many problems with the aspartame studies were minor and did not affect the conclusions, the studies could be used to assess aspartame's safety. In 1980, the FDA convened a Public Board of Inquiry (PBOI) consisting of independent advisors charged with examining the purported relationship between aspartame and brain cancer. The PBOI concluded aspartame does not cause brain damage, but it recommended against approving aspartame at that time, citing unanswered questions about cancer in laboratory rats. In 1983, the FDA approved aspartame for use in carbonated beverages and for use in other beverages, baked goods, and confections in 1993. In 1996, the FDA removed all restrictions from aspartame, allowing it to be used in all foods. Several European Union countries approved aspartame in the 1980s, with EU-wide approval in 1994. The SCF reviewed subsequent safety studies and reaffirmed the approval in 2002. The EFSA reported in 2006 that the previously established ADI was appropriate, after reviewing yet another set of studies. Compendial status British Pharmacopoeia United States Pharmacopeia Commercial uses Under the trade names Equal, NutraSweet, and Canderel, aspartame is an ingredient in approximately 6,000 consumer foods and beverages sold worldwide, including (but not limited to) diet sodas and other soft drinks, instant breakfasts, breath mints, cereals, sugar-free chewing gum, cocoa mixes, frozen desserts, gelatin desserts, juices, laxatives, chewable vitamin supplements, milk drinks, pharmaceutical drugs and supplements, shake mixes, tabletop sweeteners, teas, instant coffees, topping mixes, wine coolers, and yogurt. It is provided as a table condiment in some countries. Aspartame is less suitable for baking than other sweeteners because it breaks down when heated and loses much of its sweetness. NutraSweet Company In 1985, Monsanto bought G.D.Searle, and the aspartame business became a separate Monsanto subsidiary, NutraSweet. In March 2000, Monsanto sold it to J.W. Childs Associates Equity Partners II L.P. European use patents on aspartame expired starting in 1987, and the US patent expired in 1992. Since then, the company has competed for market share with other manufacturers, including Ajinomoto, Merisant, and the Holland Sweetener Company. Ajinomoto Many aspects of industrial synthesis of aspartame were established by Ajinomoto. In 2004, the market for aspartame, in which Ajinomoto, the world's largest aspartame manufacturer, had a 40% share, was a year, and consumption of the product was rising by 2% a year. Ajinomoto acquired its aspartame business in 2000 from Monsanto for $67 million (equivalent to $ in ). In 2007,