new round of attacks on his work that called for him to be punished by the emperor. In 1551, Charles V commissioned an inquiry in Salamanca to investigate the religious implications of his methods. Although Vesalius' work was cleared by the board, the attacks continued. Four years later one of his main detractors and one-time professors, Jacobus Sylvius, published an article that claimed that the human body itself had changed since Galen had studied it. In 1555, Vesalius became physician to Philip II, and in the same year he published a revised edition of De humani corporis fabrica. In 1564 Vesalius went on a pilgrimage to the Holy Land, some said, in penance after being accused of dissecting a living body. He sailed with the Venetian fleet under James Malatesta via Cyprus. When he reached Jerusalem he received a message from the Venetian senate requesting him again to accept the Paduan professorship, which had become vacant on the death of his friend and pupil Fallopius. After struggling for many days with adverse winds in the Ionian Sea, he was shipwrecked on the island of Zakynthos. Here he soon died, in such debt that a benefactor kindly paid for his funeral. At the time of his death he was 49 years old. He was buried somewhere on the island of Zakynthos (Zante). For some time, it was assumed that Vesalius's pilgrimage was due to the pressures imposed on him by the Inquisition. Today, this assumption is generally considered to be without foundation and is dismissed by modern biographers. It appears the story was spread by Hubert Languet, a diplomat under Emperor Charles V and then under the Prince of Orange, who claimed in 1565 that Vesalius had performed an autopsy on an aristocrat in Spain while the heart was still beating, leading to the Inquisition's condemning him to death. The story went on to claim that Philip II had the sentence commuted to a pilgrimage. That story re-surfaced several times, until it was more recently revised. The decision to undertake the pilgrimage was likely just a pretext to leave the Spanish court. Its lifestyle did not please him and he longed to continue his research. Given that he could not get rid of his royal service by resignation, he managed to escape asking for the permission to go to Jerusalem. Publications De Humani Corporis Fabrica In 1543, Vesalius asked Johannes Oporinus