French Open, Hantuchová was upset in the third round by Anabel Medina Garrigues, 4–6, 7–6, 7–5. After defeating Eleni Daniilidou in the third round of the Tier III grass-court Birmingham Classic, Hantuchová returned to the top 10 for the first time since August 2003. She then lost to Marion Bartoli in the quarterfinals, in three sets. The following week at the Tier III Ordina Open in 's-Hertogenbosch, Hantuchová defeated world No. 6 Ana Ivanovic in the quarterfinals, before losing to Chakvetadze in the semifinals. This result caused Hantuchová to drop out of the top 10. Hantuchová was the tenth-seeded player at Wimbledon and did not lose a set in her first two matches. She then defeated Slovenian Katarina Srebotnik in the third round, before losing to world No. 8 Serena Williams in the fourth round. Immediately after Wimbledon, Hantuchová helped Slovakia win its Fed Cup World Group II play-off against Serbia. On an indoor hardcourt in Košice, she beat Ana Timotić and Vojislava Lukić. Hantuchová played five tournaments during the North American summer hard-court season. She began the US Open Series by losing to Chakvetadze in the semifinals of the Tier-II Stanford Classicn. This result put her back in the top ten. At the Tier-I San Diego Classic, she lost to world No. 16, Venus Williams, in the second round. The following week at the Tier-II LA Championships, Hantuchová retired from her third-round match with Elena Dementieva while trailing, 3–6, 1–4. Hantuchová once again fell out of the top 10, after losing in the second round of the Tier-II Pilot Pen Tennis tournament in New Haven to eventual runner-up Ágnes Szávay. At the US Open, Hantuchová was the ninth-seeded player but lost to Ukraine's Julia Vakulenko in the first round. It was Hantuchová's earliest loss at this tournament since her debut in 2001 and her earliest loss at a Grand Slam tournament since the 2004 French Open. Hantuchová then played four consecutive tournaments. She reached her second final of the year at the Tier-III Bali Classic, losing to Lindsay Davenport in three sets. At the Tier-III Sunfeast Open in Kolkata, Hantuchová lost in the semifinals to Maria Kirilenko, but re-entered the top 10. Traveling back to Europe, Hantuchová played in the Tier II Luxembourg Open. She defeated Patty Schnyder in the quarterfinals and Bartoli in the semifinals to advance to her third final of the year for the first time