OT || McElhinney || Amalie Arena || 19,092 || 5–3–2 || 12 || |- align="center" bgcolor="ffcccc" | 11 || October 29 || @ New York Rangers || 1–4 || || Vasilevskiy || Madison Square Garden || 17,196 || 5–4–2 || 12 || |- align="center" bgcolor="ccffcc" | 12 || October 30 || @ New Jersey Devils || 7–6 || OT || McElhinney || Prudential Center || 13,152 || 6–4–2 || 14 || |- |- align="center" bgcolor="ffcccc" | 13 || November 1 || @ New York Islanders || 2–5 || || Vasilevskiy || Nassau Coliseum || 12,043 || 6–5–2 || 14 || |- align="center" bgcolor="ccffcc" | 14 || November 8 || @ Buffalo Sabres || 3–2 || || Vasilevskiy || Ericsson Globe† || 13,230 || 7–5–2 || 16 || |- align="center" bgcolor="ccffcc" | 15 || November 9 || Buffalo Sabres || 5–3 || || McElhinney || Ericsson Globe† || 13,339 || 8–5–2 || 18 || |- align="center" bgcolor="ccffcc" | 16 || November 14 || New York Rangers || 9–3 || || Vasilevskiy || Amalie Arena || 19,092 || 9–5–2 || 20 || |- align="center" bgcolor="ffcccc" | 17 || November 16 || Winnipeg Jets || 3–4 || || Vasilevskiy || Amalie Arena || 19,092 || 9–6–2 || 20 || |- align="center" bgcolor="ffcccc" | 18 || November 19 || @ St. Louis Blues || 1–3 || || Vasilevskiy || Enterprise Center || 18,096 || 9–7–2 || 20 || |- align="center" bgcolor="ccffcc" | 19 || November 21 || @ Chicago Blackhawks || 4–2 || || McElhinney || United Center || 21,336 || 10–7–2 || 22 || |- align="center" bgcolor="ccffcc" | 20 || November 23 || Anaheim Ducks || 6–2 || || Vasilevskiy || Amalie Arena || 19,092 || 11–7–2 || 24 || |- align="center" bgcolor="ccffcc" | 21 || November 25 || Buffalo Sabres || 5–2 || || Vasilevskiy || Amalie Arena || 19,092 || 12–7–2 || 26 || |- align="center" bgcolor="ffcccc" | 22 || November 27 || St. Louis Blues || 3–4 || || Vasilevskiy || Amalie Arena || 19,092 || 12–8–2 || 26 || |- align="center" bgcolor="B0C4DE" | 23 || November 29 || @ Washington Capitals || 3–4 || OT || Vasilevskiy || Capital One Arena || 18,573 || 12–8–3 || 27 || |- align="center" bgcolor="ffcccc" | 24 || November 30 || Carolina Hurricanes || 2–3 || || McElhinney || Amalie Arena || 19,092 || 12–9–3 || 27 || |- | colspan=10 | †