comprehensive nutmeg plantation system on the islands during the 17th century. As a result of the Dutch interregnum during the Napoleonic Wars, the British invaded and temporarily took control of the Banda Islands from the Dutch and transplanted nutmeg trees, complete with soil, to Sri Lanka, Penang, Bencoolen, and Singapore. From these locations they were transplanted to their other colonial holdings elsewhere, notably Zanzibar and Grenada. The national flag of Grenada, adopted in 1974, shows a stylised split-open nutmeg fruit. The Dutch retained control of the Spice Islands until World War II. It has been suggested that Connecticut received its nickname ("the Nutmeg State", "Nutmegger") from the claim that some unscrupulous Connecticut traders would whittle "nutmeg" out of wood, creating a "wooden nutmeg", a term which later came to mean any type of fraud. This narrative may have to do with the issue that one has to grate to obtain the spice powder, not crack a nutmeg, and this may not have been widely known by some purchasers of the product. Production In 2019, global production of nutmeg was 142,000 tonnes, led by Indonesia, Guatemala, and India, having 38,000 to 43,000 tonnes each and a combined 85% of the world total. Psychoactivity and toxicity Although used as a folk treatment for some ailments, nutmeg has no proven medicinal value. Effects Ingested in small amounts as a spice, nutmeg produces no noticeable physiological or neurological response, but in large doses, both raw nutmeg freshly ground from kernels and nutmeg oil have psychoactive effects, which appear to derive from anticholinergic-like hallucinogenic mechanisms attributed to myristicin and elemicin. Myristicin—a monoamine oxidase inhibitor and psychoactive substance—can cause convulsions, palpitations, nausea, eventual dehydration, and generalized body pain when consumed in large amounts. Nutmeg usage may increase endocannabinoids like anandamide and 2-AG levels or delay their breakdown by inhibiting FAAH and MAGL. Nutmeg may interact with anxiolytic drugs, produce allergic reactions, cause contact dermatitis, and evoke acute episodes of psychosis. Varying considerably from person to person, nutmeg intoxication may occur with side effects, such as delirium, anxiety, confusion, headaches, nausea, dizziness, dry mouth, eye irritation, and amnesia. Intoxication takes several hours to reach maximum effect, and effects may last for several days. Rarely, nutmeg overdose causes death, especially if the nutmeg is combined with other drugs. Incidents of fatal poisoning from nutmeg and myristicin individually are uncommon. Nutmeg poisonings occur by accidental consumption in children and