One study investigating genetic underpinnings of obsessive-compulsive disorder and Tourette disorder found that while CDH2 variants are likely not disease-causing as single entities, they may confer risk when examined as part of a panel of related cell–cell adhesion genes. Further studies in larger cohorts will be required to unequivocally determine this. In human dilated cardiomyopathy, it was shown that Cadherin-2 expression was enhanced and arranged in a disarrayed fashion, suggesting that disorganization of Cadherin-2 protein in heart disease may be a component of remodeling. Interactions Cadherin-2 has been shown to interact with: Beta-catenin, CDH11, type IIb RPTPs including PTPmu (CTNND1), CTNNA1, LRRC7, PTPRM) PTPrho (PTPRT), and Plakoglobin. XIRP1 SCARB2 See also ADH-1 References Further reading External links Clusters of differentiation