number for prime quadruplets {p, p+2, p+6, p+8} is (). Prime quintuplets If {p, p+2, p+6, p+8} is a prime quadruplet and p−4 or p+12 is also prime, then the five primes form a prime quintuplet which is the closest admissible constellation of five primes. The first few prime quintuplets with p+12 are: {5, 7, 11, 13, 17}, {11, 13, 17, 19, 23}, {101, 103, 107, 109, 113}, {1481, 1483, 1487, 1489, 1493}, {16061, 16063, 16067, 16069, 16073}, {19421, 19423, 19427, 19429, 19433}, {21011, 21013, 21017, 21019, 21023}, {22271, 22273, 22277, 22279, 22283}, {43781, 43783, 43787, 43789, 43793}, {55331, 55333, 55337, 55339, 55343} ... . The first prime quintuplets with p−4 are: {7, 11, 13, 17, 19}, {97, 101, 103, 107, 109}, {1867, 1871, 1873, 1877, 1879}, {3457, 3461, 3463, 3467, 3469}, {5647, 5651, 5653, 5657, 5659}, {15727, 15731, 15733, 15737, 15739}, {16057, 16061, 16063, 16067, 16069}, {19417, 19421, 19423, 19427, 19429}, {43777, 43781, 43783, 43787, 43789}, {79687, 79691, 79693, 79697, 79699}, {88807, 88811, 88813, 88817, 88819} ... . A prime quintuplet contains two close pairs of twin primes, a prime quadruplet, and three overlapping prime triplets. It is not known if there are infinitely many prime quintuplets. Once again, proving the twin prime conjecture might not necessarily prove that there are also infinitely many prime quintuplets. Also, proving that there are infinitely many prime quadruplets might not necessarily prove that there are infinitely many prime quintuplets. The Skewes number for prime quintuplets {p, p+2, p+6, p+8, p+12} is (). Prime sextuplets If both p−4 and p+12 are prime then it becomes a prime sextuplet. The first few: {7, 11, 13, 17, 19, 23}, {97, 101, 103, 107, 109, 113}, {16057, 16061, 16063, 16067, 16069, 16073}, {19417, 19421, 19423, 19427, 19429, 19433}, {43777, 43781, 43783, 43787, 43789, 43793} Some sources also call {5, 7, 11, 13, 17, 19} a prime sextuplet. Our definition, all cases of primes {p-4, p, p+2, p+6, p+8, p+12}, follows from defining a prime sextuplet as the closest admissible constellation of six primes. A prime sextuplet contains two close pairs of twin primes, a prime quadruplet, four overlapping prime triplets, and two overlapping prime quintuplets. All prime sextuplets except {7, 11, 13, 17, 19, 23} are of the form {210n + 97, 210n + 101, 210n + 103, 210n + 107, 210n + 109, 210n + 113} for some integer n. (This structure is necessary to