in an organic compound does not ensure toxicity. Some organochlorides are considered safe enough for consumption in foods and medicines. For example, peas and broad beans contain the natural chlorinated plant hormone 4-chloroindole-3-acetic acid (4-Cl-IAA); and the sweetener sucralose (Splenda) is widely used in diet products. , at least 165 organochlorides had been approved worldwide for use as pharmaceutical drugs, including the natural antibiotic vancomycin, the antihistamine loratadine (Claritin), the antidepressant sertraline (Zoloft), the anti-epileptic lamotrigine (Lamictal), and the inhalation anesthetic isoflurane. Rachel Carson brought the issue of DDT pesticide toxicity to public awareness with her 1962 book Silent Spring. While many countries have phased out the use of some types of organochlorides such as the US ban on DDT, persistent DDT, PCBs, and other organochloride residues continue to be found in humans and mammals across the planet many years after production and use have been limited. In Arctic areas, particularly high levels are found in marine mammals. These chemicals concentrate in mammals, and are even found in human breast milk. In some species of marine mammals, particularly those that produce milk with a high fat content, males typically have far higher levels, as females reduce their concentration by transfer to their offspring through lactation. See also Organic halide References External links "Formation of Chlorinated Hydrocarbons in Weathering Plant Material" article at SLAC website "The oxidation of chlorinated hydrocarbons" article from The Institute for Green Oxidation Chemistry at the Carnegie Mellon University website