(), charm (), bottom (), and top (). Antiparticles of quarks are called antiquarks, and are denoted by a bar over the symbol for the corresponding quark, such as for an up antiquark. As with antimatter in general, antiquarks have the same mass, mean lifetime, and spin as their respective quarks, but the electric charge and other charges have the opposite sign. Quarks are spin- particles, which means they are fermions according to the spin–statistics theorem. They are subject to the Pauli exclusion principle, which states that no two identical fermions can simultaneously occupy the same quantum state. This is in contrast to bosons (particles with integer spin), of which any number can be in the same state. Unlike leptons, quarks possess color charge, which causes them to engage in the strong interaction. The resulting attraction between different quarks causes the formation of composite particles known as hadrons (see "Strong interaction and color charge" below). The quarks that determine the quantum numbers of hadrons are called valence quarks; apart from these, any hadron may contain an indefinite number of virtual "sea" quarks, antiquarks, and gluons, which do not influence its quantum numbers. There are two families of hadrons: baryons, with three valence quarks, and mesons, with a valence quark and an antiquark. The most common baryons are the proton and the neutron, the building blocks of the atomic nucleus. A great number of hadrons are known (see list of baryons and list of mesons), most of them differentiated by their quark content and the properties these constituent quarks confer. The existence of "exotic" hadrons with more valence quarks, such as tetraquarks () and pentaquarks (), was conjectured from the beginnings of the quark model but not discovered until the early 21st century. Elementary fermions are grouped into three generations, each comprising two leptons and two quarks. The first generation includes up and down quarks, the second strange and charm quarks, and the third bottom and top quarks. All searches for a fourth generation of quarks and other elementary fermions have failed, and there is strong indirect evidence that no more than three generations exist. Particles in higher generations generally have greater mass and less stability, causing them to decay into lower-generation particles by means of weak interactions. Only first-generation (up and down) quarks occur commonly in nature. Heavier quarks can only be created in high-energy collisions (such as in those