Jesse is an American sitcom television series created by Ira Ungerleider and starring Christina Applegate, that ran on NBC from September 24, 1998, to May 25, 2000, for two seasons of a total 42 episodes. The series was produced by Bright/Kauffman/Crane Productions in association with Warner Bros. Television. Synopsis The show stars Christina Applegate as single mother Jesse Warner, raising her nine-year-old son, Little John, in Buffalo, New York. She works for her overbearing father in a German-themed bar, serving beer while wearing a dirndl. Jesse's love interest, a Chilean named Diego (Bruno Campos), gains a rival when her former husband comes to town, intent on winning her back. In the second season, Jesse becomes a nurse and stories revolve around her friends instead of her family. Cast Main Christina Applegate as Jesse Warner Bruno Campos as Diego Vasquez Eric Lloyd as "Little John" Warner Liza Snyder as Linda Jennifer Milmore as Carrie John Lehr as John Warner, Jr. (season 1) David DeLuise as Darren Warner (season 1) George Dzundza as John Warner, Sr. (season 1) Kevin Rahm as Dr. Danny Kozak (season 2) Darryl Theirse as Kurt Bemis (guest season 1; main season 2) Recurring Michael Weatherly as Roy Bently (season 1) Michael Welch as Gabe (season 2) Jacqueline Obradors as Irma (season 2) Episodes While Jesse was in the top 20 in the Nielsen ratings regularly, the show lost much of the audience from Friends, its powerful lead-in. In season 2, Jesse lost almost 20% of the Friends audience. As a result, NBC decided to cancel the show after its second season. A total of 42 episodes were produced. Season 1 (1998–99) Season 2 (1999–2000) References External links 1990s American sitcoms 1998 American television series debuts 2000s American sitcoms 2000 American television series endings English-language television shows NBC original programming Television series by Warner Bros. Television Studios Television shows set in Buffalo, New York