|| 7–1 || Rick Wise (1–1) || Bob Veale (1–2) || Barry Lersch (1) || 4,930 || 3–8 |- style="background:#bfb" | 12 || April 21 || @ Mets || 2–1 (11) || Woodie Fryman (2–1) || Ron Taylor (0–1) || Barry Lersch (2) || 9,286 || 4–8 |- style="background:#bbb" | – || April 22 || @ Mets || colspan=6 | Postponed (wet grounds and rain); Makeup: September 5 as a traditional double-header |- style="background:#bbb" | – || April 23 || @ Expos || colspan=6 | Postponed (rain); Makeup: September 19 as a traditional double-header |- style="background:#bfb" | 13 || April 24 || @ Expos || 7–1 || Rick Wise (2–1) || Mudcat Grant (1–1) || None || 5,116 || 5–8 |- style="background:#bfb" | 14 || April 25 || Cardinals || 5–1 || Grant Jackson (2–1) || Bob Gibson (1–2) || None || 7,710 || 6–8 |- style="background:#fbb" | 15 || April 26 || Cardinals || 4–10 || Ron Willis (1–0) || Barry Lersch (0–2) || Joe Hoerner (3) || 8,942 || 6–9 |- style="background:#bfb" | 16 || April 27 || Cardinals || 1–0 || Jerry Johnson (1–2) || Ray Washburn (2–2) || None || 7,565 || 7–9 |- style="background:#fbb" | 17 || April 28 || Cubs || 1–2 (10) || Ted Abernathy (2–0) || Rick Wise (2–2) || None || 4,438 || 7–10 |- style="background:#fbb" | 18 || April 29 || Cubs || 0–10 || Ferguson Jenkins (4–1) || Grant Jackson (2–2) || None || 3,811 || 7–11 |- style="background:#bfb" | 19 || April 30 || Cubs || 3–1 || Woodie Fryman (3–1) || Bill Hands (3–2) || None || 2,930 || 8–11 |- |- style="background:#bfb" | 20 || May 2 || @ Cardinals || 7–2 || Jerry Johnson (2–2) || Ray Washburn (2–3) || Turk Farrell (1) || 17,916 || 9–11 |- style="background:#bfb" | 21 || May 3 || @ Cardinals || 4–1 || Rick Wise (3–2) || Steve Carlton (2–3) || None || 16,796 || 10–11 |- style="background:#bfb" | 22 || May 4 || @ Cardinals || 5–0 || Grant Jackson (3–2) || Dave Giusti (2–3) || None || 15,511 || 11–11 |- style="background:#bfb" | 23 || May 6 || Astros || 5–4 || Turk Farrell (1–0) || Dooley Womack (1–1) || None || 3,544 || 12–11 |- style="background:#fbb" | 24 || May 7 || Astros || 1–6 || Larry Dierker (4–3) || Jerry Johnson (2–3) || None