@ Cardinals || 3–2 (12) || Roger Craig (1–0) || Dennis Aust (0–1) || Ray Culp (1) || 8,219 || 1–0 |- style="background:#bfb" | 2 || April 14 || @ Cardinals || 5–4 || Darold Knowles (1–0) || Larry Jaster (0–1) || None || 7,223 || 2–0 |- style="background:#bfb" | 3 || April 15 || Reds || 4–3 || Roger Craig (2–0) || Jack Baldschun (0–1) || None || 29,007 || 3–0 |- style="background:#fbb" | 4 || April 16 || Reds || 0–4 || Jim Maloney (1–0) || Ray Culp (0–1) || None || 6,298 || 3–1 |- style="background:#bfb" | 5 || April 17 || Reds || 3–1 || Chris Short (1–0) || Joe Nuxhall (0–1) || None || 13,852 || 4–1 |- style="background:#bbb" | – || April 18 || Braves || colspan=6 | Postponed (rain); Makeup: June 13 as a traditional double-header |- style="background:#fbb" | 6 || April 19 || Braves || 1–3 || Clay Carroll (1–0) || Jim Bunning (0–1) || None || 7,476 || 4–2 |- style="background:#fbb" | 7 || April 20 || Braves || 1–8 || Ken Johnson (1–1) || Ray Culp (0–2) || None || 6,855 || 4–3 |- style="background:#fbb" | 8 || April 21 || Braves || 4–5 || Phil Niekro (1–0) || Chris Short (1–1) || None || 5,744 || 4–4 |- style="background:#bfb" | 9 || April 22 || @ Reds || 9–7 || Darold Knowles (2–0) || Don Nottebart (0–1) || Bob Buhl (1) || 10,266 || 5–4 |- style="background:#bbb" | – || April 23 || @ Reds || colspan=6 | Postponed (wet grounds and rain); Makeup: June 15 as a traditional double-header |- style="background:#fbb" | 10 || April 24 (1) || @ Reds || 2–3 (6) || Sammy Ellis (1–1) || Ray Culp (0–3) || None || 7,248 || 5–5 |- style="background:#bbb" | – || April 24 (2) || @ Reds || colspan=6 | Postponed (rain); Makeup: August 27 as a traditional double-header |- style="background:#bfb" | 11 || April 25 || @ Pirates || 5–0 || Jim Bunning (1–1) || Bob Veale (1–1) || None || 9,564 || 6–5 |- style="background:#bbb" | – || April 27 || Mets || colspan=6 | Postponed (rain); Makeup: July 7 |- style="background:#bfb" | 12 || April 29 || @ Cubs || 5–1 || Jim Bunning (2–1) || Dick Ellsworth (0–2) || None || 4,053 || 7–5 |- style="background:#bfb" | 13 || April 30 || @