2002, authors from Sapienza University of Rome stated on the basis of a comprehensive literature review that "clinical observation without treatment is advisable when possible". Therapeutic options include surgery, radiation therapy, and chemotherapy. Surgery is used to remove single lymph nodes, central nervous system lesions, or localized cutaneous disease. In 2014, Dalia and colleagues wrote that for patients with extensive or systemic Destombes–Rosai–Dorfman disease, "a standard of care has not been established" concerning radiotherapy and chemotherapy. History In 1965, Pierre-Paul Louis Lucien Destombes had described, in French, four patients having "adenitis with lipid excess" which is recognized as the original description of the condition. Therefore, the condition is sometimes called "Destombes-Rosai-Dorfman disease". Four years later, in 1969, pathologists Juan Rosai and Ronald Dorfman published a paper on "sinus histiocytosis with massive lymphadenopathy". With the discoveries that the condition can occur outside the head/neck region and in tissues other than lymph nodes, the condition later became known as "Rosai-Dorfman disease". See also List of cutaneous conditions References External links Lymphoid-related cutaneous conditions Rare diseases