The play concerns "Lady" Bright, who is a forty-year-old "screaming preening queen". On a sultry summer day in the 1960s, while in his apartment on the Upper West Side of Manhattan, "Lady" Bright slowly loses his mind. It is a complex and comic tragedy of striking originality, and one of Wilson's most notable and finest works. At its heart, the work is a penetrating study of loneliness and isolation. It was one of off-off-Broadway's first significant successes, running for over 200 performances. The Madness of Lady Bright set a record as the longest-running play at Caffe Cino. In 1965, Wilson began writing plays for Ellen Stewart's La MaMa Experimental Theatre Club in the East Village. His first full-length plays premiered at La MaMa, including Balm in Gilead, which depicted a doomed romance in an urban greasy spoon diner inhabited by junkies, prostitutes and thieves. Balm in Gilead premiered at La MaMa in 1965, directed by Marshall W. Mason. The play was revived in 1984 by Circle Repertory Company and the Steppenwolf Theatre Company, and directed by John Malkovich. Later in 1965, Wilson wrote and directed Miss Williams for a benefit performance at La MaMa called "BbAaNnGg!". In 1965, Wilson's plays Home Free! and No Trespassing were produced for La MaMa Repertory Troupe's first European tour. His play This is the Rill Speaking was produced alongside Jean-Claude van Itallie's War and Rochelle Owens' Homo for La MaMa Repertory Troupe's second European tour, in 1966. His play Untitled was produced with work by Sam Shepard, Tom Eyen, Leonard Melfi, Paul Foster, and Owens, all directed by Tom O'Horgan, for La MaMa Repertory Troupe's third European tour, in 1967. In addition to writing his own plays at La MaMa, Wilson did set design for work by other playwrights. In 1966, he designed the set for Foster's The Madonna in the Orchard, directed by O'Horgan at La MaMa. He then designed the set for Donald Julian's In Praise of Folly, directed by Mason at La MaMa in 1969. Wilson's play The Sand Castle was first produced at La MaMa in 1965, as directed by Mason, and was again directed by Mason at La MaMa in 1967. Wilson participated in the inaugural National Playwrights Conference in 1965 at the Eugene O'Neill Theater Center along with Sam Shepard, Edward Albee, and John Guare. His 1966 play The Rimers of Eldritch addressed hypocrisy and narrow-mindedness in a