The Jews were also forced to labor at the restoration of the walls of Rome without any compensation. Cum nimis absurdum limited each ghetto in the Papal States to one synagogue. In the early 16th century, there were at least seven synagogues across Rome, each serving as the house of worship for distinct demographic subgroup: Roman Jews (Benè Romì), Sicilian Jews, Italian Jews (that were neither Benè Romì nor Sicilian), German Ashkenazim, French Provençal, Castilian Sephardim, and Catalan Sephardim. On one occasion the pope had secretly given orders to one of his nephews to burn the Jewish quarter during the night. However, Alexander Farnese, hearing of the infamous proposal, succeeded in frustrating it. Many Jews abandoned Rome and Ancona and went to Ferrara and Pesaro. Here the Duke of Urbino welcomed them graciously in the hope of directing the extensive commerce of the Levant to the new port of Pesaro, which was, at that time, exclusively in the hands of the Jews of Ancona. Among the many who were forced to leave Rome was the Marano Amato Lusitano, a distinguished physician, who had often attended Pope Julius III. He had even been invited to become physician to the King of Poland, but had declined the offer in order to remain in Italy. He fled from the Inquisition to Pesaro, where he openly professed Judaism. Expulsion from Papal States Paul IV was followed by the tolerant pope Pius IV, who was succeeded by Pius V, who restored all the anti-Jewish bulls of his predecessors—not only in his own immediate domains, but throughout the Christian world. In Lombardy, the expulsion of the Jews was threatened, and, although this extreme measure was not put into execution, they were tyrannized in countless ways. At Cremona and at Lodi their books were confiscated. In Genoa, from which the Jews were expelled at this time, an exception was made in favor of Joseph Hakohen. In his Emek Habachah he narrates the history of these persecutions. He had no desire to take advantage of the exception, though, and went to Casale Monferrato, where he was graciously received even by the Christians. In this same year the pope directed his persecutions against the Jews of Bologna. Many of the wealthiest Jews were imprisoned and tortured to force false confessions from them. When Rabbi Ishmael Ḥanina was being racked, he declared that should the pains of torture elicit from