League In the 2010–11 UEFA Champions League, on 14–20 July 2010, Sheriff defeated Dinamo Tirana in the second qualifying round (3–1, 0–1). Then, on 4 August, the club defeated Dinamo Zagreb on penalties (6–5) after identical 1–1 draws at home and away, thereby reaching the play-off round. On 18–24 August, in the play-off round against Basel, Sheriff lost 1–0 in Switzerland before losing 3–0 at home. 2010–11 UEFA Europa League Dropping to the 2010–11 UEFA Europa League after their play-off defeat to Basel, Sheriff was drawn into Group E alongside Dynamo Kyiv, AZ and BATE Borisov. After losing their first match 2–1 away against AZ on 15 September 2010, on 30 September, Sheriff defeated Dynamo Kyiv 2–0 at home. After losing two-straight matches against BATE – 0–1 at home and 3–1 away on 21 October and 4 November respectively – on 2 December, Sheriff drew 1–1 with AZ at home, then on 15 December, Sheriff drew 0–0 against Dynamo Kyiv away in Kyiv. Accumulating five points, Sheriff failed to progress past the group stage after finishing last in Group E. 2013–14 UEFA Europa League In the 2013–14 UEFA Europa League, Sheriff played in a group with Tottenham Hotspur, Anzhi Makhachkala and Tromsø, in which they finished third. 2017–18 UEFA Europa League In the 2017–18 UEFA Europa League, Sheriff played in a group with Lokomotiv Moscow, Copenhagen, Fastav Zlín, in which they finished third once more. 2021–22 UEFA Champions League In the 2021–22 UEFA Champions League, Sheriff became the first Moldovan team to qualify for the group stages of the competition after a 3–0 aggregate win over Dinamo Zagreb. They were drawn into Group D to face Inter Milan, Real Madrid and Shakhtar Donetsk. On 15 September, Sheriff won their opening group game, 2–0 against Shakhtar Donetsk, before following it up with an upset 2–1 away victory over Real Madrid at the Santiago Bernabéu on 28 September 2021, with Sébastien Thill scoring the winning goal in the 89th minute. Despite losing their next three games against Inter Milan and Real Madrid, they secured qualification for the preliminary knockout round of the Europa League on 24 November 2021 when Shakhtar Donetsk lost to Inter Milan. They ended their campaign with a 1–1 away draw with Shakhtar Donetsk, which meant they ended up with a very respectable 7 points from their 6 games. 2021–22 UEFA Europa League Sheriff had serious squad problems before