Márquez would remain inactive for almost another year as a fourth fight between him and Vázquez was scheduled for May 2010. Due to Vázquez's inactivity he was stripped of his title, meaning that the fourth meeting between the pair would be a non-title fight. Márquez, who was a greater than 2-1 favourite for the fight, once again predicted that he would be victorious by knockout. The fourth fight between Vázquez and Márquez was generally considered to be the least entertaining of the series. The fight was also the most one-sided of the series with Márquez easily outboxing Vázquez. After a dominating opening round for Márquez he was able to open a deep cut over Vázquez's left eye in the second round before opening another over his right eye in the third. The cuts left Vázquez's vision severely impaired. Not helped by his poor vision, Vázquez was knocked down early in round three by a Márquez right hand. Although Vázquez was able to beat the referee's count, he was to be stopped later in the round after taking a series of heavy shots. After Márquez was declared the winner, and with the series standing equal, both fighters expressed an interest in a fifth meeting. This has not been encouraged by the boxing media and even Frank Espinoza, Vazquez's longtime handler, stated that "His career is over" This opinion was echoed by several other boxing writers who claimed that, due to the injuries Vazquez suffered to his eyes, he should retire. Instead of a fifth fight with Vázquez, Márquez fought Juan Manuel López and lost after failing to come out for the ninth round. References Boxing rivalries Boxing on Showtime