In enzymology, a nicotinate dehydrogenase () is an enzyme that catalyzes the chemical reaction nicotinate + H2O + NADP+ 6-hydroxynicotinate + NADPH + H+ The 3 substrates of this enzyme are nicotinate, H2O, and NADP+, whereas its 3 products are 6-hydroxynicotinate, NADPH, and H+. Classification This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor. Nomenclature The systematic name of this enzyme class is nicotinate:NADP+ 6-oxidoreductase (hydroxylating). Other names in common use include nicotinic acid hydroxylase, and nicotinate hydroxylase. Biological role This enzyme participates in nicotinate and nicotinamide metabolism. It has 2 cofactors: FAD, and Iron. References EC 1.17.1 NADPH-dependent enzymes Flavoproteins Iron enzymes Enzymes of unknown structure