the transplant, Enzo comes back to the Philippines and meets Bianca. She sees that Enzo and her ex-boyfriend are opposites but gives him a chance. After seeing the real Enzo, she appreciates him more and they slowly fall in love with each other but she still couldn't move on from her ex-boyfriend. Until a near death experience for Enzo changes her heart completely. John Lloyd Cruz as Enzo Bea Alonzo as Bianca Joel Torre as Dante Liza Lorena as Lourdes Chat Silayan as Azon Chanda Romero as Josie Mico Palanca as Kiko Anna Larrucea as Rhoda Alyson Lualhati as Carla Dominic Ochoa as Jojo Vivian Foz as Nelly Kathleen Hermosa - Janice Mandy Ochoa - Edgar Joshua Dionisio as Xavier Trivia Prats and Evangelista were from Ang Tanging Ina (both film released in May and later became TV sitcom in August) while Cruz and Alonzo were from Kay Tagal Kang Hinintay (2 weeks before ended its 1-year run on November 13). Theme song The theme song, Please Be Careful With My Heart popularized by Hans and Heart Evangelista-Escudero and it was originally performed by Jose Mari Chan and Regine Velasquez-Alcasid. It was later used in Your Song'''s My Last Romance and in the 2012 morning drama series Be Careful With My Heart''. External links The Global Filipino Source My First Romance 2003 films 2000s Tagalog-language films 2000s romance films Star Cinema films Philippine romance films 2000s English-language films Films directed by Don Cuaresma