countries. Society and culture Cost In British Columbia, Canada the cost of the PPIs varies significantly from to per dose while all agents in the class appear more or less equally effective. Regulatory approval A comparative table of FDA-approved indications for PPIs is shown below. Research COVID-19 According to one study proton-pump inhibitors may increase the severity of symptoms of COVID-19. References External links Gastroenterology Proton-pump inhibitors World Health Organization essential medicines