Montepulciano is a town in the province of Siena in southern Tuscany, Italy. Montepulciano may also refer to: Montepulciano (grape), a red Italian wine grape variety Montepulciano d'Abruzzo, a red Italian wine made from the Montepulciano grape in the Abruzzo region Vino Nobile di Montepulciano, a red Italian wine produced in the town of Montepulciano, Italy See also Club Montepulciano, a former London nightclub Lago di Montepulciano, a lake in the Province of Siena, Tuscany, Italy