BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene. Function The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site. Clinical significance BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively. Interactions BAG1 has been shown to interact with: Androgen receptor, C-Raf, Calcitriol receptor, Glucocorticoid receptor, HSPA8, HBEGF, PPP1R15A, NR1B1, and SIAH1. References External links Further reading Ageing Oncogenes Aging-related genes Aging-related proteins Co-chaperones