Scotland Yard, with Beth as their supervising officer and Chief Inspector Charles Grayson as hers, but they also work for private citizens. They are often assisted by the new Baker Street Irregulars: the football player Wiggins, the Cockney Deidre, and the paraplegic Tennyson, who communicates through electronic beeps (which Holmes understands after learning about 22nd century advances in technology and Morse code). The primary villains are Moriarty and Fenwick (who Moriarty has manipulated into being his loyal henchman), appearing as they do in almost half of the produced episodes. Each episode is inspired by one of the literary works of Sir Arthur Conan Doyle. Many of these are direct rewrites of the original stories—such as "The Adventure of the Empty House", "The Adventure of the Speckled Band", "The Five Orange Pips", "The Red-Headed League", and "The Adventure of the Engineer's Thumb"—while others are drastically different from the stories on which they are based. Visually, the series is a blend of traditional 2-D and 3-D CGI animation. Voice cast Jason Gray-Stanford as Sherlock Holmes: The Great Detective himself, Holmes was brought back in the 22nd century to combat the clone of his nemesis, Professor Moriarty. Despite initial trouble with adapting to the era, Holmes acclimatizes and uses his knowledge of the future to often help his allies out of death traps. John Payne as Dr. John H. Watson: A compudroid that initially worked as Lestrade's assistant. He later read the original Dr. John H. Watson's journals and was able to emulate his persona from them. He currently resides at 221B Baker Street with Holmes. Akiko Morison as Inspector Beth Lestrade: A descendant of Inspector G. Lestrade, Holmes' old ally from Scotland Yard. Often annoyed with Holmes' constant disregard for protocol, she nonetheless appreciates his continued help, despite direct orders from Grayson. Viv Leacock as Wiggins, leader of the new Baker Street Irregulars. Wiggins was once a football player, but has since retired from the profession due to an injury. He has shown intelligence and reasoning skills that were enough to impress even Holmes. Jennifer Copping as Deidre, another of the Irregulars, who is a fashionable young woman with a Cockney accent. In contrast to the more outlandish rest of the cast, she provides the perspective of a more typical member of New London society. Richard Newman as Professor James Moriarty: A clone of the original created by Fenwick, hoping to use