onscreen role in the ABC miniseries When We Rise while still a student at Yale. In the series, Majors portrayed real-life gay activist Ken Jones; as part of his research for the role, he met with Jones before playing him. That same year, Majors appeared in his first feature film role as Corporal Henry Woodson in the revisionist Western film Hostiles, written and directed by Scott Cooper. The film had its world premiere at the Telluride Film Festival on September 2, 2017. It was also screened at the Toronto International Film Festival on September 10, 2017. More roles followed, in the 2018 films White Boy Rick and Out of Blue. Both of these films screened at the 2018 Toronto International Film Festival, with the latter competing for the Platform Prize. In 2019, Majors rose to prominence after starring in Joe Talbot's critically acclaimed independent feature film The Last Black Man in San Francisco, for which he received an Independent Spirit Award nomination. The film had its world premiere at the Sundance Film Festival on January 26, 2019. It was released by A24 in the United States on June 7, 2019. Former President of the United States Barack Obama rated it as one of the best films of 2019. Majors's performance was praised by critics: Manohla Dargis of The New York Times called his performance "a mournful heartbreaker", while Rolling Stone described his turn as "both deeply sensitive and charmingly left-of-center". Majors also appeared in three other 2019 film releases: Captive State, Gully, and Jungleland. In 2020, Majors starred alongside Chadwick Boseman and Delroy Lindo in Spike Lee's war drama film Da 5 Bloods, which was released on Netflix. That year, he also garnered wider notice for portraying Atticus Freeman in the HBO television series Lovecraft Country. His performance in Lovecraft Country was favorably reviewed by critics; Vogue dubbed him "the emotional core of the show". Majors debuted in the Marvel Cinematic Universe Disney+ series Loki as "He Who Remains". In 2021, Majors starred as the lead actor in Jeymes Samuel's directorial debut film The Harder They Fall, acting alongside Idris Elba, Zazie Beetz, Regina King and Delroy Lindo. In 2023, he starred in Magazine Dreams and Creed III as Damian 'Dame' Anderson. He portrayed Kang the Conqueror and several other variants of the character in Ant-Man and the Wasp: Quantumania. In 2023, Majors confirmed he will be playing Dennis Rodman