their activity has been linked to several disorders including cognitive ageing and neurodegeneration, as well as cancer, diabetes and obesity. Examples Human genes that encode proteins with phosphoprotein phosphatase activity include: Protein serine/threonine phosphatase PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, PPP4C PPP5C, PPP6C Protein tyrosine phosphatase CDC14s: CDC14A, CDC14B, CDC14C, CDKN3 Phosphatase and tensin homologs: PTEN slingshot: SSH1, SSH2, SSH3 Dual-specificity phosphatase DUSP1, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9 DUSP10, DUSP11, DUSP12, DUSP13, DUSP14, DUSP15, DUSP16, DUSP18, DUSP19 DUSP21, DUSP22, DUSP23, DUSP26, DUSP27, DUSP28 Ungrouped CTDP1 CTDSP1, CTDSP2, CTDSPL DULLARD EPM2A ILKAP MDSP PGAM5 PHLPP1, PHLPP2 PPEF1, PPEF2 PPM1A, PPM1B, PPM1D, PPM1E, PPM1F, PPM1G, PPM1H, PPM1J, PPM1K, PPM1L, PPM1M, PPM1N PPTC7 PTPMT1 SSU72 UBLCP1 References Enzymes Post-translational modification Signal transduction