Hudson gained fame playing Winston Zeddemore in the 1984 feature film Ghostbusters and its 1989 sequel, Ghostbusters II. He auditioned to reprise the role for the animated series, The Real Ghostbusters, but it was given to Arsenio Hall. He had a major supporting role as the mentally challenged handyman Solomon in The Hand that Rocks the Cradle (1992). Hudson was cast as Warden Leo Glynn on HBO's series Oz, and his son Ernie Hudson Jr. co-starred with him as Muslim inmate Hamid Khan. Hudson also appears as the character Munro in Congo (1995) and as Police Sergeant Albrecht in The Crow (1994). He switched gears when he played a preacher opening the eyes of a small town's prejudice in the 1950s in A Stranger in the Kingdom. He played Harry McDonald, the FBI superior of Sandra Bullock's character in the feature film Miss Congeniality (2000). He is in the Stargate SG-1 episode "Ethon" as Pernaux. He appeared as Reggie in the 1995 film The Basketball Diaries. In 2006, he appeared in the television movie The Ron Clark Story as Principal Turner. In 2008, he began a recurring role as Dr. Fields on The Secret Life of the American Teenager. He had a recurring role on the final season of Law & Order as Lt. Anita Van Buren's boyfriend and then fiancé. In 2011, he played Stuart Owens in Torchwood: Miracle Day. Beginning in 2015, Hudson was cast in a recurring role as Jacob, an organic farmer who is the romantic interest for Frankie Bergstein (Lily Tomlin) in the series Grace and Frankie. Hudson appeared in the 2016 Ghostbusters reboot, playing Bill Jenkins, the uncle of Leslie Jones's lead character Pattie Tolan. In 2019, Hudson began starring in L.A.'s Finest, playing the estranged father of Gabrielle Union's character. Hudson called it "a very different show", citing the duality of having to protect people as a member of law enforcement while having unresolved relationships that need to be reconciled. Spectrum canceled the series after two seasons the following year. In August 2019, he confirmed his involvement in Ghostbusters: Afterlife directed by Jason Reitman, joining original cast members Sigourney Weaver, Dan Aykroyd, Bill Murray and Annie Potts. Hudson described himself as being welled by emotions after he put on his jumpsuit and proton pack, as he had previously "accepted that [a film] was never going to happen". Hudson appeared in the 2022 drama