In enzymology, a 6-oxohexanoate dehydrogenase () is an enzyme that catalyzes the chemical reaction 6-oxohexanoate + NADP+ + H2O adipate + NADPH + 2 H+ The 3 substrates of this enzyme are 6-oxohexanoate, NADP+, and H2O, whereas its 3 products are adipate, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-oxohexanoate:NADP+ oxidoreductase. This enzyme participates in caprolactam degradation. References EC 1.2.1 NADPH-dependent enzymes Enzymes of unknown structure