23,388 || 3–10 |- |- align="center" bgcolor="#bbffbb" | 14 || December 1, 1988 || Philadelphia || W 109–107 || Charlotte Coliseum || 21,716 || 4–10 |- align="center" bgcolor="edbebf" | 15 || December 3, 1988 || @ Houston || L 104–108 || The Summit || 16,611 || 4–11 |- align="center" bgcolor="#bbffbb" | 16 || December 9, 1988 || New Jersey || W 96–95 || Charlotte Coliseum || 23,388 || 5–11 |- align="center" bgcolor="edbebf" | 17 || December 10, 1988 || @ New Jersey || L 112–121 (OT) || Brendan Byrne Arena || || 5–12 |- align="center" bgcolor="edbebf" | 18 || December 13, 1988 || @ Indiana || L 104–115 || Market Square Arena || || 5–13 |- align="center" bgcolor="#bbffbb" | 19 || December 14, 1988 || Indiana || W 115–106 || Charlotte Coliseum || 22,601 || 6–13 |- align="center" bgcolor="edbebf" | 20 || December 16, 1988 || Dallas || L 98–107 || Charlotte Coliseum || 23,388 || 6–14 |- align="center" bgcolor="edbebf" | 21 || December 17, 1988 || @ Detroit ||