modified animals including a version of the Cre-Lox recombination technique. While widely used in transgenic research, the strong anabolic effect of Tamoxifen on bone might confound this approach, especially as it relates to bone-targeted constructs. Tamoxifen may be effective in the treatment of mania in people with bipolar disorder. This is thought to be due to blockade of protein kinase C (PKC), an enzyme that regulates neuron activity in the brain. Researchers believe PKC is overactive during the mania in bipolar patients. , endoxifen, a major active metabolite of tamoxifen with a 4-fold more potent PKC inhibition, was in phase III clinical trials for bipolar disorder. References Further reading External links Aromatase inhibitors AstraZeneca brands Chemopreventive agents Dimethylamino compounds Glycine receptor agonists GPER agonists Hepatotoxins Hormonal antineoplastic drugs IARC Group 1 carcinogens Mood stabilizers Phenol ethers Prodrugs Progonadotropins Selective estrogen receptor modulators Triphenylethylenes World Anti-Doping Agency prohibited substances Wikipedia medicine articles ready to translate Orphan drugs