|| 9,077 || 1–2 |- style="background:#fbb" | 4 || April 17 || Braves || 4–8 || Bob Buhl (1–0) || Robin Roberts (0–2) || None || 6,632 || 1–3 |- style="background:#bfb" | 5 || April 19 || @ Pirates || 4–3 || Jim Owens (1–0) || Harvey Haddix (0–1) || None || 11,443 || 2–3 |- style="background:#fbb" | 6 || April 20 || @ Pirates || 2–4 || Vern Law (2–0) || Don Cardwell (1–1) || None || 10,403 || 2–4 |- style="background:#fbb" | 7 || April 21 || @ Pirates || 5–11 || Fred Green (1–0) || Humberto Robinson (0–1) || Roy Face (1) || 9,451 || 2–5 |- style="background:#bfb" | 8 || April 22 || Reds || 10–7 || Robin Roberts (1–2) || Jay Hook (1–1) || Rubén Gómez (1) || 12,254 || 3–5 |- style="background:#bfb" | 9 || April 23 || Reds || 3–2 (13) || Turk Farrell (1–0) || Bill Henry (0–1) || None || 5,168 || 4–5 |- style="background:#bfb" | 10 || April 24 (1) || Reds || 9–5 || Chris Short (1–0) || Bob Purkey (0–1) || Turk Farrell (1) || see 2nd game || 5–5 |- style="background:#fbb" | 11 || April 24 (2) || Reds || 4–10 || Don Newcombe (1–0) || Jim Owens (1–1) || Jim Brosnan (1) || 19,873 || 5–6 |- style="background:#bbb" | – || April 26 || Pirates || colspan=6 | Postponed (rain); Makeup: July 8 as a traditional double-header |- style="background:#fbb" | 12 || April 27 || Pirates || 2–3 || Vern Law (3–0) || Jack Meyer (0–1) || None || 9,233 || 5–7 |- style="background:#fbb" | 13 || April 28 || Pirates || 0–3 || Bob Friend (3–0) || John Buzhardt (0–2) || None || 8,789 || 5–8 |- style="background:#fbb" | 14 || April 29 || @ Braves || 3–5 || Juan Pizarro (1–1) || Jim Owens (1–2) || Warren Spahn (1) || 12,480 || 5–9 |- style="background:#bbb" | – || April 30 || @ Braves || colspan=6 | Postponed (rain); Makeup: August 18 |- |- style="background:#fbb" | 15 || May 1 || @ Braves || 4–5 || Lew Burdette (2–1) || Don Cardwell (1–2) || Don McMahon (1) || 17,884 || 5–10 |- style="background:#fbb" | 16 || May 2 || @ Cubs || 7–8 || Ben Johnson (1–1) || Humberto Robinson (0–2) || None || 2,807 || 5–11 |- style="background:#bfb" | 17 || May 3 ||