call it shori. History Evidence of ayahuasca use dates back at least 1,000 years, as demonstrated by a bundle containing the residue of ayahuasca ingredients and various other preserved shamanic substances in a cave in southwestern Bolivia, discovered in 2010. In the 16th century, Christian missionaries from Spain first encountered indigenous western Amazonian basin South Americans using ayahuasca; their earliest reports described it as "the work of the devil". In 1905, the active chemical constituent of B. caapi was named telepathine, but in 1927, it was found to be identical to a chemical already isolated from Peganum harmala and was given the name harmine. Beat writer William S. Burroughs read a paper by Richard Evans Schultes on the subject and while traveling through South America in the early 1950s sought out ayahuasca in the hopes that it could relieve or cure opiate addiction (see The Yage Letters). Ayahuasca became more widely known when the McKenna brothers published their experience in the Amazon in True Hallucinations. Dennis McKenna later studied pharmacology, botany, and chemistry of ayahuasca and oo-koo-he, which became the subject of his master's thesis. Richard Evans Schultes allowed Claudio Naranjo to make a special journey by canoe up the Amazon River to study ayahuasca with the South American Indians. He brought back samples of the beverage and published the first scientific description of the effects of its active alkaloids. In Brazil, a number of modern religious movements based on the use of ayahuasca have emerged, the most famous being Santo Daime and the União do Vegetal (or UDV), usually in an animistic context that may be shamanistic or, more often (as with Santo Daime and the UDV), integrated with Christianity. Both Santo Daime and União do Vegetal now have members and churches throughout the world. Similarly, the US and Europe have started to see new religious groups develop in relation to increased ayahuasca use. Some Westerners have teamed up with shamans in the Amazon forest regions, forming ayahuasca healing retreats that claim to be able to cure mental and physical illness and allow communication with the spirit world. In recent years, the brew has been popularized by Wade Davis (One River), English novelist Martin Goodman in I Was Carlos Castaneda, Chilean novelist Isabel Allende, writer Kira Salak, author Jeremy Narby (The Cosmic Serpent), author Jay Griffiths (Wild: An Elemental Journey), American novelist Steven Peck, radio personality Robin Quivers, and