But deeply concerned about Imperial arrogance, he was to pick up with France again when Francis I was freed after the Treaty of Madrid (1526): the Pope entered into the League of Cognac together with France, Venice, and Francesco II Sforza of Milan. Clement VII issued an invective against Charles V, who in reply defined him a "wolf" instead of a "shepherd", menacing the summoning of a council about the Lutheran question. Like his cousin Pope Leo X, Clement was considered too generous to his Medici relatives, draining the Vatican treasuries. This included the assignment of positions all the way up to Cardinal, lands, titles, and money. These actions prompted reform measures after Clement's death to help prevent such excessive nepotism. Evangelization In his 1529 bull "Intra Arcana" Clement VII gave a grant of permissions and privileges to Charles V and the Spanish Empire, which included the power of patronage within their colonies in the Americas. Sack of Rome The Pope's wavering politics also caused the rise of the Imperial party inside the Curia: Cardinal Pompeo Colonna's soldiers pillaged Vatican Hill and gained control of the whole of Rome in his name. The humiliated Pope promised therefore to bring the Papal States to the Imperial side again. But soon after, Colonna left the siege and went to Naples, not keeping his promises and dismissing the Cardinal from his charge. From this point on, Clement VII could do nothing but follow the fate of the French party to the end. Soon he found himself alone in Italy too, as Alfonso d'Este, duke of Ferrara, had supplied artillery to the Imperial army, causing the League Army to keep a distance behind the horde of Landsknechts led by Charles III, Duke of Bourbon and Georg von Frundsberg, allowing them to reach Rome without harm. Charles of Bourbon died while mounting a ladder during the short siege and his starving troops, unpaid and left without a guide, felt free to ravage Rome from 6 May 1527. The many incidents of murder, rape, and vandalism that followed ended the splendours of Renaissance Rome forever. Clement VII, who had displayed no more resolution in his military than in his political conduct, was shortly afterwards (6 June) obliged to surrender himself together with the Castel Sant'Angelo, where he had taken refuge. He agreed to pay a ransom of 400,000 ducati in exchange for his life; conditions included