Member of Parliament on the opposition benches. She did not contest her seat in the next election. She was elected as a National Executive Member of the National Democratic Congress in 2005 and in 2008 she was appointed as National Communications Director of the NDC, replacing John Dramani Mahama, who had become the vice presidential candidate of the NDC as the running mate of John Atta Mills, the party's presidential candidate. The 2008 presidential campaign and the role she played in managing the party's communication strategy for that election made her a more prominent political figure and she became one of the main spokespersons for the NDC. Minister of Trade and Industry, 2009–2013 After the NDC victory in the 2008 elections Tetteh became the Spokesperson for the newly elected Government while the process of making new appointments was ongoing and in February 2009 President John Atta Mills nominated her for the position of Minister of Trade and Industry. Following her confirmation by Parliament she took over the portfolio and held the position of Minister of Trade and Industry from February 2009 to January 2013. During her tenure as Minister of Trade and Industry she was also a member of the Government's economic management team, a member of the board of the Millennium Development Authority responsible for the oversight of the implementation of the first Millennium Challenge Corporation Compact in Ghana. She also served on the National Development Planning Commission, and was the Chairperson of the Ghana Free Zones Board (GFZB). Back to Parliament, 2013–2017 When John Mahama succeeded the deceased President Atta Mills in 2012, he also appointed Tetteh as the Communications Director for his 2012 election campaign. She also decided to contest for a parliamentary seat once again and was elected to the newly created Awutu Senya West constituency seat in the December 2012 election after serving as member of parliament for Awutu Senya Constituency from 2001 to 2005. She won the seat after getting 23,032 votes representing 55.47% against his closest contender Oppey Abbey also a former Member of Parliament for Awutu Senya Constituency who got 18,487 votes representing 44.53%. She lost the seat to George Andah in the 2016 parliamentary election who got 28,867 votes, 52.27% against her 25,664 votes representing 46.87%. Minister of Foreign Affairs, 2013–2017 Following the elections, Tetteh was nominated by President Mahama as Minister for Foreign Affairs and appointed as such in January