of physics that will account for consciousness." Penrose responded to criticism of The Emperor's New Mind with his follow-up 1994 book Shadows of the Mind, and in 1997 with The Large, the Small and the Human Mind. In those works, he also combined his observations with those of anesthesiologist Stuart Hameroff. Penrose and Hameroff have argued that consciousness is the result of quantum gravity effects in microtubules, which they dubbed Orch-OR (orchestrated objective reduction). Max Tegmark, in a paper in Physical Review E, calculated that the time scale of neuron firing and excitations in microtubules is slower than the decoherence time by a factor of at least 10,000,000,000. The reception of the paper is summed up by this statement in Tegmark's support: "Physicists outside the fray, such as IBM's John A. Smolin, say the calculations confirm what they had suspected all along. 'We're not working with a brain that's near absolute zero. It's reasonably unlikely that the brain evolved quantum behavior'". Tegmark's paper has been widely cited by critics of the Penrose–Hameroff position. In their reply to Tegmark's paper, also published in Physical Review E, the physicists Scott Hagan, Jack Tuszyński and Hameroff claimed that Tegmark did not address the Orch-OR model, but instead a model of his own construction. This involved superpositions of quanta separated by 24 nm rather than the much smaller separations stipulated for Orch-OR. As a result, Hameroff's group claimed a decoherence time seven orders of magnitude greater than Tegmark's, but still well short of the 25 ms required if the quantum processing in the theory was to be linked to the 40 Hz gamma synchrony, as Orch-OR suggested. To bridge this gap, the group made a series of proposals. They supposed that the interiors of neurons could alternate between liquid and gel states. In the gel state, it was further hypothesized that the water electrical dipoles are oriented in the same direction, along the outer edge of the microtubule tubulin subunits. Hameroff et al. proposed that this ordered water could screen any quantum coherence within the tubulin of the microtubules from the environment of the rest of the brain. Each tubulin also has a tail extending out from the microtubules, which is negatively charged, and therefore attracts positively charged ions. It is suggested that this could provide further screening. Further to this, there was a suggestion that the microtubules could be pumped into a coherent