had 241 regulated and authorized laboratories for the sale of medicines. Of these, the majority (60%) have national capital. Multinational companies had approximately 52.44% of the market, with 34.75% in commercialized packaging. Brazilian laboratories represent 47.56% of the market in sales and 65.25% in cases sold. In the distribution of drug sales by state, São Paulo ranked first: São Paulo's pharmaceutical industry had a turnover of R $53.3 billion, 76.8% of total sales throughout the country. The companies that benefited the most from the sale of drugs in the country in 2015 were EMS, Hypermarcas (NeoQuímica), Sanofi (Medley), Novartis, Aché, Eurofarma, Takeda, Bayer, Pfizer and GSK. In food industry, in 2019, Brazil was the second largest exporter of processed foods in the world, with a value of US$34.1 billion in exports. The revenue of the Brazilian food and beverage industry in 2019 was R $699.9 billion, 9.7% of the country's gross domestic product. In 2015, the food and beverage industrial sector in Brazil comprised 34,800 companies (not counting bakeries), the vast majority of which were small. These companies employed more than 1,600,000 workers, making the food and beverage industry the largest employer in manufacturing. There are around 570 large companies in Brazil, which account for a good part of the industry's total income. São Paulo created companies such as: , Vigor, Minerva Foods, Bauducco, Santa Helena, Marilan, Ceratti, Fugini, Chocolates Pan, Embaré, among others. Minas Gerais created food companies of national importance such as Itambé and Pif Paf Alimentos. Espírito Santo created Chocolates Garoto and Rio de Janeiro created Piraquê and Granfino. In the Footwear industry, in 2019 Brazil produced 972 million pairs. Exports were around 10%, reaching almost 125 million pairs. Brazil ranks fourth among world producers, behind China, India and Vietnam, and 11th among the largest exporters. Of the pairs produced, 49% were made of plastic or rubber, 28.8% were made of synthetic laminate, and only 17.7% were made of leather. The largest pole in Brazil is in Rio Grande do Sul, but São Paulo has important shoe centers, such as the one in the city of Franca, specialized in men's footwear, in the city of Jaú, specialized in women's footwear and in the city of Birigui, specialized in footwear. children. Jaú, Franca and Birigui represent 92% of footwear production in the state of São Paulo. Birigui has 350 companies, which generate around 13 thousand jobs, producing 45.9