time he and his men reached another village, many of them were sick from hunger and eating "noxious plants", and near death. Seven men died in that village. His men threatened to mutiny if the expedition turned back to attempt to rejoin Pizarro, the party being over 100 leagues downstream at this point. He accepted to change the purpose of the expedition to discover new lands in the name of the king of Spain, and the men built a larger boat in which to navigate downstream. After a journey of down the Napo River, they reached a further major confluence, at a point near modern Iquitos, and then followed the upper Amazon, now known as the Solimões, for a further to its confluence with the Rio Negro (near modern Manaus), which they reached on 3 June 1542. Regarding the initial mission of finding cinnamon, Pizarro reported to the king that they had found cinnamon trees, but that they could not be profitably harvested. True cinnamon (Cinnamomum Verum) is not native to South America. Other related cinnamon-containing plants (of the family Lauraceae) are fairly common in that part of the Amazon and Pizarro probably saw some of these. The expedition reached the mouth of the Amazon on 24 August 1542, demonstrating the practical navigability of the Great River. In 1560, another Spanish conquistador, Lope de Aguirre, may have made the second descent of the Amazon. Historians are uncertain whether the river he descended was the Amazon or the Orinoco River, which runs more or less parallel to the Amazon further north. Portuguese explorer Pedro Teixeira was the first European to travel up the entire river. He arrived in Quito in 1637, and returned via the same route. From 1648 to 1652, Portuguese Brazilian bandeirante António Raposo Tavares led an expedition from São Paulo overland to the mouth of the Amazon, investigating many of its tributaries, including the Rio Negro, and covering a distance of over . In what is currently in Brazil, Ecuador, Bolivia, Colombia, Peru, and Venezuela, several colonial and religious settlements were established along the banks of primary rivers and tributaries for trade, slaving, and evangelization among the indigenous peoples of the vast rainforest, such as the Urarina. In the late 1600s, Czech Jesuit Father Samuel Fritz, an apostle of the Omagus established some forty mission villages. Fritz proposed that the Marañón River must be the source of the