James Bryan Herrick (11 August 1861 in Oak Park, Illinois – 7 March 1954 in Chicago, Illinois) was an American physician and professor of medicine who practiced and taught in Chicago. He is credited with the description of sickle-cell disease and was one of the first physicians to describe the symptoms of myocardial infarction. Biography Herrick was born in Oak Park, Illinois, of parents Origen White Herrick and Dora Kettlestrings Herrick (who was considered the oldest native daughter of Oak Park, because her father had homesteaded there). He attended Oak Park and River Forest High School and nearby Rock River Seminary. He received a BA degree from the University of Michigan in 1882, after which he taught school in Peoria, Illinois and Oak Park. Herrick married Zellah P. Davies of Oak Park. After a few years of teaching in the public schools he entered Rush Medical College, and received a medical degree in 1888. He interned at Cook County Hospital, after which he opened a private practice in the Chicago area. He also obtained a part-time teaching position at Rush College, and was listed as a full professor there from 1900 through 1927. He was also on the staff of Presbyterian Hospital in Chicago from 1895 through 1945. Medical discoveries Herrick studied and taught at various Chicago hospitals. His first discovery, in 1910, was that of sickle-shaped red blood cells on the blood film of a dental student from Grenada. His description of the student's disease was known for many years as Herrick's syndrome, and is now known as sickle-cell disease. The condition is prevalent in West Africa. Herrick's second major contribution was a landmark article on myocardial infarction ("heart attack") in JAMA in 1912. He proposed that thrombosis in the coronary artery leads to the symptoms and abnormalities of heart attacks and that this was not inevitably fatal. While Herrick was not the first to propose this, ultimately his article was the most influential, although at the time it received only limited attention. In 1918 he was one of the first to encourage electrocardiography in the diagnosis of myocardial infarction. Herrick is not closely associated with genetics, but his discoveries turned out to be inherited traits, so his contributions pointed other researchers toward genetically-based conditions. Books A Handbook of Medical Diagnosis for Students (1895) - 435 pages James Bryan Herrick - an appreciation - a compilation of Herrick papers,