village extreme longevity - a dozen of those living here are over the age of 100 (for c. 1,000 total inhabitants). The origin of the mutation has been traced back to a couple who lived in Limone in the 17th century. Research has been ongoing to develop pharmaceutical treatments against heart disease based on mimicking the beneficial effects of the ApoA-1 mutation. Gallery Sources External links Official Site Cities and towns in Lombardy Populated places on Lake Garda