fever". Society and culture Blood donation Outbreaks of dengue fever increase the need for blood products while decreasing the number of potential blood donors due to potential infection with the virus. Someone who has a dengue infection is typically not allowed to donate blood for at least the next six months. Awareness efforts A National Dengue Day is held in India on 16 May in an effort to raise awareness in affected countries. Efforts are ongoing as of 2019 to make it a global event. The Philippines has an awareness month in June since 1998. Research Research efforts to prevent and treat dengue include various means of vector control, vaccine development, and antiviral drugs. A vaccine candidate, TAK-003, has shown 73% efficacy in a clinical trial of more than 20,000 children in endemic regions and 90% efficacy for hospitalized patients. Vector With regards to vector control, a number of novel methods have been used to reduce mosquito numbers with some success including the placement of the guppy (Poecilia reticulata) or copepods in standing water to eat the mosquito larvae. There are also trials with genetically modified male A. aegypti that after release into the wild mate with females, and render their offspring unable to fly. Wolbachia In 2021 research in Yogyakarta, Indonesia, infected A. aegypti with the wMel strain of Wolbachia pipientis. Infected mosquitos were less susceptible to dengue virus infection. Odds ratio of intervention clusters versus control clusters was .23 (95% confidence interval [CI], 0.15 to 0.35; P=0.004). Treatment Apart from the attempts to control the spread of the Aedes mosquito there are ongoing efforts to develop antiviral drugs that would be used to treat attacks of dengue fever and prevent severe complications. Discovery of the structure of the viral proteins may aid the development of effective drugs. There are several plausible targets. The first approach is inhibition of the viral RNA-dependent RNA polymerase (coded by NS5), which copies the viral genetic material, with nucleoside analogs. Secondly, it may be possible to develop specific inhibitors of the viral protease (coded by NS3), which splices viral proteins. Finally, it may be possible to develop entry inhibitors, which stop the virus entering cells, or inhibitors of the 5′ capping process, which is required for viral replication. Carica papaya leaf extract has been studied and has been used for treatment and in hospitals. As of 2020, studies have shown positive benefits on