May 3 || @ Dodgers || 14–8 || Orville Jorgens (1–1) || Ralph Birkofer (0–2) || Wayne LaMaster (1) || 5,105 || 6–5 |- style="background:#fbb" | 12 || May 4 || Cubs || 7–14 || Roy Parmelee (2–0) || Hugh Mulcahy (0–1) || None || 3,000 || 6–6 |- style="background:#fbb" | 13 || May 5 || Cubs || 4–17 || Charlie Root (1–1) || Syl Johnson (0–2) || None || 4,000 || 6–7 |- style="background:#fbb" | 14 || May 6 || Cubs || 0–1 || Bill Lee (2–3) || Claude Passeau (1–2) || None || || 6–8 |- style="background:#fbb" | 15 || May 7 || Pirates || 3–8 || Joe Bowman (3–0) || Wayne LaMaster (3–2) || None || 4,000 || 6–9 |- style="background:#bbb" | – || May 8 || Pirates || colspan=6 | Postponed (rain); Makeup: July 18 as a traditional double-header |- style="background:#fbb" | 16 || May 9 || Reds || 10–21 || Peaches Davis (1–2) || Hugh Mulcahy (0–2) || None || 7,000 || 6–10 |- style="background:#bfb" | 17 || May 10 || Reds || 10–3 || Bucky Walters (2–1) || Lee Grissom (1–3) || None || 500 || 7–10 |- style="background:#fbb" | 18 || May 11 || Reds || 3–12 || Al Hollingsworth (1–0) || Wayne LaMaster (3–3) || None || 1,000 || 7–11 |- style="background:#fbb" | 19 || May 12 || Cardinals || 3–15 || Bill McGee (1–0) || Claude Passeau (1–3) || None || 2,500 || 7–12 |- style="background:#fbb" | 20 || May 13 || Cardinals || 4–5 || Lon Warneke (4–1) || Hugh Mulcahy (0–3) || Si Johnson (1) || 1,500 || 7–13 |- style="background:#bbb" | – || May 14 || @ Giants || colspan=6 | Postponed (rain); Makeup: May 15 as a traditional double-header |- style="background:#bfb" | 21 || May 15 || @ Giants || 6–2 || Syl Johnson (1–2) || || None || || 8–13 |- style="background:#fbb" | 22 || May 15 || @ Giants || 1–2 || Hal Schumacher (2–4) || Wayne LaMaster (3–4) || None || 22,633 || 8–14 |- style="background:#bfb" | 23 || May 16 || @ Giants || 6–0 || Claude Passeau (2–3) || Cliff Melton (1–3) || None || 18,950 || 9–14 |- style="background:#fbb" | 24 || May 18 || @ Pirates || 1–2 || Cy Blanton (4–1) || Hugh Mulcahy (0–4) || None || 2,500 || 9–15 |- style="background:#bfb" | 25 || May 19 ||