level of internal gas may exhibit a visible blue glow when plate voltage is applied. The getter (being a highly reactive metal) is effective against many atmospheric gases but has no (or very limited) chemical reactivity to inert gases such as helium. One progressive type of failure, especially with physically large envelopes such as those used by camera tubes and cathode-ray tubes, comes from helium infiltration. The exact mechanism is not clear: the metal-to-glass lead-in seals are one possible infiltration site. Gas and ions within the tube contribute to grid current which can disturb operation of a vacuum-tube circuit. Another effect of overheating is the slow deposit of metallic vapors on internal spacers, resulting in inter-element leakage. Tubes on standby for long periods, with heater voltage applied, may develop high cathode interface resistance and display poor emission characteristics. This effect occurred especially in pulse and digital circuits, where tubes had no plate current flowing for extended times. Tubes designed specifically for this mode of operation were made. Cathode depletion is the loss of emission after thousands of hours of normal use. Sometimes emission can be restored for a time by raising heater voltage, either for a short time or a permanent increase of a few percent. Cathode depletion was uncommon in signal tubes but was a frequent cause of failure of monochrome television cathode-ray tubes. Usable life of this expensive component was sometimes extended by fitting a boost transformer to increase heater voltage. Other failures Vacuum tubes may develop defects in operation that make an individual tube unsuitable in a given device, although it may perform satisfactorily in another application. Microphonics refers to internal vibrations of tube elements which modulate the tube's signal in an undesirable way; sound or vibration pick-up may affect the signals, or even cause uncontrolled howling if a feedback path (with greater than unity gain) develops between a microphonic tube and, for example, a loudspeaker. Leakage current between AC heaters and the cathode may couple into the circuit, or electrons emitted directly from the ends of the heater may also inject hum into the signal. Leakage current due to internal contamination may also inject noise. Some of these effects make tubes unsuitable for small-signal audio use, although unobjectionable for other purposes. Selecting the best of a batch of nominally identical tubes for critical applications can produce better results. Tube pins can develop non-conducting or high resistance