tumors Small cell ovarian cancer (SCCO) are generally classified into epithelial tumors associated with distinctive endocrine features. The World Health Organisation (WHO) recognises SCCO as two distinct entities: Small Cell Ovarian Cancer of Hypercalcemic Type (SCCOHT) and Small Cell Ovarian Cancer of Pulmonary Type (SCCOPT). Small cell tumours are rare and aggressive, they contribute to less than 2% of all gynaecologic malignancies. The average age of diagnosis is 24 years old, and the majority of patients also present with hypercalcemia (62%). It typically present with a unilateral large tumor. Most women die within a year of diagnosis. Treatment For more general information, see ovarian cancer. Research suggests that in the first line treatment of Endometrial Ovarian Cancer (EOC), Pegylated Liposomal Doxorubicin paired with Carboplatin is a satisfactory alternative to Paclitaxel with Carboplatin. In people with platinum-sensitive relapsed EOC, research has found that Pegylated Liposomal Doxorubicin with Carboplatin is a better treatment than Paclitaxel with Carboplatin. For advanced cancer of this histology, the US National Cancer Institute recommends a method of chemotherapy that combines intravenous (IV) and intraperitoneal (IP) administration. Preferred chemotherapeutic agents include a platinum drug with a taxane. Metastases For surface epithelial-stromal tumors, the most common sites of metastasis are the pleural cavity (33%), the liver (26%), and the lungs (3%). Effect on fertility Fertility subsequent to treatment of surface epithelial-stromal tumors depends mainly on histology and initial staging to separate it into early borderline (or more benign) versus advanced stages of borderline (or more malignant). Conservative management (without bilateral oophorectomy) of early stage borderline tumors have been estimated to result in chance of over 50% of spontaneous pregnancy with a low risk of lethal recurrence of the tumor (0.5%). On the other hand, in cases of conservative treatment in advanced stage borderline tumors, spontaneous pregnancy rates have been estimated to be 35% and the risk of lethal recurrence 2%. References Sources External links Johns Hopkins: "Surface Epithelial Tumors" Diagram: "Epithelial Stromal Ovarian Tumors" Small Cell Ovarian Cancer Research Collaboration & Patients Registry Gynaecological cancer