"Murphy's Law" was released 4 March 2020. During the subsequent pandemic quarantine, her home performances for a livestream concert were released as a series of six short films. Her fifth solo album Róisín Machine was released 2 October 2020. It includes ten tracks, with singles "Simulation" and "Jealousy" released several years prior, together with more recently produced songs "Incapable", "Narcissus", "Murphy's Law", and "Something More". Murphy portrayed the blood witch Mercury in the 2022 Netflix series The Bastard Son & The Devil Himself. Style Electronic Beats described Murphy as "this adolescent century's true art-pop queen," writing that "her sensuous and ominous output is scattered across various genres and moods." AllMusic described her as "a purveyor of adventurous, omnivorous pop that blended influences as far-flung as disco and hot jazz." Australian publication OutInPerth called her "Ireland's queen of the avant-garde." Drowned in Sound'''s Giuseppe Zevolli wrote that "she's merged pop, house, and disco with an avant-garde sensibility and a stunning, shape-shifting visual output that never ceases to provoke." Critic Mark Fisher located her music in a glam lineage that includes Roxy Music, Grace Jones, and the New Romantics, noting Murphy's attention to the cultivation of artifice and persona. The sound of Moloko's early work drew on electronic and trip hop influences before transitioning to a more organic sound. According to Elizabeth Vincentelli of The New York Times, "it was only after [Moloko's] breakup that Murphy truly refined her trademark fusion of glossy sheen and playful experimentation." Her diverse solo work has included collaborations with experimental jazz composer Matthew Herbert and electronic producer Eddie Stevens, drawing variously on house music, ballroom culture, and avant-garde electronica. Murphy has a contralto vocal range, which has been described as distinctive, smoky and jazzy. Heather Phares described it as "combin[ining] a wild variety of voices and textures, from impassively chilly to gorgeously lilting to gleefully offbeat." The first performers that left an impression on her were Kim Gordon from Sonic Youth and Kim Deal from the Pixies. Iggy Pop also inspired her for his "energy - and he's a giver". She stated that her biggest influences were Siouxsie Sioux, Grace Jones and Björk. She was also inspired by Italian female singers such as Mina and Patty Pravo for the way they owned the stage when they moved. She described her performances as "a bit like The Rocky Horror Picture Show" and her audiences were said to