Jews were expelled from Spain in 1492, many of them found refuge in Italy, where they were given protection by King Ferdinand I of Naples. One of the refugees, Don Isaac Abravanel, even received a position at the Neapolitan court, which he retained under the succeeding king, Alfonso II. The Spanish Jews were also well received in Ferrara by Duke Ercole d'Este I and in Tuscany through the mediation of Jehiel of Pisa and his sons. But at Rome and Genoa they experienced all the vexations and torments that hunger, plague, and poverty bring with them, and they were forced to accept baptism to escape starvation. In a few cases, the refugees exceeded in number the Jews already domiciled, and thus gave the determining vote in matters of communal interest and in the direction of studies. Popes Alexander VI to Clement VII were indulgent toward Jews, having more urgent matters to occupy them. After the 1492 expulsion of Jews from Spain, some 9,000 impoverished Spanish Jews arrived at the borders of the Papal States. Alexander VI welcomed them into Rome, declaring that they were "permitted to lead their life, free from interference from Christians, to continue in their own rites, to gain wealth, and to enjoy many other privileges." He similarly allowed the immigration of Jews expelled from Portugal in 1497 and from Provence in 1498. The popes and many of the most influential cardinals openly violated one of the most severe enactments of the Council of Basel, namely, that prohibiting Christians from employing Jewish physicians; they even gave the latter positions at the papal court. The Jewish communities of Naples and of Rome received the greatest number of accessions; but many Jews passed on from these cities to Ancona, Venice, Calabria, and thence to Florence and Padua. Venice, imitating the odious measures of the German cities, assigned to the Jews a special quarter (ghetto). Expulsion from Naples The ultra-Catholic party tried with all the means at its disposal to introduce the Inquisition into the Neapolitan realm, then under Spanish rule. Charles V, upon his return from his victories in Africa, was on the point of exiling the Jews from Naples when Benvenida, wife of Samuel Abravanel, caused him to defer the action. A few years later, in 1533, a similar decree was proclaimed, but upon this occasion also Samuel Abravanel and others were able through their influence to avert