The Moro reflex is an infantile reflex that develops between 28 and 32 weeks of gestation and disappears at 3–6 months of age. It is a response to a sudden loss of support and involves three distinct components: spreading out the arms (abduction) pulling the arms in (adduction) crying (usually) It is distinct from the startle reflex. Unlike the startle reflex, the Moro reflex does not decrease with repeated stimulation. The primary significance of the Moro reflex is in evaluating integration of the central nervous system. Eliciting the Moro reflex Ernst Moro elicited the Moro reflex by slapping the pillow on both sides of the infant's head. Other methods have been used since then, including rapidly lowering the infant (while supported) to a sudden stop and pinching the skin of the abdomen. Today, the most common method is the head drop, where the infant is supported in both hands and tilted suddenly so the head is a few centimeters lower than the level of the body. Clinical significance The Moro reflex may be observed in incomplete form in premature birth after the 25th week of gestation, and is usually present in complete form by week 30 (third trimester). Absence or asymmetry of either abduction or adduction by 2 to 3 months age can be regarded as abnormal, as can persistence of the reflex in infants older than 6 months. Furthermore, absence during the neonatal period may warrant assessment for the possibility of developmental complications such as birth injury or interference with brain formation. Asymmetry of the Moro reflex is especially useful to note, as it is almost always a feature of root, plexus, or nerve disease. The Moro reflex is impaired or absent in infants with kernicterus. An exaggerated Moro reflex can be seen in infants with severe brain damage that occurred in-utero, including microcephaly and hydranencephaly. Exaggeration of the Moro reflex, either due to low threshold or excessive clutching, often occurs in newborns with moderate hypoxic-ischemic encephalopathy. The Moro reflex is also exaggerated in infants withdrawing from narcotics. Persistence of the Moro reflex beyond 6 months of age is noted only in infants with severe neurological defects, including cerebral palsy. History The Moro reflex was first described in western medicine by Austrian pediatrician Ernst Moro (1874–1951) in 1918. Moro referred to it as the Umklammerungsreflex (embracing reflex). In this publication, he stated: "When a young infant is placed on