important economic activity in the city is generated by the Port of Saint John. Saint John has a long history of brewers, such as Simeon Jones, The Olands, and James Ready. The city is now home to Moosehead Breweries, James Ready Brewing Co., Big Tide Brewing Co., Picaroon's and other craft brewers. The Moosehead Brewery (established in 1867, is Canada's only nationally distributed independent brewery [M. Nicholson]), James Ready Brewing Co., the New Brunswick Power Corporation which operates three electrical generating stations in the region including the Point Lepreau Nuclear Generating Station, Bell Aliant which operates out of the former New Brunswick Telephone headquarters, the Horizon Health Network, which operates 5 hospitals in the Saint John area, and numerous information technology companies. There are also a number of call centres which were established in the 1990s under provincial government incentives. Maritime industries Saint John is a major Canadian port, and the only city on the Bay of Fundy. Until the first decade of the 21st century, Canada's largest shipyard (Irving Shipbuilding) had been an important employer in the city. During the 1980s-early 1990s the shipyard was responsible for building 9 of the 12 multi-purpose patrol frigates for the Canadian Navy. However, the Irving family closed the shipyard in 2003 and centralized in Halifax leaving the Saint John dry dock sitting idle. Ecological research on surrounding marine life of the Bay of Fundy and the Saint John and Kennebecasis Rivers is centred in the city. The University of New Brunswick's Marine Biology department in Saint John as well as local NGO's and the federal Department of Fisheries and Oceans heads the majority of research and monitoring work on marine life and environments. Traditional fisheries (lobster, scallops etc.) still make up the livelihood for many Saint Johners today. Aquaculture, primarily Atlantic Salmon farming, has grown to be a major employer in the region as the decline of other traditional wild fisheries has unfolded in recent decades. Cooke Aquaculture, one of the largest companies in the industry is headquartered in Saint John. Prior to the opening of the St. Lawrence Seaway in 1959, the Port of Saint John functioned as the winter port for Montreal, Quebec when shipping was unable to traverse the sea ice in the Gulf of St. Lawrence and St. Lawrence River. The Canadian Pacific Railway opened a line to Saint John from Montreal in 1889 across the state of