December 5 | @ Detroit Pistons | | Antawn Jamison (22) | Anderson Varejão (14) | Mo Williams (10) | The Palace of Auburn Hills13,081 | 7–13 |- bgcolor="#ffcccc" | 21 | December 7 | @ Philadelphia 76ers | | J. J. Hickson (18) | Anderson Varejão (8) | Mo Williams (7) | Wells Fargo Center10,662 | 7–14 |- bgcolor="#ffcccc" | 22 | December 8 | Chicago Bulls | | Antawn Jamison (21) | Anderson Varejão (12) | Mo Williams (10) | Quicken Loans Arena20,562 | 7–15 |- bgcolor="#ffcccc" | 23 | December 11 | @ Houston Rockets | | Antawn Jamison (24) | Anderson Varejão (8) | Mo Williams (9) | Toyota Center15,532 | 7–16 |- bgcolor="#ffcccc" | 24 | December 12 | @ Oklahoma City Thunder | | Anthony Parker (12) | Anderson Varejão (16) | Mo Williams (4) | Oklahoma City Arena18,203 | 7–17 |- bgcolor="#ffcccc" | 25 | December 15 | @ Miami Heat | | Daniel Gibson (26) | Anderson Varejão (15) | Mo Williams (9) | American Airlines Arena19,899 | 7–18 |- bgcolor="#ffcccc" | 26 | December 17 | @ Indiana Pacers | | Mo Williams (22) | Antawn Jamison (7) | Mo Williams (11) | Conseco Fieldhouse12,021 | 7–19 |- bgcolor="#ccffcc" | 27 | December 18 | New York Knicks | | Mo Williams (23) | Anderson Varejão (17) | Mo Williams (14) | Quicken Loans Arena20,562 | 8–19 |- bgcolor="#ffcccc" | 28 | December 20 | Utah Jazz | | Daniel Gibson (29) | J. J. Hickson (9) | Mo Williams (10) | Quicken Loans Arena20,562 | 8–20 |- bgcolor="#ffcccc" | 29 | December 22, 2010 | @ Atlanta | | Antawn Jamison (23) | Anderson Varejão (13) | Mo Williams (11) | Philips Arena12,610 | 8–21 |- bgcolor="#ffcccc" | 30 | December 26 | Minnesota Timberwolves | | Antawn Jamison (24) | Anderson Varejão (12) | Mo Williams (11) | Quicken Loans Arena20,562 | 8–22 |- bgcolor="#ffcccc" | 31 | December 28 | Orlando Magic | | Antawn Jamison (21) | Anderson Varejão (9) | Mo Williams (8) | Quicken Loans Arena20,562 | 8–23 |- bgcolor="#ffcccc" | 32 | December 29 | @ Charlotte Bobcats | | Ramon Sessions (22) | Anderson Varejão (10) | Anthony Parker (6) | Time Warner Cable Arena15,287 | 8–24 |- bgcolor="#ffcccc" | 33 | January 1 | @ Chicago Bulls | | J. J. Hickson