Ādur-hormizd and of Anāhīd. Some individual martyrdoms are recorded from the reign of Khosrow I (), but there were likely no mass persecutions. While according to a peace treaty of 562 between Khosrow and his Roman counterpart Justinian I (), Persia's Christians were granted the freedom of religion; proselytism was, however, a capital crime. By this time the Church of the East and its head, the Catholicose of the East, were integrated into the administration of the empire and mass persecution was rare. The Sassanian policy shifted from tolerance of other religions under Shapur I to intolerance under Bahram I and apparently a return to the policy of Shapur until the reign of Shapur II. The persecution at that time was initiated by Constantine's conversion to Christianity which followed that of Armenian king Tiridates in about 301. The Christians were thus viewed with suspicions of secretly being partisans of the Roman Empire. This did not change until the fifth century when the Church of the East broke off from the Church of the West. Zoroastrian elites continued viewing the Christians with enmity and distrust throughout the fifth century with threat of persecution remaining significant, especially during war against the Romans. Zoroastrian high priest Kartir, refers in his inscription dated about 280 on the Ka'ba-ye Zartosht monument in the Naqsh-e Rostam necropolis near Zangiabad, Fars, to persecution (zatan – "to beat, kill") of Christians ("Nazareans n'zl'y and Christians klstyd'n"). Kartir took Christianity as a serious opponent. The use of the double expression may be indicative of the Greek-speaking Christians deported by Shapur I from Antioch and other cities during his war against the Romans. Constantine's efforts to protect the Persian Christians made them a target of accusations of disloyalty to Sasanians. With the resumption of Roman-Sasanian conflict under Constantius II, the Christian position became untenable. Zoroastrian priests targeted clergy and ascetics of local Christians to eliminate the leaders of the church. A Syriac manuscript in Edessa in 411 documents dozens executed in various parts of western Sasanian Empire. In 341, Shapur II ordered the persecution of all Christians. In response to their subversive attitude and support of Romans, Shapur II doubled the tax on Christians. Shemon Bar Sabbae informed him that he could not pay the taxes demanded from him and his community. He was martyred and a forty-year-long period of persecution of Christians began. The Council of Seleucia-Ctesiphon gave up