Venus Williams in England. Hantuchová had a successful US Open series run, where she reached the semifinals in Cincinnati, getting upset by No. 74 Akiko Morigami. In Stanford, Hantuchová lost to Clijsters in the quarterfinals. After a second-round loss in San Diego to Sugiyama, Hantuchová reached her fourth final in Los Angeles, getting a walkover in the quarterfinals over Sharapova, and got revenge against Dementieva in the semifinals. In the final, for the seventh time in their head-to-head, Clijsters defeated Hantuchová in straight sets. For the third time at the event, Hantuchová made the quarterfinals in New Haven, before losing to Davenport. Hantuchová lost to eventual quarterfinalist Venus Williams in the third round at the US Open. She won the mixed doubles, completing a career grand slam in mixed doubles. She has largely retired from the mixed doubles since then, saying that she "felt like it's time to move on and focus on my singles." In Luxembourg, Hantuchová made her eighth quarterfinal of the season, losing to Nathalie Dechy. In Filderstadt the following week, Hantuchová made the semifinals, her third of the year, defeating No. 10 Patty Schnyder in the second round and Flavia Pennetta in the quarterfinals. She lost to Davenport in the semifinals. At the final Tier-I event of the year, Hantuchová pushed Davenport to three sets and had match points in the second set in Zurich, before losing. In her final event of the year, in Linz, Hantuchová made her tenth quarterfinal, losing to Schnyder. Hantuchová finished 2005 with a 3–10 record against the top 10, 37–25 overall record, with 2–1 on indoor carpet, 3–4 on clay, 2–3 on grass, and 30–17 on hardcourts, reaching ten quarterfinals, three semifinals, and one final. 2006: French Open doubles final Hantuchová reached the quarterfinals of Sydney in 2006 with a win over top-ten player Patty Schnyder and got to the semifinals of Auckland. She continued this form at the Australian Open with her third-round victory over defending champion and seven-time Grand Slam winner Serena Williams, who had entered the tournament with a lack of match practice and questions over her fitness. This victory (the only over Serena in her career) ensured that Hantuchová would progress to the fourth round of a Grand Slam tournament for the first time in three years. She lost to fourth-seeded Maria Sharapova in straight sets in the fourth round. Thereafter, she was unable to find