Nash as the owner once again. Cast Eddie Murphy as Pluto Nash, a successful businessman, a retired smuggler and ex-convict who deals in animals, clothing and drugs. Murphy also portrays Rex Crater, a criminal entrepreneur & businessman operating out of Moon Beach and Pluto Nash's clone created by Marucci and the geneticist Dr. Runa Pendankin from the DNA taken from Pluto's removed appendix back when Pluto was incarcerated. Randy Quaid as Bruno, an old, inferior 63 Deluxe model android, Pluto's childhood friend, and smuggling partner. Rosario Dawson as Dina Lake, an aspiring singer from Salt Lake City and daughter of Pluto's old friend Nicky Sticks who is stranded on the moon and asks Pluto for help finding a job to earn money for a ticket back to Earth. Jay Mohr as Anthony Frankowski / Tony Francis, a former Polish singer who owned a washed-up polka club until Pluto bought it. Francis relocated to Moon Beach. Peter Boyle as Rowland, a retired police detective with connections to the FBI and an old friend of Pluto and Flura. Luis Guzmán as Felix Laranga, a smuggler from Puerto Rico and fan of Pluto Nash who deals in animals and contraband casino chips and dice. Joe Pantoliano as Mogan, one of Rex Crater's henchmen. James Rebhorn as Belcher, Rex Crater's personal assistant who used to work for Marucci. Pam Grier as Flura Nash, the mother of Pluto Nash. John Cleese as James, the holographic chauffeur of the limousine that Pluto hijacks. Burt Young as Gino, a mobster that nearly killed Tony Francis through battery acid ingestion. Lillo Brancato as Larry, a mobster working for Gino. Victor Varnado as Kelp, one of Rex Crater's henchmen. Alissa Kramer and Heidi Kramer as Gina and Filomina Francis, Tony's cloned wives (he does not care which is the original). Miguel A. Núñez Jr. as Miguel, Pluto's assistant. Illeana Douglas as Dr. Mona Zimmer, the operator of a cosmetic surgery station and an apprentice of Dr. Pendankin. Stu "Large" Riley as Club Pluto Bouncer, an unnamed bouncer that is loyal to Pluto. Serge Houde as an FBI Agent Terry Haig as Security Guard, who leads the arrest of Bruno for accidentally breaking a robotic slot machine. Cornelia Sharpe as a Tony Francis Fan Mark Camacho as Robot holding cell clerk who guards Bruno pending the repairs to the robotic slot machine. Alec Baldwin as Michael Zoroaster Marucci (uncredited), the