the paw pads and eye rims towards bluish grey if B/- or taupe if b/b, and slight to moderate reduction of eye color from brown towards amber in a B/- animal, or from hazel towards light amber in a b/b animal. D is completely dominant to d. This dilution gene can occur in almost any breed, where blue gene is the most common. Also, there are some breeds that come in dilute but with no specific color, such as the Weimaraner or the Slovakian Pointer. Some breeds that are commonly known to have dilution genes are "Italian greyhounds, whippets, Tibetan mastiffs, greyhounds, Staffordshire bull terriers, and Neapolitan mastiffs". Color gene interactions I (intensity) locus The alleles responsible for pheomelanin dilution (changing of a dog's coat from tan to cream or white) was found to be the result of a mutation in MFSD12 in 2019. and occurs in breeds that do not exhibit dark gold or red phenotypes. Two alleles are theorised to occur at the I locus: I = Non-diluted pigment i = Diluted pigment It's been observed that I and i interact with semi-dominance, so that there are three distinct phenotypes. I/i heterozygotes are paler than I/I animals but normally darker than i/i animals. i results in diluted phaeomelanin such as cream, yellow, and white. Unlike d/d, it allows the skin and eyes to remain dark. It does not effect eumelanin (black/brown/blue/lilac) pigment, i.e. leaving a cream Afghan with a very black mask. This is not to be confused with the cream or white in Nordic Breeds such as the Siberian Husky, or cream roan in the Australian Cattle Dog, whose cream and white coats are controlled by genes in the Extension E Locus. Red Pigment Pigment Intensity for dogs who are darker than Tan (shades of gold to red) has been attributed to a mutation upstream of KITLG, in the same genes responsible for coat color in mice and hair color in humans. The mutation is the result of a Copy Number Variant, or duplication of certain instructions within a gene, that controls the distribution of pigment in a dog's hair follicle. As such, there are no genetic markers for red pigment. Dogs with a higher CNV were observed to have darker, richer colors such as deep gold, red, and chestnut. Dogs with a lower CNV were observed to have lighter gold and orange colors. This mutation not