in metropolitan Toledo, and automobile manufacturing has been important at least since Kirk started manufacturing automobiles, which began operations early in the 20th century. The largest employer in Toledo was Jeep for much of the 20th century. Since the late 20th century, industrial restructuring reduced the number of these well-paying jobs. The University of Toledo is influential in the city, contributing to the prominence of healthcare as the city's biggest employer. The metro area contains four Fortune 500 companies: Dana Holding Corporation, Owens Corning, The Andersons, and Owens Illinois. ProMedica is a Fortune 1000 company headquartered in Toledo. One SeaGate is the location of Fifth Third Bank's Northwest Ohio headquarters. Glass industry Toledo is known as the Glass City because of its long history of glass manufacturing, including windows, bottles, windshields, construction materials, and glass art, of which the Toledo Museum of Art has a large collection. Several large glass companies have their origins here. Owens-Illinois, Owens Corning, Libbey Incorporated, Pilkington North America (formerly Libbey-Owens-Ford), and Therma-Tru have long been a staple of Toledo's economy. Other offshoots and spinoffs of these companies also continue to play important roles in Toledo's economy. Fiberglass giant Johns Manville's two plants in the metro area were originally built by a subsidiary of Libbey-Owens-Ford. Automotive industry Several Fortune 500 automotive-related companies had their headquarters in Toledo, including Electric AutoLite, Sheller-Globe Corporation, Champion Spark Plug, Questor, and Dana Holding Corporation. Only the latter still operates as an independent entity. Faurecia Exhaust Systems, a $2 billion subsidiary of France's Faurecia SA, is in Toledo. Toledo is the Jeep headquarters and has two production facilities dubbed the Toledo Complex, one in the city and one in suburban Perrysburg. During World War II, the city's industries produced important products for the military, particularly the Willys Jeep. Willys-Overland was a major automaker headquartered in Toledo until 1953. Industrial restructuring and loss of jobs caused the city to adopt new strategies to retain its industrial companies. It offered tax incentives to DaimlerChrysler to expand its Jeep plant. In 2001, a taxpayer lawsuit was filed against Toledo that challenged the constitutionality of that action. In 2006, the city won the case by a unanimous ruling by the U.S. Supreme Court in DaimlerChrysler Corp. v. Cuno. General Motors also has operated a transmission plant in Toledo since 1916. It manufactures and assembles GM's six-speed and eight-speed rear-wheel-drive and six-speed front-wheel-drive transmissions that are