10 February 2021, Tottenham were knocked out of the FA Cup, losing 5–4 after extra time to Everton in the quarter-finals; this was the first time since 2010 that a José Mourinho-led team had conceded five goals in a match. On 23 February 2021, Tottenham lost 1–0 to Chelsea, marking the first time in his career that Mourinho had lost two consecutive home games. On 18 March, Tottenham lost 3–0 to Dinamo Zagreb after extra time in the second leg of the 2020–21 UEFA Europa League round of 16, being eliminated from the competition 3–2 on aggregate. On 19 April 2021, Mourinho was sacked by Tottenham Hotspur after 17 months in charge of the club, days before the EFL Cup Final against Manchester City. This marked the first time Mourinho had departed a club without winning a trophy since 2002. He was replaced by former Tottenham Hotspur player Ryan Mason as interim manager. Roma On 4 May 2021, Mourinho was appointed head coach of Roma from the start of the 2021–22 season, replacing compatriot Paulo Fonseca. 2021–22 season On 19 August 2021, Mourinho managed his first match with Roma in a 2–1 away win against Trabzonspor in the first leg of the UEFA Europa Conference League play-off round. Three days later, he made his return to Serie A, after eleven years, managing a 3–1 home victory over Fiorentina at Stadio Olimpico. On 26 August, Mourinho secured qualification for the Europa Conference League, after overseeing a 3–0 home win against Trabzonspor in the play-off second leg. Mourinho reached 1,000 games as a manager in a 2–1 win against Sassuolo on 12 September 2021. On 26 September against Lazio, Roma lost 2–3, Mourinho became the first Roma manager to lose his first Serie A Roma's derby since Luis Enrique in 2011. On 21 October in a Conference League game against FK Bodø/Glimt, Roma suffered a humiliating 1–6 defeat, Mourinho blamed the defeat on 'not having a very good squad', it was the first time that one of Mourinho's sides conceded 6 goals in one match. Ten days later against Milan, Mourinho suffered his first home defeat in league games in Italy, before this match he was unbeaten in 43 matches in a row. On 4 December against Inter, Roma was defeated 3–0, it was the first time in Mourinho's career that one of his teams was 3–0 down at half-time, he said