Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene. Function This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. In mouse embryonic stem cells, Suv39h1 expression is repressed by OCT4 protein through the induction of an antisense long non-coding RNA. Interactions SUV39H1 has been shown to interact with: CBX1, CBX5, DNMT3A, HDAC1, HDAC3, HDAC9, Histone deacetylase 2, MBD1, RUNX1, Retinoblastoma protein, and SBF1. PIN1 References Further reading