This list of important publications in medicine, is organized by field. Some reasons why a particular publication might be regarded as important: Topic creator – A publication that created a new topic Breakthrough – A publication that changed scientific knowledge significantly Influence – A publication which has significantly influenced the world or has had a massive impact on the teaching of medicine. The definitive bibliographic source of books and articles demonstrating the history of medicine and identifying the first publications in the field is "Garrison and Morton". (Morton, Leslie T. (Leslie Thomas), Morton's medical bibliography : an annotated check-list of texts illustrating the history of medicine (Garrison and Morton). -- 5th ed. / edited by Jeremy M. Norman. -- Aldershot, Hants, England ; Brookfield, Vt., USA : Scolar Press, Gower, c1991. xxiv, 1243 p. .) It is also available electronically, for a fee. Foundations De Materia Medica Author: Pedanius Dioscorides Publication data: De Materia Medica, 50–70 Online version: Online version of first volume Description: This five-volume work was a precursor to all modern pharmacopeias. In fact, it remained in use until the 16th century, though with some additional commentary and additions from Arabian and Indian sources. Importance: Topic creator, Breakthrough, Impact The Canon of Medicine Author: Avicenna (Ibn Sina) Publication data: The Canon of Medicine, 1025 Description: This fourteen-volume medical encyclopedia was the first of its kind and remained the most popular medical textbook in both Europe and the Islamic world up until the 17th century and continued to be in use as late as the 19th century. Among other things, the book is known for the discovery of contagious diseases, and the introduction of experimental medicine, clinical trials, randomized controlled trials, efficacy tests, and clinical pharmacology. The work is considered one of the most famous books in the history of medicine. Importance: Topic creator, Breakthrough, Impact Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus Author: William Harvey Publication data: 1628 Description: The work in which Harvey explained the circulation of the blood. Importance: Breakthrough, Impact The Principles and Practice of Medicine: Designed for the Use of Practitioners and Students of Medicine Author: William Osler Publication data: Online version: Description: First published in 1892 while Osler was Professor of Medicine at Johns Hopkins University, this textbook was, in its time, translated into French, German, Russian, Portuguese, Spanish and Chinese. It became the most significant medical textbook of the next