written language in Hesse has been Standard German since the 16th century. Before, the Low Saxon part used Middle Low German, the rest of the Land Early Modern German as prominent written languages. These had supplanted Latin in the High Middle Ages. Religion In 2016 Christianity was the most widespread religion in the state (63%). 40% of Hessians belonged to the Protestant Church in Hesse and Nassau or Evangelical Church of Hesse Electorate-Waldeck (members of the Evangelical Church in Germany), 25% adhered to the Roman Catholic Church, while other Christians constituted some 3%, the third most common religion of the Hessian population is Islam with 7% of the population. Education and Research Higher education The Hessian government has overall responsibility for the education within the state. Hesse has follow universities: Goethe University Frankfurt (43,972 students; Budget: € 666,4 Mio.) Technical University of Darmstadt (25,355 students; Budget: € 482,8 Mio.) Justus Liebig University Giessen (28,480 students; Budget: € 425,4 Mio.) Philipps University of Marburg (24,394 students; Budget: € 374,3 Mio.) University of Kassel (25,103 students; Budget: € 291,5 Mio.) No any Hesse's university belongs to German Excellence Universities. There are many international schools in Hesse, primarily centred in and around Frankfurt. Hesse is the only state in Germany where students have to study all three stanzas of the Das Deutschlandlied. Research Big Science A single existing big science facility in Hesse is GSI Helmholtz Centre for Heavy Ion Research in Darmstadt-Wixhausen with 1,520 employees. The second one Facility for Antiproton and Ion Research is in construction till 2025. In space research there are 2 European organization European Space Operations Center and European Organisation for the Exploitation of Meteorological Satellites in Darmstadt. Health & Medicine Max Planck Institue for Heart and Lung Research, Bad Nauheim Max Planck Institute for Brain Research, Frankfurt-am-Main Max Planck Institute of Biophysics, Frankfurt-am-Main , Frankfurt-am-Main Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt-am-Main Paul Ehrlich Institute (vaccines), Langen Max Planck Institute for Terrestrial Microbiology, Marburg (researh of Ebolavirus and Marburgvirus; Parasitology) with BSL4-Labor, Marburg , Marburg , Marburg Sigmund Freud Institute (psychoanalysis), Frankfurt-am-Main Informatics & Software Hessian Centre for Artificial Intelligence, HQ in Darmstadt, more locations in Hesse German Research Centre for Artificial Intelligence, Darmstadt Center for Advanced Security Research Darmstadt, Darmstadt , Darmstadt , Darmstadt Others , Darmstadt , HQ in Kassel, other location in Rothwesten and Bad Hersfeld , Hanau Max-Planck-Institut für europäische Rechtsgeschichte, Frankfurt-am-Main