Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene. Function The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. MYBL2 is deregulated in various cancer types and can contribute to cancer progression. Interactions MYBL2 has been shown to interact with: CDK9 CREB-binding protein Cyclin A1 Cyclin-dependent kinase inhibitor 1C EP300 PARP1 Retinoblastoma-like protein 1 References Further reading External links Transcription factors