Isabella was the great-great-grandmother of Pope Innocent X, who was therefore descended in a direct line from Alexander. He is an ancestor of virtually all royal houses of Europe, mainly the southern and western ones, for being the ancestor of Dona Luisa de Guzmán, wife of King John IV of Portugal, of the House of Braganza. Death Cesare was preparing for another expedition in August 1503 when, after he and his father had dined with Cardinal Adriano Castellesi on 6 August, they were taken ill with fever a few days later. Cesare, who "lay in bed, his skin peeling and his face suffused to a violet colour" as a consequence of certain drastic measures to save him, eventually recovered; but the aged Pontiff apparently had little chance. Burchard's Diary provides a few details of the pope's final illness and death at age 72: Saturday, 12 August 1503, the pope fell ill in the morning. After the hour of vespers, between six and seven o'clock a fever appeared and remained permanently. On 15 August thirteen ounces of blood were drawn from him and the tertian ague supervened. On Thursday, 17 August, at nine o'clock in the forenoon he took medicine. On Friday, the 18th, between nine and ten o'clock he confessed to the Bishop Gamboa of Carignola, who then read Mass to him. After his Communion he gave the Eucharist to the pope who was sitting in bed. Then he ended the Mass at which were present five cardinals, Serra, Juan and Francesco Borgia, Casanova and Loris. The pope told them that he felt very bad. At the hour of vespers after Gamboa had given him Extreme Unction, he died. As for his true faults, known only to his confessor, Pope Alexander VI apparently died genuinely repentant. The bishop of Gallipoli, Alexis Celadoni, spoke of the pontiff's contrition during his funeral oration to the electors of Alexander's successor, pope Pius III: When at last the pope was suffering from a very severe sickness, he spontaneously requested, one after another, each of the last sacraments. He first made a very careful confession of his sins, with a contrite heart, and was affected even to the shedding of tears, I am told; then he received in Communion the most Sacred Body and Extreme Unction was administered to him. The interregnum witnessed again the ancient "tradition" of violence and rioting. Cesare, too ill to