In enzymology, a dehydrogluconate dehydrogenase () is an enzyme that catalyzes the chemical reaction 2-dehydro-D-gluconate + acceptor 2,5-didehydro-D-gluconate + reduced acceptor Thus, the two substrates of this enzyme are 2-dehydro-D-gluconate and acceptor, whereas its two products are 2,5-didehydro-D-gluconate and reduced acceptor. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is 2-dehydro-D-gluconate:acceptor 2-oxidoreductase. Other names in common use include ketogluconate dehydrogenase, alpha-ketogluconate dehydrogenase, 2-keto-D-gluconate dehydrogenase, and 2-oxogluconate dehydrogenase. It has 2 cofactors: FAD, and Flavoprotein. References EC 1.1.99 Flavoproteins Enzymes of unknown structure