In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) () is an enzyme that catalyzes the chemical reaction a 2-oxoaldehyde + NAD+ + H2O a 2-oxo acid + NADH + H+ The 3 substrates of this enzyme are 2-oxoaldehyde, NAD+, and H2O, whereas its 3 products are 2-oxo acid, NADH, and H+. This enzyme participates in pyruvate metabolism. Nomenclature This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include: alpha-ketoaldehyde dehydrogenase methylglyoxal dehydrogenase NAD+-linked alpha-ketoaldehyde dehydrogenase 2-ketoaldehyde dehydrogenase NAD+-dependent alpha-ketoaldehyde dehydrogenase 2-oxoaldehyde dehydrogenase (NAD+) See also 2-oxoaldehyde dehydrogenase (NADP+) References EC 1.2.1 NADH-dependent enzymes Enzymes of unknown structure