such as Mint1 and neurexin Higher levels of Neuroligin 1 Increased glutamate release at synapses and reduced GABA release affecting the E/I balance in maturing neural circuits Down-regulation of GluN2B resulting in disruption of synaptic E/I balance Even slight changes in CASK expression in humans leads to dysregulation of the formation of presynapses, especially in inhibitory neurones. Interactions CASK has been shown to interact with: KCNJ4 APBA1 ATP2B4 CINAP and TBR1 DLG1 DLG4 F11 receptor ID1 KCNJ12 LIN7A Nephrin Parkin (ligase) RPH3A SDC2 External links CASK Research Foundation - A non-profit based in the UK for research, information and support into CASK related disorders including MICPCH Angelina CASK Neurological Research Foundation - A non-profit based in Australia creating research grants for research into CASK gene related disorders. References Further reading External links EC 2.7.11