bulimia, and post-traumatic stress disorder, as well as borderline personality disorder. MAOIs appear to be particularly effective in the management of bipolar depression according to a retrospective-analysis. There are reports of MAOI efficacy in obsessive–compulsive disorder (OCD), trichotillomania, dysmorphophobia, and avoidant personality disorder, but these reports are from uncontrolled case reports. MAOIs can also be used in the treatment of Parkinson's disease by targeting MAO-B in particular (therefore affecting dopaminergic neurons), as well as providing an alternative for migraine prophylaxis. Inhibition of both MAO-A and MAO-B is used in the treatment of clinical depression and anxiety disorders. NMDA receptor antagonists NMDA receptor antagonists like Ketamine and Esketamine are rapid-acting antidepressants and seem to work via blockade of the ionotropic glutamate NMDA receptor. Others See the list of antidepressants and management of depression for other drugs that are not specifically characterized. Adjuncts Adjunct medications are an umbrella category of substances that increase the potency or "enhance" antidepressants. They work by affecting variables very close to the antidepressant, sometimes affecting a completely different mechanism of action. This may be attempted when depression treatments have not been successful in the past. Common types of adjunct medication techniques generally fall into the following categories: Two or more antidepressants taken together From the same class (affecting the same area of the brain, often at a much higher level) From different classes (affecting multiple parts of the brain not covered simultaneously by either drug alone) An antipsychotic combined with an antidepressant, particularly atypical antipsychotics such as Aripiprazole (Abilify), Quetiapine (Seroquel), Olanzapine (Zyprexa), and Risperidone (Risperdal). It is unknown if undergoing psychological therapy at the same time as taking anti-depressants enhances the anti-depressive effect of the medication. Less common adjuncts Lithium has been used to augment antidepressant therapy in those who have failed to respond to antidepressants alone. Furthermore, Lithium dramatically decreases the suicide risk in recurrent depression. There is some evidence for the addition of a thyroid hormone, triiodothyronine, in patients with normal thyroid function. Psychopharmacologists have also tried adding a stimulant, in particular, D-amphetamine. However, the use of stimulants in cases of treatment-resistant depression is relatively controversial. A review article published in 2007 found psychostimulants may be effective in treatment-resistant depression with concomitant antidepressant therapy, but a more certain conclusion could not be drawn due to substantial deficiencies in the studies available for consideration, and the somewhat contradictory nature of their results. History Before the