that according to Gaelen's theory that blood was continually produced in the liver, the absurdly large figure of 540 pounds of blood would have to be produced every day. Having this simple mathematical proportion at hand—which would imply a seemingly impossible role for the liver—Harvey went on to demonstrate how the blood circulated in a circle by means of countless experiments initially done on serpents and fish: tying their veins and arteries in separate periods of time, Harvey noticed the modifications which occurred; indeed, as he tied the veins, the heart would become empty, while as he did the same to the arteries, the organ would swell up. This process was later performed on the human body: the physician tied a tight ligature onto the upper arm of a person. This would cut off blood flow from the arteries and the veins. When this was done, the arm below the ligature was cool and pale, while above the ligature it was warm and swollen. The ligature was loosened slightly, which allowed blood from the arteries to come into the arm, since arteries are deeper in the flesh than the veins. When this was done, the opposite effect was seen in the lower arm. It was now warm and swollen. The veins were also more visible, since now they were full of blood. Various other advances in medical understanding and practice were made. French physician Pierre Fauchard started dentistry science as we know it today, and he has been named "the father of modern dentistry". Surgeon Ambroise Paré was a leader in surgical techniques and battlefield medicine, especially the treatment of wounds, and Herman Boerhaave is sometimes referred to as a "father of physiology" because of his exemplary teaching in Leiden and his textbook Institutiones medicae (1708). Chemistry Chemistry, and its antecedent alchemy, became an increasingly important aspect of scientific thought in the course of the 16th and 17th centuries. The importance of chemistry is indicated by the range of important scholars who actively engaged in chemical research. Among them were the astronomer Tycho Brahe, the chemical physician Paracelsus, Robert Boyle, Thomas Browne and Isaac Newton. Unlike the mechanical philosophy, the chemical philosophy stressed the active powers of matter, which alchemists frequently expressed in terms of vital or active principles—of spirits operating in nature. Practical attempts to improve the refining of ores and their extraction to smelt metals were an important