4 || April 7 || @ Reds || 9–1 || Jerry Koosman (1–0) || Frank Pastore (0–1) || None || 12,516 || 3–1 |- style="background:#fbb" | 5 || April 8 || @ Reds || 7–8 (11) || Mike Smith (1–0) || Larry Andersen (0–1) || None || 16,443 || 3–2 |- style="background:#bfb" | 6 || April 10 || Astros || 3–1 || John Denny (1–1) || Nolan Ryan (1–1) || Al Holland (1) || 37,236 || 4–2 |- style="background:#bfb" | 7 || April 11 || Astros || 7–6 || Bill Campbell (1–0) || Bill Dawley (0–1) || None || 20,108 || 5–2 |- style="background:#fbb" | 8 || April 13 || @ Expos || 1–5 || Charlie Lea (2–1) || Jerry Koosman (1–1) || Gary Lucas (2) || 48,060 || 5–3 |- style="background:#bfb" | 9 || April 14 || @ Expos || 4–3 || Larry Andersen (1–1) || Dan Schatzeder (0–1) || Al Holland (2) || 17,030 || 6–3 |- style="background:#bbb" | – || April 15 || @ Expos || colspan=6 | Postponed (rain); Makeup: August 7 as a traditional double-header |- style="background:#bbb" | – || April 16 || @ Pirates || colspan=6 | Postponed (rain); Makeup: June 22 as a traditional double-header |- style="background:#bfb" | 10 || April 17 || @ Pirates || 4–1 || Charles Hudson (2–0) || John Tudor (1–1) || Al Holland (3) || 34,114 || 7–3 |- style="background:#fbb" | 11 || April 18 || @ Pirates || 3–6 || John Candelaria (2–1) || Jerry Koosman (1–2) || Don Robinson (2) || 2,752 || 7–4 |- style="background:#fbb" | 12 || April 20 || Mets || 1–3 (10) || Doug Sisk (1–0) || Al Holland (0–1) || Jesse Orosco (3) || 24,096 || 7–5 |- style="background:#bfb" | 13 || April 21 || Mets || 12–2 || John Denny (2–1) || Mike Torrez (0–2) || None || 27,114 || 8–5 |- style="background:#bfb" | 14 || April 22 || Mets || 12–5 || Charles Hudson (3–0) || Ron Darling (1–2) || None || 20,348 || 9–5 |- style="background:#bbb" | – || April 23 || Pirates || colspan=6 | Postponed (rain); Makeup: June 8 as a traditional double-header |- style="background:#fbb" | 15 || April 24 || Pirates || 2–3 || John Candelaria (3–1) || Jerry Koosman (1–3) || Kent Tekulve (1) || 14,096 || 9–6 |- style="background:#bfb" | 16 || April 25 || Pirates || 8–7 || Tug McGraw (1–0) ||