era. Decline Venice's long decline started in the 15th century. Venice confronted the Ottoman Empire in the Siege of Thessalonica (1422–1430) and sent ships to help defend Constantinople against the besieging Turks in 1453. After the Fall of Constantinople, Sultan Mehmed II declared the first of a series of Ottoman-Venetian wars that cost Venice much of its eastern Mediterranean possessions. Vasco da Gama's 1497–1499 voyage opened a sea route to India around the Cape of Good Hope and destroyed Venice's monopoly. Venice's oared vessels were at a disadvantage when it came to traversing oceans, therefore Venice was left behind in the race for colonies. The Black Death devastated Venice in 1348 and struck again between 1575 and 1577. In three years, the plague killed some 50,000 people. In 1630, the Italian plague of 1629–31 killed a third of Venice's 150,000 citizens. Venice began to lose its position as a centre of international trade during the later part of the Renaissance as Portugal became Europe's principal intermediary in the trade with the East, striking at the very foundation of Venice's great wealth. France and Spain fought for hegemony over Italy in the Italian Wars, marginalising its political influence. However, Venice remained a major exporter of agricultural products and until the mid-18th century, a significant manufacturing centre. Modern age The Republic of Venice lost its independence when Napoleon Bonaparte conquered Venice on 12 May 1797 during the War of the First Coalition. Napoleon was seen as something of a liberator by the city's Jewish population. He removed the gates of the Ghetto and ended the restrictions on when and where Jews could live and travel in the city. Venice became Austrian territory when Napoleon signed the Treaty of Campo Formio on 12 October 1797. The Austrians took control of the city on 18 January 1798. Venice was taken from Austria by the Treaty of Pressburg in 1805 and became part of Napoleon's Kingdom of Italy. It was returned to Austria following Napoleon's defeat in 1814, when it became part of the Austrian-held Kingdom of Lombardy–Venetia. In 1848 a revolt briefly re-established the Venetian republic under Daniele Manin, but this was crushed in 1849. In 1866, after the Third Italian War of Independence, Venice, along with the rest of the Veneto, became part of the newly created Kingdom of Italy. From the middle of the 18th century, Trieste and papal Ancona, both of