style="background:#fbb" | 1 || April 8 || Mets || 2–7 || Randy Jones (1–0) || Steve Carlton (0–1) || None || 15,345 || 0–1 |- style="background:#fbb" | 2 || April 9 || Expos || 0–2 || Steve Rogers (1–0) || Larry Christenson (0–1) || None || 7,795 || 0–2 |- style="background:#fbb" | 3 || April 10 || Expos || 3–11 || Bill Gullickson (1–0) || Dick Ruthven (0–1) || None || 16,718 || 0–3 |- style="background:#bfb" | 4 || April 11 || Expos || 1–0 || Mike Krukow (1–0) || Ray Burris (0–1) || None || 15,397 || 1–3 |- style="background:#fbb" | 5 || April 13 || @ Mets || 2–5 || Randy Jones (2–0) || Steve Carlton (0–2) || Neil Allen (2) || 40,845 || 1–4 |- style="background:#fbb" | 6 || April 14 || @ Mets || 1–8 || Mike Scott (1–1) || Dick Ruthven (0–2) || None || 13,420 || 1–5 |- style="background:#bfb" | 7 || April 15 || @ Mets || 8–4 (13) || Warren Brusstar (1–0) || Charlie Puleo (0–1) || None || 14,634 || 2–5 |- style="background:#fbb" | 8 || April 16 || @ Cardinals || 2–3 || Bob Forsch (2–0) || Mike Krukow (1–1) || Bruce Sutter (3) || 15,003 || 2–6 |- style="background:#fbb" | 9 || April 17 || @ Cardinals || 0–6 || Joaquín Andújar (2–1) || Steve Carlton (0–3) || None || 17,457 || 2–7 |- style="background:#fbb" | 10 || April 18 || @ Cardinals || 5–6 (11) || Dave LaPoint (1–0) || Warren Brusstar (1–1) || None || 25,222 || 2–8 |- style="background:#bfb" | 11 || April 19 || @ Expos || 2–0 || Larry Christenson (1–1) || Scott Sanderson (1–1) || Ed Farmer (1) || 10,102 || 3–8 |- style="background:#bbb" | – || April 20 || @ Expos || colspan=6 | Postponed (rain); Makeup: August 12 as a traditional double-header |- style="background:#fbb" | 12 || April 21 || @ Expos || 2–5 || Steve Rogers (2–1) || Steve Carlton (0–4) || Jeff Reardon (2) || 6,448 || 3–9 |- style="background:#fbb" | 13 || April 23 || Cardinals || 2–9 || Bob Forsch (3–0) || Mike Krukow (1–2) || None || 26,617 || 3–10 |- style="background:#fbb" | 14 || April 24 || Cardinals || 4–7 || Doug Bair (1–0) || Ed Farmer (0–1) || Bruce Sutter (6) || 25,270 || 3–11 |- style="background:#bfb" | 15 || April 25 || Cardinals