In enzymology, a hydrogen dehydrogenase (NADP+) () is an enzyme that catalyzes the chemical reaction H2 + NADP+ H+ + NADPH Thus, the two substrates of this enzyme are H2 and NADP+, whereas its two products are H+ and NADPH. This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous). Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code . References EC 1.12.1 NADPH-dependent enzymes Enzymes of known structure