In enzymology, a L-aminoadipate-semialdehyde dehydrogenase () is an enzyme that catalyzes the chemical reaction L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O L-2-aminoadipate + NAD(P)H + H+ The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD+, NADP+, and H2O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H+. This enzyme participates in lysine biosynthesis and biodegradation. Nomenclature This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include: aminoadipate semialdehyde dehydrogenase, 2-aminoadipate semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, alpha-aminoadipate reductase, 2-aminoadipic semialdehyde dehydrogenase, L-alpha-aminoadipate delta-semialdehyde oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine, and dinucleotide oxidoreductase. References EC 1.2.1 NADPH-dependent enzymes NADH-dependent enzymes Enzymes of known structure