the largest city in the world in 1700 CE, with a population around one million. Trade flourished, with the Dutch and Portuguese among the most active foreigners in the kingdom, together with the Chinese and Malayans. Even Luzones merchants and warriors from Luzon, Philippines were also present. Philippines-Thailand relations already had precursors in that, Thailand often exported ceramics to several Filipino states as evidenced that when the Magellan expedition landed at the Cebu Rajahnate, they noted a Thai embassy to the king, Rajah Humabon. When the Spanish colonized the Philippines via Latin America, Spaniards and Mexicans joined the Filipinos in trading at Thailand. The Ayutthaya Period is known as the golden age of Thai literature, Art and Trade with the eastern and western world. The Ayutthaya period was also considered as "a golden age of medicine in Thailand" due to progress in the field of medicine at that time. Burmese wars Starting in the middle of the 16th century, the kingdom came under repeated attacks by the Taungoo Dynasty of Burma. The Burmese–Siamese War (1547–49) began with a Burmese invasion and a failed siege of Ayutthaya. A second siege (1563–64) led by King Bayinnaung forced King Maha Chakkraphat to surrender in 1564. The royal family was taken to Bago, Burma, with the king's second son Mahinthrathirat installed as a vassal king. In 1568, Mahinthrathirat revolted when his father managed to return from Bago as a Buddhist monk. The ensuing third siege captured Ayutthaya in 1569 and Bayinnaung made Mahathammarachathirat his vassal king. After Bayinnaung's death in 1581, Uparaja Naresuan proclaimed Ayutthaya's independence in 1584. The Thai fought off repeated Burmese invasions (1584–1593), capped by an elephant duel between King Naresuan and Burmese heir-apparent Mingyi Swa in 1593 during the fourth siege of Ayutthaya in which Naresuan famously slew Mingyi Swa. The Burmese–Siamese War (1594–1605) was a Thai attack on Burma, resulting in the capture of the Tanintharyi Region as far as Mottama in 1595 and Lan Na in 1602. Naresuan even invaded mainland Burma as far as Taungoo in 1600, but was driven back. Ayutthaya expanded its sphere of influence over a considerable area, ranging from the Islamic states on the Malay Peninsula, the Andaman seaports of present-day India, the Angkor kingdom of Cambodia, to states in northern Thailand. In the 18th century, the power of the Ayutthaya Kingdom gradually declined as fighting between princes and officials plagued its politics.