In enzymology, a glyoxylate dehydrogenase (acylating) () is an enzyme that catalyzes the chemical reaction glyoxylate + CoA + NADP+ oxalyl-CoA + NADPH + H+ The 3 substrates of this enzyme are glyoxylate, CoA, and NADP+, whereas its 3 products are oxalyl-CoA, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glyoxylate:NADP+ oxidoreductase (CoA-oxalylating). This enzyme participates in glyoxylate and dicarboxylate metabolism. References EC 1.2.1 NADPH-dependent enzymes Enzymes of unknown structure