successor, Martin V, with delight. The synod convoked by the Jews at Bologna, and continued at Forlì, sent a deputation with costly gifts to the new pope, praying him to abolish the oppressive laws promulgated by Benedict and to grant the Jews those privileges which had been accorded them under previous popes. The deputation succeeded in its mission, but the period of grace was short; for Martin's successor, Eugenius IV, at first favorably disposed toward the Jews, ultimately reenacted all the restrictive laws issued by Benedict. In Italy, however, his bull was generally disregarded. The great centers, such as Venice, Florence, Genoa, and Pisa, realized that their commercial interests were of more importance than the affairs of the spiritual leaders of the Church; and accordingly the Jews, many of whom were bankers and leading merchants, found their condition better than ever before. It thus became easy for Jewish bankers to obtain permission to establish banks and to engage in monetary transactions. Indeed, in one instance even the Bishop of Mantua, in the name of the pope, accorded permission to the Jews to lend money at interest. All the banking negotiations of Tuscany were in the hands of a Jew, Jehiel of Pisa. The influential position of this successful financier was of the greatest advantage to his coreligionists at the time of the exile from Spain. The Jews were also successful as skilled medical practitioners. William of Portaleone, physician to King Ferdinand I of Naples, and to the ducal houses of Sforza and Gonzaga, was one of the ablest of that time. He was the first of the long line of illustrious physicians in his family. Early modern period It is estimated that in 1492 Jews made up between 3% and 6% of the population of Sicily. Many Sicilian Jews first went to Calabria, which already had a Jewish community since the 4th century. In 1524 Jews were expelled from Calabria, and in 1540 from the entire Kingdom of Naples, as all these areas fell under Spanish rule and were subject to the edict of expulsion by the Spanish Inquisition. Throughout the 16th century, Jews gradually moved from the south of Italy to the north, with conditions worsening for Jews in Rome after 1556 and the Venetian Republic in the 1580s. Many Jews from Venice and the surrounding area migrated to the Polish–Lithuanian Commonwealth at this time. Refugees from Spain When