visited Sasebo, Japan, and Okinawa early in March. She returned to the Vietnam combat zone on 12 March as a unit of TG 77.7 and again served as escort and plane guard for carriers conducting air strikes in North Vietnam. She continued in that role until 2 April when she was detached and reassigned to Task Unit (TU) 70.8.9 to conduct gunfire support missions near Danang and Quang Tri. On the 6th, the warship resumed her former assignment with TG 77.7. On 24 April, she joined a different unit, TU 77.0.3, to conduct trawler surveillance in the Gulf of Tonkin. On 2 May, she returned to gunfire support duty, this time near Chu Lai, until 8 May. On that day, the destroyer resumed duty with TF 77 as a search and rescue (SAR) vessel on the southern SAR station. On 15 May, she concluded her last combat assignment of the 1966 deployment. After a week's liberty call at Hong Kong and repairs at Yokosuka, Wedderburn headed home on 3 June and arrived in San Diego 10 days later. Following local operations, the destroyer entered the Long Beach Naval Shipyard on 11 August for a three-month overhaul. She completed sea trials on 20 November and resumed normal operations on the 21st. During the first two months of 1967, Wedderburn conducted extensive refresher training exercises and, during March and early April, made preparations for overseas movement. On 8 April, she stood out of San Diego once more in company with Worden, Brush (DD-745), and Lyman K. Swenson (DD-729). She stopped at Pearl Harbor from 14 to 17 April and arrived in Yokosuka on the 27th. Three days later, she got underway for Okinawa whence she continued on to Yankee Station in the Gulf of Tonkin where she conducted plane guard duty with TG 77.6. Five days later, she shifted to shore bombardment duty near the demilitarized zone (DMZ). That assignment lasted until 27 May when she returned to the carriers on Yankee Station. She left the combat zone on 5 June and arrived in Subic Bay two days later. She made repairs and embarked two NROTC midshipmen and then departed the Philippines on 10 June to return to the Gulf of Tonkin. There, she divided her time between plane guard duty for Hancock (CVA-19) and ASW exercises with Bronstein (DE-1037) and Catfish (SS-339). She visited Kaohsiung, Taiwan, from 25 June to 10