1–4 |- style="background:#fbb" | 6 || April 15 || @ Cubs || 1–2 || Steve Trout (2–0) || Kevin Gross (0–1) || Lee Smith (2) || 8,347 || 1–5 |- style="background:#fbb" | 7 || April 16 || @ Cubs || 0–1 (10) || Dennis Eckersley (1–1) || Al Holland (0–1) || None || 11,937 || 1–6 |- style="background:#fbb" | 8 || April 17 || @ Cubs || 4–5 || George Frazier (1–0) || Kevin Gross (0–2) || Lee Smith (3) || 15,752 || 1–7 |- style="background:#fbb" | 9 || April 19 || Mets || 0–1 || Dwight Gooden (2–0) || Charles Hudson (0–1) || Jesse Orosco (1) || 32,420 || 1–8 |- style="background:#bfb" | 10 || April 20 || Mets || 7–6 || John Denny (1–1) || Ed Lynch (0–1) || Larry Andersen (1) || 24,013 || 2–8 |- style="background:#bfb" | 11 || April 21 || Mets || 10–6 || Kevin Gross (1–2) || Doug Sisk (1–1) || None || 30,186 || 3–8 |- style="background:#bfb" | 12 || April 22 || @ Expos || 9–1 || Shane Rawley (2–0) || Joe Hesketh (1–1) || None || 6,249 || 4–8 |- style="background:#fbb" | 13 || April 23 || @ Expos || 4–5 (10) || Jeff Reardon (1–0) || Charles Hudson (0–2) || None || 8,223 || 4–9 |- style="background:#fbb" | 14 || April 24 || @ Expos || 6–7 || Bryn Smith (3–0) || John Denny (1–2) || Tim Burke (1) || 10,417 || 4–10 |- style="background:#fbb" | 15 || April 26 || Cubs || 3–7 || Dennis Eckersley (3–1) || Jerry Koosman (0–1) || None || 27,187 || 4–11 |- style="background:#bfb" | 16 || April 27 || Cubs || 6–1 || Shane Rawley (3–0) || Scott Sanderson (1–1) || None || 25,220 || 5–11 |- style="background:#bfb" | 17 || April 28 || Cubs || 3–2 || Kevin Gross (2–2) || Rick Sutcliffe (3–2) || Larry Andersen (2) || 31,890 || 6–11 |- style="background:#bfb" | 18 || April 29 || Expos || 3–2 (10) || Kent Tekulve (1–0) || Bert Roberge (0–1) || None || 19,124 || 7–11 |- style="background:#bfb" | 19 || April 30 || Expos || 11–0 || Jerry Koosman (1–1) || Bill Gullickson (3–2) || None || 18,104 || 8–11 |- |- style="background:#fbb" | 20 || May 1 || Expos || 2–3 || David Palmer (2–2) || Shane Rawley (3–1) || Jeff Reardon (6) || 17,464 || 8–12