In enzymology, a CoA-disulfide reductase () is an enzyme that catalyzes the chemical reaction 2 CoA + NAD(P)+ CoA-disulfide + NAD(P)H + H+ The 3 substrates of this enzyme are CoA, NAD+, and NADP+, whereas its 4 products are CoA-disulfide, NADH, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CoA:NAD(P)+ oxidoreductase. Other names in common use include CoA-disulfide reductase (NADH2), NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase, CoADR, and coenzyme A disulfide reductase. References EC 1.8.1 NADPH-dependent enzymes NADH-dependent enzymes Enzymes of unknown structure