required to be sterilized, to have at most 300,000 spores on the exterior of the craft—and more thoroughly sterilized if they contact "special regions" containing water, or it could contaminate life-detection experiments or the planet itself. It is impossible to sterilize human missions to this level, as humans are host to typically a hundred trillion microorganisms of thousands of species of the human microbiome, and these cannot be removed while preserving the life of the human. Containment seems the only option, but it is a major challenge in the event of a hard landing (i.e. crash). There have been several planetary workshops on this issue, but with no final guidelines for a way forward yet. Human explorers could also inadvertently contaminate Earth if they return to the planet while carrying extraterrestrial microorganisms. Physical, mental and emotional health risks to colonizers The health of the humans who may participate in a colonization venture would be subject to increased physical, mental and emotional risks. NASA learned that – without gravity – bones lose minerals, causing osteoporosis. Bone density may decrease by 1% per month, which may lead to a greater risk of osteoporosis-related fractures later in life. Fluid shifts towards to the head may cause vision problems. NASA found that isolation in closed environments aboard the International Space Station led to depression, sleep disorders, and diminished personal interactions, likely due to confined spaces and the monotony and boredom of long space flight. Circadian rhythm may also be susceptible to the effects of space life due to the effects on sleep of disrupted timing of sunset and sunrise. This can lead to exhaustion, as well as other sleep problems such as insomnia, which can reduce their productivity and lead to mental health disorders. High-energy radiation is a health risk that colonizers would face, as radiation in deep space is deadlier than what astronauts face now in low Earth orbit. Metal shielding on space vehicles protects against only 25-30% of space radiation, possibly leaving colonizers exposed to the other 70% of radiation and its short and long-term health complications. Implementation Building colonies in space would require access to water, food, space, people, construction materials, energy, transportation, communications, life support, simulated gravity, radiation protection and capital investment. It is likely the colonies would be located near the necessary physical resources. The practice of space architecture seeks to transform spaceflight from a heroic test of human