This is a list of large or well-known interstate or international companies headquartered in the Seattle metropolitan area. , the Seattle metropolitan area is home to ten Fortune 500 companies: Internet retailer Amazon (#2), Costco Wholesale (#12), Microsoft (#15), coffee chain Starbucks (#125), Paccar (#159), clothing merchant Nordstrom (#289), Weyerhaeuser (#387), Expeditors International (#299), Alaska Airlines (#459) and Expedia (#500). Biotechnology Alder Biopharmaceuticals (Bothell) Dendreon – immunotherapeutics (defunct) Juno Therapeutics Seattle Genetics (Bothell) ZymoGenetics – therapeutic protein NanoString Technologies – Life Sciences Tools Computer hardware Cray Inc. – supercomputers EMC Isilon – computer storage F5 Networks – application delivery controllers Conglomerates Vulcan Inc. – investment vehicle for Paul Allen Consulting Alvarez and Marsal – management consulting, turnaround management and performance improvement Avanade – business and technology consulting and information technology consulting Slalom Consulting – management consulting and information technology consulting Design ClearSign Combustion Financial Gravity Payments Moss Adams Russell Investments Seattle Credit Union Washington Federal Savings Food and beverage American Seafoods – management company for fishing vessels in the Bering Sea Beecher's Handmade Cheese Caffe Vita Coffee Roasting Company – coffee retailer Crowd Cow – online meat delivery marketplace Darigold – dairy agricultural marketing cooperative Jones Soda – soft drink maker MOD Pizza – pizza restaurant chain Pagliacci Pizza – pizza restaurant chain Seattle's Best Coffee Starbucks – coffee retailer and coffeehouse chain Theo Chocolate – organic and fair trade chocolate manufacturer Trident Seafoods – management company for fishing vessels in the Bering Sea Tully's Coffee – coffee retailer and wholesaler Uwajimaya – Asian supermarket Healthcare CellNetix Center for Global Infectious Disease Research Emeritus Senior Living Fred Hutchinson Cancer Research Center Northwest Kidney Centers PATH The Polyclinic Providence Health and Services Remote Medical International Ventec Life Systems Insurance PEMCO – auto, home, boat, and life insurance Safeco – property insurance Trupanion – pet insurance Intellectual property Getty Images – stock photography Intellectual Ventures – patent assertion hedge fund Internet Allrecipes.com – online recipe service and forum Amazon – retail Avvo – legal services search BuddyTV – TV news, second screen technology (Business closed) Cheezburger – operates many humor web blogs such as I Can Has Cheezburger? and FAIL Blog Classmates.com – social networking service eNotes.com – educational resource service ExtraHop Networks – cloud security analytics F5 Networks – application delivery controllers findwell – online real estate brokerage Groundspeak – operators of Geocaching.com Leafly – cannabis information Onvia – government business