| 2–8 |- bgcolor="#ffcccc" | 11 | November 21 | Boston | | Al Jefferson (21) | Craig Smith (7) | Craig Smith (4) | Target Center19,107 | 2–9 |- bgcolor="#bbffbb" | 12 | November 23 | @ Detroit | | Randy Foye (23) | Craig Smith (9) | Randy Foye (14) | The Palace of Auburn Hills22,076 | 3–9 |- bgcolor="#ffcccc" | 13 | November 26 | Phoenix | | Al Jefferson (28) | Al Jefferson (17) | Mike Miller (6) | Target Center11,708 | 3–10 |- bgcolor="#bbffbb" | 14 | November 28 | @ Oklahoma City | | Craig Smith (23) | Al Jefferson (9) | Randy Foye (7) | Ford Center18,229 | 4–10 |- bgcolor="#ffcccc" | 15 | November 29 | Denver | | Randy Foye (25) | Al Jefferson (13) | Randy Foye (6) | Target Center14,197 | 4–11 |- bgcolor="#ffcccc" | 16 | December 1 | @ Charlotte | | Randy Foye (23) | Mike Miller (10) | Mike Miller (5) | Time Warner Cable Arena9,285 | 4–12 |- bgcolor="#ffcccc" | 17 | December 3 | @ Orlando | | Al Jefferson (19) | Kevin Love (12) | Randy Foye (5) | Amway Arena15,705 | 4–13 |- bgcolor="#ffcccc" | 18 | December 5 | @ New Jersey | | Randy Foye (20) | Al Jefferson (12) | Randy Foye (5) | Izod Center15,364 | 4–14 |- bgcolor="#ffcccc" | 19 | December 6 | L.A. Clippers | | Al Jefferson (28) | Kevin Love (15) | Randy Foye, Sebastian Telfair (5) | Target Center10,863 | 4–15 |- bgcolor="#ffcccc" | 20 | December 9 | Utah | | Al Jefferson (21) | Kevin Love (15) | Randy Foye, Ryan Gomes (4) | Target Center10,745 | 4–16 |- bgcolor="#ffcccc" | 21 | December 10 | @ Denver | | Al Jefferson, Randy Foye (26) | Kevin Love (14) | Randy Foye (6) | Pepsi Center14,007 | 4–17 |- bgcolor="#ffcccc" | 22 | December 12 | San Antonio | | Al Jefferson (29) | Al Jefferson (13) | Randy Foye (6) | Target Center15,336 | 4–18 |- bgcolor="#ffcccc" | 23 | December 14 | @ L.A. Lakers | | Al Jefferson (20) | Al Jefferson (13) | Randy Foye (6) | Staples Center18,997 | 4–19 |- bgcolor="#ffcccc" | 24 | December 15 | @ Sacramento | | Al Jefferson (22) | Kevin Love (15) | Kevin Ollie (5) |