In enzymology, a NADPH dehydrogenase () is an enzyme that catalyzes the chemical reaction NADPH + H+ + acceptor NADP+ + reduced acceptor The 3 substrates of this enzyme are NADPH, H+, and acceptor, whereas its two products are NADP+ and reduced acceptor. This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. It has 2 cofactors: FAD, and FMN. Nomenclature The systematic name of this enzyme class is NADPH:acceptor oxidoreductase. Other names in common use include NADPH2 diaphorase NADPH diaphorase old yellow enzyme diaphorase dihydronicotinamide adenine dinucleotide phosphate dehydrogenase NADPH-dehydrogenase NADPH-diaphorase NADPH2-dehydrogenase old yellow enzyme reduced nicotinamide adenine dinucleotide phosphate dehydrogenase TPNH dehydrogenase TPNH-diaphorase triphosphopyridine diaphorase triphosphopyridine nucleotide diaphorase NADPH2 dehydrogenase NADPH:(acceptor) oxidoreductase. References Further reading EC 1.6.99 NADPH-dependent enzymes Flavoproteins Enzymes of known structure