three priority areas for researching the occupational exposome as identified by the National Institute for Occupational Safety and Health. The National Institutes of Health (NIH) has invested in technologies supporting exposome-related research including biosensors, and supports research on gene–environment interactions. Proposed Human Exposome Project (HEP) The idea of a Human Exposome Project, analogous to the Human Genome Project, has been proposed and discussed in numerous scientific meetings, but as of 2017, no such project exists. Given the lack of clarity on how science would go about pursuing such a project, support has been lacking. Reports on the issue include: a 2011 review on the exposome and exposure science by Paul Lioy and Stephen Rappaport, "Exposure science and the exposome: an opportunity for coherence in the environmental health sciences" in the journal Environmental Health Perspectives. a 2012 report from the United States National Research Council "Exposure Science in the 21st Century: A Vision and A Strategy", outlining the challenges in systematic evaluations of the exposome. Related fields The concept of the exposome has contributed to the 2010 proposal of a new paradigm in disease phenotype, "the unique disease principle": Every individual has a unique disease process different from any other individual, considering uniqueness of the exposome and its unique influence on molecular pathologic processes including alterations in the interactome. This principle was first described in neoplastic diseases as "the unique tumor principle". Based on this unique disease principle, the interdisciplinary field of molecular pathological epidemiology (MPE) integrates molecular pathology and epidemiology. Socioeconomic drivers Global change is driven by many factors; however the five main drivers of global change are: population growth, economic growth, technological advances, attitudes, and institutions. These five main drivers of global change can stem from socioeconomic factors which in turn, these can be seen as drivers in their own regard. Socioeconomic drivers of climate change can be triggered by a social or economic demand for resources such as a demand for timber or a demand for agricultural crops. In tropical deforestation for instance, the main driver is economic opportunities that come the extraction of these resources and the conversion of this land to crop or rangelands. These drivers can be manifested at any level, from the global level demand for timber all the way to the household level. An example of how socioeconomic drivers affect climate change can be seen in the soy bean trading between Brazil and