Transubstantiation (Latin: transubstantiatio; Greek: μετουσίωσις metousiosis) is, according to the teaching of the Catholic Church, "the change of the whole substance of bread into the substance of the Body of Christ and of the whole substance of wine into the substance of the Blood of Christ". This change is brought about in the eucharistic prayer through the efficacy of the word of Christ and by the action of the Holy Spirit. However, "the outward characteristics of bread and wine, that is the 'eucharistic species', remain unaltered". In this teaching, the notions of "substance" and "transubstantiation" are not linked with any particular theory of metaphysics. The Roman Catholic Church teaches that, in the Eucharistic offering, bread and wine are changed into the body and blood of Christ. The affirmation of this doctrine was expressed, using the word "transubstantiate", by the Fourth Council of the Lateran in 1215. It was later challenged by various 14th-century reformers, John Wycliffe in particular. The manner in which the change occurs, the Roman Catholic Church teaches, is a mystery: "The signs of bread and wine become, in a way surpassing understanding, the Body and Blood of Christ." In Anglicanism, the precise terminology to be used to refer to the nature of the Eucharist has a contentious interpretation: "bread and cup" or "Body and Blood"; "set before" or "offer"; "objective change" or "new significance". In the Greek Orthodox Church, the doctrine has been discussed under the term of metousiosis, coined as a direct loan-translation of transubstantiatio in the 17th century. In Eastern Orthodoxy in general, the Sacred Mystery (Sacrament) of the Eucharist is more commonly discussed using alternative terms such as "trans-elementation" (, metastoicheiosis), "re-ordination" (, metarrhythmisis), or simply "change" (, metabole). History Summary From the earliest centuries, the Church spoke of the elements used in celebrating the Eucharist as being changed into the body and blood of Christ. Terms used to speak of the alteration included "trans-elementation." The bread and wine were said to be "made", "changed into", the body and blood of Christ. Similarly, Augustine said: "Not all bread, but only that which receives the blessing of Christ becomes the body of Christ." The term "transubstantiation" was used at least by the 11th century to speak of the change and was in widespread use by the 12th century. The Fourth Council of the Lateran used it in 1215. When later theologians adopted Aristotelian metaphysics in