help predict the effectiveness of that load getting a "one-shot-stop". For example, if an ammunition load is used in 10 torso shootings, incapacitating all but two with one shot, the "one-shot-stop" percentage for the total sample would be 80%. Some argue that this hypothesis ignores any inherent selection bias. For example, high-velocity 9×19mm Parabellum hollow point rounds appear to have the highest percentage of one-shot stops. Rather than identifying this as an inherent property of the firearm/bullet combination, the situations where these have occurred need to be considered. The 9mm has been the predominantly used caliber of many police departments, so many of these one-shot-stops were probably made by well-trained police officers, where accurate placement would be a contributory factor. However, Marshall's database of "one-shot-stops" does include shootings from law enforcement agencies, private citizens, and criminals alike. Critics of this theory point out that bullet placement is a very significant factor, but is only generally used in such one-shot-stop calculations, covering shots to the torso. Others contend that the importance of "one-shot stop" statistics is overstated, pointing out that most gun encounters do not involve a "shoot once and see how the target reacts" situation. Proponents contend that studying one-shot situations is the best way to compare cartridges as comparing a person shot once to a person shot twice does not maintain a control and has no value. Big hole school This school of thought says that the bigger the hole in the target, the higher the rate of bleed-out and thus the higher the rate of the aforementioned "one-shot stop". According to this theory, as the bullet does not pass entirely through the body, it incorporates the energy transfer and the overpenetration ideals. Those that support this theory cite the .40 S&W round, arguing that it has a better ballistic profile than the .45 ACP, and more stopping power than a 9mm. The theory centers on the "permanent cavitation" element of a handgun wound. A big hole damages more tissue. It is therefore valid to a point, but penetration is also important, as a large bullet that does not penetrate will be less likely to strike vital blood vessels and blood-carrying organs such as the heart and liver, while a smaller bullet that penetrates deep enough to strike these organs or vessels will cause faster bleed-out through a smaller hole. The ideal may therefore be a combination: a large