the head; more difficulty righting themselves; and unusual abdominal spasms. Chlorpyrifos oxon appears to particularly inhibit acetylcholinesterase in bee gut tissue as opposed to head tissue. Other organophosphate pesticides impaired bee learning and memory of smells in the laboratory. Regulation International law Chlorpyrifos is not regulated under international law or treaty. Organizations such as PANNA and the NRDC state that chlorpyrifos meets the four criteria (persistence, bioaccumulation, long-range transport, and toxicity) in Annex D of the Stockholm Convention on Persistent Organic Pollutants and should be restricted. In 2021, the European Union submitted a proposal to list chlorpyrifos in Annex A to the Stockholm Convention. National regulations Chlorpyrifos was used to control insect infestations of homes and commercial buildings in Europe until it was banned from sale in 2008. Chlorpyrifos is restricted from termite control in Singapore as of 2009. It was banned from residential use in South Africa as of 2010. It has been banned in the United Kingdom in 2016 apart from a limited use in drenching seedlings. Chlorpyrifos has not been permitted for agricultural use in Sweden at all United States In the United States, several laws directly or indirectly regulate the use of pesticides. These laws, which are implemented by the EPA, NIOSH, USDA and FDA, include: the Clean Water Act (CWA); the Endangered Species Act (ESA); the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA); the Federal Food, Drug, and Cosmetic Act (FFDCA); the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA); and the Emergency Planning and Community Right-to-Know Act (EPCRA). As a pesticide, chlorpyrifos is not regulated under the Toxic Substances Control Act (TSCA). Chlorpyrifos is sold in restricted-use products for certified pesticide applicators to use in agriculture and other settings, such as golf courses or for mosquito control. It may also be sold in ant and roach baits with childproof packaging. In 2000, manufacturers reached an agreement with the EPA to voluntarily restrict the use of chlorpyrifos in places where children may be exposed, including homes, schools and day care centers. In 2007 Pesticide Action Network North America and Natural Resources Defense Council (collectively, PANNA) submitted an administrative petition requesting a chlorpyrifos ban. On 10 August 2015, the Ninth Circuit Court of Appeals in PANNA v. EPA ordered the EPA to respond to PANNA's petition by "revok[ing] all tolerances for the insecticide chlorpyrifos", den[ying] the Petition or [issuing] a "proposed or final tolerance revocation" no