|| TD Garden || 17,850 || 43–20–5 || 91 || |- align="center" bgcolor="B0C4DE" | 69 || March 8 || @ Detroit Red Wings || 4–5 || OT || McElhinney || Little Caesars Arena || 18,841 || 43–20–6 || 92 || |- align="center" bgcolor="ffcccc" | 70 || March 10 || @ Toronto Maple Leafs || 1–2 || || Vasilevskiy || Scotiabank Arena || 19,124 || 43–21–6 || 92 || |- |- align="center" bgcolor="" | 71 || March 12 || Philadelphia Flyers || Amalie Arena |- align="center" bgcolor="" | 72 || March 14 || Detroit Red Wings || Amalie Arena |- align="center" bgcolor="" | 73 || March 15 || New Jersey Devils || Amalie Arena |- align="center" bgcolor="" | 74 || March 18 || @ Vancouver Canucks || Rogers Arena |- align="center" bgcolor="" | 75 || March 20 || @ Edmonton Oilers || Rogers Place |- align="center" bgcolor="" | 76 || March 21 || @ Calgary Flames || Scotiabank Saddledome |- align="center" bgcolor="" | 77 || March 25 || Toronto Maple Leafs || Amalie Arena |- align="center" bgcolor="" | 78 || March 27 || Columbus Blue Jackets || Amalie Arena |- align="center" bgcolor="" | 79 || March 28 || New York Rangers || Amalie Arena |- align="center" bgcolor="" | 80 || March 31 || Ottawa Senators || Amalie Arena |- align="center" bgcolor="" | 81 || April 2 || @ Columbus Blue Jackets || Nationwide Arena |- align="center" bgcolor="" | 82 || April 4 || @ Detroit Red Wings || Little Caesars Arena |- |- | Lightning score listed first; Playoffs |- align="center" bgcolor="ccffcc" | 1 || August 3 || Washington Capitals || 3–2 || SO || Vasilevskiy || 1–0–0 || 2 || |- align="center" bgcolor="ccffcc" | 2 || August 5 || @ Boston Bruins || 3–2 || || Vasilevskiy || 2–0–0 || 4 || |- align="center" bgcolor="ffcccc" | 3 || August 8 || Philadelphia Flyers || 1–4 || || Vasilevskiy || 2–1–0 || 4 || |- | colspan=9 | † Games played at Scotiabank Arena in Toronto, Ontario, Canada |- |- | Lightning score listed first; |- align="center" bgcolor="ccffcc" | 1 || August 11 || Columbus Blue Jackets || 3–2 || 5OT || Vasilevskiy || 1–0 || |- align="center" bgcolor="ffcccc" | 2 || August 13 || Columbus Blue Jackets || 1–3 || || Vasilevskiy || 1–1 || |- align="center" bgcolor="ccffcc" | 3 || August 15 || @ Columbus Blue Jackets || 3–2