Geiger counters are usually required to detect its presence. In some cases, it may lead to secondary emission of visible light upon its interaction with matter, as in the case of Cherenkov radiation and radio-luminescence. Ionizing radiation has many practical uses in medicine, research, and construction, but presents a health hazard if used improperly. Exposure to radiation causes damage to living tissue; high doses result in Acute radiation syndrome (ARS), with skin burns, hair loss, internal organ failure, and death, while any dose may result in an increased chance of cancer and genetic damage; a particular form of cancer, thyroid cancer, often occurs when nuclear weapons and reactors are the radiation source because of the biological proclivities of the radioactive iodine fission product, iodine-131. However, calculating the exact risk and chance of cancer forming in cells caused by ionizing radiation is still not well understood and currently estimates are loosely determined by population based data from the atomic bombings of Hiroshima and Nagasaki and from follow-up of reactor accidents, such as the Chernobyl disaster. The International Commission on Radiological Protection states that "The Commission is aware of uncertainties and lack of precision of the models and parameter values", "Collective effective dose is not intended as a tool for epidemiological risk assessment, and it is inappropriate to use it in risk projections" and "in particular, the calculation of the number of cancer deaths based on collective effective doses from trivial individual doses should be avoided." Ultraviolet radiation Ultraviolet, of wavelengths from 10 nm to 125 nm, ionizes air molecules, causing it to be strongly absorbed by air and by ozone (O3) in particular. Ionizing UV therefore does not penetrate Earth's atmosphere to a significant degree, and is sometimes referred to as vacuum ultraviolet. Although present in space, this part of the UVA spectrum is not of biological importance, because it does not reach living organisms on Earth. There is a zone of the atmosphere in which ozone absorbs some 98% of non-ionizing but dangerous UV-C and UV-B. This so-called ozone layer starts at about and extends upward. Some of the ultraviolet spectrum that does reach the ground is non-ionizing, but is still biologically hazardous due to the ability of single photons of this energy to cause electronic excitation in biological molecules, and thus damage them by means of unwanted reactions. An example is the formation of pyrimidine dimers in DNA, which