for L-leucine was identified in a mammalian enzyme. Mutations which alter the allosteric binding site of GTP cause permanent activation of glutamate dehydrogenase, and lead to hyperinsulinism-hyperammonemia syndrome. Regulation Allosteric regulation: This protein may use the morpheein model of allosteric regulation. Allosteric inhibitors: Guanosine triphosphate (GTP) Adenosine triphosphate (ATP) Palmitoyl-CoA Zn2+ Activators: Adenosine diphosphate (ADP) Leucine l-isoleucine l-valine Guanosine diphosphate Other Inhibitors: EGCG Additionally, Mice GLDH shows substrate inhibition by which GLDH activity decreases at high glutamate concentrations. Isozymes Humans express the following glutamate dehydrogenase isozymes: See also Anaplerotic reactions References External links EC 1.4.1 Glutamate (neurotransmitter)