took years. In 1528, sweating sickness broke out with great severity. In London, the mortality rate was great and the court was dispersed. Henry left London, frequently changing his residence; Anne Boleyn retreated to the Boleyn residence at Hever Castle, but contracted the illness; her brother-in-law, William Carey, died. Henry sent his own physician to Hever Castle to care for Anne, and shortly afterwards, she recovered. Henry was soon absorbed in securing an annulment from Catherine. He set his hopes upon a direct appeal to the Holy See, acting independently of Wolsey, to whom he at first communicated nothing of his plans related to Anne. In 1527 William Knight, the king's secretary, was sent to Pope Clement VII to sue for the annulment of Henry's marriage to Catherine, on the grounds that the dispensing bull of Julius II permitting him to marry his brother's widow, Catherine, had been obtained under false pretences. Henry also petitioned, in the event of his becoming free, a dispensation to contract a new marriage with any woman even in the first degree of affinity, whether the affinity was contracted by lawful or unlawful connection. This clearly referred to Anne. As Clement was at that time a prisoner of Charles V, the Holy Roman Emperor, as a result of the Sack of Rome in May 1527, Knight had some difficulty obtaining access. In the end he had to return with a conditional dispensation, which Wolsey insisted was technically insufficient. Henry then had no choice but to put his great matter into Wolsey's hands, who did all he could to secure a decision in Henry's favour, even going so far as to convene an ecclesiastical court in England, with a special emissary, Lorenzo Campeggio, from Clement to decide the matter. But Clement had not empowered his deputy to make a decision. He was still Charles V's hostage, and Charles V was loyal to his aunt Catherine. The pope forbade Henry to contract a new marriage until a decision was reached in Rome, not in England. Convinced that Wolsey's loyalties lay with the pope, not England, Anne, as well as Wolsey's many enemies, ensured his dismissal from public office in 1529. Cavendish, Wolsey's chamberlain, records that the servants who waited on the king and Anne at dinner in 1529 in Grafton heard her say that the dishonour Wolsey had brought upon the realm would have cost any other