nitric oxide (NO). Additionally, the UPS also plays a role in inflammatory responses as regulators of leukocyte proliferation, mainly through proteolysis of cyclines and the degradation of CDK inhibitors. Lastly, autoimmune disease patients with SLE, Sjögren syndrome and rheumatoid arthritis (RA) predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers. See also The Proteolysis Map DSS1/SEM1 protein family Exosome complex Endoplasmic-reticulum-associated protein degradation JUNQ and IPOD References Further reading The Yeast 26S Proteasome with list of subunits and pictures External links Proteasome subunit nomenclature guide 3D proteasome structures in the EM Data Bank(EMDB) Key points of proteasome function Proteins Protein complexes Organelles Apoptosis