points each, from which the mean and standard deviation were calculated. The control group had 15 data points. A multi-factor analysis of variance (ANOVA) and Tukey's test were used for the concentrations of P4, A4 and E2. The two groups were compared using a Student's "t", with statistical significance set at p < 0.05. Results show the disruptor effect of PFOS and PFOA depends on cell type. PFOS and PFOA inhibit the secretion of steroid hormones in both theca cells and granulosa cells with gonadotropic stimulus. In cells without gonadotropic stimulus, PFOS inhibit theca cells but not granulosa, while PFOA inhibit granulosa cells but not theca. These differences are explained by the different types of PPARs in cell type. The study used concentrations below the range found in human blood circulation, suggesting that this may occur in human population. These results indicated PFOS and PFOA act as endocrine disruptors on ovarian cells which could affect subsequent sexual steroids. Human data PFOA is resistant to degradation by natural processes such as metabolism, hydrolysis, photolysis, or biodegradation and has been found to persist in the environment. PFOA is found in environmental and biological fluids as the anion perfluorooctanoate. PFOA can be absorbed from ingestion and can penetrate skin. The acid headgroup of PFOA enables binding to proteins with fatty acid or hormone substrates such as serum albumin, liver fatty acid-binding protein, and the nuclear receptors PPARα and possibly CAR. In animals, PFOA is mainly present in the liver, blood, and kidneys. PFOA does not accumulate in fat tissue, unlike traditional organohalogen persistent organic pollutants. In humans, PFOA has an average elimination half-life of about three years. Because of this long half-life, PFOA has the potential to bioaccumulate. The levels of PFOA exposure in humans vary widely. While an average American might have 3 or 4 parts per billion of PFOA present in their blood serum, individuals occupationally exposed to PFOA have had blood serum levels over 100,000 parts per billion (100 parts per million or 0.01%) recorded. In a study of individuals living around DuPont's Washington Works plant, those who had no occupational exposure had a median blood serum level of 329 parts per billion while the median of those with occupational exposure was 775 parts per billion. While no amount of PFOA in humans is legally recognized as harmful, DuPont was "not satisfied" with data showing their Chinese workers accumulated an