Clark Lawrence Anderson is an internist and immunologist. He is professor emeritus in the Division of Immunology and Rheumatology, Department of Internal Medicine, Ohio State University (OSU), Columbus, Ohio, United States. Education and personal life Anderson studied medicine and biochemistry at the University of Chicago (MD 1964) after a grounding in the liberal arts at Brown University and the University of Arizona. Upon being drafted as a physician into the Army during the Vietnam War, he served three years in Germany and then continued postgraduate education in internal medicine at the University of Colorado. Subsequent to postdoctoral research in immunochemistry with Richard Farr, Percy Minden, and Howard Grey at the National Jewish Hospital in Denver, CO, he joined the faculty at the University of Rochester in 1977; and in 1986 he moved to OSU as professor in the Departments of Internal Medicine, Molecular and Cellular Biochemistry, and Molecular Genetics. Anderson is married to Carole Ann Anderson, administrator in higher education, former dean of the OSU College of Nursing, the College of Dentistry, and the Graduate School; former president of the American Association of Colleges of Nursing and fellow of the American Academy of Nursing. The couple has three daughters. Research areas Anderson's academic career, funded continuously for more than 40 years by R01 grants from the National Institutes of Health, has focused on how Immunoglobulin G (IgG) antibodies mediate their cell biological effects through the family of Fcγ receptors (a class of Fc receptors that are members of the immunoglobulin superfamily). His research contributions to biomedicine and immunology fall into four major groups: 1. The Fcγ Receptor (FcγR) family of molecules. Anderson's early work on identifying and characterizing the high affinity FcγRI and low affinity FcγRII for IgG on human monocytes and other cells was aided by his development of monoclonal antibodies (mab) to both of these receptors, mab 32.2 (US Patent US4954617A awarded in 1990) to the former in collaboration with Michael Fanger and Paul Guyre, and mab IV.3 to the latter in collaboration with R. John Looney. To facilitate the clinical application of these antibodies, Anderson enabled the establishment by Fanger and Guyre of Medarex, Inc., a biotech company since acquired by Bristol-Myers Squibb for 2.4 billion $US. Further studies by Anderson showed FcRI to be associated with the FcRγ chain, and that both receptors upon clustering mediated intracellular kinase cascades that triggered various biological effects. This early