Jack Sanford (0–1) || Don McMahon (1) || 31,624 || 1–1 |- style="background:#fbb" | 3 || April 19 || Braves || 0–5 || Warren Spahn (1–0) || Curt Simmons (0–1) || None || 8,579 || 1–2 |- style="background:#bfb" | 4 || April 20 || Braves || 3–2 || Robin Roberts (1–0) || Bob Rush (0–1) || None || 16,366 || 2–2 |- style="background:#fbb" | 5 || April 21 || Redlegs || 2–4 (14) || Hal Jeffcoat (1–0) || Jim Hearn (0–1) || Johnny Klippstein (1) || 11,764 || 2–3 |- style="background:#bfb" | 6 || April 23 || Pirates || 8–1 || Jack Sanford (1–1) || Ron Blackburn (1–1) || None || 7,668 || 3–3 |- style="background:#fbb" | 7 || April 24 || Pirates || 4–7 || Bob Friend (2–0) || Curt Simmons (0–2) || Roy Face (1) || 7,456 || 3–4 |- style="background:#fbb" | 8 || April 25 || @ Braves || 0–4 || Bob Rush (1–1) || Robin Roberts (1–1) || None || 15,891 || 3–5 |- style="background:#fbb" | 9 || April 26 || @ Braves || 2–4 || Bob Buhl (3–0) || Ray Semproch (1–1) || None || 15,391 || 3–6 |- style="background:#bfb" | 10 || April 27 || @ Braves || 6–2 || Jack Sanford (2–1) || Lew Burdette (1–2) || None || 18,408 || 4–6 |- style="background:#bfb" | 11 || April 29 || @ Giants || 7–4 || Curt Simmons (1–2) || Ramón Monzant (2–2) || Turk Farrell (1) || 6,801 || 5–6 |- style="background:#fbb" | 12 || April 30 || @ Giants || 1–10 || Johnny Antonelli (2–1) || Robin Roberts (1–2) || None || 7,886 || 5–7 |- |- style="background:#bfb" | 13 || May 1 || @ Giants || 7–0 || Ray Semproch (2–1) || Rubén Gómez (2–1) || None || 6,728 || 6–7 |- style="background:#fbb" | 14 || May 2 || @ Giants || 2–4 || Mike McCormick (1–0) || Jack Sanford (2–2) || Marv Grissom (2) || 13,486 || 6–8 |- style="background:#bfb" | 15 || May 3 || @ Giants || 4–2 || Curt Simmons (2–2) || Ramón Monzant (2–3) || Turk Farrell (2) || 13,073 || 7–8 |- style="background:#fbb" | 16 || May 4 (1) || @ Dodgers || 7–8 || Don Bessent (1–0) || Robin Roberts (1–3) || Ed Roebuck (2) || see 2nd game || 7–9 |- style="background:#fbb" | 17 || May 4 (2) || @ Dodgers || 2–15