other important molecules in EMT and ventricular inlet separation. This has been shown to lead to pericardial effusion and peripheral hemorrhage in E12.5 mice, which succumb due to heart failure before weaning age. This data could have important implications for human medicine by suggesting that mutations with the GATA4 transcription factor could be responsible for AV cushion defects in humans with improper septal formation leading to congenital heart disease. Interactions GATA4 has been shown to interact with NKX2-5, TBX5, Serum response factor HAND2, and HDAC2. GATA4 has also been shown to interact with Erbb3, FOG-1, and FOG-2. Clinical relevance Mutations in this gene have been associated to cases of congenital diaphragmatic hernia. Atrial septal defects, tetralogy of Fallot, and ventricular septal defects associated with GATA4 mutation were also seen in South Indian patients. See also GATA transcription factor References Further reading External links Transcription factors