of 18.70 mL/kg BW. The median lethal dose in the female lab rats was found to be 19.52 mL/kg BW (15.64 mL/kg BW lower, 24.35 mL/kg BW upper). The sauce was found to be a mild skin irritant and a moderate to severe eye irritant. The toxicity to the eye is mainly caused by vinegar. In art and culture In 1894 composer George W. Chadwick composed the Burlesque Opera of Tabasco, a musical comedy that conductor Paul Mauffray revived in 2018 with support from McIlhenny Company. Tabasco has appeared in many movies and cartoons, as well as on television. It featured in two James Bond films in the 1970s, The Man with the Golden Gun and The Spy Who Loved Me, as well as a shot of the iconic bottle in Sidney Lumet's 1974 film Murder on the Orient Express. Some appearances date as far back as the Our Gang short Birthday Blues in 1932 and Charlie Chaplin's Modern Times in 1936. In Back to the Future Part III, the saloon bartender uses Tabasco as an ingredient for an instant hangover cure he calls "wake-up juice". Tabasco sauce was also an important element in the television series Roswell about alien/human hybrid teenagers who craved foods that were sweet and spicy and often carried bottles of Tabasco sauce with them. When the network tried to cancel the series in the first season, thousands of fans mailed bottles of Tabasco to the network to show their support. The series continued for three seasons. See also Condiment List of brand name condiments List of hot sauces Tabasco Road Water pepper References Works cited Further reading . External links How It's Made: Tabasco Sauce Products introduced in 1868 Acadiana Brand name condiments Hot sauces Iberia Parish, Louisiana Tourist attractions in Iberia Parish, Louisiana Cajun cuisine McIlhenny family Military food of the United States British Royal Warrant holders