fortunei and R. griffithianum. Other examples include the PJM hybrids, formed from a cross between Rhododendron carolinianum and R. dauricum, and named after Peter J. Mezitt of Weston Nurseries, Massachusetts. Uses Pharmacology Rhododendron species have long been used in traditional medicine. Animal studies and in vitro research have identified possible anti-inflammatory and hepatoprotective activities which may be due to the antioxidant effects of flavonoids or other phenolic compounds and saponins the plant contains. Xiong et al. have found that the root of the plant is able to reduce the activity of NF-κB in rats. Toxicology Some species of rhododendron are poisonous to grazing animals because of a toxin called grayanotoxin in their pollen and nectar. People have been known to become ill from eating honey made by bees feeding on rhododendron and azalea flowers. Xenophon described the odd behaviour of Greek soldiers after having consumed honey in a village surrounded by Rhododendron ponticum during the march of the Ten Thousand in 401 BCE. Pompey's soldiers reportedly suffered lethal casualties following the consumption of honey made from Rhododendron deliberately left behind by Pontic forces in 67 BCE during the Third Mithridatic War. Later, it was recognized that honey resulting from these plants has a slightly hallucinogenic and laxative effect. The suspect rhododendrons are Rhododendron ponticum and Rhododendron luteum (formerly Azalea pontica), both found in northern Asia Minor. Eleven similar cases during the 1980s have been documented in Istanbul, Turkey. Rhododendron is extremely toxic to horses, with some animals dying within a few hours of ingesting the plant, although most horses tend to avoid it if they have access to good forage. The effects of R. ponticum were mentioned in the 2009 film Sherlock Holmes as a proposed way to arrange a fake execution. It was also mentioned in the third episode of Season 2 of BBC's Sherlock, speculated to have been a part of Sherlock's fake death scheme. Culture Symbolism In the language of flowers, the Rhododendron symbolizes danger and to beware. Rhododendron arboreum (lali guransh) is the national flower of Nepal. R. ponticum is the state flower of Indian-administered Kashmir and Pakistan-controlled Kashmir. Rhododendron niveum is the state tree of Sikkim in India. Rhododendron arboreum is also the state tree of the state of Uttarakhand, India. Pink Rhododendron (Rhododendron campanulatum) is the state flower of Himachal Pradesh, India. Rhododendron is also the provincial flower of Jiangxi, China and the state