the late 17th century. Also, Leibniz did a great deal of work with developing consistent and useful notation and concepts. Newton provided some of the most important applications to physics, especially of integral calculus. By the middle of the 17th century, European mathematics had changed its primary repository of knowledge. In comparison to the last century which maintained Hellenistic mathematics as the starting point for research, Newton, Leibniz and their contemporaries increasingly looked towards the works of more modern thinkers. Newton came to calculus as part of his investigations in physics and geometry. He viewed calculus as the scientific description of the generation of motion and magnitudes. In comparison, Leibniz focused on the tangent problem and came to believe that calculus was a metaphysical explanation of change. Importantly, the core of their insight was the formalization of the inverse properties between the integral and the differential of a function. This insight had been anticipated by their predecessors, but they were the first to conceive calculus as a system in which new rhetoric and descriptive terms were created. Newton Newton completed no definitive publication formalizing his fluxional calculus; rather, many of his mathematical discoveries were transmitted through correspondence, smaller papers or as embedded aspects in his other definitive compilations, such as the Principia and Opticks. Newton would begin his mathematical training as the chosen heir of Isaac Barrow in Cambridge. His aptitude was recognized early and he quickly learned the current theories. By 1664 Newton had made his first important contribution by advancing the binomial theorem, which he had extended to include fractional and negative exponents. Newton succeeded in expanding the applicability of the binomial theorem by applying the algebra of finite quantities in an analysis of infinite series. He showed a willingness to view infinite series not only as approximate devices, but also as alternative forms of expressing a term. Many of Newton's critical insights occurred during the plague years of 1665–1666 which he later described as, "the prime of my age for invention and minded mathematics and [natural] philosophy more than at any time since." It was during his plague-induced isolation that the first written conception of fluxionary calculus was recorded in the unpublished De Analysi per Aequationes Numero Terminorum Infinitas. In this paper, Newton determined the area under a curve by first calculating a momentary rate of change and then extrapolating the total area. He began by reasoning