Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene. Function This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) and physiological roles have been identified in mouse Natural Killer T cells and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human. Interactions Zinc finger and BTB domain-containing protein 16 has been shown to interact with: Angiotensin II receptor type 1, BCL6, BMI1, Calcitriol receptor, FHL2, GATA1, GATA2, HDAC1, HDAC4, HDAC5, HDAC6, Heparin-binding EGF-like growth factor, Nuclear receptor co-repressor 2, Promyelocytic leukemia protein RUNX1T1, Retinoic acid receptor alpha, SIN3A, SIN3B, and ZBTB32. See also Zbtb7 References Further reading External links Transcription factors