"turns in an able performance as Dr. Calvin, the convenient character." With revenue of $347 million worldwide, the film remains Moynahan's most commercially successful picture to date. Her next movie was 2005's Lord of War, a political crime thriller, as Ava Fontaine Orlov, the wife of Nicolas Cage's character. In 2006, Maxim named her number 96 on its annual "Hot 100" list. In September 2006, away from film, Moynahan worked as Whitney Crane in the ABC television drama series Six Degrees co-starring alongside Jay Hernandez, Erika Christensen, Hope Davis, Dorian Missick, and Campbell Scott. The series centered on six residents of New York City and their relationships and connections with one another, based on the idea of six degrees of separation. It debuted on September 20, 2006, and was watched by almost 13.3 million viewers. Six Degrees debuted to varied reception, with David Hinckley of the New York Daily News writing, "In theory, it's an intriguing concept for a series. But in practice, Six Degrees doesn't work at all in drawing you in at the start." After one season, the series was cancelled in May 2007. Moynahan's next film role was in the November 2006 thriller Unknown, about a group of individuals kidnapped and trying to escape their captors together. She was next seen in 2007, in Gray Matters, working with Heather Graham and Tom Cavanagh, before being cast in Henry Bean's comedy-drama Noise, as Helen Owen, the wife of David Owen (Tim Robbins). The movie was screened at a special presentation at the 2007 Rome Film Festival and was released in theaters in 2008. In December 2008, Moynahan guest-starred in two episodes of the ABC television comedy-drama Eli Stone, playing the titular character's (Jonny Lee Miller) ex-girlfriend. Returning to film, Moynahan appeared in Ramona and Beezus, playing the mother to Joey King and Selena Gomez's characters. The film was directed by Elizabeth Allen and released in July 2010. The following year, Moynahan worked with Aaron Eckhart, Michelle Rodriguez, and Michael Peña in the action science-fiction feature Battle: Los Angeles (2011). Away from film, Moynahan stars in the CBS television show Blue Bloods, playing Assistant District Attorney Erin Reagan. In November 2009, she signed a deal with Garnier to appear in television and print advertising promoting their skincare products (Ultra-Lift). In 2014, Moynahan appeared as the late wife of the title character in the action film John Wick, also appearing