|| Martin || PNC Arena || || 0–2–0 || |- align="center" bgcolor="ccffcc" | 3 || September 20 || Nashville Predators || 3–1 || || McElhinney || Amalie Arena || 13,456 || 1–2–0 || |- align="center" bgcolor="B0C4DE" | 4 || September 21 || @ Nashville Predators || 4–5 || OT || Wedgewood || Bridgestone Arena || || 1–2–1 || |- align="center" bgcolor="ffcccc" | 5 || September 24 || @ Florida Panthers || 3–6 || || Vasilevskiy || BB&T Center || 8,744 || 1–3–1 || |- align="center" bgcolor="ccffcc" | 6 || September 26 || @ Florida Panthers || 4–2 || || McElhinney || BB&T Center || 8,611 || 2–3–1 || |- align="center" bgcolor="B0C4DE" | 7 || September 28 || Florida Panthers || 0–1 || SO || Vasilevskiy || Amalie Arena || 14,732 || 2–3–2 || |- |- | Lightning score listed first; Regular season |- align="center" bgcolor="ccffcc" | 1 || October 3 || Florida Panthers || 5–2 || || Vasilevskiy || Amalie Arena || 19,092 || 1–0–0 || 2 || |- align="center" bgcolor="ffcccc" | 2 || October 5 || @ Florida Panthers || 3–4 || || Vasilevskiy || BB&T Center || 17,424 || 1–1–0 || 2 || |- align="center" bgcolor="B0C4DE" | 3 || October 6 || @ Carolina Hurricanes || 3–4 || OT || McElhinney || PNC Arena || 14,125 || 1–1–1 || 3 || |- align="center" bgcolor="ccffcc" | 4 || October 10 || @ Toronto Maple Leafs || 7–3 || || Vasilevskiy || Scotiabank Arena || 19,387 || 2–1–1 || 5 || |- align="center" bgcolor="ffcccc" | 5 || October 12 || @ Ottawa Senators || 2–4 || || McElhinney || Canadian Tire Centre || 11,023 || 2–2–1 || 5 || |- align="center" bgcolor="ccffcc" | 6 || October 15 || @ Montreal Canadiens || 3–1 || || Vasilevskiy || Bell Centre || 20,406 || 3–2–1 || 7 || |- align="center" bgcolor="ccffcc" | 7 || October 17 || @ Boston Bruins || 4–3 || SO || Vasilevskiy || TD Garden || 17,193 || 4–2–1 || 9 || |- align="center" bgcolor="ffcccc" | 8 || October 19 || Colorado Avalanche || 2–6 || || Vasilevskiy || Amalie Arena || 19,092 || 4–3–1 || 9 || |- align="center" bgcolor="ccffcc" | 9 || October 23 || Pittsburgh Penguins || 3–2 || || Vasilevskiy || Amalie Arena || 19,092 || 5–3–1 || 11 || |- align="center" bgcolor="B0C4DE" | 10 || October 26 || Nashville Predators || 2–3 ||