Spruce Creek may refer to: Canada Spruce Creek (British Columbia), a stream in the Atlin Country United States Colorado Spruce Creek (Larimer County, Colorado), a tributary of the Big Thompson River Florida Spruce Creek Airport, in Port Orange Spruce Creek High School, in Port Orange Spruce Creek (Florida), a tributary of the Halifax River Iowa Spruce Creek (Iowa) a tributary of the Upper Mississippi River Maine Spruce Creek (Maine), a creek in York County, Maine New York Spruce Creek (New York), crossed by the Salisbury Center Bridge in Herkimer County Pennsylvania Spruce Creek (Pennsylvania), a tributary of the Little Juniata River Spruce Creek, Pennsylvania, an unincorporated community Spruce Creek Township, Huntingdon County, Pennsylvania West Virginia Spruce Creek (West Virginia), a stream in Ritchie County