Docking protein 1 is a protein that in humans is encoded by the DOK1 gene. Function Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. Interactions DOK1 has been shown to interact with: ABL1 and CD117, INPP5D, LYN, RASA1, RET, SH2D1A, SHC1, and TEC. References Further reading