SNPs. A number of additional miR-206 regulatory modules have been identified, such as the lncRNA HOTAIR mediated up-regulation of Bcl-w through sequestration of miR-206 which in turn enhances cellular proliferation in breast cancer cells. This study indicates miR-206 can interact with other non-coding RNAs to control a variety of tumorigenic process in a number of cancer systems. In support of this, SNHG14 can also sponge miR-206 thereby modulating the abundance of YWHAZ in cervical cancer. Together, these studies and the numerous studies not cited here due to space limitations, clearly show the therapeutic potential of a miRNA such as miR-206 in the oncological setting. Outside the realm of tumor biology, miR-206 is of clinical interest due to the continued detection of this miRNA in samples from those with type 2 diabetes (TIID) and non-alcoholic fatty liver disease (NAFLD). In some studies the therapeutic delivery of miR-206 in a dietary obese mouse model resulted in reduced lipid and glucose production within the liver. The ability of miR-206 to facilitate insulin signaling and modulate lipogenesis indicates miR-206 may be a novel therapy for those with hyperglycemia. Mir-206 has also recently been identified as a biomarker for certain limb dystrophies, while circulating miR-206 levels are associative with preeclampsia. References MicroRNA Breast cancer Hormones Estradiol Cancer