2–6 |- style="background:#fbb" | 9 || April 22 || Cubs || 4–6 (11) || Don Elston (3–0) || Turk Farrell (1–1) || None || 3,996 || 2–7 |- style="background:#bfb" | 10 || April 23 (1) || Cubs || 1–0 || Frank Sullivan (1–1) || Dick Ellsworth (0–1) || None || see 2nd game || 3–7 |- style="background:#bfb" | 11 || April 23 (2) || Cubs || 6–0 || Art Mahaffey (1–1) || Bob Anderson (0–2) || None || 16,027 || 4–7 |- style="background:#bbb" | – || April 25 || @ Pirates || colspan=6 | Postponed (rain and wet grounds); Makeup: June 25 as a traditional double-header |- style="background:#fbb" | 12 || April 26 || @ Pirates || 2–3 || Vinegar Bend Mizell (2–0) || Dallas Green (1–1) || None || 9,420 || 4–8 |- style="background:#fbb" | 13 || April 28 || @ Cardinals || 9–10 (11) || Al Cicotte (1–2) || Dallas Green (1–2) || None || 5,620 || 4–9 |- style="background:#bfb" | 14 || April 29 || @ Cardinals || 3–2 || Art Mahaffey (2–1) || Ray Sadecki (1–1) || None || 6,175 || 5–9 |- style="background:#bfb" | 15 || April 30 || @ Cardinals || 11–7 (10) || Turk Farrell (2–1) || Larry Jackson (0–2) || None || 8,194 || 6–9 |- |- style="background:#fbb" | 16 || May 1 || @ Reds || 2–3 || Jim O'Toole (2–2) || Robin Roberts (0–4) || None || 2,089 || 6–10 |- style="background:#fbb" | 17 || May 2 || @ Reds || 2–3 || Ken Hunt (2–1) || Dallas Green (1–3) || Jim Brosnan (3) || 3,026 || 6–11 |- style="background:#fbb" | 18 || May 3 || @ Reds || 3–9 || Jim Maloney (1–1) || John Buzhardt (0–2) || Bill Henry (1) || 4,018 || 6–12 |- style="background:#fbb" | 19 || May 4 || @ Reds || 0–4 || Joey Jay (1–3) || Art Mahaffey (2–2) || None || 3,087 || 6–13 |- style="background:#fbb" | 20 || May 5 || Giants || 2–4 || Juan Marichal (2–1) || Frank Sullivan (1–2) || None || 15,674 || 6–14 |- style="background:#bbb" | – || May 6 || Giants || colspan=6 | Postponed (rain); Makeup: July 28 as a traditional double-header |- style="background:#fbb" | 21 || May 7 || Giants || 0–7 || Billy Loes (3–1) || Robin Roberts (0–5) || None || 9,985 || 6–15 |- style="background:#fbb" | 22 || May 8