it is significantly enriched for proteins with roles in endocytosis. Nevertheless, orthologous SH3 domain-mediated interactions are highly rewired between worm and yeast. Proteins with SH3 domain Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 p54 S6 kinase 2 (S6K2) SH3D21 ARMH3 (potentially) STAC3 Some myosins SH3 and multiple ankyrin repeat domains: SHANK1, SHANK2, SHANK3 YAP1 ARHGAP12 vexin (VXN) TANGO1 Integrase Focal Adhesion Kinase (FAK, PTK2) Proline-rich tyrosine kinase (Pyk2, CADTK, PTK2beta) TRIP10 (cip4) See also Src homology 2 domain-containing Structural domain References External links Nash Lab Protein Interaction Domains in Signal Transduction - The SH3 domain GENEART - Screen your protein against all human SH3 domains in a single phage display cycle Protein domains