can be detected from amniotic fluid or chorionic villi samples with BACs-on-Beads technology. G-banded karyotype of a carrier is also useful. Treatment There is not a specific way to treat the condition as the brain damage caused by this condition occurs in the early stages of embryo development. Intensive treatment is rarely needed in infants and they can be treated in neonatal pathology departments. Children may be treated by speech, physical and occupational therapists. If infants have difficulty in suction or swallowing, then physical therapy should begin in the first weeks of life. Heart abnormalities often require surgical correction and specialist attention. Prognosis Once the child has survived the first few years of life, the prognosis is good and the mortality level is low. In a series of case reports, the mortality rate was about 10%, with 75% of deaths occurring within 3 months of birth, and 90% within the 1st year. References External links Autosomal monosomies and deletions Rare syndromes Rare genetic syndromes Syndromes affecting the nervous system Chromosomal abnormalities