33–15–5 || 71 || |- align="center" bgcolor="ccffcc" | 54 || February 6 || Pittsburgh Penguins || 4–2 || || Vasilevskiy || Amalie Arena || 19,092 || 34–15–5 || 73 || |- align="center" bgcolor="ccffcc" | 55 || February 8 || New York Islanders || 3–1 || || Vasilevskiy || Amalie Arena || 19,092 || 35–15–5 || 75 || |- align="center" bgcolor="ccffcc" | 56 || February 10 || @ Columbus Blue Jackets || 2–1 || OT || McElhinney || Nationwide Arena || 17,131 || 36–15–5 || 77 || |- align="center" bgcolor="ccffcc" | 57 || February 11 || @ Pittsburgh Penguins || 2–1 || OT || Vasilevskiy || PPG Paints Arena || 18,445 || 37–15–5 || 79 || |- align="center" bgcolor="ccffcc" | 58 || February 13 || Edmonton Oilers || 3–1 || || Vasilevskiy || Amalie Arena || 19,092 || 38–15–5 || 81 || |- align="center" bgcolor="ccffcc" | 59 || February 15 || Philadelphia Flyers || 5–3 || || Vasilevskiy || Amalie Arena || 19,092 || 39–15–5 || 83 || |- align="center" bgcolor="ccffcc" | 60 || February 17 || @ Colorado Avalanche || 4–3 || OT || McElhinney || Pepsi Center || 18,107 || 40–15–5 || 85 || |- align="center" bgcolor="ffcccc" | 61 || February 20 || @ Vegas Golden Knights || 3–5 || || Vasilevskiy || T-Mobile Arena || 18,376 || 40–16–5 || 85 || |- align="center" bgcolor="ffcccc" | 62 || February 22 || @ Arizona Coyotes || 3–7 || || Vasilevskiy || Gila River Arena || 14,825 || 40–17–5 || 85 || |- align="center" bgcolor="ffcccc" | 63 || February 25 || Toronto Maple Leafs || 3–4 || || Vasilevskiy || Amalie Arena || 19,092 || 40–18–5 || 85 || |- align="center" bgcolor="ffcccc" | 64 || February 27 || Chicago Blackhawks || 2–5 || || McElhinney || Amalie Arena || 19,092 || 40–19–5 || 85 || |- align="center" bgcolor="ccffcc" | 65 || February 29 || Calgary Flames || 4–3 || || Vasilevskiy || Amalie Arena || 19,092 || 41–19–5 || 87 || |- |- align="center" bgcolor="ffcccc" | 66 || March 3 || Boston Bruins || 1–2 || || Vasilevskiy || Amalie Arena || 19,092 || 41–20–5 || 87 || |- align="center" bgcolor="ccffcc" | 67 || March 5 || Montreal Canadiens || 4–0 || || Vasilevskiy || Amalie Arena || 19,092 || 42–20–5 || 89 || |- align="center" bgcolor="ccffcc" | 68 || March 7 || @ Boston Bruins || 5–3 || || Vasilevskiy