"father of metallurgy". In 1605, Sir Francis Bacon published The Proficience and Advancement of Learning, which contains a description of what would later be known as the scientific method. In 1605, Michal Sedziwój publishes the alchemical treatise A New Light of Alchemy which proposed the existence of the "food of life" within air, much later recognized as oxygen. In 1615 Jean Beguin published the Tyrocinium Chymicum, an early chemistry textbook, and in it draws the first-ever chemical equation. In 1637 René Descartes publishes Discours de la méthode, which contains an outline of the scientific method. The Dutch chemist Jan Baptist van Helmont's work Ortus medicinae was published posthumously in 1648; the book is cited by some as a major transitional work between alchemy and chemistry, and as an important influence on Robert Boyle. The book contains the results of numerous experiments and establishes an early version of the law of conservation of mass. Working during the time just after Paracelsus and iatrochemistry, Jan Baptist van Helmont suggested that there are insubstantial substances other than air and coined a name for them – "gas", from the Greek word chaos. In addition to introducing the word "gas" into the vocabulary of scientists, van Helmont conducted several experiments involving gases. Jan Baptist van Helmont is also remembered today largely for his ideas on spontaneous generation and his 5-year tree experiment, as well as being considered the founder of pneumatic chemistry. Robert Boyle Anglo-Irish chemist Robert Boyle (1627–1691) is considered to have initiated the gradual separation of chemistry from alchemy. Although skeptical of elements and convinced of alchemy, Boyle played a key part in elevating the "sacred art" as an independent, fundamental and philosophical discipline. He is best known for Boyle's law, which he presented in 1662, though he was not the first to discover it. The law describes the inversely proportional relationship between the absolute pressure and volume of a gas, if the temperature is kept constant within a closed system. Boyle is also credited for his landmark publication The Sceptical Chymist (1661), which advocated for a rigorous approach to experimentation among chemists. In the work, Boyle questioned some commonly held alchemical theories and argued for practitioners to be more “philosophical” and less commercially focused. He rejected the classical four elements of earth, fire, air, and water, and proposed a mechanistic alternative of atoms and chemical reactions that could be subject to rigorous