CGP-35348 is a compound used in scientific research which acts as an antagonist at GABAB receptors. CGP-35348 was ineffective up to 100 μM to antagonize the inhibitory release of GABA elicited by baclofen, doing it selective as GABAB heteroreceptor antagonist. Moreover, CGP-35348 was about threefold less potent to antagonize gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) than baclofen and SKF-97,541. References GABAB receptor antagonists Phosphinic acids