In enzymology, a hexose oxidase () is an enzyme that catalyzes the chemical reaction D-glucose + O2 D-glucono-1,5-lactone + H2O2 Thus, the two substrates of this enzyme are D-glucose and O2, whereas its two products are D-glucono-1,5-lactone and H2O2. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is D-hexose:oxygen 1-oxidoreductase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, copper. References EC 1.1.3 Copper enzymes Enzymes of unknown structure