11 || Expos || 6–2 || Steve Ontiveros (2–0) || Pascual Pérez (0–1) || None || 14,429 || 5–2 |- style="background:#bfb" | 8 || April 12 || Expos || 6–3 || Don Carman (1–0) || Kevin Gross (1–1) || Steve Bedrosian (1) || 15,461 || 6–2 |- style="background:#fbb" | 9 || April 14 || Cubs || 4–6 || Scott Sanderson (1–0) || Bruce Ruffin (0–2) || Mitch Williams (5) || 20,851 || 6–3 |- style="background:#bbb" | – || April 15 || Cubs || colspan=6 | Postponed (rain); |- style="background:#fbb" | 10 || April 16 || Cubs || 3–5 || Rick Sutcliffe (3–0) || Floyd Youmans (0–2) || Mitch Williams (6) || 32,249 || 6–4 |- style="background:#fbb" | 11 || April 17 || @ Mets || 2–5 || Sid Fernandez (1–0) || Don Carman (1–1) || Randy Myers (2) || 28,087 || 6–5 |- style="background:#bfb" | 12 || April 18 || @ Mets || 7–1 || Larry McWilliams (1–0) || Ron Darling (0–3) || None || 26,300 || 7–5 |- style="background:#fbb" | 13 || April 19 || @ Mets || 2–4 || Randy Myers (1–1) || Steve Bedrosian (1–1) || None || 25,694 || 7–6 |- style="background:#bfb" | 14 || April 20 || @ Pirates || 9–4 || Ken Howell (2–0) || Mike Dunne (1–1) || None || 6,977 || 8–6 |- style="background:#bfb" | 15 || April 21 || @ Pirates || 3–2 || Floyd Youmans (1–2) || Doug Drabek (1–1) || Steve Bedrosian (2) || 15,221 || 9–6 |- style="background:#fbb" | 16 || April 22 || @ Pirates || 3–4 || Jeff Robinson (2–2) || Don Carman (1–2) || None || 14,669 || 9–7 |- style="background:#fbb" | 17 || April 23 || @ Pirates || 4–6 || Logan Easley (1–0) || Steve Bedrosian (1–2) || None || 16,816 || 9–8 |- style="background:#bfb" | 18 || April 24 || @ Astros || 8–4 || Greg A. Harris (1–0) || Bob Forsch (0–1) || None || 9,088 || 10–8 |- style="background:#fbb" | 19 || April 25 || @ Astros || 1–4 || Mike Scott (3–1) || Ken Howell (2–1) || None || 12,584 || 10–9 |- style="background:#fbb" | 20 || April 26 || @ Astros || 5–6 || Danny Darwin (2–1) || Jeff Parrett (1–1) || Dave Smith (3) || 11,195 || 10–10 |- style="background:#fbb" | 21 || April 28 || Reds || 0–3 || José Rijo (1–0) || Don Carman (1–3)