17th century, the Shaybanid Dynasty was replaced by the Janid Dynasty. Another factor contributing to the weakness of the Uzbek khanates in this period was the general decline of trade moving through the region. This change had begun in the previous century when ocean trade routes were established from Europe to India and China, circumventing the Silk Route. As European-dominated ocean transport expanded and some trading centers were destroyed, cities such as Bukhara, Merv, and Samarkand in the Khanate of Bukhora and Khiva and Urganch (Urgench) in Khorazm began to steadily decline. The Uzbeks' struggle with Iran also led to the cultural isolation of Central Asia from the rest of the Islamic world. In addition to these problems, the struggle with the nomads from the northern steppe continued. In the 17th and 18th centuries, Kazakh nomads and Mongols continually raided the Uzbek khanates, causing widespread damage and disruption. In the beginning of the 18th century, the Khanate of Bukhara lost the fertile Fergana region, and a new Uzbek khanate was formed in Quqon. Afghan Pashtun conquest An Uzbek Khanate existed in Maimana. The Pashtuns battled and conquered the Uzbeks and forced them into a state of subjugation and discrimination. Out of anti-Russian strategic interests, the British assisted the Afghan conquest of the Uzbek Khanates. The British gave weapons to the Afghans and backed the Afghan colonization of northern Afghanistan, which involved sending a huge number of Pashtun colonists onto Uzbek land. Furthermore, British literature from the period demonized the Uzbeks. Soviet-era arrivals in Afghanistan from Uzbekistan are referred to as Jogi. Russo-Soviet era Russian Empire In the 19th century, Russian interest in the area increased greatly, sparked by nominal concern over British designs on Central Asia; by anger over the situation of Russian citizens held as slaves; and by the desire to control the trade in the region and to establish a secure source of cotton for Russia. When the United States Civil War prevented cotton delivery from Russia's primary supplier, the southern United States, Central Asian cotton assumed much greater importance for Russia. As soon as the Russian conquest of the Caucasus was completed in the late 1850s, the Russian Ministry of War began to send military forces against the Central Asian khanates. Three major population centers of the khanates - Tashkent, Bukhara, and Samarkand — were captured in 1865, 1867, and 1868, respectively. In 1868 the Khanate of