Profilin-1 is a protein that in humans is encoded by the PFN1 gene. Function The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome. Mutations in this gene may be a rare cause of amyotrophic lateral sclerosis, also called Lou Gehrig's disease. Interactions Profilin 1 has been shown to interact with: FMNL1, MLLT4 Vasodilator-stimulated phosphoprotein, WASF1, and WASL. References Further reading