In enzymology, a long-chain-fatty-acyl-CoA reductase () is an enzyme that catalyzes the chemical reaction a long-chain aldehyde + CoA + NADP+ a long-chain acyl-CoA + NADPH + H+ The 3 substrates of this enzyme are long-chain aldehyde, CoA, and NADP+, whereas its 3 products are long-chain acyl-CoA, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming). Other names in common use include acyl-CoA reductase, and acyl coenzyme A reductase. References EC 1.2.1 NADPH-dependent enzymes Enzymes of unknown structure