|| 40,809 || 1–2 |- style="background:#fbb" | 4 || April 12 || Expos || 3–5 || Balor Moore (1–0) || Jim Lonborg (0–1) || Mike Marshall (1) || 5,130 || 1–3 |- style="background:#bfb" | 5 || April 13 || Mets || 7–1 || Larry Christenson (1–0) || Jon Matlack (1–1) || None || 7,127 || 2–3 |- style="background:#bfb" | 6 || April 14 || Mets || 7–3 || Steve Carlton (2–1) || Jim McAndrew (0–1) || None || 11,063 || 3–3 |- style="background:#fbb" | 7 || April 15 || Mets || 1–2 || Harry Parker (1–0) || Jim Lonborg (0–2) || Tug McGraw (2) || 30,718 || 3–4 |- style="background:#bfb" | 8 || April 17 || @ Expos || 9–6 || Dick Selma (1–1) || Mike Marshall (0–2) || Bill Wilson (1) || 7,831 || 4–4 |- style="background:#fbb" | 9 || April 18 || @ Expos || 1–2 || Steve Renko (1–0) || Steve Carlton (2–2) || None || 13,728 || 4–5 |- style="background:#fbb" | 10 || April 19 || @ Expos || 5–6 || Mike Torrez (1–3) || Larry Christenson (1–1) || Tom Walker (1) || 12,359 || 4–6 |- style="background:#bfb" | 11 || April 21 || Cardinals || 7–4 || Jim Lonborg (1–2) || Scipio Spinks (0–3) || Mac Scarce (1) || 8,031 || 5–6 |- style="background:#bfb" | 12 || April 22 (1) || Cardinals || 4–2 || Steve Carlton (3–2) || Reggie Cleveland (0–2) || None || see 2nd game || 6–6 |- style="background:#bfb" | 13 || April 22 (2) || Cardinals || 2–1 || Bill Wilson (1–0) || Bob Gibson (0–2) || None || 18,042 || 7–6 |- style="background:#fbb" | 14 || April 24 || @ Braves || 2–11 || Carl Morton (1–1) || Larry Christenson (1–2) || Ron Schueler (1) || 3,405 || 7–7 |- style="background:#fbb" | 15 || April 25 || @ Braves || 2–5 || Gary Gentry (2–2) || Jim Lonborg (1–3) || Phil Niekro (1) || 2,866 || 7–8 |- style="background:#bfb" | 16 || April 27 || @ Reds || 3–1 || Steve Carlton (4–2) || Ross Grimsley (3–1) || None || 13,690 || 8–8 |- style="background:#bfb" | 17 || April 28 || @ Reds || 1–0 || Dick Ruthven (1–0) || Don Gullett (3–2) || Mac Scarce (2) || 14,126 || 9–8 |- style="background:#fbb" | 18 || April 29 || @ Reds || 0–8 || Jack Billingham (4–0) || Larry Christenson