originally formulated for endotherms, it can also be applied to ectotherms, which derive body temperature from the environment. In their view, ectotherms with lower surface area-to-volume ratios would heat up and cool down more slowly, and this resistance to temperature change might be adaptive in "thermally heterogeneous environments". Alho said that there has been a renewed interest in Allen's rule due to global warming and the "microevolutionary changes" that are predicted by the rule. In humans Marked differences in limb lengths have been observed when different portions of a given human population reside at different altitudes. Environments at higher altitudes generally experience lower ambient temperatures. In Peru, individuals who lived at higher elevations tended to have shorter limbs, whereas those from the same population who inhabited the more low-lying coastal areas generally had longer limbs and larger trunks. Katzmarzyk and Leonard similarly noted that human populations appear to follow the predictions of Allen's rule.:494 There is a negative association between body mass index and mean annual temperature for indigenous human populations,:490 meaning that people who originate from colder regions have a heavier build for their height and people who originate from warmer regions have a lighter build for their height. Relative sitting height is also negatively correlated with temperature for indigenous human populations,:487–88 meaning that people who originate from colder regions have proportionally shorter legs for their height and people who originate from warmer regions have proportionally longer legs for their height. In 1968, A.T. Steegman investigated the assumption that Allen's rule caused the structural configuration of the Arctic Mongoloid face. Steegman did an experiment that involved the survival of rats in the cold. Steegman said that the rats with narrow nasal passages, broader faces, shorter tails and shorter legs survived the best in the cold. Steegman said that the experimental results had similarities with the Arctic Mongoloids, particularly the Eskimo and Aleut, because these have similar morphological features in accordance with Allen's rule: a narrow nasal passage, relatively large heads, long to round heads, large jaws, relatively large bodies, and short limbs. Mechanism A contributing factor to Allen's rule in vertebrates may be that the growth of cartilage is at least partly dependent on temperature. Temperature can directly affect the growth of cartilage, providing a proximate biological explanation for this rule. Experimenters raised mice either at 7 degrees, 21 degrees or 27 degrees Celsius and then measured their tails