and serotonin neurotransmission through the same receptor as amphetamine, TAAR1. The prophylactic use of MAO-B inhibitors to slow natural human aging in otherwise healthy individuals has been proposed, but remains a highly controversial topic. Selective inhibitors Species-dependent divergences may hamper the extrapolation of inhibitor potencies. Reversible Natural Geiparvarin Desmethoxyyangonin, a constituent of kava extract; modest affinity Catechin and epicatechin. Garlic Rosiridin (in vitro) Synthetic Safinamide and analogs 5H-Indeno[1,2-c]pyridazin-5-ones (see 3d model) Substituted chalcones 2-(N-Methyl-N-benzylaminomethyl)-1H-pyrrole 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine 2-Thiazolylhydrazone 3,5-Diaryl pyrazole Pyrazoline derivatives Several coumarin derivatives and #C19* (see 3d model) Phenylcoumarins, extremely subtype selective and further analogs (see 3d model) Chromone-3-phenylcarboxamides Isatins Phthalimides 8-Benzyloxycaffeines and CSC analogs (E,E)-8-(4-phenylbutadien-1-yl)caffeines, with A2A antagonistic component Indazole- and Indole-5-carboxamides Irreversible (covalent) Selegiline (Eldepryl, Zelapar, Emsam) Rasagiline (Azilect) See also Monoamine oxidase A References