as well as to seek the mythical golden town of El Dorado. The first expedition was led by Ambrosius Ehinger, who established Maracaibo in 1529. After the deaths of first Ehinger (1533), then Nikolaus Federmann, and Georg von Speyer (1540), Philipp von Hutten persisted in exploring of the interior. In absence of von Hutten from the capital of the province, the crown of Spain claimed the right to appoint a governor. On Hutten's return to the capital, Santa Ana de Coro, in 1546, the Spanish governor Juan de Carvajal had Hutten and Bartholomeus VI. Welser executed. Subsequently, Charles V revoked Welser's concession. The Welsers transported German miners to the colony, in addition to 4,000 African slaves to plant sugar cane plantations. Many of the German colonists died from tropical diseases, to which they had no immunity, or through frequent wars with the indigenous inhabitants. Late 15th century to early 17th century Native caciques (leaders) such as Guaicaipuro () and Tamanaco (died 1573) attempted to resist Spanish incursions, but the newcomers ultimately subdued them; Tamanaco was put to death by order of Caracas' founder, Diego de Losada. In the 16th century, during the Spanish colonization, indigenous peoples such as many of the Mariches, themselves descendants of the Kalina, were converted to Roman Catholicism. Some of the resisting tribes or leaders are commemorated in place names, including Caracas, Chacao and Los Teques. The early colonial settlements focused on the northern coast, but in the mid-18th century, the Spanish pushed farther inland along the Orinoco River. Here, the Ye'kuana (then known as the Makiritare) organized serious resistance in 1775 and 1776. Spain's eastern Venezuelan settlements were incorporated into New Andalusia Province. Administered by the Royal Audiencia of Santo Domingo from the early 16th century, most of Venezuela became part of the Viceroyalty of New Granada in the early 18th century, and was then reorganized as an autonomous Captaincy General starting in 1777. The town of Caracas, founded in the central coastal region in 1567, was well-placed to become a key location, being near the coastal port of La Guaira whilst itself being located in a valley in a mountain range, providing defensive strength against pirates and a more fertile and healthy climate. Independence and 19th century After a series of unsuccessful uprisings, Venezuela, under the leadership of Francisco de Miranda, a Venezuelan marshal who had fought in the American Revolution and the French