the appointment of surgeon to the Gardes Françaises regiment, taking part in several battles during the War of the Austrian Succession. This experience would instill in him a deep aversion to violence which is evident in his philosophical writings. Much of his time, however, was spent in Paris, and it is likely that during this time he made the acquaintance of Maupertuis and the Marquise de Châtelet. It was in these years, during an attack of fever, that he made observations on himself with reference to the action of quickened blood circulation upon thought, which led him to the conclusion that mental processes were to be accounted for as the effects of organic changes in the brain and nervous system. This conclusion he worked out in his earliest philosophical work, the Histoire naturelle de l'âme (1745). So great was the outcry caused by its publication that La Mettrie was forced to quit his position with the French Guards, taking refuge in Leiden. There he developed his doctrines still more boldly and completely in L'Homme machine, a hastily written treatise based upon consistently materialistic and quasi-atheistic principles. La Mettrie's materialism was in many ways the product of his medical concerns, drawing on the work of 17th-century predecessors such as the Epicurean physician Guillaume Lamy. The ethical implications of these principles would later be worked out in his Discours sur le bonheur; La Mettrie considered it his magnum opus. Here he developed his theory of remorse, i.e. his view about the inauspicious effects of the feelings of guilt acquired at early age during the process of enculturation. This was the idea which brought him the enmity of virtually all thinkers of the French Enlightenment, and a damnatio memoriae which was lifted only a century later by Friedrich Albert Lange in his Geschichte des Materialismus. Philosophy Julien de La Mettrie is considered one of the most influential determinists of the eighteenth century. He believed that mental processes were caused by the body. He expressed these thoughts in his most important work Man a Machine. There he also expressed his belief that humans worked like a machine. This theory can be considered to build off the work of Descartes and his approach to the human body working as a machine. La Mettrie believed that man, body and mind, worked like a machine. Although he helped further Descartes' view of mechanization in explaining human bodily