Woodie Fryman (0–1) || John Buzhardt (1) || 16,415 || 1–2 |- style="background:#fbb" | 4 || April 13 || @ Astros || 3–4 || Dave Giusti (1–0) || Grant Jackson (0–1) || None || 13,164 || 1–3 |- style="background:#fbb" | 5 || April 14 (1) || @ Giants || 2–13 || Juan Marichal (1–0) || Rick Wise (0–1) || None || see 2nd game || 1–4 |- style="background:#fbb" | 6 || April 14 (2) || @ Giants || 1–3 || Ray Sadecki (1–0) || Chris Short (1–1) || None || 18,314 || 1–5 |- style="background:#fbb" | 7 || April 16 || @ Dodgers || 3–5 || Mike Kekich (1–0) || Larry Jackson (0–2) || Hank Aguirre (1) || 16,571 || 1–6 |- style="background:#bfb" | 8 || April 17 || Dodgers || 3–2 || Woodie Fryman (1–1) || Don Drysdale (1–1) || Turk Farrell (1) || 15,817 || 2–6 |- style="background:#bfb" | 9 || April 19 || Astros || 2–1 || Chris Short (2–1) || Dave Giusti (1–1) || None || 6,671 || 3–6 |- style="background:#bfb" | 10 || April 20 || Astros || 7–1 || Larry Jackson (1–2) || Larry Dierker (1–2) || None || 3,738 || 4–6 |- style="background:#bfb" | 11 || April 21 || Astros || 8–0 || Woodie Fryman (2–1) || Don Wilson (1–1) || None || 5,634 || 5–6 |- style="background:#bfb" | 12 || April 22 || Giants || 2–1 (10) || Rick Wise (1–1) || Frank Linzy (1–2) || None || 4,231 || 6–6 |- style="background:#fbb" | 13 || April 23 || Giants || 1–7 || Juan Marichal (3–0) || Chris Short (2–2) || None || 8,618 || 6–7 |- style="background:#bbb" | – || April 24 || Giants || colspan=6 | Postponed (rain); Makeup: June 18 as a traditional double-header |- style="background:#fbb" | 14 || April 26 || @ Braves || 1–3 || Pat Jarvis (1–2) || Larry Jackson (1–3) || None || 10,614 || 6–8 |- style="background:#bfb" | 15 || April 27 || @ Braves || 4–1 || Woodie Fryman (3–1) || Dick Kelley (1–2) || None || 14,207 || 7–8 |- style="background:#bfb" | 16 || April 28 || @ Braves || 4–3 || Rick Wise (2–1) || Phil Niekro (2–2) || Turk Farrell (2) || 13,442 || 8–8 |- style="background:#fbb" | 17 || April 30 || @ Mets || 0–1 || Don Cardwell (1–2) || Chris Short (2–3) || None || 3,771 ||