Afadin is a protein that in humans is encoded by the AFDN gene. Function Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998).[supplied by OMIM] Interactions Afadin has been shown to interact with: BCR gene, EPHB3, F11 receptor, HRAS and LMO2, PVRL1, PVRL3, Profilin 1, RAP1A, RAP1GAP, SORBS1, SSX2IP, Tight junction protein 1, and USP9X. References Further reading