of aromatase The inhibition of aromatase can cause hypoestrogenism (low estrogen levels). The following natural products have been found to have inhibiting effects on aromatase. Apigenin Catechin Chalcones Eriodictyol Hesperetin Isoliquiritigenin Mangostin Myosmine Nicotine Resveratrol Vitamin E Zinc Extracts of certain (white button variety: Agaricus bisporus) mushrooms have been shown to inhibit aromatase in vitro. Pharmaceutical aromatase inhibitors Aromatase inhibitors, which stop the production of estrogen in postmenopausal women, have become useful in the management of patients with breast cancer whose lesion was found to be estrogen receptor positive. Inhibitors that are in current clinical use include anastrozole, exemestane, and letrozole. Aromatase inhibitors are also beginning to be prescribed to men on testosterone replacement therapy as a way to keep estrogen levels from spiking once doses of testosterone are introduced to their systems. See also Steroidogenic enzyme References Further reading External links "U.S. study of gay sheep may shed light on sexuality", via WikiNews, 15 August 2005. EC 1.14.14 19