CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene. Function Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'ménage à trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM] Interactions MNAT1 has been shown to interact with: Cyclin H, Cyclin-dependent kinase 7, Estrogen receptor alpha, MCM7, MTA1, P53, and POU2F1. References Further reading External links