In enzymology, a hexadecanal dehydrogenase (acylating) () is an enzyme that catalyzes the chemical reaction hexadecanal + CoA + NAD+ hexadecanoyl-CoA + NADH + H+ The 3 substrates of this enzyme are hexadecanal, CoA, and NAD+, whereas its 3 products are hexadecanoyl-CoA, NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hexadecanal:NAD+ oxidoreductase (CoA-acylating). This enzyme is also called fatty acyl-CoA reductase. References EC 1.2.1 NADH-dependent enzymes Enzymes of unknown structure