Tolnaftate (INN) is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol. Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm. Mechanism Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase, an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal cell membrane) in a similar way to terbinafine. Uses Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans. Side effects Side effects that may occur include: allergic reactions like: skin rash itching or hives swelling of the face, lips, or tongue inflammation, redness, or pain at the affected area Less severe side effects include: dry skin mild skin irritation, burning, or itching at the affected area See also Liranaftate, a similar thiocarbamate antifungal References External links Medline's entry for tolnaftate Antifungals Naphthol esters Thiocarbamates Merck & Co. brands Bayer brands 3-Tolyl compounds 2-Naphthyl compounds