basis, and directed him to prepare and distribute to state health officers forms for the uniform compilation of vital statistics. This statistical information was published in the service's journal, Public Health Reports. The 1902 law also expanded the Hygienic Laboratory, which Wyman had moved to Washington, D.C. in 1891. Under Wyman's administration, the Laboratory significantly increased its research activities, including studies on diseases such as hookworm and Rocky Mountain spotted fever, and was provided with a new building in 1901. The 1902 Biologics Control Act gave the Laboratory responsibility for the regulation of biological products such as vaccines and antitoxins. In the early years of the twentieth century, Surgeon General Wyman found himself in the midst of a controversy over the San Francisco plague of 1900–1904. The service first became involved in the situation in 1900 when MHS physician Joseph J. Kinyoun, stationed in San Francisco, confirmed by bacteriological analysis that the death of a laborer in the city's Chinatown section was due to bubonic plague. Many local officials and business leaders, as well as Chinatown residents, concerned about how fears of plague would affect their lives and businesses, denied the existence of the disease and/or resisted quarantine and immunization efforts. When Wyman attempted to enforce an embargo on interstate travel for Californians without proper health certificates, the Governor of the state, Henry Gage, persuaded President McKinley to lift the travel ban. By 1903, however, the situation had become serious enough that an emergency conference was held in Washington, D.C., and a recommendation was made that all traffic between California and the rest of the country be halted unless Federal authorities were permitted to carry out their eradication campaign. Faced with the threat of a national boycott, San Francisco officials cooperated with Wyman and the service, and a successful campaign to eliminate the disease was led by Public Health Service physician Rupert Blue (who later served as Surgeon General). The service under Wyman also cooperated with state and local health authorities in the control of other infectious diseases such as yellow fever. Wyman was involved in the creation of the Pan American Sanitary Bureau in 1902. From the time of its organization until 1936, the Surgeons General of the Public Health Service served as the Directors of the Bureau, with Wyman as Director until his death in 1911. Many of Wyman's health policies and principles were adopted by the Bureau.