co-stars Julia Whelan and Meredith Deane, at the 22nd Young Artist Awards. 2001–2005: Breakthrough Wood made her teenage debut as a leading film actress in 2001's Little Secrets, directed by Blair Treu, where she played 14-year-old aspiring concert violinist Emily Lindstrom. For that role, she was nominated for Best Leading Young Actress at the 24th Young Artist Awards. Wood next played a supporting role in Andrew Niccol's 2002 satirical science fiction film Simone, which starred Al Pacino. That same year, Wood was recognized as One to Watch at the Young Hollywood Awards. Wood's breakout movie role followed with Catherine Hardwicke's 2003 film Thirteen. She starred as Tracy Louise Freeland, a young teen who sinks into a downward spiral of hard drugs, sex, and petty crime. Her performance garnered critical acclaim, earning her Golden Globe and Screen Actors Guild nominations for Best Lead Actress. During the time of Thirteens release, Wood was featured on the cover of Vogue, with the magazine naming her as one of the "It Girls" of Hollywood. She similarly appeared, along with eight other teen actresses, on the cover of Vanity Fairs Young Hollywood issue in July 2003. A supporting role opposite Cate Blanchett and Tommy Lee Jones in Ron Howard's The Missing, in which she played the kidnapped daughter Lilly Gilkeson, followed the same year, earning her a nomination for Best Leading Young Actress at the 25th Young Artist Awards. In 2005, Wood appeared opposite Kevin Costner and Joan Allen in the Mike Binder-directed The Upside of Anger, a well-reviewed film in which Wood played Lavender "Popeye" Wolfmeyer, one of four sisters dealing with their father's absence. Her character also narrated the film. Wood's next two starring roles were in dark independent films. In the 2005 Sundance Film Festival Grand Jury Prize nominee Pretty Persuasion, a black comedy focusing on the themes of sexual harassment in schools and attitudes about women in media and society, Wood played Kimberly Joyce, a manipulative, sexually active high-schooler. One critic commented, "Wood does flip cynicism with such precise, easy rhythms and with such obvious pleasure in naughtiness that she's impossible to hate." David Jacobson's neo-western Down in the Valley premiered later that year, in which Wood's character, Tobe, falls in love with an older man, played by Edward Norton, a cowboy who is at odds with modern society. Of her performance, it was written that "Wood conveys every bit of