it is not necessary to refrigerate it. Cyanoacrylates are moisture-sensitive, and moving from a cool to a hot location will create condensation; after removing from the refrigerator, it is best to let the adhesive reach room temperature before opening. After opening, it should be used within 30 days. Open containers should not be refrigerated. Another manufacturer says that the maximum shelf life of 12 months is obtained for some of their cyanoacrylates if the original containers are stored at . User forums and some manufacturers say that an almost unlimited shelf life is attainable by storing unopened at , the typical temperature of a domestic freezer, and allowing the contents to reach room temperature before use. Opening a container while chilled may cause moisture from the air to condense in the container; however, reports from hobbyists suggest that storing cyanoacrylate in a freezer can preserve opened cyanoacrylate indefinitely. As cyanoacrylates age, they polymerize, become thicker, and cure more slowly. They can be thinned with a cyanoacrylate of the same chemical composition with lower viscosity. Storing cyanoacrylates below will nearly stop the polymerization process and prevent aging. References Further reading derma+flex QS 510k Letter: http://www.accessdata.fda.gov/cdrh_docs/pdf10/K101276.pdf LiquiBand 510k Letter: http://www.accessdata.fda.gov/cdrh_docs/pdf8/K083531.pdf External links Was Super Glue invented to seal battle wounds in Vietnam? (from The Straight Dope) Cyanoacrylate Toxicity Cyanoacrylate Adhesive / Super Glue Safety Data Sheets Safety in the Home: Super Glue - Queensland Health Cyanoacrylate Technical Data Sheet Alcohol-Catalyzed α-Cyanoacrylate Adhesive Compositions, filed June 1954, issued October 1956. 3M Activators, Primers and Debonder Application note on measuring cure kinetics of cyanoacrylate glues Adhesives American inventions Medical treatments Monomers Synthetic resins Cyanoacrylate esters