WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene. Function This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. Interactions Wee1-like protein kinase has been shown to interact with YWHAB and PIN1. References Further reading External links EC 2.7.11