|| @ Padres || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || July 28 || @ Padres || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || July 29 || @ Padres || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || July 31 || @ Dodgers || colspan=6 | Game cancelled: players' strike|- |- style="background:#bbb" | – || August 1 || @ Dodgers || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || August 2 || @ Dodgers || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || August 4 || Cubs || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || August 5 || Cubs || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || August 6 || Cubs || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || August 7 || @ Expos || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || August 8 || @ Expos || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || August 9 (1) || @ Expos || colspan=6 | Game cancelled: players' strike|- style="background:#bbb" | – || August 9 (2) || @ Expos || colspan=6 | Game cancelled: players' strike|- style="background:#bbcaff;" | – || August 9 ||colspan="7" | 1981 Major League Baseball All-Star Game at Cleveland Stadium in Cleveland |- style="background:#fbb" | 56 || August 10 || Cardinals || 3–7 || Bob Forsch (7–2) || Larry Christenson (2–6) || Bruce Sutter (12) || 60,561 || 0–1(34–22) |- style="background:#bfb" | 57 || August 11 || Cardinals || 6–5 (10) || Ron Reed (2–0) || Jim Kaat (3–2) || None || 24,549 || 1–1(35–22) |- style="background:#fbb" | 58 || August 12 || Cardinals || 3–11 || Bob Sykes (1–0) || Dick Ruthven (8–4) || Mark Littell (2) || 23,566 || 1–2(35–23) |- style="background:#fbb" | 59 || August 13 || Cardinals || 2–5 || John Martin (4–1) || Steve Carlton (9–2) || Bruce Sutter (13) || 26,783 || 1–3(35–24) |- style="background:#bfb" | 60 || August 14 || @ Mets || 8–4 || Larry Christenson (3–6) || Mike Scott (3–5) || Mike Proly (2) || 34,136 || 2–3(36–24) |- style="background:#fbb" | 61 || August 15 || @ Mets || 1–3 || Pete Falcone (2–3) || Nino Espinosa (2–5) || Neil Allen (8) || 14,309 || 2–4(36–25) |- style="background:#fbb" | 62 || August 16 || @ Mets || 2–5 || Pat Zachry (6–7)