and are allowed in shops other than pharmacies in the US. Preparation, dosage, toxicity Henbane leaves and herbage without roots are chopped and dried and are then used for medicinal purposes or in incense and smoking blends, in making beer and tea, and in seasoning wine. Henbane leaves are boiled in oil to derive henbane oil. Henbane seeds are an ingredient in incense blends. In all preparations, the dosage has to be carefully estimated due to the high toxicity of henbane. For some therapeutic applications, dosages like 0.5 g and 1.5– 3 g were used. The lethal dosage is not known. Henbane is toxic to cattle, wild animals, fish, and birds. Not all animals are susceptible; for example, the larvae of some Lepidoptera species, including cabbage moths, eat henbane. Pigs are immune to henbane toxicity and are reported to enjoy the effects of the plant. Psychoactive material Hyoscyamine, scopolamine, and other tropane alkaloids have been found in the foliage and seeds of the plant. The standard alkaloid content has been reported to be 0.03% to 0.28%. Its psychoactive and pharmacological effects are a result of these alkaloids exerting an anticholinergic mechanism of action which blocks the function of acetylcholine in the brain and antagonizes the muscarinic receptors. This results in an altered state of consciousness, hallucinogenic experiences, and typically, delirium. This mechanism of action is not only linked to dangerous effects and accidents, but dementia as well. Since toxicity/lethality is such a major concern with plants like henbane; many traditional preparations of henbane or other similar scopolamine-containing plants were designed to be applied transdermally, often in “magical ointments” by herbalists, witches and cunning folk. The purpose of this was to absorb the primary and transdermally-active alkaloid scopolamine through the skin, thus eliminating the risk of the additional toxicity from atropine and hyoscyamine that is inevitably present with oral ingestion of the plant but not when used topically. Effects Henbane ingestion by humans is followed simultaneously by peripheral inhibition and central stimulation. Common effects of henbane ingestion include hallucinations, dilated pupils, narcosis, restlessness, and flushed skin. Less common effects are tachycardia, convulsions, vomiting, hypertension, hyperpyrexia, and ataxia. Initial effects typically last for three to four hours, while aftereffects may last up to three days. The side effects of henbane ingestion are dryness in the mouth, confusion, visual illusions, bizarre thoughts, locomotor and memory disturbances, and farsightedness, similar in style to those