regained their independence. By the Peace of Antalcidas (387 BCE), which ended the Corinthian War, Persia regained control over Ionia. In 334 BCE, the Macedonian Greek king Alexander the Great conquered the Anatolian peninsula from the Achaemenid Persian Empire. Alexander's conquest opened up the interior of Asia Minor to Greek settlement and influence. Following the death of Alexander the Great and the subsequent breakup of the Macedonian Empire, Anatolia was ruled by a series of Hellenistic kingdoms, such as the Attalids of Pergamum and the Seleucids, the latter controlling most of Anatolia. A period of peaceful Hellenization followed, such that the local Anatolian languages had been supplanted by Greek by the 1st century BCE. In 133 BCE the last Attalid king bequeathed his kingdom to the Roman Republic; western and central Anatolia came under Roman control, but Hellenistic culture remained predominant. Mithridates VI Eupator, ruler of the Kingdom of Pontus in northern Anatolia, waged war against the Roman Republic in the year 88 BCE in order to halt the advance of Roman hegemony in the Aegean Sea region. Mithridates VI sought to dominate Asia Minor and the Black Sea region, waging several hard-fought but ultimately unsuccessful wars (the Mithridatic Wars) to break Roman dominion over Asia and the Hellenic world. He has been called the greatest ruler of the Kingdom of Pontus. Further annexations by Rome, in particular of the Kingdom of Pontus by Pompey, brought all of Anatolia under Roman control, except for the southeastern frontier with the Parthian Empire, which remained unstable for centuries, causing a series of military conflicts that culminated in the Roman–Parthian Wars (54 BCE – 217 CE). Early Christian Period After the first division of the Roman Empire, Anatolia became part of the Eastern Roman Empire, otherwise known as the Byzantine Empire or Byzantium. In the 1st century CE, Anatolia became one of the first places where Christianity spread, so that by the 4th century CE, western and central Anatolia were overwhelmingly Christian and Greek-speaking. Byzantine Anatolia was one of the wealthiest and most densely populated places in the Later Roman Empire. Anatolia's wealth grew during the 4th and 5th centuries thanks, in part, to the Pilgrim's Road that ran through the peninsula. Literary evidence about the rural landscape stems from the Christian hagiographies of the 6th-century Nicholas of Sion and 7th-century Theodore of Sykeon. Large and prosperous urban centers of Byzantine Anatolia included