a post-synaptic neurotoxin, which reversibly blocks the nicotinic acetylcholine receptors. A bite of the Thailand Cobra therefore leads to muscle paralysis. Because of that paralysis, respiratory problems may develop, which can lead to death. The moment when the neurotoxin begins affecting the body can vary from minutes to a few hours after the bite. At first, the venom will cause weakness as a consequence of the nerve transmission blocking. The first real symptoms of paralysis will be palpebral ptosis (drooping of the eyelids) and external ophthalmoplegia, which is also an eye movement disorder. The reason for this is that the ocular muscles are more susceptible, in comparison with other muscles, for the nerve transmission blocking. The next muscles affected are the facial and neck muscles followed by the respiratory muscles and the limbs after another few hours. By then, the victim gets trouble breathing and will not survive this for a very long time. Toxicity The Naja Kaouthia venom is a member of the snake three-finger toxin family in the subfamily type II alpha-neurotoxin. The lethal dose (LD50) of α-cobratoxin is 0,1 mg/kg by intravenous injection into mice15. The toxin occurs as a monomer but can form a homodimer or heterodimers with cytotoxins 1,2, and 3 through disulfide linkage. The monomeric form can bind with high affinity to muscular, Torpedo, and neuronal alpha-7 nicotinic acetylcholine receptors (nAChR). As mentioned before, binding to the nAChR it prevents acetylcholine binding to the receptor, which causes paralysis. Antitoxin and vaccines In the last few years there are some new developments to create an antitoxin or a vaccine for the toxic snake bites. Genetic vaccine In 2005 a genetic vaccine for cobratoxin was developed which encodes for a non-toxic cobratoxin variant. To develop this non-toxic component, some alterations were made in the cDNA for the cobratoxin. Two residues, critical for binding to the nicotinic acetylcholine receptors, were substituted (Asp27 to Arg and Arg33 to Gly).This created protein has the same 3D-structure as the original toxin but leads also to protective immunity. This synthesized vaccine could protect a victim against a dangerous snake venom. Because of these promising results, the creation of a global health program must be considered which can save people who are at risk of a snakebite. Rediocides A and G Rediocides A and G are found to be a possible antitoxin for α-cobratoxin. These rediocides bind at the same nicotinic acetylcholine